SLAMF7-CAR T cells prepared by Sleeping Beauty gene-transfer for immunotherapy of multiple myeloma – a rare hematologic disease

Project Information

CARAMBA

Grant agreement ID: 754658

DOI

10.3030/754658

Project closed

EC signature date 22 November 2017

Start date 1 January 2018

End date 30 June 2023

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 6 097 875,00

EU contribution

€ 6 097 875,00

Coordinated by

UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (5)

Final dissemination activity on project results
Summer school for young investigators
Report on stakeholder involvement after kick-off meeting
Regulatory workshop
Launch of website and social media accounts

Documents, reports (1)

Publication on the use of patient reported outcomes in CART clinical trials

Publications

Peer reviewed articles (17)

Disrupting N-glycan expression on tumor cells boosts chimeric antigen receptor T cell efficacy against solid malignancies

Author(s): Beatrice Greco, Valeria Malacarne, Federica De Girardi, Giulia Maria Scotti, Francesco Manfredi, Elia Angelino, Camilla Sirini, Barbara Camisa, Laura Falcone, Marta Angiola Moresco, Katia Paolella, Mattia Di Bono, Rossana Norata, Francesca Sanvito, Silvia Arcangeli, Claudio Doglioni, Fabio Ciceri, Chiara Bonini, Andrea Graziani, Attilio Bondanza, Monica Casucci
Published in: Science Translational Medicine, Issue 14, 2022, Page(s) eabg3072, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.abg3072

CAR density influences antitumoral efficacy of BCMA CAR T cells and correlates with clinical outcome

Author(s): Paula Rodriguez-Marquez, Maria E Calleja-Cervantes, Guillermo Serrano, Aina Oliver-Caldes, Maria L Palacios-Berraquero, Angel Martin-Mallo, Cristina Calviño, Marta Español-Rego, Candela Ceballos, Teresa Lozano, Patxi San Martin-Uriz, Amaia Vilas-Zornoza, Saray Rodriguez-Diaz, Rebeca Martinez-Turrillas, Patricia Jauregui, Diego Alignani, Maria C Viguria, Margarita Redondo, Mariona Pascal, Beatriz
Published in: Science Advances, Issue 8 (39), 2022, Page(s) eabo0514, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abo0514

CAR T cell manufacturing from naive/stem memory T lymphocytes enhances antitumor responses while curtailing cytokine release syndrome

Author(s): Silvia Arcangeli, Camilla Bove, Claudia Mezzanotte, Barbara Camisa, Laura Falcone, Francesco Manfredi, Eugenia Bezzecchi, Rita El Khoury, Rossana Norata, Francesca Sanvito, Maurilio Ponzoni, Beatrice Greco, Marta Angiola Moresco, Matteo G. Carrabba, Fabio Ciceri, Chiara Bonini, Attilio Bondanza, and Monica Casucci
Published in: The Journal of Clinical Investigation, Issue 132, 2022, Page(s) e150807, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci150807

Toxicities of Chimeric Antigen Receptor T Cell Therapy in Multiple Myeloma: An Overview of Experience From Clinical Trials, Pathophysiology, and Management Strategies.

Author(s): Xiang Zhou; Leo Rasche; K. Martin Kortüm; Sophia Danhof; Michael Hudecek; Hermann Einsele
Published in: Frontiers in Immunology, Issue 11, 2020, Page(s) 620312, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2020.620312

Siglec-6 is a novel target for CAR T-cell therapy in acute myeloid leukemia

Author(s): Hardikkumar Jetani, Almudena Navarro-Bailón, Marius Maucher, Silke Frenz, Christina Verbruggen, Ana Yeguas, María Belén Vidriales, Marcos González, Judit Rial Saborido, Sabrina Kraus, Katrin Mestermann, Simone Thomas, Halvard Bonig, Maik Luu, Razieh Monjezi, Dimitrios Mougiakakos, Markus Sauer, Hermann Einsele, Michael Hudecek
Published in: Blood, Issue 138, 2021, Page(s) 1830-1842, ISSN 1528-0020
Publisher: The American Society of Hematology
DOI: 10.1182/blood.2020009192

Non-viral therapeutic cell engineering with the Sleeping Beauty transposon system

Author(s): Michael Hudecek, Zoltán Ivics
Published in: Current Opinion in Genetics & Development, Issue 52, 2018, Page(s) 100-108, ISSN 0959-437X
Publisher: Elsevier BV
DOI: 10.1016/j.gde.2018.06.003

All-trans retinoic acid works synergistically with the γ-secretase inhibitor crenigacestat to augment BCMA on multiple myeloma and the efficacy of BCMA-CAR T cells

Author(s): Estefanía García-Guerrero Luis G. Rodríguez-Lobato Belén Sierro-Martínez Sophia Danhof Stephan Bates Silke Frenz Larissa Haertle Ralph Götz Markus Sauer Leo Rasche K. Martin Kortüm Jose A. Pérez-Simón Hermann Einsele Michael Hudecek Sabrina R. Prommersberger
Published in: Haematologica, Issue 108, 2023, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2022.281339

