Immune Signatures for Therapy Stratification in Major Mood Disorders

Informations projet

MOODSTRATIFICATION

N° de convention de subvention: 754740

DOI

10.3030/754740

Projet clôturé

Date de signature de la CE 5 Decembre 2017

Date de début 1 Janvier 2018

Date de fin 30 Juin 2023

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total

€ 5 963 750,00

Contribution de l’UE

€ 5 963 750,00

Coordonné par

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Demonstrators, pilots, prototypes (2)

A kit protocol for the discriminating serum cytokines/growth factors

A kit protocol for the ELISA’s for hCRP, IL-6, IL-10, CCL2, PTX3, sCD25, IL-7, SCF, IGFBP-2 and BDNF (or a selection of those factors) and other found serum cytokines and growth factors discriminating active mood disorders and helpful in determining therapy responsiveness.

A PAXGENE kit protocol

A kit protocol for a Q-PCR on PAXGENE material for the key genes of cluster 1 and 2 , the IFN cluster and, if relevant, also for growth and apoptosis genes discriminating active mood disorders and helpful in determining therapy responsiveness.

Websites, patent fillings, videos etc. (18)

Website update M12

The 6 monthly update of the web-site www.moodinflame.eu (with a newsletters and photographs of our open houses

List of seminars for patients M24

Reports and programs of seminars organized for patient organizations

Website update M66

Update of the website as described earlier

Website update M1

The 6 monthly update of the web-site www.moodinflame.eu (with a newsletters and photographs of our open houses

Website update M30

The 6 monthly update of the web-site www.moodinflame.eu (with a newsletters and photographs of our open houses

General public communications M24

A two-yearly list of lay press articles, television documentaries and other general public communications

General public communications M60

A twoyearly list of lay press articles television documentaries and other general public communications

Website update M42

The 6 monthly update of the website wwwmoodinflameeu with a newsletters and photographs of our open houses

Website update M6

The 6 monthly update of the web-site www.moodinflame.eu (with a newsletters and photographs of our open houses

Website update M60

Update of the website as described earlier

Website update M36

The 6 monthly update of the web-site www.moodinflame.eu (with a newsletters and photographs of our open houses

Website update M24

The 6 monthly update of the web-site www.moodinflame.eu (with a newsletters and photographs of our open houses

Neuro-immunology book

A neuroimmunology book for psychiatrists

Website update M18

The 6 monthly update of the web-site www.moodinflame.eu (with a newsletters and photographs of our open houses

List of seminars for patients M52

Reports and programs of seminars organized for patient organizations

Website update M52

The 6 monthly update of the website wwwmoodinflameeu with a newsletters and photographs of our open houses

Neuro-immunology course programs M24

The programs of neuroimmunology courses organized for psychiatrists

Neuro-immunology course programs M60

The programs of neuroimmunology courses organized for psychiatrists

Documents, reports (20)

Scientific publication list M66

List of scientific publications till M66

Scientific publication list M52

A yearly list of scientific publications and publications in clinical journals

Abstract list M66

Lists of abstracts of presentations at scientifiv meetings till M66

Kick off report

Report of the kick off meeting

Abstract list M52

A yearly list of abstracts of contributions to scientific meetings

Ethical approval thymosin alpha study

First study subject approvals package for the thymosin clinical investigations

Approval immune stratification studies (IMMUNOSTRATA)

First study subject approvals package for the study with immune stratification IMMUNOSTRATA

Fourth annual meeting report

Report of the fourth annual meeting of the general assembly

Scientific publication list M24

A yearly list of scientific publications and publications in clinical journals

Abstract list M24

A yearly list of abstracts of contributions to scientific meetings

In silico brain analysis for inflammation/growth pathways

Report on the in silico analysis of human brain bank specimens of patients and controls with regard to IL17 TGFbeta BDNF and inflammation eg IL6 TNF CCL20 linked pathways

Midterm recruitment immune stratification study (IMMUNOSTRATA)

