Personalized And/Or Generalized Integrated Biomaterial Risk Assessment

Deliverables

Documents, reports (1)

CI and project website

This report will summarize the results from task 11.1.

Publications

Peer reviewed articles (27)

Improving the colonization and functions of Wharton’s Jelly-derived mesenchymal stem cells by a synergetic combination of porous polyurethane scaffold with an albumin-derived hydrogel

Author(s): G Lutzweiler, J Barthes, A L Charles, V Ball, B Louis, B Geny, N E Vrana
Published in: Biomedical Materials, Issue 16/1, 2021, Page(s) 015005, ISSN 1748-605X
DOI: 10.1088/1748-605x/abaf05

New Smart Antimicrobial Hydrogels, Nanomaterials, and Coatings: Earlier Action, More Specific, Better Dosing?

Author(s): Lorène Tallet, Varvara Gribova, Lydie Ploux, Nihal Engin Vrana, Philippe Lavalle
Published in: Advanced Healthcare Materials, Issue 10/1, 2021, Page(s) 2001199, ISSN 2192-2640
DOI: 10.1002/adhm.202001199

Personalization of medical device interfaces: decreasing implant-related complications by modular coatings and immunoprofiling

Author(s): Nihal Engin Vrana, Kaia Palm, Philippe Lavalle
Published in: Future Science OA, Issue 6/8, 2020, Page(s) FSO607, ISSN 2056-5623
DOI: 10.2144/fsoa-2020-0074

The Overview of Porous, Bioactive Scaffolds as Instructive Biomaterials for Tissue Regeneration and Their Clinical Translation

Author(s): Gaëtan Lutzweiler, Albana Ndreu Halili, Nihal Engin Vrana
Published in: Pharmaceutics, Issue 12/7, 2020, Page(s) 602, ISSN 1999-4923
DOI: 10.3390/pharmaceutics12070602

Polyarginine Decorated Polydopamine Nanoparticles With Antimicrobial Properties for Functionalization of Hydrogels

Author(s): Céline Muller, Emine Berber, Gaetan Lutzweiler, Ovidiu Ersen, Mounib Bahri, Philippe Lavalle, Vincent Ball, Nihal E. Vrana, Julien Barthes
Published in: Frontiers in Bioengineering and Biotechnology, Issue 8, 2020, ISSN 2296-4185
DOI: 10.3389/fbioe.2020.00982

Enabling personalized implant and controllable biosystem development through 3D printing

Author(s): Neerajha Nagarajan, Agnes Dupret-Bories, Erdem Karabulut, Pinar Zorlutuna, Nihal Engin Vrana
Published in: Biotechnology Advances, 2018, ISSN 0734-9750
DOI: 10.1016/j.biotechadv.2018.02.004

Assessment of cortical bone fracture resistance curves by fusing artificial neural networks and linear regression

Author(s): Arso M. Vukicevic, Gordana R. Jovicic, Milos N. Jovicic, Vladimir L. Milicevic, Nenad D. Filipovic
Published in: Computer Methods in Biomechanics and Biomedical Engineering, Issue 21/2, 2018, Page(s) 169-176, ISSN 1025-5842
DOI: 10.1080/10255842.2018.1431220

Immune Assisted Tissue Engineering via Incorporation of Macrophages in Cell-Laden Hydrogels Under Cytokine Stimulation

Author(s): Julien Barthes, Camille Dollinger, Celine B. Muller, Urmas Liivas, Agnes Dupret-Bories, Helena Knopf-Marques, Nihal E. Vrana
Published in: Frontiers in Bioengineering and Biotechnology, Issue 6, 2018, ISSN 2296-4185
DOI: 10.3389/fbioe.2018.00108

In vitro Models and On-Chip Systems: Biomaterial Interaction Studies With Tissues Generated Using Lung Epithelial and Liver Metabolic Cell Lines

Author(s): Milica Nikolic, Tijana Sustersic, Nenad Filipovic
Published in: Frontiers in Bioengineering and Biotechnology, Issue 6, 2018, ISSN 2296-4185
DOI: 10.3389/fbioe.2018.00120

The Importance of Controlled Mismatch of Biomechanical Compliances of Implantable Scaffolds and Native Tissue for Articular Cartilage Regeneration

Author(s): Michael Gasik, Alexandra Zühlke, Anne-Marie Haaparanta, Virpi Muhonen, Kaisa Laine, Yevgen Bilotsky, Minna Kellomäki, Ilkka Kiviranta
Published in: Frontiers in Bioengineering and Biotechnology, Issue 6, 2018, ISSN 2296-4185
DOI: 10.3389/fbioe.2018.00187

