A combined in vitro and in vivo approach to dissect biochemical network evolution.

Project Information

EvoCellBio

Grant agreement ID: 758132

DOI 10.3030/758132

Project closed

EC signature date 21 November 2017

Start date 1 February 2018

End date 31 January 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 500 000,00

EU contribution € 1 500 000,00

Coordinated by

TECHNISCHE UNIVERSITEIT DELFT
Netherlands

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (7)

Evolved interactions stabilize many coexisting phases in multicomponent liquids

Author(s): David Zwicker and Liedewij Laan
Published in: PNAS, 2022, ISSN 1091-6490
Publisher: National Academy of Science
DOI: 10.1073/pnas.2201250119

Predicting evolution using regulatory architecture

Author(s): Philippe Nghe, Marjon de Vos, Enzo Kingma, Manjunatha Kogenaru, Frank Poelwijk, Liedewij Laan, Sander Tans
Published in: Annu Rev Biophys, 2020, ISSN 1936-1238
Publisher: Annual Review
DOI: 10.1146/annurev-biophys-070317-032939

Pleiotropy drives evolutionary repair of the responsiveness of polarized cell growth to environmental cues

Author(s): Enzo Kingma, Eveline T. Diepeveen, Leila Iñigo de la Cruz, Liedewij Laan
Published in: Frontiers Microbiology, 2023, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2023.1076570

Redundancy and the role of protein copy numbers in the cell polarization machinery of budding yeast

Author(s): Fridtjof Brauns, Leila M. Iñigo de la Cruz, Werner K.-G. Daalman, Ilse de Bruin, Jacob Halatek, Liedewij Laan and Erwin Frey
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-42100-0

The Path towards Predicting Evolution as Illustrated in Yeast Cell Polarity

Author(s): Werner Daalman, Els Sweep, Liedewij Laan
Published in: Cells, Issue 9/12, 2020, Page(s) 2534, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells9122534

Complexity and self-organization in the evolution of cell polarization

Author(s): Marieke Glazenburg and Liedewij Laan
Published in: Journal of Cell Science, 2023, ISSN 1477-9137
Publisher: Company of Biologists
DOI: 10.1242/jcs.259639

A tractable physical model for the yeast polarity predicts epistasis and fitness

Author(s): Werner Karl-Gustav Daalman, Els Sweep, and Liedewij Laan
Published in: Phil. Trans. R. Soc. B, 2023, ISSN 0962-8436
Publisher: Royal Society of London
DOI: 10.1098/rstb.2022.0044

Other (3)

The GEF Cdc24 and GAP Rga2 synergistically regulate Cdc42 GTPase cycling

Author(s): Sophie Tschirpke, Werner K-G. Daalman, Liedewij Laan
Published in: 2023
Publisher: Biorxiv
DOI: 10.1101/2023.06.26.546500

A guide to the in vitro reconstitution of Cdc42 GTPase activity and its regulation

Author(s): Sophie Tschirpke, Frank van Opstal, Ramon van der Valk , Daalman Werner K-G., Liedewij Laan
Published in: 2023
Publisher: na
DOI: 10.1101/2023.04.24.538075

Saturated Transposon Analysis in Yeast as a One-step Method to Quantify the Fitness Effects of Gene Disruptions on a Genome-Wide Scale

Author(s): Enzo Kingma, Floor Dolsma, Leila Margarita Iñigo De La Cruz, Liedewij Laan
Published in: 2023, ISSN 2692-8205
Publisher: Biorxiv
DOI: 10.1101/2023.09.08.556793