Physiologically Anchored Tools for Realistic nanOmateriaL hazard aSsessment

Livrables

Critical toxicity data for IVIVE based on existing in vivo sub-acute and (sub)chronic oral and inhalation studies

A written report of tabulated data collected from a variety of sources as described in Task 2.1.

Report on reproducibility, transferability & end-user feedback on at least one harmonised advanced in vitro lung model

SOPs for harmonized models will be reported together with reproducibility transferability and enduser feed back report

Advanced long term exposure ecotoxicity bioassays for a variety of species across a food chain

A report detailing the advanced ecotoxicity bioassays for algae, daphnids and zebrafish embryos accounting explicitly for long-term environmentally relevant ENM exposure

Materials acquisition, physicochemical intrinsic properties and endotoxin evaluation on Tier 1 and 2 ENM

A report summarizing the key features of the ENM sub-sampled or newly synthesized material sub-samples obtained from JRC-Ispra and the Fraunhofer Institute. This will include detail of each ENMs intrinsic physico-chemical characteristics and their endotoxin contamination status.

Read across for conservancy of effects of ENM across divergent taxa

A report summarizing interspeciesnanoread across modeling based on predicting toxic effects across species when the data on common MoA is available in a tested species under the realistic exposure scenarios

ENM dispersibility and physicochemical exposure relevant properties

Report detailing the physico-chemical characteristics of each ENM in relevant liquid media (corresponding to the applied experimental conditions) after dispersion using the harmonised probe-dispersion protocol developed in NANoREG.

Report on reproducibility, transferability & end-user feedback on at least one harmonised advanced GIT and liver model

SOPs for harmonized models will be reported together with reproducibility transferability and enduser feed back report

Experimental determination of the (long-term) fate of ENM in advanced lung, GIT and liver cell models

Report summarizing the interaction of the Tier 1 ENM with the lung, gut and liver models from WP3-5. This will include ENM uptake, intra-cellular fate and translocation across the cellular membrane within each test system.

Effects of subchronic oral exposure to ENM

A report that will summarize newly derived data from tissues of existing studies as well as one new 90-day oral study according to OECD TG 408.

Biodistribution of ENM after oral and inhalation exposure

A report presenting newly generated data on biodistribution and organ burdens of ENM after single and repeated exposure that will be used in WP6 as well as WP3 and WP4 to define concentrations in in vitro studies

Effects of repeated dose inhalation studies with ENM

A report that will summarize newly derived data generated from existing stored tissues obtained through previously conducted and on-going studies.

In vivo dosimetry modelling and experimental design report

Report summarizing the exposure regimen for the selected ENM in each in vivo system based on several combined dosimetry models to facilitate consideration of comparable doses in the in vitro experiments

Environmental fate and dosimetry in relevant environmental compartments

Summary report detailing the fate and dosimetry of Tier 1 ENM in environmental matrices (water and sediment based systems including test organims) as defined in WP5.

SOPs Handbook describing test methods which could be taken up by ISO and OECD

A report collating all PATROLS SOPs into a handbook that will be available for free download ebook

Report on reproducibility and transferability of harmonised advanced algal and daphnid ecotoxicity test systems

SOPs for harmonized ecotoxicity model will be reported together with reproducibility transferability and enduser feed back report

Identification of key events with predictive value for effects due to chronic ENM exposure

Report on the KEs/pathways of developed AOPs based on established and putative AOPs, published toxicity data and meta-analyses with the aim of enabling WP3 and 4 to develop targeted in vitro bioassays with enhanced predictive value. The report will also provide data addressing knowledge gaps based on existing data and AOPs.

Compare and contrast advanced human lung models to cross-species models

Report summarizing the comparison between toxicity endpoint data andor AOPs data generated across species in WP5 Task 53 with lung model data

Management framework & shared server for information management established

A report summarizing the management tools provided to facilitate the day-day project coordination.

Environmental dosimetry modelling and dose-response prediction report

Report detailing the outputs from modelling bioaccumulation data and ENM redistribution kinetics across the ecological taxa assessed

Compare and contrast 3D GIT and liver models to cross-species models

Report summerizing the comparison between toxicity endpoint data and/or AOPs data generated across species in WP5 (Task 5.3) with GIT and liver model data.

Guidance document for the design of a large-scale multi-centre ring test

Guidance document required for future validation of the test methods developed

Physicochemical hazard concern phenomena, with specific focus on dissolution and hydrochemical reactivity

Report providing an overview of the dissolution rates redox and photocatalytic activity radical formation capacity of the selected ENM in standard media as well as in specific in vitro and simulant biological media

Report detailing IVIVE models

Summary report specifiying the IVIVE models developed including uncertainty factors regarding interanimal and interspecies differences

In vitro dosimetry modelling and experimental design report

Report summarizing the exposure regimen for the selected ENM in each in vitro system based on several combined dosimetry models.

PATROLS MODA

Report on the developed MODA for WP6.

SOPs on programming codes

Report providing SOPs on the programming codes An appendix containing the background data generated whilst developing the SOP will be included

SOPs for ENM characterisation, reactivity and behaviour in biological matrices

This report will consist of the SOPs developed through Task 14 and 15 for fate and dose characterization An appendix containing the background data generated whilst developing the SOP will be included

Six-monthly E-newsletters documenting updates

Electronic newsletters will be prepared every 6-months for dissemination of PATROLS achievements and updates through a wide contacts distribution list.

