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Dissecting the cellular and molecular dynamics of bone marrow fibrosis for improved diagnostics and treatment

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Non-canonical Hedgehog signaling mediates profibrotic hematopoiesis-stroma crosstalk in myeloproliferative neoplasms

Author(s): Pritchard JE, Pearce JE, Snoeren IAM, Fuchs SNR, Götz K, Peisker F, Wagner S, Benabid A, Lutterbach N, Klöker V, Nagai JS, Hannani MT, Galyga AK, Sistemich E, Banjanin B, Flosdorf N, Bindels E, Olschok K, Biaesch K, Chatain N, Bhagwat N, Dunbar A, Sarkis R, Naveiras O, Berres ML, Koschmieder S, Levine RL, Costa IG, Gleitz HFE, Kramann R, Schneider RK
Published in: Cell Reports, 2024, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2023.113608

Inflammatory bone marrow microenvironment

Author(s): Nils B. Leimkühler, Rebekka K. Schneider
Published in: Hematology, Issue 2019/1, 2019, Page(s) 294-302, ISSN 1520-4391
Publisher: American Society of Hematology
DOI: 10.1182/hematology.2019000045

Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis

Author(s): Leimkühler NB, Gleitz HFE, Ronghui L, Snoeren IAM, Fuchs SNR, Nagai JS, Banjanin B, Lam KH, Vogl T, Kuppe C, Stalmann USA, Büsche G, Kreipe H, Gütgemann I, Krebs P, Banz Y, Boor P, Tai EW, Brümmendorf TH, Koschmieder S, Crysandt M, Bindels E, Kramann R, Costa IG, Schneider RK.
Published in: Cell Stem Cell, 2021, Page(s) 2051-2064, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2020.11.004

Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN

Author(s): Helene Gleitz, Aurelien J.F. Dugourd, Nils Bastian Leimkühler, Inge A.M Snoeren, Stijn N.R. Fuchs, Sylvia Menzel, Susanne Ziegler, Nicolaus Kroeger, Ioanna Triviai, Guntram Büsche, Hans Kreipe, Bella Banjanin, Jessica Pritchard, Remco Hoogenboezem, Eric Bindels, Neele Schumacher, Stefan Rose-John, Shannon Elf, Julio Saez-Rodriguez, Rafael Kramann, Rebekka K Schneider
Published in: Blood, 2020, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2019004095

Understanding deregulated cellular and molecular dynamics in the haematopoietic stem cell niche to develop novel therapeutics for bone marrow fibrosis

Author(s): Hélène FE Gleitz, Rafael Kramann, Rebekka K Schneider
Published in: The Journal of Pathology, Issue 245/2, 2018, Page(s) 138-146, ISSN 0022-3417
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/path.5078

Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome

Author(s): Flavia Ribezzo, Inge A. M. Snoeren, Susanne Ziegler, Jacques Stoelben, Patricia A. Olofsen, Almira Henic, Monica Ventura Ferreira, Si Chen, Ursula S. A. Stalmann, Guntram Buesche, Remco M. Hoogenboezem, Rafael Kramann, Uwe Platzbecker, Marc H. G. P. Raaijmakers, Benjamin L. Ebert, Rebekka K. Schneider
Published in: Leukemia, Issue 33/7, 2019, Page(s) 1759-1772, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/s41375-018-0350-3

Collaborative effect of Csnk1a1 haploinsufficiency and mutant p53 in Myc induction can promote leukemic transformation

Author(s): Fuchs SNR, Stalmann USA, Snoeren IAM, Bindels E, Schmitz S, Banjanin B, Hoogenboezem RM, van Herk S, Saad M, Walter W, Haferlach T, Seillier L, Saez-Rodriguez J, Dugourd AJF, Lehmann KV, Ben-Neriah Y, Gleitz HFE, Schneider RK
Published in: Blood, 2024, Page(s) 766-779, ISSN 2473-9529
Publisher: Blood Advances
DOI: 10.1182/bloodadvances.2022008926

Dissecting the Functional Reprogramming of the Microenvironment in Bone Marrow Fibrosis at the Single Cell Level

Author(s): Nils B. Leimkühler, Li Ronghui, Hélène F.E. Gleitz, Inge A. M. Snoeren, Stijn N.R. Fuchs, Christoph Kuppe, Ursula S. A. Stalmann, Guntram Buesche, Hans Kreipe, Ines Gütgemann, Philippe Krebs, Yara Banz, Peter Boor, Evelyn Wing-Ying Tai, Tim H. Brümmendorf, Steffen Koschmieder, Martina Crysandt, Eric Bindels, Rafael Kramann, Ivan G. Costa, Rebekka K. Schneider
Published in: SSRN Electronic Journal, 2020, ISSN 1556-5068
Publisher: Sneak Peek Cell Press
DOI: 10.2139/ssrn.3493957

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