SLAMF7-CAR T cells prepared by Sleeping Beauty gene-transfer for immunotherapy of multiple myeloma – a rare hematologic disease | CARAMBA | Project | Results | H2020 | CORDIS

Risultati finali

Final dissemination activity on project results
Summer school for young investigators
Report on stakeholder involvement after kick-off meeting
Regulatory workshop
Launch of website and social media accounts

Publication on the use of patient reported outcomes in CART clinical trials

Pubblicazioni

Disrupting N-glycan expression on tumor cells boosts chimeric antigen receptor T cell efficacy against solid malignancies

Autori: Beatrice Greco, Valeria Malacarne, Federica De Girardi, Giulia Maria Scotti, Francesco Manfredi, Elia Angelino, Camilla Sirini, Barbara Camisa, Laura Falcone, Marta Angiola Moresco, Katia Paolella, Mattia Di Bono, Rossana Norata, Francesca Sanvito, Silvia Arcangeli, Claudio Doglioni, Fabio Ciceri, Chiara Bonini, Andrea Graziani, Attilio Bondanza, Monica Casucci
Pubblicato in: Science Translational Medicine, Numero 14, 2022, Pagina/e eabg3072, ISSN 1946-6234
Editore: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.abg3072

CAR density influences antitumoral efficacy of BCMA CAR T cells and correlates with clinical outcome

Autori: Paula Rodriguez-Marquez, Maria E Calleja-Cervantes, Guillermo Serrano, Aina Oliver-Caldes, Maria L Palacios-Berraquero, Angel Martin-Mallo, Cristina Calviño, Marta Español-Rego, Candela Ceballos, Teresa Lozano, Patxi San Martin-Uriz, Amaia Vilas-Zornoza, Saray Rodriguez-Diaz, Rebeca Martinez-Turrillas, Patricia Jauregui, Diego Alignani, Maria C Viguria, Margarita Redondo, Mariona Pascal, Beatriz
Pubblicato in: Science Advances, Numero 8 (39), 2022, Pagina/e eabo0514, ISSN 2375-2548
Editore: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abo0514

CAR T cell manufacturing from naive/stem memory T lymphocytes enhances antitumor responses while curtailing cytokine release syndrome

Autori: Silvia Arcangeli, Camilla Bove, Claudia Mezzanotte, Barbara Camisa, Laura Falcone, Francesco Manfredi, Eugenia Bezzecchi, Rita El Khoury, Rossana Norata, Francesca Sanvito, Maurilio Ponzoni, Beatrice Greco, Marta Angiola Moresco, Matteo G. Carrabba, Fabio Ciceri, Chiara Bonini, Attilio Bondanza, and Monica Casucci
Pubblicato in: The Journal of Clinical Investigation, Numero 132, 2022, Pagina/e e150807, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci150807

Siglec-6 is a novel target for CAR T-cell therapy in acute myeloid leukemia

Autori: Hardikkumar Jetani, Almudena Navarro-Bailón, Marius Maucher, Silke Frenz, Christina Verbruggen, Ana Yeguas, María Belén Vidriales, Marcos González, Judit Rial Saborido, Sabrina Kraus, Katrin Mestermann, Simone Thomas, Halvard Bonig, Maik Luu, Razieh Monjezi, Dimitrios Mougiakakos, Markus Sauer, Hermann Einsele, Michael Hudecek
Pubblicato in: Blood, Numero 138, 2021, Pagina/e 1830-1842, ISSN 1528-0020
Editore: The American Society of Hematology
DOI: 10.1182/blood.2020009192

Non-viral therapeutic cell engineering with the Sleeping Beauty transposon system

Autori: Michael Hudecek, Zoltán Ivics
Pubblicato in: Current Opinion in Genetics & Development, Numero 52, 2018, Pagina/e 100-108, ISSN 0959-437X
Editore: Elsevier BV
DOI: 10.1016/j.gde.2018.06.003

All-trans retinoic acid works synergistically with the γ-secretase inhibitor crenigacestat to augment BCMA on multiple myeloma and the efficacy of BCMA-CAR T cells

Autori: Estefanía García-Guerrero Luis G. Rodríguez-Lobato Belén Sierro-Martínez Sophia Danhof Stephan Bates Silke Frenz Larissa Haertle Ralph Götz Markus Sauer Leo Rasche K. Martin Kortüm Jose A. Pérez-Simón Hermann Einsele Michael Hudecek Sabrina R. Prommersberger
Pubblicato in: Haematologica, Numero 108, 2023, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2022.281339