Midterm recruitment report for immune stratification prediction for the outcome of physical endurance therapy for MDD

Third annual meeting report

Report of the third annual meeting of the general assembly

First annual meeting report

Report of the first annual meeting of the general assembly

Socio-political contacts M60

Reports of the liaison officer with the Dutch Ministry of Health other health care officials and EU officials involved in health care policy making

Midterm meeting report

Report of the midterm meeting of the general assembly, with special emphasis on the decisions made with regard to the final composition of the immune signatures and the decisions made on the choice for anti-inflammatory and T cell enforcement therapies

Data management plan

A data management plan

Ethical approval treatment as usual study

First study subject approvals package for the study with treatment as usual (simple recording of improvement of mood state in patients)

Ethical approval IL-2 study

First study subject approvals package for the low dose IL-2 clinical investigations

Mood state in CVID

Report on the study on the prevalence of fatigue and depression in CVID patients with and without reduced numbers of T cells

Open Research Data Pilot (1)

Open data bank of MOODSTRATIFICATION

A comprehensive data bank of the laboratory and clinical data of MOODSTRATIFICATION open to the scientific community at large

Publications

Peer reviewed articles (26)

Childhood trauma, suicide risk and inflammatory phenotypes of depression: insights from monocyte gene expression

Auteurs: Carmen Schiweck, Stephan Claes, Lukas Van Oudenhove, Ginette Lafit, Thomas Vaessen, Gommaar Op de Beeck, Raf Berghmans, Annemarie Wijkhuijs, Norbert Müller, Volker Arolt, Hemmo Drexhage, Elske Vrieze
Publié dans: Translational Psychiatry, Numéro 10/1, 2020, ISSN 2158-3188
Éditeur: Nature Publishing Group
DOI: 10.1038/s41398-020-00979-z

Reduced numbers of naïve CD4 + T cells and an altered CD4/CD8 balance in depressed common variable immune deficiency (CVID) patients. Is thymosin-α1 a possible treatment?

Auteurs: Olivia Manusama 1, Sajni Singh 1, Rik A Brooimans 1, Annemarie Wijkhuijs 1, Marianne van der Ent 1, Hemmo A Drexhage 2, Virgil A Dalm 1
Publié dans: International Immunopharmacology, Numéro 2023 June, 2023, ISSN 1878-1705
Éditeur: Elsevier
DOI: 10.1016/j.intimp.2023.110168

Selective association of cytokine levels and kynurenine/tryptophan ratio with alterations in white matter microstructure in bipolar but not in unipolar depression

Auteurs: Comai S, Melloni E, Lorenzi C, Bollettini I, Vai B, Zanardi R, Colombo C, Valtorta F, Benedetti F, Poletti S
Publié dans: Selective association of cytokine levels and kynurenine/tryptophan ratio with alterations in white matter microstructure in bipolar but not in unipolar depression, 2022, ISSN 0924-977X
Éditeur: Elsevier BV
DOI: 10.1016/j.euroneuro.2021.11.003

T-cell defects and postpartum depression

Auteurs: Lauren M. Osborne, Janneke Gilden, Astrid M. Kamperman, Witte J.G. Hoogendijk, Julie Spicer, Hemmo A. Drexhage, Veerle Bergink
Publié dans: Brain, Behavior, and Immunity, Numéro 87, 2020, Page(s) 397-403, ISSN 0889-1591
Éditeur: Academic Press
DOI: 10.1016/j.bbi.2020.01.007

Circulating inflammatory markers impact cognitive functions in bipolar depression

Auteurs: Poletti S, Mazza MG, Calesella F, Vai B, Lorenzi C, Manfredi E, Colombo C, Zanardi R, Benedetti F
Publié dans: Circulating inflammatory markers impact cognitive functions in bipolar depression, 2021, ISSN 0022-3956
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.jpsychires.2021.05.071

Depression and suicidality: A link to premature T helper cell aging and increased Th17 cells