PATROLS database

A comprehensive project database system containing the physicochemical toxicological and other related data generated by WP15 as well as in vivo data collected from other sources

Publications

Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure

Auteurs: Samantha V. Llewellyn, Gillian E. Conway, Ume-Kulsoom Shah, Stephen J. Evans, Gareth J.S. Jenkins, Martin J.D. Clift, Shareen H. Doak
Publié dans: Journal of Visualized Experiments, Numéro 160, 2020, ISSN 1940-087X
Éditeur: MYJoVE Corporation
DOI: 10.3791/61141

The influence of exposure approaches to <i>in vitro</i> lung epithelial barrier models to assess engineered nanomaterial hazard

Auteurs: Meldrum, Kirsty; Evans, Stephen J.; Vogel, Ulla; Tran, Lang; Doak, Shareen H.; Clift, Martin J. D.
Publié dans: Nanotoxicology, Numéro 1, 2022, ISSN 1743-5390
Éditeur: Informa Healthcare
DOI: 10.1080/17435390.2022.2051627

Translating Scientific Advances in the AOP Framework to Decision Making for Nanomaterials

Auteurs: James D. Ede, Vladimir Lobaskin, Ulla Vogel, Iseult Lynch, Sabina Halappanavar, Shareen H. Doak, Megan G. Roberts, Jo Anne Shatkin
Publié dans: Nanomaterials, Numéro 10/6, 2020, Page(s) 1229, ISSN 2079-4991
Éditeur: MDPI
DOI: 10.3390/nano10061229

Optimization of an air-liquid interface in vitro cell co-culture model to estimate the hazard of aerosol exposures

Auteurs: Rui-Wen He, Hedwig M. Braakhuis, Rob J. Vandebriel, Yvonne C.M. Staal, Eric R. Gremmer, Paul H.B. Fokkens, Claudia Kemp, Jolanda Vermeulen, Remco H.S. Westerink, Flemming R. Cassee
Publié dans: Journal of Aerosol Science, Numéro 153, 2021, Page(s) 105703, ISSN 0021-8502
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.jaerosci.2020.105703

Breathing in vitro: Designs and applications of engineered lung models

Auteurs: Roberta Nossa, Joana Costa, Ludovica Cacopardo, Arti Ahluwalia
Publié dans: Journal of Tissue Engineering, Numéro 12, 2021, Page(s) 204173142110086, ISSN 2041-7314
Éditeur: Sage Publishing
DOI: 10.1177/20417314211008696

Oxidative stress actuated by cellulose nanocrystals and nanofibrils in aquatic organisms of different trophic levels

Auteurs: Zhuang Wang, Lan Song, Nan Ye, Qi Yu, Yujia Zhai, Fan Zhang, Martina G. Vijver, Willie J.G.M. Peijnenburg
Publié dans: NanoImpact, Numéro 17, 2020, Page(s) 100211, ISSN 2452-0748
Éditeur: Elsevier
DOI: 10.1016/j.impact.2020.100211

The Road to Achieving the European Commission's Chemicals Strategy for Nanomaterial Sustainability—A PATROLS Perspective on New Approach Methodologies

Auteurs: Doak, Shareen H.; Clift, Martin J. D.; Costa, Anna; Delmaar, Christiaan; Gosens, Ilse; Halappanavar, Sabina; Kelly, Sean; Pejinenburg, Willie J. G. M.; Rothen‐Rutishauser, Barbara; Schins, Roel P. F.; Stone, Vicki; Tran, Lang; Vijver, Martina G.; Vogel, Ulla; Wohlleben, Wendel; Cassee, Flemming R.
Publié dans: SMall, Numéro 1, 2022, ISSN 1613-6829
Éditeur: Wiley
DOI: 10.1002/smll.202200231

Adverse Outcome Pathway Development for Assessment of Lung Carcinogenicity by Nanoparticles

Auteurs: Penny Nymark, Hanna L. Karlsson, Sabina Halappanavar, Ulla Vogel
Publié dans: Frontiers in Toxicology, Numéro 3, 2021, ISSN 2673-3080
Éditeur: Frontiers Media SA
DOI: 10.3389/ftox.2021.653386

Effects of humic substances on the aqueous stability of cerium dioxide nanoparticles and their toxicity to aquatic organisms

Auteurs: Qi Yu, Zhuang Wang, Yujia Zhai, Fan Zhang, Martina G. Vijver, Willie J.G.M. Peijnenburg
Publié dans: Science of The Total Environment, Numéro 781, 2021, Page(s) 146583, ISSN 0048-9697
Éditeur: Elsevier BV
DOI: 10.1016/j.scitotenv.2021.146583

Ingested Engineered Nanomaterials Affect the Expression of Mucin Genes—An In Vitro-In Vivo Comparison