Mathematical Modelling of Polymer Trajectory during Electrospinning

Author(s): I. Ferouka, T. Šušteršič, M. Živanović, N. Filipović
Published in: Jorunal of the Serbian Society for Computational Mechanics, Issue Vol 12, No 2, 2018, ISSN 1820-6530
DOI: 10.24874/jsscm.2018.12.02.02

Numerical simulation of electrospinning process in commercial and in-house software PAK

Author(s): Tijana Šušteršič, Liliana Liverani, Aldo R Boccaccini, Slobodan Savić, Aco Janićijević, Nenad Filipović
Published in: Materials Research Express, Issue 6/2, 2019, Page(s) 025305, ISSN 2053-1591
DOI: 10.1088/2053-1591/aaeb08

A Foreign Body Response-on-a-Chip Platform

Author(s): Fatemeh Sharifi, Su Su Htwe, Martina Righi, Hua Liu, Anna Pietralunga, Ozlem Yesil-Celiktas, Sushila Maharjan, Byung-Hyun Cha, Su Ryon Shin, Mehmet Remzi Dokmeci, Nihal Engin Vrana, Amir M. Ghaemmaghami, Ali Khademhosseini, Yu Shrike Zhang
Published in: Advanced Healthcare Materials, 2019, Page(s) 1801425, ISSN 2192-2640
DOI: 10.1002/adhm.201801425

Editorial: Adverse Reactions to Biomaterials: State of the Art in Biomaterial Risk Assessment, Immunomodulation and in vitro Models for Biomaterial Testing

Author(s): Nihal Engin Vrana, Amir M. Ghaemmaghami, Pinar Zorlutuna
Published in: Frontiers in Bioengineering and Biotechnology, Issue 7, 2019, ISSN 2296-4185
DOI: 10.3389/fbioe.2019.00015

Modulation of Cellular Colonization of Porous Polyurethane Scaffolds via the Control of Pore Interconnection Size and Nanoscale Surface Modifications

Author(s): G. Lutzweiler, J. Barthes, G. Koenig, H. Kerdjoudj, J. Mayingi, F. Boulmedais, P. Schaaf, W. Drenckhan, N. E. Vrana
Published in: ACS Applied Materials & Interfaces, Issue 11/22, 2019, Page(s) 19819-19829, ISSN 1944-8244
DOI: 10.1021/acsami.9b04625

Use of Nanoparticles in Tissue Engineering and Regenerative Medicine

Author(s): Milad Fathi-Achachelouei, Helena Knopf-Marques, Cristiane Evelise Ribeiro da Silva, Julien Barthès, Erhan Bat, Aysen Tezcaner, Nihal Engin Vrana
Published in: Frontiers in Bioengineering and Biotechnology, Issue 7, 2019, ISSN 2296-4185
DOI: 10.3389/fbioe.2019.00113

Multifunctional polymeric implant coatings based on gelatin, hyaluronic acid derivative and chain length-controlled poly(arginine)

Author(s): Helena Knopf-Marques, Julien Barthes, Sarah Lachaal, Angela Mutschler, Céline Muller, Florent Dufour, Morgane Rabineau, Edwin-Joffrey Courtial, Julie Bystroňová, Christophe Marquette, Philippe Lavalle, Nihal Engin Vrana
Published in: Materials Science and Engineering: C, Issue 104, 2019, Page(s) 109898, ISSN 0928-4931
DOI: 10.1016/j.msec.2019.109898

The effect of healing phenotype-inducing cytokine formulations within soft hydrogels on encapsulated monocytes and incoming immune cells

Author(s): Ivana Ščigalková, Julie Bystroňová, Lenka Kovářová, Martin Pravda, Vladimír Velebný, Vladimir Riabov, Harald Klüter, Julia Kzhyshkowska, Nihal Engin Vrana
Published in: RSC Advances, Issue 9/37, 2019, Page(s) 21396-21404, ISSN 2046-2069
DOI: 10.1039/c9ra02878a

A composite Gelatin/hyaluronic acid hydrogel as an ECM mimic for developing mesenchymal stem cell‐derived epithelial tissue patches

Author(s): Pramod Kumar, Sait Ciftci, Julien Barthes, Helena Knopf‐Marques, Céline Blandine Muller, Christian Debry, Nihal E. Vrana, Amir M. Ghaemmaghami
Published in: Journal of Tissue Engineering and Regenerative Medicine, Issue 14/1, 2019, Page(s) 45-57, ISSN 1932-6254
DOI: 10.1002/term.2962