CRISISS: A Novel, Transcriptionally and Post-Translationally Inducible CRISPR/Cas9-Based Cellular Suicide Switch

Author(s): Maximilian Amberger, Esther Grueso and Zoltán Ivics
Published in: International Journal of Molecular Sciences, Issue 24, 2023, Page(s) 9799, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24129799

Latest Advances for the Sleeping Beauty Transposon System: 23 Years of Insomnia but Prettier than Ever

Author(s): Maximilian Amberger, Zoltán Ivics
Published in: BioEssays, Issue 42/11, 2020, Page(s) 2000136, ISSN 0265-9247
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/bies.202000136

Current Limitations and Perspectives of Chimeric Antigen Receptor-T-Cells in Acute Myeloid Leukemia

Author(s): Marius Maucher, Micha Srour, Sophia Danhof, Hermann Einsele, Michael Hudecek, Ibrahim Yakoub-Agha
Published in: Cancers, Issue 13, 2021, Page(s) 6157, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13246157

CD4 CAR-T cells targeting CD19 play a key role in exacerbating cytokine release syndrome, while maintaining long-term responses

Author(s): Camilla Bove, Silvia Arcangeli, Laura Falcone, Barbara Camisa, Rita El Khoury, Beatrice Greco, Anna De Lucia, Alice Bergamini, Attilio Bondanza, Fabio Ciceri , Chiara Bonini, Monica Casucci
Published in: Journal for Immunotherapy of Cancer, Issue 11, 2023, Page(s) e005878, ISSN 2051-1426
Publisher: BMJ Publishing Group Ltd and Society for Immunotherapy of Cancer
DOI: 10.1136/jitc-2022-005878

Novel targets and technologies for CAR-T cells in multiple myeloma and acute myeloid leukemia

Author(s): Sabrina Prommersberger, Hardikkumar Jetani, Sophia Danhof, Razieh Monjezi, Thomas Nerreter, Julia Beckmann, Herrmann Einsele, Michael Hudecek
Published in: Current Research in Translational Medicine, Issue 66/2, 2018, Page(s) 37-38, ISSN 2452-3186
Publisher: ELSEVIER
DOI: 10.1016/j.retram.2018.03.006

The era of in vivo T cell engineering

Author(s): Gustavo Campos Ramos Michael Hudecek
Published in: Med, Issue 3, 2022, Page(s) 85-86, ISSN 2666-6340
Publisher: Cell Press
DOI: 10.1016/j.medj.2022.01.012

Antibody‐Based CAR T Cells Produced by Lentiviral Transduction

Author(s): Sabrina Prommersberger, Michael Hudecek, Thomas Nerreter
Published in: Current Protocols in Immunology, Issue 128/1, 2020, ISSN 1934-3671
Publisher: Greene Pub. Associates
DOI: 10.1002/cpim.93

CARAMBA: a first-in-human clinical trial with SLAMF7 CAR-T cells prepared by virus-free Sleeping Beauty gene transfer to treat multiple myeloma.

Author(s): Sabrina Prommersberger; Michael Reiser; Michael Reiser; Julia Beckmann; Sophia Danhof; Maximilian Amberger; Patricia Quade-Lyssy; Patricia Quade-Lyssy; Hermann Einsele; Michael Hudecek; Halvard Bonig; Halvard Bonig; Halvard Bonig; Zoltán Ivics
Published in: Gene Therapy, Issue 2, 2021, Page(s) 560-571, ISSN 0969-7128
Publisher: Nature Publishing Group
DOI: 10.1038/s41434-021-00254-w

Targeting the extra domain A of fibronectin for cancer therapy with CAR-T cells

Author(s): Celia Martín-Otal, Aritz Lasarte-Cia, Diego Serrano, Noelia Casares, Enrique Conde, Flor Navarro, Inés Sánchez-Moreno, Marta Gorraiz, Patricia Sarrión, Alfonso Calvo, Carlos E De Andrea, José Echeveste, Amaia Vilas, Juan Roberto Rodriguez-Madoz, Jesús San Miguel, Felipe Prosper, Sandra Hervas-Stubbs, Juan Jose Lasarte, Teresa Lozano
Published in: J Immunother Cancer, Issue 10(8), 2022, Page(s) e004479, ISSN 2051-1426
Publisher: BMJ
DOI: 10.1136/jitc-2021-004479

Jumping Ahead with Sleeping Beauty: Mechanistic Insights into Cut-and-Paste Transposition.

Author(s): Matthias T Ochmann; Zoltán Ivics
Published in: Viruses, Vol 13, Iss 76, p 76 (2021), Issue 4, 2021, Page(s) 76, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13010076

Other (1)

Genomic Analyses of SLAMF7 CAR-T Cells Manufactured by Sleeping Beauty Transposon Gene Transfer for Immunotherapy of Multiple Myeloma

Author(s): Csaba Miskey, Maximilian Amberger, Michael Reiser, Sabrina Prommersberger, Julia Beckmann, Markus Machwirth, Hermann Einsele, Michael Hudecek, Halvard Bonig, Zoltán Ivics,
Published in: BioRXiv, Issue 24 June 2019, 2019
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/675009