Auteurs: Gerrit Bredeck; Angela A. M. Kämpfer; Adriana Sofranko; Tina Wahle; Veronika Büttner; Catrin Albrecht; Roel P. F. Schins
Publié dans: Nanomaterials, Vol 11, Iss 2621, p 2621 (2021), Numéro 11, 2021, ISSN 2079-4991
Éditeur: MDPI
DOI: 10.3390/nano11102621

Introducing WikiPathways as a Data-Source to Support Adverse Outcome Pathways for Regulatory Risk Assessment of Chemicals and Nanomaterials

Auteurs: Marvin Martens, Tim Verbruggen, Penny Nymark, Roland Grafström, Lyle D. Burgoon, Hristo Aladjov, Fernando Torres Andón, Chris T. Evelo, Egon L. Willighagen
Publié dans: Frontiers in Genetics, Numéro 9, 2018, ISSN 1664-8021
Éditeur: Frontiers Media
DOI: 10.3389/fgene.2018.00661

Validation and Demonstration of an Atmosphere-Temperature-pH-Controlled Stirred Batch Reactor System for Determination of (Nano)Material Solubility and Dissolution Kinetics in Physiological Simulant Lung Fluids

Auteurs: Holmfred, Else; Loeschner, Katrin; Sloth, Jens J.; Jensen, Keld Alstrup
Publié dans: Nanomaterials, Numéro vol. 12 , no. 3 , 517, 2022, ISSN 2079-4991
Éditeur: MDPI
DOI: 10.3390/nano12030517

Adverse outcome pathways as a tool for the design of testing strategies to support the safety assessment of emerging advanced materials at the nanoscale

Auteurs: Sabina Halappanavar, Sybille van den Brule, Penny Nymark, Laurent Gaté, Carole Seidel, Sarah Valentino, Vadim Zhernovkov, Pernille Høgh Danielsen, Andrea De Vizcaya, Henrik Wolff, Tobias Stöger, Andrey Boyadziev, Sarah Søs Poulsen, Jorid Birkelund Sørli, Ulla Vogel
Publié dans: Particle and Fibre Toxicology, Numéro 17/1, 2020, ISSN 1743-8977
Éditeur: BioMed Central
DOI: 10.1186/s12989-020-00344-4

Opportunities and Challenges for Integrating New In Vitro Methodologies in Hazard Testing and Risk Assessment

Auteurs: Natalie Burden, Martin J. D. Clift, Gareth J. S. Jenkins, Briony Labram, Fiona Sewell
Publié dans: Small, Numéro 17/15, 2021, Page(s) 2006298, ISSN 1613-6810
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202006298

Particulate and drug-induced toxicity assessed in novel quadruple cell human primary hepatic disease models of steatosis and pre-fibrotic NASH

Auteurs: Ali Kermanizadeh; Jessica Valli; Katarzyna Sanchez; Simon Hutter; Agnieszka Pawlowska; Graeme Whyte; Wolfgang Moritz; Vicki Stone
Publié dans: Archives of Toxicology, Numéro 7/2021, 2021, ISSN 0340-5761
Éditeur: Springer Verlag
DOI: 10.1007/s00204-021-03181-2

Microbiota-dependent TLR2 signaling reduces silver nanoparticle toxicity to zebrafish larvae

Auteurs: Brinkmann, Bregje W; Koch, Bjørn E V; Peijnenburg, Willie J G M; Vijver, Martina G
Publié dans: Ecotoxicology and Environmental Safety, Numéro 3, 2022, ISSN 0147-6513
Éditeur: Academic Press
DOI: 10.1016/j.ecoenv.2022.113522

Interlaboratory comparison of an intestinal triple culture to confirm transferability and reproducibility

Auteurs: Kämpfer, Angela A. M.; Shah, Ume-Kulsoom; Chu, Shui L.; Busch, Mathias; Büttner, Veronika; He, Ruiwen; Rothen-Rutishauser, Barbara; Schins, Roel P. F.; Jenkins, Gareth J.
Publié dans: In Vitro Models, Numéro 3, 2022, ISSN 2731-3441
Éditeur: Springer
DOI: 10.1007/s44164-022-00025-w

New insights into organ-specific oxidative stress mechanisms using a novel biosensor zebrafish

Auteurs: Sulayman Mourabit, Jennifer A. Fitzgerald, Robert P. Ellis, Aya Takesono, Cosima S. Porteus, Maciej Trznadel, Jeremy Metz, Matthew J. Winter, Tetsuhiro Kudoh, Charles R. Tyler
Publié dans: Environment International, Numéro 133, 2019, Page(s) 105138, ISSN 0160-4120
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2019.105138

Use of EpiAlveolar Lung Model to Predict Fibrotic Potential of Multiwalled Carbon Nanotubes

Auteurs: Hana Barosova, Anna G. Maione, Dedy Septiadi, Monita Sharma, Laetitia Haeni, Sandor Balog, Olivia O’Connell, George R. Jackson, David Brown, Amy J. Clippinger, Patrick Hayden, Alke Petri-Fink, Vicki Stone, Barbara Rothen-Rutishauser
Publié dans: ACS Nano, Numéro 14/4, 2020, Page(s) 3941-3956, ISSN 1936-0851
Éditeur: American Chemical Society
DOI: 10.1021/acsnano.9b06860

