Objective Nanotechnology promises significant scientific, economic and societal benefits, but commercialization and growth are threatened by safety uncertainties. Classical hazard testing strategies to define the human and environmental health impact of engineered nanomaterials (ENM) commonly apply unrealistic acute, high-doses to models that do not reflect the in vivo environment. Furthermore, existing in vitro and in silico hazard detection methods are not accurately predictive. PATROLS addresses these limitations by establishing and standardizing the next generation of advanced safety assessment tools for improved prediction of the adverse effects caused by chronic ENM exposure in human and environmental systems. PATROLS will deliver: 1) physiologically representative multi-cellular in vitro 3D lung, gastrointestinal tract and liver models; 2) cross-species models integrating human and environmental safety testing; 3) innovative ecotoxicity bioassays in several organisms across a food chain; 4) robust in silico models for dosimetry, interspecies toxicity extrapolation and hazard prediction. ENM characterization under physiologically relevant experimental conditions will be integral to this realistic, exposure driven strategy. A systems biology approach will also be adopted to identify key events linked to adverse outcome pathways, informing mechanism-based endpoints associated with real-life ENM exposures. These objectives will be achieved by an international network of world-leading academic, governmental, industrial, SME, risk assessment agency and NGO partners. The innovative in vitro and in silico nanosafety testing tools developed by PATROLS will balance speed, cost and biological complexity, while reducing uncertainty via improved predictive power. The smart targeted testing approach will drive a paradigm shift in (eco)toxicology towards mechanism-based ENM hazard assessment to support policy development in human and environmental nanosafety regulatory frameworks. Fields of science medical and health scienceshealth sciencespublic healthmedical and health sciencesclinical medicineoncologysocial sciencessociologygovernancecrisis managementengineering and technologynanotechnologynano-materialsmedical and health sciencesbasic medicinetoxicology Programme(s) H2020-EU.2.1.2. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies Main Programme H2020-EU.2.1.2.2. - Ensuring the safe and sustainable development and application of nanotechnologies Topic(s) NMBP-29-2017 - Advanced and realistic models and assays for nanomaterial hazard assessment Call for proposal H2020-NMBP-2016-2017 See other projects for this call Sub call H2020-NMBP-2017-two-stage Funding Scheme RIA - Research and Innovation action Coordinator SWANSEA UNIVERSITY Net EU contribution € 1 511 623,50 Address SINGLETON PARK SA2 8PP Swansea United Kingdom See on map Region Wales West Wales and The Valleys Swansea Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 511 623,50 Participants (23) Sort alphabetically Sort by Net EU contribution Expand all Collapse all THE UNIVERSITY OF EXETER United Kingdom Net EU contribution € 590 886,25 Address THE QUEEN'S DRIVE NORTHCOTE HOUSE EX4 4QJ Exeter See on map Region South West (England) Devon Devon CC Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 590 886,25 UNIVERSITE DE FRIBOURG Switzerland Net EU contribution € 863 390,00 Address AVENUE DE L EUROPE 20 1700 Fribourg See on map Region Schweiz/Suisse/Svizzera Espace Mittelland Fribourg / Freiburg Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 863 390,00 HERIOT-WATT UNIVERSITY United Kingdom Net EU contribution € 1 166 363,75 Address Riccarton EH14 4AS Edinburgh See on map Region Scotland Eastern Scotland Edinburgh Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 166 363,75 UNIVERSITEIT LEIDEN Netherlands Net EU contribution € 850 467,50 Address RAPENBURG 70 2311 EZ Leiden See on map Region West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 850 467,50 UNIVERSITA DI PISA Italy Net EU contribution € 384 930,00 Address LUNGARNO PACINOTTI 43/44 56126 Pisa See on map Region Centro (IT) Toscana Pisa Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 384 930,00 UNIVERSITE CATHOLIQUE DE LOUVAIN Belgium Net EU contribution € 428 826,25 Address PLACE DE L UNIVERSITE 1 1348 Louvain La Neuve See on map Region Région wallonne