Auteurs: Carmen Schiweck, Mireia Valles-Colomer, Volker Arolt, Norbert Müller, Jeroen Raes, Annemarie Wijkhuijs, Stephan Claes, Hemmo Drexhage, Elske Vrieze
Publié dans: Brain, Behavior, and Immunity, Numéro 87, 2020, Page(s) 603-609, ISSN 0889-1591
Éditeur: Academic Press
DOI: 10.1016/j.bbi.2020.02.005

Higher baseline interleukin-1β and TNF-α hamper antidepressant response in major depressive disorder

Auteurs: Benedetti F, Poletti S, Vai B, Mazza GM, Lorenzi C, Brioschi S, Aggio V, Branchi I, Colombo C, Furlan R, Zanardi R
Publié dans: Higher baseline interleukin-1β and TNF-α hamper antidepressant response in major depressive disorder, 2021, ISSN 0924-977X
Éditeur: Elsevier BV
DOI: 10.1016/j.euroneuro.2020.11.009

Premature T cell aging in major depression: A double hit by the state of disease and cytomegalovirus infection

Auteurs: Maria S Simon 1, Magdalini Ioannou 2, Gara Arteaga-Henríquez 3 4, Annemarie Wijkhuijs 5, Raf Berghmans 6, Richard Musil 1, Norbert Müller 1, Hemmo A Drexhage 5
Publié dans: Brain Behav Immun Health, Numéro 2023, 2023, ISSN 2666-3546
Éditeur: elsevier
DOI: 10.1016/j.bbih.2023.100608

The state of the art in the EU horizon 2020 project MOODSTRATIFICATION

Auteurs: Drexhage H.A.
Publié dans: Journal of Affective Disorders Reports Volume 12, Numéro 12, 2023, ISSN 2666-9153
Éditeur: Elsevier
DOI: 10.1016/j.jadr.2023.100537

Proinflammatory Cytokines Predict Brain Metabolite Concentrations in the Anterior Cingulate Cortex of Patients With Bipolar Disorder

Auteurs: Sara Poletti, Mario Gennaro Mazza, Benedetta Vai, Cristina Lorenzi, Cristina Colombo, Francesco Benedetti
Publié dans: Frontiers in Psychiatry, Numéro 11, 2020, ISSN 1664-0640
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2020.590095

Cause-specific life years lost in individuals with treatment-resistant depression: A Danish nationwide register-based cohort study

Auteurs: Kathrine Bang Madsen, Oleguer Plana-Ripoll, Katherine L. Musliner, Jean-Christophe Philippe Debost, Liselotte Vogdrup Petersen, Trine Munk-Olsen
Publié dans: Journal of Affective Disorders, Numéro 280, 2021, Page(s) 250-257, ISSN 0165-0327
Éditeur: Elsevier BV
DOI: 10.1016/j.jad.2020.11.042

Old and New Biomarkers for Infection, Inflammation, and Autoimmunity in Treatment-Resistant Affective and Schizophrenic Spectrum Disorders

Auteurs: Scheiber C, Schulz T, Schneider JM, Bechter K, Schneider EM
Publié dans: Old and New Biomarkers for Infection, Inflammation, and Autoimmunity in Treatment-Resistant Affective and Schizophrenic Spectrum Disorders, 2022, ISSN 1424-8247
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph15030299

Autoimmune psychosis: an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune origin

Auteurs: Thomas A Pollak, Belinda R Lennox, Sabine Müller, Michael E Benros, Harald Prüss, Ludger Tebartz van Elst, Hans Klein, Johann Steiner, Thomas Frodl, Bernhard Bogerts, Li Tian, Laurent Groc, Alkomiet Hasan, Bernhard T Baune, Dominique Endres, Ebrahim Haroon, Robert Yolken, Francesco Benedetti, Angelos Halaris, Jeffrey H Meyer, Hans Stassen, Marion Leboyer, Dietmar Fuchs, Markus Otto, David A Brow
Publié dans: The Lancet Psychiatry, Numéro 7/1, 2020, Page(s) 93-108, ISSN 2215-0366
Éditeur: Elsevier Limited
DOI: 10.1016/s2215-0366(19)30290-1

Efficacy of Sertraline Plus Placebo or Add-On Celecoxib in Major Depressive Disorder: Macrophage Migration Inhibitory Factor as a Promising Biomarker for Remission After Sertraline-Results From a Randomized Controlled Clinical Trial.