The fate and toxicity of Pb-based perovskite nanoparticles on soil bacterial community: Impacts of pH, humic acid, and divalent cations

Auteurs: Yujia Zhai, Zhuang Wang, Guiyin Wang, Willie J.G.M. Peijnenburg, Martina G. Vijver
Publié dans: Chemosphere, Numéro 249, 2020, Page(s) 126564, ISSN 0045-6535
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.chemosphere.2020.126564

Using AOP-Wiki to support the ecotoxicological risk assessment of nanomaterials: first steps in the development of novel adverse outcome pathways

Auteurs: Karolina Jagiello; Beata Judzinska; Anita Sosnowska; Iseult Lynch; Sabina Halappanavar; Tomasz Puzyn
Publié dans: Environmental science: nano, Numéro 3, 2022, ISSN 2051-8161
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d1en01127h

Correlation analysis of single- and multigenerational endpoints in Daphnia magna toxicity tests: A case-study using TiO2 nanoparticles

Auteurs: Nederstigt, Tom A.P.; Peijnenburg, Willie J.G.M.; Blom, Rody; Vijver, Martina G.
Publié dans: ecotoxicology and environmental safety, Numéro 3, 2022, ISSN 0147-6513
Éditeur: Academic Press
DOI: 10.1016/j.ecoenv.2022.113792

Colonizing microbiota protect zebrafish larvae against silver nanoparticle toxicity

Auteurs: Bregje W. Brinkmann, Bjørn E. V. Koch, Herman P. Spaink, Willie J. G. M. Peijnenburg, Martina G. Vijver
Publié dans: Nanotoxicology, Numéro 14/6, 2020, Page(s) 725-739, ISSN 1743-5390
Éditeur: Informa Healthcare
DOI: 10.1080/17435390.2020.1755469

Simulating Nanomaterial Transformation in Cascaded Biological Compartments to Enhance the Physiological Relevance of In Vitro Dosing Regimes: Optional or Required?

Auteurs: Samantha V. Llewellyn, Angela Kämpfer, Johannes G. Keller, Klaus Vilsmeier, Veronika Büttner, Didem Ag Seleci, Roel P. F. Schins, Shareen H. Doak, Wendel Wohlleben
Publié dans: Small, 2021, Page(s) 2004630, ISSN 1613-6810
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202004630

Applicability of nanomaterial-specific guidelines within long-term Daphnia magna toxicity assays: A case study on multigenerational effects of nTiO2 and nCeO2 exposure in the presence of artificial daylight

Auteurs: Nederstigt, Tom A.P.; Peijnenburg, Willie J.G.M.; Bleeker, Eric A.J.; Vijver, Martina G.
Publié dans: Regulatory Toxicology and Pharmacology, Numéro 1, 2022, ISSN 0273-2300
Éditeur: Academic Press
DOI: 10.1016/j.yrtph.2022.105156

The preparation temperature influences the physicochemical nature and activity of nanoceria

Auteurs: Robert A Yokel, Wendel Wohlleben, Johannes Georg Keller, Matthew L Hancock, Jason M Unrine, D Allan Butterfield, Eric A Grulke
Publié dans: Beilstein Journal of Nanotechnology, Numéro 12, 2021, Page(s) 525-540, ISSN 2190-4286
Éditeur: Beilstein-Institut Zur Forderung der Chemischen Wissenschaften
DOI: 10.3762/bjnano.12.43

Development of a Quasi‐QSAR Model for Prediction of the Immobilization Response of <i>Daphnia magna</i> Exposed to Metal‐Based Nanomaterials

Auteurs: Bunmahotama, Warisa; Vijver, Martina G.; Peijnenburg, Willie
Publié dans: Environmental Toxicology and Chemistry, Numéro 1, 2022, ISSN 1552-8618
Éditeur: Wiley
DOI: 10.1002/etc.5322

An Inflamed Human Alveolar Model for Testing the Efficiency of Anti-inflammatory Drugs in vitro

Auteurs: Barbara Drasler, Bedia Begum Karakocak, Esma Bahar Tankus, Hana Barosova, Jun Abe, Mauro Sousa de Almeida, Alke Petri-Fink, Barbara Rothen-Rutishauser
Publié dans: Frontiers in Bioengineering and Biotechnology, Numéro 8, 2020, ISSN 2296-4185
Éditeur: Frontiers Media SA
DOI: 10.3389/fbioe.2020.00987

Inter-laboratory variability of A549 epithelial cells grown under submerged and air-liquid interface conditions

Auteurs: Hana Barosova, Kirsty Meldrum, Bedia Begum Karakocak, Sandor Balog, Shareen H. Doak, Alke Petri-Fink, Martin J.D. Clift, Barbara Rothen-Rutishauser
Publié dans: Toxicology in Vitro, Numéro 75, 2021, Page(s) 105178, ISSN 0887-2333
Éditeur: Elsevier BV
DOI: 10.1016/j.tiv.2021.105178

Advanced In Vitro Testing Strategies and Models of the Intestine for Nanosafety Research

Auteurs: Angela A. M. Kämpfer, Mathias Busch, Roel P. F. Schins
Publié dans: Chemical Research in Toxicology, Numéro 33/5, 2020, Page(s) 1163-1178, ISSN 0893-228X
Éditeur: American Chemical Society
DOI: 10.1021/acs.chemrestox.0c00079