Prov. Brabant Wallon Arr. Nivelles Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 428 826,25 UNIVERSITE DE NAMUR ASBL Belgium Net EU contribution € 538 712,50 Address RUE DE BRUXELLES 61 5000 Namur See on map Region Région wallonne Prov. Namur Arr. Namur Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 538 712,50 DANMARKS TEKNISKE UNIVERSITET Denmark Net EU contribution € 821 238,00 Address ANKER ENGELUNDS VEJ 101 2800 Kongens Lyngby See on map Region Danmark Hovedstaden Københavns omegn Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 821 238,00 QSAR LAB SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA Poland Net EU contribution € 353 193,75 Address UL. TRZY LIPY 3 80-172 Gdansk See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Makroregion północny Pomorskie Trójmiejski Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 353 193,75 HARVARD GLOBAL RESEARCH AND SUPPORT SERVICES INC. United States Net EU contribution € 0,00 Address OFFICE OF THE GENERAL COUNSEL, HOLYOKE CENTER, SUITE 980, MASSACHUSETTS AVENUE 1350 02138 Cambridge See on map Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 10 000,00 UNIVERSITY OF SOUTH CAROLINA United States Net EU contribution € 0,00 Address HAMPTON STREET 1600 ANNEX 208 SC29208 Columbia See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 105 000,00 DET NATIONALE FORSKNINGSCENTER FOR ARBEJDSMILJØ Denmark Net EU contribution € 758 366,00 Address LERSO PARKALLE 105 2100 Kobenhavn See on map Region Danmark Hovedstaden Byen København Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 758 366,00 RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU Netherlands Net EU contribution € 881 765,00 Address Antonie Van Leeuwenhoeklaan 9 3721 MA Bilthoven See on map Region West-Nederland Utrecht Utrecht Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 881 765,00 EUROPEAN RESEARCH SERVICES GMBH Germany Net EU contribution € 311 250,00 Address HUEFFERSTR. 5 48149 Muenster See on map Region Nordrhein-Westfalen Münster Münster, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 311 250,00 UNITED KINGDOM RESEARCH AND INNOVATION United Kingdom Net EU contribution € 88 656,25 Address POLARIS HOUSE NORTH STAR AVENUE SN2 1FL Swindon See on map Region South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Swindon Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 88 656,25 KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE South Korea Net EU contribution € 0,00 Address GAJEONG-RO YUSEONG-GU 267 305-340 DAEJEON See on map Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 279 167,50 INSTITUTE OF OCCUPATIONAL MEDICINE United Kingdom Net EU contribution € 370 816,25 Address Research Avenue North, Riccarton 45 EH14 4AP Edinburgh See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Scotland Eastern Scotland Edinburgh Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 370 816,25 CONSIGLIO NAZIONALE DELLE RICERCHE Italy Net EU contribution € 441 845,00 Address PIAZZALE ALDO MORO 7 00185 Roma See on map Region Centro (IT) Lazio Roma Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 441 845,00 IUF - LEIBNIZ-INSTITUT FUR UMWELTMEDIZINISCHE FORSCHUNG GMBH Germany Net EU contribution € 597 252,50 Address AUF M HENNEKAMP 50 40225 Dusseldorf See on map Region Nordrhein-Westfalen Düsseldorf Düsseldorf, Kreisfreie Stadt Activity type Other Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 597 252,50 BASF SE Germany Net EU contribution € 684 842,50 Address CARL BOSCH STRASSE 38 67063 Ludwigshafen Am Rhein See on map Region Rheinland-Pfalz Rheinhessen-Pfalz Ludwigshafen am Rhein, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 684 842,50 INSPHERO AG Switzerland Net EU contribution € 481 961,25 Address WAGISTRASSE 27 8952 Schlieren See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 481 961,25 MISVIK BIOLOGY OY Finland Net EU contribution € 336 325,00 Address KARJAKATU 35 B 20520 Turku See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Manner-Suomi Etelä-Suomi Varsinais-Suomi Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 336 325,00 NANOTECHNOLOGY INDUSTRIES ASSOCIATION Belgium Net EU contribution € 251 468,75 Address AVENUE DE TERVUEREN 143 1150 Bruxelles / Brussel See on map Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Activity type Other Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 251 468,75
