SLAMF7-CAR T cells prepared by Sleeping Beauty gene-transfer for immunotherapy of multiple myeloma – a rare hematologic disease | CARAMBA | Project | Results | H2020 | CORDIS

Livrables

Final dissemination activity on project results
Summer school for young investigators
Report on stakeholder involvement after kick-off meeting
Regulatory workshop
Launch of website and social media accounts

Publication on the use of patient reported outcomes in CART clinical trials

Publications

Disrupting N-glycan expression on tumor cells boosts chimeric antigen receptor T cell efficacy against solid malignancies

Auteurs: Beatrice Greco, Valeria Malacarne, Federica De Girardi, Giulia Maria Scotti, Francesco Manfredi, Elia Angelino, Camilla Sirini, Barbara Camisa, Laura Falcone, Marta Angiola Moresco, Katia Paolella, Mattia Di Bono, Rossana Norata, Francesca Sanvito, Silvia Arcangeli, Claudio Doglioni, Fabio Ciceri, Chiara Bonini, Andrea Graziani, Attilio Bondanza, Monica Casucci
Publié dans: Science Translational Medicine, Numéro 14, 2022, Page(s) eabg3072, ISSN 1946-6234
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.abg3072

CAR density influences antitumoral efficacy of BCMA CAR T cells and correlates with clinical outcome

Auteurs: Paula Rodriguez-Marquez, Maria E Calleja-Cervantes, Guillermo Serrano, Aina Oliver-Caldes, Maria L Palacios-Berraquero, Angel Martin-Mallo, Cristina Calviño, Marta Español-Rego, Candela Ceballos, Teresa Lozano, Patxi San Martin-Uriz, Amaia Vilas-Zornoza, Saray Rodriguez-Diaz, Rebeca Martinez-Turrillas, Patricia Jauregui, Diego Alignani, Maria C Viguria, Margarita Redondo, Mariona Pascal, Beatriz
Publié dans: Science Advances, Numéro 8 (39), 2022, Page(s) eabo0514, ISSN 2375-2548
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abo0514

CAR T cell manufacturing from naive/stem memory T lymphocytes enhances antitumor responses while curtailing cytokine release syndrome

Auteurs: Silvia Arcangeli, Camilla Bove, Claudia Mezzanotte, Barbara Camisa, Laura Falcone, Francesco Manfredi, Eugenia Bezzecchi, Rita El Khoury, Rossana Norata, Francesca Sanvito, Maurilio Ponzoni, Beatrice Greco, Marta Angiola Moresco, Matteo G. Carrabba, Fabio Ciceri, Chiara Bonini, Attilio Bondanza, and Monica Casucci
Publié dans: The Journal of Clinical Investigation, Numéro 132, 2022, Page(s) e150807, ISSN 0021-9738
Éditeur: American Society for Clinical Investigation
DOI: 10.1172/jci150807

Siglec-6 is a novel target for CAR T-cell therapy in acute myeloid leukemia

Auteurs: Hardikkumar Jetani, Almudena Navarro-Bailón, Marius Maucher, Silke Frenz, Christina Verbruggen, Ana Yeguas, María Belén Vidriales, Marcos González, Judit Rial Saborido, Sabrina Kraus, Katrin Mestermann, Simone Thomas, Halvard Bonig, Maik Luu, Razieh Monjezi, Dimitrios Mougiakakos, Markus Sauer, Hermann Einsele, Michael Hudecek
Publié dans: Blood, Numéro 138, 2021, Page(s) 1830-1842, ISSN 1528-0020
Éditeur: The American Society of Hematology
DOI: 10.1182/blood.2020009192

Non-viral therapeutic cell engineering with the Sleeping Beauty transposon system

Auteurs: Michael Hudecek, Zoltán Ivics
Publié dans: Current Opinion in Genetics & Development, Numéro 52, 2018, Page(s) 100-108, ISSN 0959-437X
Éditeur: Elsevier BV
DOI: 10.1016/j.gde.2018.06.003

All-trans retinoic acid works synergistically with the γ-secretase inhibitor crenigacestat to augment BCMA on multiple myeloma and the efficacy of BCMA-CAR T cells

Auteurs: Estefanía García-Guerrero Luis G. Rodríguez-Lobato Belén Sierro-Martínez Sophia Danhof Stephan Bates Silke Frenz Larissa Haertle Ralph Götz Markus Sauer Leo Rasche K. Martin Kortüm Jose A. Pérez-Simón Hermann Einsele Michael Hudecek Sabrina R. Prommersberger
Publié dans: Haematologica, Numéro 108, 2023, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
DOI: 10.3324/haematol.2022.281339