Oral toxicity of titanium dioxide P25 at repeated dose 28-day and 90-day in rats

Auteurs: Min Beom Heo, Minjeong Kwak, Kyu Sup An, Hye Jin Kim, Hyeon Yeol Ryu, So Min Lee, Kyung Seuk Song, In Young Kim, Ji-Hwan Kwon, Tae Geol Lee
Publié dans: Particle and Fibre Toxicology, Numéro 17/1, 2020, ISSN 1743-8977
Éditeur: BioMed Central
DOI: 10.1186/s12989-020-00350-6

Oxygen Consumption Characteristics in 3D Constructs Depend on Cell Density

Auteurs: Chiara Magliaro, Giorgio Mattei, Flavio Iacoangeli, Alessandro Corti, Vincenzo Piemonte, Arti Ahluwalia
Publié dans: Frontiers in Bioengineering and Biotechnology, Numéro 7, 2019, ISSN 2296-4185
Éditeur: Frontiers
DOI: 10.3389/fbioe.2019.00251

Prediction of the Joint Toxicity of Multiple Engineered Nanoparticles: The Integration of Classic Mixture Models and In Silico Methods

Auteurs: Fan Zhang, Zhuang Wang, Martina G. Vijver, Willie J. G. M. Peijnenburg
Publié dans: Chemical Research in Toxicology, 2020, ISSN 0893-228X
Éditeur: American Chemical Society
DOI: 10.1021/acs.chemrestox.0c00300

Nanomaterials and Innate Immunity: A Perspective of the Current Status in Nanosafety

Auteurs: James G. Cronin, Nicholas Jones, Catherine A. Thornton, Gareth J. S. Jenkins, Shareen H. Doak, Martin J. D. Clift
Publié dans: Chemical Research in Toxicology, Numéro 33/5, 2020, Page(s) 1061-1073, ISSN 0893-228X
Éditeur: American Chemical Society
DOI: 10.1021/acs.chemrestox.0c00051

Method for extraction of nanoscale plastic debris from soil

Auteurs: Fazel Abdolahpur Monikh, Nikki Doornhein, Stefan Romeijn, Martina G. Vijver, Willie J. G. M. Peijnenburg
Publié dans: Analytical Methods, Numéro 13/13, 2021, Page(s) 1576-1583, ISSN 1759-9660
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d0ay02308f

Understanding the Development, Standardization, and Validation Process of Alternative In Vitro Test Methods for Regulatory Approval from a Researcher Perspective

Auteurs: Aurora Bas, Nicole Burns, Andrew Gulotta, James Junker, Barbara Drasler, Roman Lehner, Lothar Aicher, Samuel Constant, Alke Petri‐Fink, Barbara Rothen‐Rutishauser
Publié dans: Small, 2021, Page(s) 2006027, ISSN 1613-6810
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202006027

Dissolution Rate of Nanomaterials Determined by Ions and Particle Size under Lysosomal Conditions: Contributions to Standardization of Simulant Fluids and Analytical Methods

Auteurs: Ilaria Zanoni; Johannes G. Keller; Ursula G. Sauer; Philipp Müller; Lan Ma-Hock; Keld A. Jensen; Anna Luisa Costa; Wendel Wohlleben
Publié dans: Chemical Research in Toxicology, Numéro 3, 2022, ISSN 1520-5010
Éditeur: ACS Publications

A “point-of-entry” bioaccumulation study of nanoscale pigment copper phthalocyanine in aquatic organisms

Auteurs: Chengfang Pang, Lars M. Skjolding, Henriette Selck, Anders Baun
Publié dans: Environmental Science: Nano, Numéro 8/2, 2021, Page(s) 554-564, ISSN 2051-8153
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d0en00705f

Interaction between a nano-formulation of atrazine and rhizosphere bacterial communities: atrazine degradation and bacterial community alterations

Auteurs: Yujia Zhai, Fazel Abdolahpur Monikh, Juan Wu, Renato Grillo, Daniel Arenas-Lago, Gopala Krishna Darbha, Martina G. Vijver, Willie J. G. M. Peijnenburg
Publié dans: Environmental Science: Nano, Numéro 7/11, 2020, Page(s) 3372-3384, ISSN 2051-8153
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d0en00638f

The application of existing genotoxicity methodologies for grouping of nanomaterials: towards an integrated approach to testing and assessment

Auteurs: Verdon, Rachel; Stone, Vicki; Murphy, Fiona; Christopher, Emily; Johnston, Helinor; Doak, Shareen; Vogel, Ulla; Haase, Andrea; Kermanizadeh, Ali
Publié dans: Particle and Fibre Toxicology, Numéro 19, 2022, ISSN 1743-8977
Éditeur: BioMed Central
DOI: 10.1186/s12989-022-00476-9

Effect on Mouse Liver Morphology of CeO2, TiO2 and Carbon Black Nanoparticles Translocated from Lungs or Deposited Intravenously

