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Physiologically Anchored Tools for Realistic nanOmateriaL hazard aSsessment

Objective

Nanotechnology promises significant scientific, economic and societal benefits, but commercialization and growth are threatened by safety uncertainties. Classical hazard testing strategies to define the human and environmental health impact of engineered nanomaterials (ENM) commonly apply unrealistic acute, high-doses to models that do not reflect the in vivo environment. Furthermore, existing in vitro and in silico hazard detection methods are not accurately predictive. PATROLS addresses these limitations by establishing and standardizing the next generation of advanced safety assessment tools for improved prediction of the adverse effects caused by chronic ENM exposure in human and environmental systems. PATROLS will deliver: 1) physiologically representative multi-cellular in vitro 3D lung, gastrointestinal tract and liver models; 2) cross-species models integrating human and environmental safety testing; 3) innovative ecotoxicity bioassays in several organisms across a food chain; 4) robust in silico models for dosimetry, interspecies toxicity extrapolation and hazard prediction. ENM characterization under physiologically relevant experimental conditions will be integral to this realistic, exposure driven strategy. A systems biology approach will also be adopted to identify key events linked to adverse outcome pathways, informing mechanism-based endpoints associated with real-life ENM exposures. These objectives will be achieved by an international network of world-leading academic, governmental, industrial, SME, risk assessment agency and NGO partners. The innovative in vitro and in silico nanosafety testing tools developed by PATROLS will balance speed, cost and biological complexity, while reducing uncertainty via improved predictive power. The smart targeted testing approach will drive a paradigm shift in (eco)toxicology towards mechanism-based ENM hazard assessment to support policy development in human and environmental nanosafety regulatory frameworks.

Call for proposal

H2020-NMBP-2017-two-stage
See other projects for this call

Coordinator

SWANSEA UNIVERSITY
Address
Singleton Park
SA2 8PP Swansea
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 511 623,50

Participants (23)

THE UNIVERSITY OF EXETER
United Kingdom
EU contribution
€ 590 886,25
Address
The Queen's Drive Northcote House
EX4 4QJ Exeter
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE FRIBOURG
Switzerland
EU contribution
€ 863 390
Address
Avenue De L Europe 20
1700 Fribourg
Activity type
Higher or Secondary Education Establishments
HERIOT-WATT UNIVERSITY
United Kingdom
EU contribution
€ 1 166 363,75
Address
Riccarton
EH14 4AS Edinburgh
Activity type
Higher or Secondary Education Establishments
UNIVERSITEIT LEIDEN
Netherlands
EU contribution
€ 850 467,50
Address
Rapenburg 70
2311 EZ Leiden
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DI PISA
Italy
EU contribution
€ 384 930
Address
Lungarno Pacinotti 43/44
56126 Pisa
Activity type
Higher or Secondary Education Establishments
UNIVERSITE CATHOLIQUE DE LOUVAIN
Belgium
EU contribution
€ 428 826,25
Address
Place De L Universite 1
1348 Louvain La Neuve
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE NAMUR ASBL
Belgium
EU contribution
€ 538 712,50
Address
Rue De Bruxelles 61
5000 Namur
Activity type
Higher or Secondary Education Establishments
DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 821 238
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Activity type
Higher or Secondary Education Establishments
QSAR LAB SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA
Poland
EU contribution
€ 353 193,75
Address
Al Grunwaldzka 190/102
80-266 Gdansk
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
HARVARD GLOBAL RESEARCH AND SUPPORT SERVICES INC.
United States
EU contribution
€ 0
Address
Office Of The General Counsel, Holyoke Center, Suite 980, Massachusetts Avenue 1350
02138 Cambridge
Activity type
Research Organisations
UNIVERSITY OF SOUTH CAROLINA
United States
EU contribution
€ 0
Address
Hampton Street 1600 Annex 208
SC29208 Columbia
Activity type
Higher or Secondary Education Establishments
DET NATIONALE FORSKNINGSCENTER FORARBEJDSMILJO
Denmark
EU contribution
€ 758 366
Address
Lerso Parkalle 105
2100 Kobenhavn
Activity type
Research Organisations
RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU
Netherlands
EU contribution
€ 881 765
Address
Antonie Van Leeuwenhoeklaan 9
3721 MA Bilthoven
Activity type
Research Organisations
EUROPEAN RESEARCH SERVICES GMBH
Germany
EU contribution
€ 311 250
Address
Roentgenstrasse 19
48149 Muenster
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNITED KINGDOM RESEARCH AND INNOVATION
United Kingdom
EU contribution
€ 88 656,25
Address
Polaris House North Star Avenue
SN2 1FL Swindon
Activity type
Research Organisations
KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE
South Korea
EU contribution
€ 0
Address
Gajeong-ro Yuseong-gu 267
305-340 Daejeon
Activity type
Research Organisations
INSTITUTE OF OCCUPATIONAL MEDICINE
United Kingdom
EU contribution
€ 370 816,25
Address
Research Avenue North, Riccarton 45
EH14 4AP Edinburgh
Activity type
Research Organisations
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 441 845
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
INSTITUT FUR UMWELTMEDIZINISCHE FORSCHUNG AN DER HEINRICH-HEINE-UNIVERSITAT DUSSELDORF GMBH
Germany
EU contribution
€ 597 252,50
Address
Auf M Hennekamp 50
40225 Duesseldorf
Activity type
Other
BASF SE
Germany
EU contribution
€ 684 842,50
Address
Carl Bosch Strasse 38
67063 Ludwigshafen Am Rhein
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSPHERO AG
Switzerland
EU contribution
€ 481 961,25
Address
Wagistrasse 27
8952 Schlieren
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MISVIK BIOLOGY OY
Finland
EU contribution
€ 336 325
Address
Karjakatu 35 B
20520 Turku
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NANOTECHNOLOGY INDUSTRIES ASSOCIATION
Belgium
EU contribution
€ 251 468,75
Address
Avenue De Tervueren 143
1150 Bruxelles
Activity type
Other