CRISISS: A Novel, Transcriptionally and Post-Translationally Inducible CRISPR/Cas9-Based Cellular Suicide Switch

Auteurs: Maximilian Amberger, Esther Grueso and Zoltán Ivics
Publié dans: International Journal of Molecular Sciences, Numéro 24, 2023, Page(s) 9799, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24129799

Latest Advances for the Sleeping Beauty Transposon System: 23 Years of Insomnia but Prettier than Ever

Auteurs: Maximilian Amberger, Zoltán Ivics
Publié dans: BioEssays, Numéro 42/11, 2020, Page(s) 2000136, ISSN 0265-9247
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/bies.202000136

Current Limitations and Perspectives of Chimeric Antigen Receptor-T-Cells in Acute Myeloid Leukemia

Auteurs: Marius Maucher, Micha Srour, Sophia Danhof, Hermann Einsele, Michael Hudecek, Ibrahim Yakoub-Agha
Publié dans: Cancers, Numéro 13, 2021, Page(s) 6157, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13246157

CD4 CAR-T cells targeting CD19 play a key role in exacerbating cytokine release syndrome, while maintaining long-term responses

Auteurs: Camilla Bove, Silvia Arcangeli, Laura Falcone, Barbara Camisa, Rita El Khoury, Beatrice Greco, Anna De Lucia, Alice Bergamini, Attilio Bondanza, Fabio Ciceri , Chiara Bonini, Monica Casucci
Publié dans: Journal for Immunotherapy of Cancer, Numéro 11, 2023, Page(s) e005878, ISSN 2051-1426
Éditeur: BMJ Publishing Group Ltd and Society for Immunotherapy of Cancer
DOI: 10.1136/jitc-2022-005878

Novel targets and technologies for CAR-T cells in multiple myeloma and acute myeloid leukemia

Auteurs: Sabrina Prommersberger, Hardikkumar Jetani, Sophia Danhof, Razieh Monjezi, Thomas Nerreter, Julia Beckmann, Herrmann Einsele, Michael Hudecek
Publié dans: Current Research in Translational Medicine, Numéro 66/2, 2018, Page(s) 37-38, ISSN 2452-3186
Éditeur: ELSEVIER
DOI: 10.1016/j.retram.2018.03.006

The era of in vivo T cell engineering

Auteurs: Gustavo Campos Ramos Michael Hudecek
Publié dans: Med, Numéro 3, 2022, Page(s) 85-86, ISSN 2666-6340
Éditeur: Cell Press
DOI: 10.1016/j.medj.2022.01.012

Antibody‐Based CAR T Cells Produced by Lentiviral Transduction

Auteurs: Sabrina Prommersberger, Michael Hudecek, Thomas Nerreter
Publié dans: Current Protocols in Immunology, Numéro 128/1, 2020, ISSN 1934-3671
Éditeur: Greene Pub. Associates
DOI: 10.1002/cpim.93

CARAMBA: a first-in-human clinical trial with SLAMF7 CAR-T cells prepared by virus-free Sleeping Beauty gene transfer to treat multiple myeloma.

Auteurs: Sabrina Prommersberger; Michael Reiser; Michael Reiser; Julia Beckmann; Sophia Danhof; Maximilian Amberger; Patricia Quade-Lyssy; Patricia Quade-Lyssy; Hermann Einsele; Michael Hudecek; Halvard Bonig; Halvard Bonig; Halvard Bonig; Zoltán Ivics
Publié dans: Gene Therapy, Numéro 2, 2021, Page(s) 560-571, ISSN 0969-7128
Éditeur: Nature Publishing Group
DOI: 10.1038/s41434-021-00254-w

Genomic Analyses of SLAMF7 CAR-T Cells Manufactured by Sleeping Beauty Transposon Gene Transfer for Immunotherapy of Multiple Myeloma

Auteurs: Csaba Miskey, Maximilian Amberger, Michael Reiser, Sabrina Prommersberger, Julia Beckmann, Markus Machwirth, Hermann Einsele, Michael Hudecek, Halvard Bonig, Zoltán Ivics,
Publié dans: BioRXiv, Numéro 24 June 2019, 2019
Éditeur: Cold Spring Harbor Laboratory
DOI: 10.1101/675009

SLAMF7-CAR T cells prepared by Sleeping Beauty gene-transfer for immunotherapy of multiple myeloma – a rare hematologic disease

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