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GRACIOUS: Grouping, Read-Across, CharacterIsation and classificatiOn framework for regUlatory risk assessment of manufactured nanomaterials and Safer design of nano-enabled products

Objective

Manufacturing and functionalising materials at the nanoscale leads to a whole array of nanomaterials (NMs) varying in e.g. size, morphology and surface characteristics. Apart from expected benefits, distinctive properties of NMs may also affect (environmental) health risks. Safety assessment requires sufficient information for each NM, but testing every unique NM for their potential adverse effects is virtually impossible. More efficient ways to obtain safety information are needed, which could be achieved by applying grouping and read-across approaches to NMs. On a conceptual level, regulatory accepted approaches for grouping and read-across for NMs already exist, but actual application remains difficult as the required knowledge is not systematically brought together, lacks data curation or is still missing. GRACIOUS will address this urgent need by developing a framework for grouping and read-across based on physicochemical, release, exposure, environmental fate, toxicokinetic and toxicological information. This framework will be delivered as a practical e-tool, fit-for-purpose for various key (regulatory and industrial) stakeholders, who will be engaged from the start of the project. To develop the framework, GRACIOUS will build upon currently available approaches by collating, curating and assimilating existing and new knowledge on intrinsic and extrinsic physicochemical properties in relation to their (environmental) health risk. The resulting framework will support safe innovation by enabling considerations of safety a.o. via grouping and read-across in industrial decision making at various stages of product development. For regulators and policy makers, GRACIOUS will facilitate actual application of grouping and read-across of NMs to enable risk analysis of NMs without extensive testing.

Field of science

  • /engineering and technology/nanotechnology/nano-materials

Call for proposal

H2020-NMBP-2017-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

HERIOT-WATT UNIVERSITY
Address
Riccarton
EH14 4AS Edinburgh
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 833 487,50

Participants (24)

BASF SE
Germany
EU contribution
€ 669 618,75
Address
Carl Bosch Strasse 38
67063 Ludwigshafen Am Rhein
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
GREENDECISION SRL
Italy
EU contribution
€ 386 362,50
Address
Via Torino 155/A
30172 Venezia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSTITUTE OF OCCUPATIONAL MEDICINE
United Kingdom
EU contribution
€ 327 475
Address
Research Avenue North, Riccarton 45
EH14 4AP Edinburgh
Activity type
Research Organisations
EUROPEAN RESEARCH SERVICES GMBH
Germany
EU contribution
€ 301 537,50
Address
Roentgenstrasse 19
48149 Muenster
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
YORDAS LIMITED
United Kingdom
EU contribution
€ 117 000
Address
50-54 Berry Lane
PR3 3JP Longridge Preston
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
DET NATIONALE FORSKNINGSCENTER FORARBEJDSMILJO
Denmark
EU contribution
€ 411 162,50
Address
Lerso Parkalle 105
2100 Kobenhavn
Activity type
Research Organisations
BUNDESINSTITUT FUER RISIKOBEWERTUNG
Germany
EU contribution
€ 416 955
Address
Max Dohrn Strasse 8-10
10589 Berlin
Activity type
Research Organisations
UNITED KINGDOM RESEARCH AND INNOVATION

Participation ended

United Kingdom
EU contribution
€ 97 133,75
Address
Polaris House North Star Avenue
SN2 1FL Swindon
Activity type
Research Organisations
UNIVERSITAT WIEN
Austria
EU contribution
€ 309 037,50
Address
Universitatsring 1
1010 Wien
Activity type
Higher or Secondary Education Establishments
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Italy
EU contribution
€ 217 502,50
Address
Via Morego 30
16163 Genova
Activity type
Research Organisations
RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU
Netherlands
EU contribution
€ 531 968,75
Address
Antonie Van Leeuwenhoeklaan 9
3721 MA Bilthoven
Activity type
Research Organisations
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 217 588,75
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
ACONDICIONAMIENTO TARRASENSE ASSOCIACION
Spain
EU contribution
€ 383 287,50
Address
Carrer De La Innovacio 2
08225 Terrassa
Activity type
Research Organisations
Nouryon PULP AND PERFORMANCE CHEMICALS AB
Sweden
EU contribution
€ 99 975
Address
.
445 80 Bohus
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
IDEACONSULT LIMITED LIABILITY COMPANY
Bulgaria
EU contribution
€ 216 593,75
Address
Angel Kanchev 4
1000 Sofia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION
Belgium
EU contribution
€ 323 947,50
Address
Rue De La Loi 200
1049 Brussels
Activity type
Research Organisations
UNILEVER U.K. CENTRAL RESOURCES LIMITED
United Kingdom
EU contribution
€ 118 568,75
Address
Unilever House, Victoria Embankment 100
EC4Y 0DY London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
THINKWORKS BV
Netherlands
EU contribution
€ 223 093,75
Address
Rotterdamseweg 183 C
2629 HD Delft
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ARIZONA BOARD OF REGENTS
United States
EU contribution
€ 0
Address
660 S Mill Avenue Centerpoint 312
85281 Tempe
Activity type
Higher or Secondary Education Establishments
DUKE UNIVERSITY
United States
EU contribution
€ 0
Address
Allen Building 207
27708 Durham Nc
Activity type
Higher or Secondary Education Establishments
ATHINA-EREVNITIKO KENTRO KAINOTOMIAS STIS TECHNOLOGIES TIS PLIROFORIAS, TON EPIKOINONION KAI TIS GNOSIS
Greece
EU contribution
€ 138 468,75
Address
Artemidos 6 Kai Epidavrou
151 25 Maroussi
Activity type
Research Organisations
EIDGENOSSISCHE MATERIALPRUFUNGS- UND FORSCHUNGSANSTALT
Switzerland
EU contribution
€ 173 787,50
Address
Ueberlandstrasse 129
8600 Dubendorf
Activity type
Higher or Secondary Education Establishments
YORDAS GMBH
Germany
EU contribution
€ 132 162,50
Address
Aussere Nurnberger Strasse 62
91301 Forchheim
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UK CENTRE FOR ECOLOGY & HYDROLOGY
United Kingdom
EU contribution
€ 352 653,75
Address
Maclean Building Benson Lane
OX10 8BB Oxford
Activity type
Research Organisations