Auteurs: Justyna Modrzynska, Alicja Mortensen, Trine Berthing, Gitte Ravn-Haren, Józef Szarek, Anne Thoustrup Saber, Ulla Vogel
Publié dans: Applied Nano, Numéro 2/3, 2021, Page(s) 222-241, ISSN 2673-3501
Éditeur: Applied Nano
DOI: 10.3390/applnano2030016

In Vitro Three‐Dimensional Liver Models for Nanomaterial DNA Damage Assessment

Auteurs: Samantha V. Llewellyn, Marije Niemeijer, Penny Nymark, Martijn J. Moné, Bob Water, Gillian E. Conway, Gareth J. S. Jenkins, Shareen H. Doak
Publié dans: Small, 2021, Page(s) 2006055, ISSN 1613-6810
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202006055

Assessment of nanomaterial-induced hepatotoxicity using a 3D human primary multi-cellular microtissue exposed repeatedly over 21 days - the suitability of the in vitro system as an in vivo surrogate

Auteurs: Ali Kermanizadeh, Trine Berthing, Ewa Guzniczak, Melanie Wheeldon, Graeme Whyte, Ulla Vogel, Wolfgang Moritz, Vicki Stone
Publié dans: Particle and Fibre Toxicology, Numéro 16/1, 2019, ISSN 1743-8977
Éditeur: BioMed Central
DOI: 10.1186/s12989-019-0326-0

Correction to: An Integrated In Vitro-In Silico Approach for Silver Nanoparticle Dosimetry in Cell Cultures.

Auteurs: Poli, Daniele; Mattei, Giorgio; Ucciferri, Nadia; Ahluwalia, Arti
Publié dans: Annals of Biomedical Engineering, Numéro 48 (2020), 2020, Page(s) 1441, ISSN 0090-6964
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s10439-020-02463-7

Multicellular Human Alveolar Model Composed of Epithelial Cells and Primary Immune Cells for Hazard Assessment

Auteurs: Hana Barosova, Barbara Drasler, Alke Petri-Fink, Barbara Rothen-Rutishauser
Publié dans: Journal of Visualized Experiments, Numéro 159, 2020, ISSN 1940-087X
Éditeur: MYJoVE Corporation
DOI: 10.3791/61090

Impacts of a novel controlled-release TiO2-coated (nano-) formulation of carbendazim and its constituents on freshwater macroinvertebrate communities

Auteurs: Nederstigt, Tom A.P.; Peijnenburg, Willie J.G.M.; Schrama, Maarten; van Ommen, J. Ruud; Vijver, Martina G.
Publié dans: science of the total environment, Numéro 1, 2022, ISSN 0048-9697
Éditeur: Elsevier BV
DOI: 10.1016/j.scitotenv.2022.156554

Compositional and predicted functional dynamics of soil bacterial community in response to single pulse and repeated dosing of titanium dioxide nanoparticles

Auteurs: Yujia Zhai, Gang Liu, Thijs Bosker, Elise Baas, Willie J.G.M. Peijnenburg, Martina G. Vijver
Publié dans: NanoImpact, Numéro 16, 2019, Page(s) 100187, ISSN 2452-0748
Éditeur: Elsevier
DOI: 10.1016/j.impact.2019.100187

Transcriptomics‐Based and AOP‐Informed Structure–Activity Relationships to Predict Pulmonary Pathology Induced by Multiwalled Carbon Nanotubes

Auteurs: Karolina Jagiello, Sabina Halappanavar, Anna Rybińska‐Fryca, Andrew Willliams, Ulla Vogel, Tomasz Puzyn
Publié dans: Small, 2021, Page(s) 2003465, ISSN 1613-6810
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202003465

Using 3D gastrointestinal tract in vitro models with microfold cells and mucus secreting ability to assess the hazard of copper oxide nanomaterials

Auteurs: Victor C. Ude, David M. Brown, Vicki Stone, Helinor J. Johnston
Publié dans: Journal of Nanobiotechnology, Numéro 17/1, 2019, ISSN 1477-3155
Éditeur: BioMed Central
DOI: 10.1186/s12951-019-0503-1

The importance of inter-individual Kupffer cell variability in the governance of hepatic toxicity in a 3D primary human liver microtissue model

Auteurs: Ali Kermanizadeh, David M. Brown, Wolfgang Moritz, Vicki Stone
Publié dans: Scientific Reports, Numéro 9/1, 2019, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-019-43870-8

Real-time cellular impedance monitoring and imaging of biological barriers in a dual-flow membrane bioreactor

Auteurs: L. Cacopardo, J. Costa, S. Giusti, L. Buoncompagni, S. Meucci, A. Corti, G. Mattei, A. Ahluwalia
Publié dans: Biosensors and Bioelectronics, Numéro 140, 2019, Page(s) 111340, ISSN 0956-5663
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.bios.2019.111340

Method for Extraction and Quantification of Metal-Based Nanoparticles in Biological Media: Number-Based Biodistribution and Bioconcentration

Auteurs: Fazel Abdolahpur Monikh, Latifeh Chupani, Eliska Zusková, Ruud Peters, Marie Vancová, Martina G. Vijver, Petr Porcal, Willie J.G.M. Peijnenburg
Publié dans: Environmental Science & Technology, Numéro 53/2, 2018, Page(s) 946-953, ISSN 0013-936X
Éditeur: American Chemical Society
DOI: 10.1021/acs.est.8b03715