CRISISS: A Novel, Transcriptionally and Post-Translationally Inducible CRISPR/Cas9-Based Cellular Suicide Switch

Autori: Maximilian Amberger, Esther Grueso and Zoltán Ivics
Pubblicato in: International Journal of Molecular Sciences, Numero 24, 2023, Pagina/e 9799, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24129799

Latest Advances for the Sleeping Beauty Transposon System: 23 Years of Insomnia but Prettier than Ever

Autori: Maximilian Amberger, Zoltán Ivics
Pubblicato in: BioEssays, Numero 42/11, 2020, Pagina/e 2000136, ISSN 0265-9247
Editore: John Wiley & Sons Inc.
DOI: 10.1002/bies.202000136

Current Limitations and Perspectives of Chimeric Antigen Receptor-T-Cells in Acute Myeloid Leukemia

Autori: Marius Maucher, Micha Srour, Sophia Danhof, Hermann Einsele, Michael Hudecek, Ibrahim Yakoub-Agha
Pubblicato in: Cancers, Numero 13, 2021, Pagina/e 6157, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13246157

CD4 CAR-T cells targeting CD19 play a key role in exacerbating cytokine release syndrome, while maintaining long-term responses

Autori: Camilla Bove, Silvia Arcangeli, Laura Falcone, Barbara Camisa, Rita El Khoury, Beatrice Greco, Anna De Lucia, Alice Bergamini, Attilio Bondanza, Fabio Ciceri , Chiara Bonini, Monica Casucci
Pubblicato in: Journal for Immunotherapy of Cancer, Numero 11, 2023, Pagina/e e005878, ISSN 2051-1426
Editore: BMJ Publishing Group Ltd and Society for Immunotherapy of Cancer
DOI: 10.1136/jitc-2022-005878

Novel targets and technologies for CAR-T cells in multiple myeloma and acute myeloid leukemia

Autori: Sabrina Prommersberger, Hardikkumar Jetani, Sophia Danhof, Razieh Monjezi, Thomas Nerreter, Julia Beckmann, Herrmann Einsele, Michael Hudecek
Pubblicato in: Current Research in Translational Medicine, Numero 66/2, 2018, Pagina/e 37-38, ISSN 2452-3186
Editore: ELSEVIER
DOI: 10.1016/j.retram.2018.03.006

The era of in vivo T cell engineering

Autori: Gustavo Campos Ramos Michael Hudecek
Pubblicato in: Med, Numero 3, 2022, Pagina/e 85-86, ISSN 2666-6340
Editore: Cell Press
DOI: 10.1016/j.medj.2022.01.012

Antibody‐Based CAR T Cells Produced by Lentiviral Transduction

Autori: Sabrina Prommersberger, Michael Hudecek, Thomas Nerreter
Pubblicato in: Current Protocols in Immunology, Numero 128/1, 2020, ISSN 1934-3671
Editore: Greene Pub. Associates
DOI: 10.1002/cpim.93

CARAMBA: a first-in-human clinical trial with SLAMF7 CAR-T cells prepared by virus-free Sleeping Beauty gene transfer to treat multiple myeloma.

Autori: Sabrina Prommersberger; Michael Reiser; Michael Reiser; Julia Beckmann; Sophia Danhof; Maximilian Amberger; Patricia Quade-Lyssy; Patricia Quade-Lyssy; Hermann Einsele; Michael Hudecek; Halvard Bonig; Halvard Bonig; Halvard Bonig; Zoltán Ivics
Pubblicato in: Gene Therapy, Numero 2, 2021, Pagina/e 560-571, ISSN 0969-7128
Editore: Nature Publishing Group
DOI: 10.1038/s41434-021-00254-w

Genomic Analyses of SLAMF7 CAR-T Cells Manufactured by Sleeping Beauty Transposon Gene Transfer for Immunotherapy of Multiple Myeloma

Autori: Csaba Miskey, Maximilian Amberger, Michael Reiser, Sabrina Prommersberger, Julia Beckmann, Markus Machwirth, Hermann Einsele, Michael Hudecek, Halvard Bonig, Zoltán Ivics,
Pubblicato in: BioRXiv, Numero 24 June 2019, 2019
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/675009

SLAMF7-CAR T cells prepared by Sleeping Beauty gene-transfer for immunotherapy of multiple myeloma – a rare hematologic disease

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