Auteurs: Simon MS, Burger B, Weidinger E, Arteaga-Henríquez G, Zill P, Musil R, Drexhage HA, Müller N
Publié dans: Efficacy of Sertraline Plus Placebo or Add-On Celecoxib in Major Depressive Disorder: Macrophage Migration Inhibitory Factor as a Promising Biomarker for Remission After Sertraline-Results From a Randomized Controlled Clinical Trial., 2021, ISSN 1664-0640
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2021.615261

Low-Grade Inflammation as a Predictor of Antidepressant and Anti-Inflammatory Therapy Response in MDD Patients: A Systematic Review of the Literature in Combination With an Analysis of Experimental Data Collected in the EU-MOODINFLAME Consortium

Auteurs: Gara Arteaga-Henríquez, Maria S. Simon, Bianka Burger, Elif Weidinger, Annemarie Wijkhuijs, Volker Arolt, Tom K. Birkenhager, Richard Musil, Norbert Müller, Hemmo A. Drexhage
Publié dans: Frontiers in Psychiatry, Numéro 10, 2019, ISSN 1664-0640
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2019.00458

The circulating levels of CD4+ t helper cells are higher in bipolar disorder as compared to major depressive disorder

Auteurs: Karlijn Becking, Bartholomeus C.M. Haarman, Laura Grosse, Willem A. Nolen, Stephan Claes, Volker Arolt, Robert A. Schoevers, Hemmo A. Drexhage
Publié dans: Journal of Neuroimmunology, Numéro 319, 2018, Page(s) 28-36, ISSN 0165-5728
Éditeur: Elsevier BV
DOI: 10.1016/j.jneuroim.2018.03.004

Activation and deactivation steps in the tryptophan breakdown pathway in major depressive disorder: A link to the monocyte inflammatory state of patients

Auteurs: Gara Arteaga-Henriquez 1, Bianka Burger 2, Elif Weidinger 3, Laura Grosse 4, Natalie Moll 5, Gregor Schuetze 5, Markus Schwarz 5, Annemarie Wijkhuijs 6, Gommaar Op de Beeck 7, Raf Berghmans 7, Marjan A Versnel 6, Volker Arolt 8, Norbert Müller 2, Hemmo A Drexhage 6
Publié dans: Activation and deactivation steps in the tryptophan breakdown pathway in major depressive disorder: A link to the monocyte inflammatory state of patients, 2021, ISSN 0278-5846
Éditeur: Elsevier BV
DOI: 10.1016/j.pnpbp.2020.110226

Bidirectional associations between treatment-resistant depression and general medical conditions

Auteurs: Madsen KB, Momen NC, Petersen LV, Plana-Ripoll O, Haarman BCM, Drexhage H, Mortensen PB, McGrath JJ, Munk-Olsen T
Publié dans: Bidirectional associations between treatment-resistant depression and general medical conditions, 2021, ISSN 0924-977X
Éditeur: Elsevier BV
DOI: 10.1016/j.euroneuro.2021.04.021

Psychological Symptoms in Primary Immunodeficiencies: a Common Comorbidity?