Unveiling the Colours of Cellulose Nitrate Black and White Film-based Negatives in Colonial Photography

Auteurs: Élia Roldão, A. Jorge Parola, Márcia Vilarigues, Bertrand Lavédrine, Ana Maria Ramos
Publié dans: Studies in Conservation, Numéro 65/2, 2020, Page(s) 118-126, ISSN 0039-3630
Éditeur: Maney Publishing
DOI: 10.1080/00393630.2019.1662672

The Use of Nanomaterial In Vivo Organ Burden Data for In Vitro Dose Setting

Auteurs: Lan Ma‐Hock, Ursula G. Sauer, Emmanuel Ruggiero, Johannes‐Georg Keller, Wendel Wohlleben, Robert Landsiedel
Publié dans: Small, Numéro 17/15, 2021, Page(s) 2005725, ISSN 1613-6810
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202005725

An Integrated In Vitro–In Silico Approach for Silver Nanoparticle Dosimetry in Cell Cultures

Auteurs: Daniele Poli, Giorgio Mattei, Nadia Ucciferri, Arti Ahluwalia
Publié dans: Annals of Biomedical Engineering, Numéro 48/4, 2020, Page(s) 1271-1280, ISSN 0090-6964
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s10439-020-02449-5

Model Complexity as Determining Factor for In Vitro Nanosafety Studies: Effects of Silver and Titanium Dioxide Nanomaterials in Intestinal Models

Auteurs: Angela A. M. Kämpfer, Mathias Busch, Veronika Büttner, Gerrit Bredeck, Burkhard Stahlmecke, Bryan Hellack, Isabelle Masson, Adriana Sofranko, Catrin Albrecht, Roel P. F. Schins
Publié dans: Small, Numéro Monthly, 2020, Page(s) 2004223, ISSN 1613-6810
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202004223

Allometric Scaling of physiologically-relevant organoids

Auteurs: Chiara Magliaro, Andrea Rinaldo, Arti Ahluwalia
Publié dans: Scientific Reports, Numéro 9/1, 2019, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-019-48347-2

Adaptation of the in vitro micronucleus assay for genotoxicity testing using 3D liver models supporting longer-term exposure durations

Auteurs: Gillian E Conway, Ume-Kulsoom Shah, Samantha Llewellyn, Tereza Cervena, Stephen J Evans, Abdullah S Al Ali, Gareth J Jenkins, Martin J D Clift, Shareen H Doak
Publié dans: Mutagenesis, Numéro 35/4, 2020, Page(s) 319-330, ISSN 0267-8357
Éditeur: Oxford University Press
DOI: 10.1093/mutage/geaa018

TiO2@BSA nano-composites investigated through orthogonal multi-techniques characterization platform

Auteurs: Simona Ortelli, Anna L. Costa, Ilaria Zanoni, Magda Blosi, Otmar Geiss, Ivana Bianchi, Dora Mehn, Francesco Fumagalli, Giacomo Ceccone, Giuditta Guerrini, Luigi Calzolai
Publié dans: Colloids and Surfaces B: Biointerfaces, Numéro 207, 2021, Page(s) 112037, ISSN 0927-7765
Éditeur: Elsevier BV
DOI: 10.1016/j.colsurfb.2021.112037

A Small-Scale Setup for Algal Toxicity Testing of Nanomaterials and Other Difficult Substances

Auteurs: Lars Michael Skjolding, Susanne Kruse, Sara Nørgaard Sørensen, Rune Hjorth, Anders Baun
Publié dans: Journal of Visualized Experiments, Numéro 164, 2020, ISSN 1940-087X
Éditeur: MYJoVE Corporation
DOI: 10.3791/61209

An Alternative Perspective towards Reducing the Risk of Engineered Nanomaterials to Human Health

Auteurs: Martin J. D. Clift, Gareth J. S. Jenkins, Shareen H. Doak
Publié dans: Small, Numéro 16/36, 2020, Page(s) 2002002, ISSN 1613-6810
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202002002

Adsorption of titanium dioxide nanoparticles onto zebrafish eggs affects colonizing microbiota

Auteurs: Bregje W. Brinkmann, Wouter F. Beijk, Redmar C. Vlieg, S. John T. van Noort, Jorge Mejia, Julien L. Colaux, Stéphane Lucas, Gerda Lamers, Willie J.G.M. Peijnenburg, Martina G. Vijver
Publié dans: Aquatic Toxicology, Numéro 232, 2021, Page(s) 105744, ISSN 0166-445X
Éditeur: Elsevier BV
DOI: 10.1016/j.aquatox.2021.105744

Dosimetry in vitro – exploring the sensitivity of deposited dose predictions vs. affinity, polydispersity, freeze-thawing, and analytical methods

Auteurs: Johannes G. Keller, Daniel F. Quevedo, Lara Faccani, Anna L. Costa, Robert Landsiedel, Kai Werle, Wendel Wohlleben
Publié dans: Nanotoxicology, Numéro Monthly, 2020, Page(s) 1-14, ISSN 1743-5390
Éditeur: Informa Healthcare
DOI: 10.1080/17435390.2020.1836281

