A combined in vitro and in vivo approach to dissect biochemical network evolution.

Publicaciones

Evolved interactions stabilize many coexisting phases in multicomponent liquids

Autores: David Zwicker and Liedewij Laan
Publicado en: PNAS, 2022, ISSN 1091-6490
Editor: National Academy of Science
DOI: 10.1073/pnas.2201250119

Predicting evolution using regulatory architecture

Autores: Philippe Nghe, Marjon de Vos, Enzo Kingma, Manjunatha Kogenaru, Frank Poelwijk, Liedewij Laan, Sander Tans
Publicado en: Annu Rev Biophys, 2020, ISSN 1936-1238
Editor: Annual Review
DOI: 10.1146/annurev-biophys-070317-032939

Pleiotropy drives evolutionary repair of the responsiveness of polarized cell growth to environmental cues

Autores: Enzo Kingma, Eveline T. Diepeveen, Leila Iñigo de la Cruz, Liedewij Laan
Publicado en: Frontiers Microbiology, 2023, ISSN 1664-302X
Editor: Frontiers Media
DOI: 10.3389/fmicb.2023.1076570

Redundancy and the role of protein copy numbers in the cell polarization machinery of budding yeast

Autores: Fridtjof Brauns, Leila M. Iñigo de la Cruz, Werner K.-G. Daalman, Ilse de Bruin, Jacob Halatek, Liedewij Laan and Erwin Frey
Publicado en: Nature Communications, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-42100-0

The Path towards Predicting Evolution as Illustrated in Yeast Cell Polarity

Autores: Werner Daalman, Els Sweep, Liedewij Laan
Publicado en: Cells, Edición 9/12, 2020, Página(s) 2534, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells9122534

Complexity and self-organization in the evolution of cell polarization

Autores: Marieke Glazenburg and Liedewij Laan
Publicado en: Journal of Cell Science, 2023, ISSN 1477-9137
Editor: Company of Biologists
DOI: 10.1242/jcs.259639

A tractable physical model for the yeast polarity predicts epistasis and fitness

Autores: Werner Karl-Gustav Daalman, Els Sweep, and Liedewij Laan
Publicado en: Phil. Trans. R. Soc. B, 2023, ISSN 0962-8436
Editor: Royal Society of London
DOI: 10.1098/rstb.2022.0044

The GEF Cdc24 and GAP Rga2 synergistically regulate Cdc42 GTPase cycling

Autores: Sophie Tschirpke, Werner K-G. Daalman, Liedewij Laan
Publicado en: 2023
Editor: Biorxiv
DOI: 10.1101/2023.06.26.546500

A guide to the in vitro reconstitution of Cdc42 GTPase activity and its regulation

Autores: Sophie Tschirpke, Frank van Opstal, Ramon van der Valk , Daalman Werner K-G., Liedewij Laan
Publicado en: 2023
Editor: na
DOI: 10.1101/2023.04.24.538075

Saturated Transposon Analysis in Yeast as a One-step Method to Quantify the Fitness Effects of Gene Disruptions on a Genome-Wide Scale

Autores: Enzo Kingma, Floor Dolsma, Leila Margarita Iñigo De La Cruz, Liedewij Laan
Publicado en: 2023, ISSN 2692-8205
Editor: Biorxiv
DOI: 10.1101/2023.09.08.556793

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