SLAMF7-CAR T cells prepared by Sleeping Beauty gene-transfer for immunotherapy of multiple myeloma – a rare hematologic disease

Deliverables

Websites, patent fillings, videos etc. (3)

Report on stakeholder involvement after kick-off meeting

Regulatory workshop

Launch of website and social media accounts

Publications

Peer reviewed articles (13)

Disrupting N-glycan expression on tumor cells boosts chimeric antigen receptor T cell efficacy against solid malignancies

Author(s): Beatrice Greco, Valeria Malacarne, Federica De Girardi, Giulia Maria Scotti, Francesco Manfredi, Elia Angelino, Camilla Sirini, Barbara Camisa, Laura Falcone, Marta Angiola Moresco, Katia Paolella, Mattia Di Bono, Rossana Norata, Francesca Sanvito, Silvia Arcangeli, Claudio Doglioni, Fabio Ciceri, Chiara Bonini, Andrea Graziani, Attilio Bondanza, Monica Casucci
Published in: Science Translational Medicine, 14, 2022, Page(s) eabg3072, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.abg3072

CAR T cell manufacturing from naive/stem memory T lymphocytes enhances antitumor responses while curtailing cytokine release syndrome

Author(s): Silvia Arcangeli, Camilla Bove, Claudia Mezzanotte, Barbara Camisa, Laura Falcone, Francesco Manfredi, Eugenia Bezzecchi, Rita El Khoury, Rossana Norata, Francesca Sanvito, Maurilio Ponzoni, Beatrice Greco, Marta Angiola Moresco, Matteo G. Carrabba, Fabio Ciceri, Chiara Bonini, Attilio Bondanza, and Monica Casucci
Published in: The Journal of Clinical Investigation, 132, 2022, Page(s) e150807, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci150807

Siglec-6 is a novel target for CAR T-cell therapy in acute myeloid leukemia

Author(s): Hardikkumar Jetani, Almudena Navarro-Bailón, Marius Maucher, Silke Frenz, Christina Verbruggen, Ana Yeguas, María Belén Vidriales, Marcos González, Judit Rial Saborido, Sabrina Kraus, Katrin Mestermann, Simone Thomas, Halvard Bonig, Maik Luu, Razieh Monjezi, Dimitrios Mougiakakos, Markus Sauer, Hermann Einsele, Michael Hudecek
Published in: Blood, 138, 2021, Page(s) 1830-1842, ISSN 1528-0020
Publisher: The American Society of Hematology
DOI: 10.1182/blood.2020009192

Non-viral therapeutic cell engineering with the Sleeping Beauty transposon system

Author(s): Michael Hudecek, Zoltán Ivics
Published in: Current Opinion in Genetics & Development, 52, 2018, Page(s) 100-108, ISSN 0959-437X
Publisher: Elsevier BV
DOI: 10.1016/j.gde.2018.06.003

CAR T-Cells in Multiple Myeloma: State of the Art and Future Directions

Author(s): Luis Gerardo Rodríguez-Lobato, Maya Ganzetti, Carlos Fernández de Larrea, Michael Hudecek, Hermann Einsele, Sophia Danhof
Published in: Frontiers in Oncology, 10, 2020, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2020.01243

All-trans retinoic acid works synergistically with the γ-secretase inhibitor crenigacestat to augment BCMA on multiple myeloma and the efficacy of BCMA-CAR T cells

Author(s): Estefanía García-Guerrero Luis G. Rodríguez-Lobato Belén Sierro-Martínez Sophia Danhof Stephan Bates Silke Frenz Larissa Haertle Ralph Götz Markus Sauer Leo Rasche K. Martin Kortüm Jose A. Pérez-Simón Hermann Einsele Michael Hudecek Sabrina R. Prommersberger
Published in: Haematologica, 108, 2023, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2022.281339

Latest Advances for the Sleeping Beauty Transposon System: 23 Years of Insomnia but Prettier than Ever

Author(s): Maximilian Amberger, Zoltán Ivics
Published in: BioEssays, 42/11, 2020, Page(s) 2000136, ISSN 0265-9247
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/bies.202000136

Current Limitations and Perspectives of Chimeric Antigen Receptor-T-Cells in Acute Myeloid Leukemia

Author(s): Marius Maucher, Micha Srour, Sophia Danhof, Hermann Einsele, Michael Hudecek, Ibrahim Yakoub-Agha
Published in: Cancers, 13, 2021, Page(s) 6157, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13246157

CD4 CAR-T cells targeting CD19 play a key role in exacerbating cytokine release syndrome, while maintaining long-term responses

Author(s): Camilla Bove, Silvia Arcangeli, Laura Falcone, Barbara Camisa, Rita El Khoury, Beatrice Greco, Anna De Lucia, Alice Bergamini, Attilio Bondanza, Fabio Ciceri , Chiara Bonini, Monica Casucci
Published in: Journal for Immunotherapy of Cancer, 11, 2023, Page(s) e005878, ISSN 2051-1426
Publisher: BMJ Publishing Group Ltd and Society for Immunotherapy of Cancer
DOI: 10.1136/jitc-2022-005878

Novel targets and technologies for CAR-T cells in multiple myeloma and acute myeloid leukemia

Author(s): Sabrina Prommersberger, Hardikkumar Jetani, Sophia Danhof, Razieh Monjezi, Thomas Nerreter, Julia Beckmann, Herrmann Einsele, Michael Hudecek
Published in: Current Research in Translational Medicine, 66/2, 2018, Page(s) 37-38, ISSN 2452-3186
Publisher: ELSEVIER
DOI: 10.1016/j.retram.2018.03.006

The era of in vivo T cell engineering

Author(s): Gustavo Campos Ramos Michael Hudecek
Published in: Med, 3, 2022, Page(s) 85-86, ISSN 2666-6340
Publisher: Cell Press
DOI: 10.1016/j.medj.2022.01.012

Antibody‐Based CAR T Cells Produced by Lentiviral Transduction

Author(s): Sabrina Prommersberger, Michael Hudecek, Thomas Nerreter
Published in: Current Protocols in Immunology, 128/1, 2020, ISSN 1934-3671
Publisher: Greene Pub. Associates
DOI: 10.1002/cpim.93

CARAMBA: a first-in-human clinical trial with SLAMF7 CAR-T cells prepared by virus-free Sleeping Beauty gene transfer to treat multiple myeloma.

Author(s): Sabrina Prommersberger; Michael Reiser; Michael Reiser; Julia Beckmann; Sophia Danhof; Maximilian Amberger; Patricia Quade-Lyssy; Patricia Quade-Lyssy; Hermann Einsele; Michael Hudecek; Halvard Bonig; Halvard Bonig; Halvard Bonig; Zoltán Ivics
Published in: Gene Therapy, 2, 2021, Page(s) 560-571, ISSN 0969-7128
Publisher: Nature Publishing Group
DOI: 10.1038/s41434-021-00254-w

Other (1)

Genomic Analyses of SLAMF7 CAR-T Cells Manufactured by Sleeping Beauty Transposon Gene Transfer for Immunotherapy of Multiple Myeloma

Author(s): Csaba Miskey, Maximilian Amberger, Michael Reiser, Sabrina Prommersberger, Julia Beckmann, Markus Machwirth, Hermann Einsele, Michael Hudecek, Halvard Bonig, Zoltán Ivics,
Published in: BioRXiv, 24 June 2019, 2019
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/675009