Auteurs: Manusama OR, van Beveren NJM, van Hagen PM, Drexhage HA, Dalm VASH
Publié dans: Psychological Symptoms in Primary Immunodeficiencies: a Common Comorbidity?, 2022, ISSN 0271-9142
Éditeur: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10875-022-01207-7

Inflammatory monocyte gene signature predicts beneficial within group effect of simvastatin in patients with schizophrenia spectrum disorders in a secondary analysis of a randomized controlled trial

Auteurs: Mareike Aichholzer 1, Shiral S Gangadin 2 3, Iris E C Sommer 2 3, Annemarie Wijkhuis 4, Lot D de Witte 5, René S Kahn 5, Sabine Bahn 6, Hemmo A Drexhage 4, Carmen Schiweck 1
Publié dans: Brain Behaviour Immun Health 2022, Numéro 2022, 2022, ISSN 2666-3546
Éditeur: Elsevier Inc.
DOI: 10.1016/j.bbih.2022.100551

Early labor force exits in patients with treatment-resistant depression: an assessment of work years lost in a Danish nationwide register-based cohort study

Auteurs: Kathrine Bang Madsen, Liselotte Vogdrup Petersen, Oleguer Plana-Ripoll, Katherine L. Musliner, Jean-Christophe Philippe Debost, Frederikke Hordam Gronemann, Preben Bo Mortensen, Trine Munk-Olsen
Publié dans: Therapeutic Advances in Psychopharmacology, Numéro 10, 2020, Page(s) 204512532097379, ISSN 2045-1253
Éditeur: Katherine Bang Madsen
DOI: 10.1177/2045125320973791

Brain-immune crosstalk in the treatment of major depressive disorder.

Auteurs: Branchi I, Poggini S, Capuron L, Benedetti F, Poletti S, Tamouza R, Drexhage HA, Penninx BWJH, Pariante CM; European College of Neuropsychopharmacology (ECNP) ImmunoNeuroPsychiatry Thematic Working Group and Marion Leboyer
Publié dans: Brain-immune crosstalk in the treatment of major depressive disorder., 2021, ISSN 0924-977X
Éditeur: Elsevier BV
DOI: 10.1016/j.euroneuro.2020.11.016

Sticky Situation: The Link Between Peripheral Inflammation, Neuroinflammation, and Severe Mental Illness

Auteurs: Jakub Tomasik 1, Carmen Schiweck 2, Hemmo A Drexhage 3
Publié dans: Biologic Psychiatry, Numéro 2023, 2023, ISSN 1873-2402
Éditeur: Elsevier
DOI: 10.1016/j.biopsych.2022.10.017

Towards precision medicine: What are the stratification hypotheses to identify homogeneous inflammatory subgroups

Auteurs: Ioannou M, Foiselle M, Mallet J, Stam EL, Godin O, Dubertret C, Terro E, Sommer IEC, Haarman BCM, Leboyer M, Schoevers RA.
Publié dans: Towards precision medicine: What are the stratification hypotheses to identify homogeneous inflammatory subgroups, 2021, ISSN 0924-977X
Éditeur: Elsevier BV
DOI: 10.1016/j.euroneuro.2020.11.001

Activated PI3Kδ syndrome, an immunodeficiency disorder, leads to sensorimotor deficits recapitulated in a murine model – ScienceDirect

Auteurs: Serra I, Manusama OR, Fabian M.P. Kaiser FMP, Floriano II
Publié dans: Activated PI3Kδ syndrome, an immunodeficiency disorder, leads to sensorimotor deficits recapitulated in a murine model – ScienceDirect, 2021, ISSN 2666-3546
Éditeur: Elsevier Inc
DOI: 10.1016/j.bbih.2021.100377

Treatment-resistant depression and labor market affiliation in the Danish welfare society: a register-based study

Auteurs: Frederikke Hørdam Gronemann, Thomas Lund, Louise Lindholdt, Kathrine Bang Madsen, Martin Balslev Jørgensen, Merete Nordentoft & Merete Osler
Publié dans: Treatment-resistant depression and labor market affiliation in the Danish welfare society: a register-based study, 2022, ISSN 0933-7954
Éditeur: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00127-022-02243-9

Book chapters (1)

Wederkerige interacties tussen chronische stress en het neuro-endiocriene en immuun systeem. In: Het lichaam en het psychisch functioneren.

Auteurs: Moss CS, Drexhage HA, Rutten S.
Publié dans: 2022
Éditeur: Bohn Stafleu, van Loghum