Time dependent impact of copper oxide nanomaterials on the expression of genes associated with oxidative stress, metal binding, inflammation and mucus secretion in single and co-culture intestinal in vitro models

Auteurs: Victor C. Ude, David M. Brown, Vicki Stone, Helinor J. Johnston
Publié dans: Toxicology in Vitro, Numéro 74, 2021, Page(s) 105161, ISSN 0887-2333
Éditeur: Elsevier BV
DOI: 10.1016/j.tiv.2021.105161

Acute hazard assessment of silver nanoparticles following intratracheal instillation, oral and intravenous injection exposures

Auteurs: Kermanizadeh, Ali; Jacobsen, Nicklas R.; Mroczko, Agnieszka; Brown, David; Stone, Vicki
Publié dans: Nanotoxicology, Numéro 1, 2022, ISSN 1743-5390
Éditeur: Informa Healthcare
DOI: 10.1080/17435390.2021.2020350

An Air-liquid Interface Bronchial Epithelial Model for Realistic, Repeated Inhalation Exposure to Airborne Particles for Toxicity Testing

Auteurs: Hedwig M. Braakhuis, Ruiwen He, Rob J. Vandebriel, Eric R. Gremmer, Edwin Zwart, Jolanda P. Vermeulen, Paul Fokkens, John Boere, Ilse Gosens, Flemming R. Cassee
Publié dans: Journal of Visualized Experiments, Numéro 159, 2020, ISSN 1940-087X
Éditeur: MYJoVE Corporation
DOI: 10.3791/61210

A review of hepatic nanotoxicology - summation of recent findings and considerations for the next generation of study designs.

Auteurs: Ali Kermanizadeh; Vicki Stone; Leagh G. Powell
Publié dans: Journal of Toxicology and Environmental Health, Part B, Numéro 1, 2020, Page(s) 137-176, ISSN 1521-6950
Éditeur: Taylor & Francis Online
DOI: 10.1080/10937404.2020.1751756

Understanding the impact of more realistic low-dose, prolonged engineered nanomaterial exposure on genotoxicity using 3D models of the human liver

Auteurs: Samantha V. Llewellyn, Gillian E. Conway, Ilaria Zanoni, Amalie Kofoed Jørgensen, Ume-Kulsoom Shah, Didem Ag Seleci, Johannes G. Keller, Jeong Won Kim, Wendel Wohlleben, Keld Alstrup Jensen, Anna Costa, Gareth J. S. Jenkins, Martin J. D. Clift, Shareen H. Doak
Publié dans: Journal of Nanobiotechnology, Numéro 19/1, 2021, ISSN 1477-3155
Éditeur: BioMed Central
DOI: 10.1186/s12951-021-00938-w

The variances in cytokine production profiles from non- or activated THP-1, Kupffer cell and human blood derived primary macrophages following exposure to either alcohol or a panel of engineered nanomaterials

Auteurs: Ali Kermanizadeh, David M. Brown, Vicki Stone
Publié dans: PLOS ONE, Numéro 14/8, 2019, Page(s) e0220974, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0220974

Colonizing microbiota protect zebrafish larvae against silver nanoparticle toxicity.

Auteurs: Bjørn E. V. Koch; Willie J.G.M. Peijnenburg; Herman P. Spaink; Bregje W. Brinkmann; Martina G. Vijver
Publié dans: VOLUME=14;ISSUE=6;STARTPAGE=725;ENDPAGE=739;TITLE=Nanotoxicology, Numéro 12, 2020, ISSN 1040-8398
Éditeur: Taylor & Francis
DOI: 10.6084/m9.figshare.12181941.v1

Additional file 1 of Understanding the impact of more realistic low-dose, prolonged engineered nanomaterial exposure on genotoxicity using 3D models of the human liver

Auteurs: Llewellyn, Samantha V.; Conway, Gillian E.; Zanoni, Ilaria; Jørgensen, Amalie Kofoed; Shah, Ume-Kulsoom; Seleci, Didem Ag; Keller, Johannes G.; Kim, Jeong Won; Wohlleben, Wendel; Jensen, Keld Alstrup; Costa, Anna; Jenkins, Gareth J. S.; Clift, Martin J. D.; Doak, Shareen H.
Publié dans: Springer Nature, Numéro 2, 2021, Page(s) N/A, ISSN 1476-4660
Éditeur: Springer
DOI: 10.6084/m9.figshare.14870570

Engineering Gels with Time-Evolving Viscoelasticity

Auteurs: Giorgio Mattei, Ludovica Cacopardo, Arti Ahluwalia
Publié dans: Materials, Numéro 13/2, 2020, Page(s) 438, ISSN 1996-1944
Éditeur: MDPI Open Access Publishing
DOI: 10.3390/ma13020438

Allometric Scaling of physiologically-relevant organoids

Auteurs: Chiara Magliaro, Andrea Rinaldo, Arti Ahluwalia
Publié dans: BioRxiv, Numéro Regular online, 2019, ISSN 1476-4687
Éditeur: Cold Spring Harbor Laboratory
DOI: 10.1101/559682

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