Validation of Milner's visco-elastic theory of sintering for the generation of porous polymers with finely tuned morphology

Author(s): Gaëtan Lutzweiler, Jean Farago, Emeline Oliveira, Léandro Jacomine, Ozan Erverdi, Nihal Engin Vrana, Aouatef Testouri, Pierre Schaaf, Wiebke Drenckhan
Published in: Soft Matter, Issue 16/7, 2020, Page(s) 1810-1824, ISSN 1744-683X
DOI: 10.1039/c9sm01991j

Dual growth factor delivery using PLGA nanoparticles in silk fibroin/PEGDMA hydrogels for articular cartilage tissue engineering

Author(s): Milad Fathi‐Achachelouei, Dilek Keskin, Erhan Bat, Nihal E. Vrana, Aysen Tezcaner
Published in: Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2019, ISSN 1552-4973
DOI: 10.1002/jbm.b.34544

Controlling porous titanium/soft tissue interactions with an innovative surface chemical treatment: Responses of macrophages and fibroblasts

Author(s): Julien Barthes, Martina Cazzola, Celine Muller, Camille Dollinger, Christian Debry, Sara Ferraris, Silvia Spriano, Nihal E. Vrana
Published in: Materials Science and Engineering: C, 2020, Page(s) 110845, ISSN 0928-4931
DOI: 10.1016/j.msec.2020.110845

Adjustment of Cell Adhesion on Polyurethane Structures via Control of the Hard/Soft Segment Ratio

Author(s): Gaëtan Lutzweiler, Julien Barthes, Nihal Engin Vrana, Michel Rawiso, Benoît Louis, Josselin Mayingi, Albane Carre, Wiebke Drenckhan, Pierre Schaaf
Published in: Macromolecular Materials and Engineering, 2020, Page(s) 2000093, ISSN 1438-7492
DOI: 10.1002/mame.202000093

Polyanionic Hydrogels as Reservoirs for Polycationic Antibiotic Substitutes Providing Prolonged Antibacterial Activity

Author(s): Varvara Gribova, Fouzia Boulmedais, Agnès Dupret-Bories, Cynthia Calligaro, Bernard Senger, Nihal Engin Vrana, Philippe Lavalle
Published in: ACS Applied Materials & Interfaces, 2020, ISSN 1944-8244
DOI: 10.1021/acsami.9b23140

Immune-Instructive Polymers Control Macrophage Phenotype and Modulate the Foreign Body Response In Vivo

Author(s): Hassan M. Rostam, Leanne E. Fisher, Andrew L. Hook, Laurence Burroughs, Jeni C. Luckett, Grazziela P. Figueredo, Chidimma Mbadugha, Alvin C.K. Teo, Arsalan Latif, Lisa Kämmerling, Mitchell Day, Karen Lawler, David Barrett, Somaia Elsheikh, Mohammad Ilyas, David A. Winkler, Morgan R. Alexander, Amir M. Ghaemmaghami
Published in: Matter, 2020, ISSN 2590-2385
DOI: 10.1016/j.matt.2020.03.018

Metabolic characterisation of THP-1 macrophage polarisation using LC–MS-based metabolite profiling

Author(s): Alaa Abuawad, Chidimma Mbadugha, Amir M. Ghaemmaghami, Dong-Hyun Kim
Published in: Metabolomics, Issue 16/3, 2020, ISSN 1573-3882
DOI: 10.1007/s11306-020-01656-4

Recent Advances in Antiinflammatory Material Design

Author(s): Eloïse Lebaudy, Sylvie Fournel, Philippe Lavalle, Nihal Engin Vrana, Varvara Gribova
Published in: Advanced Healthcare Materials, Issue 10/1, 2021, Page(s) 2001373, ISSN 2192-2640
DOI: 10.1002/adhm.202001373

Conference proceedings (18)

Effect of Preprocessing on Performance of Neural Networks for Microscopy Image Classification

Author(s): Arban Uka, Xhoena Polisi, Julien Barthes, Albana Ndreu Halili, Florenc Skuka, Nihal Engin Vrana
Published in: 2020 International Conference on Computing, Electronics & Communications Engineering (iCCECE), 2020, Page(s) 162-165
DOI: 10.1109/iccece49321.2020.9231071

Modelling of Monocytes Behaviour inside the Bioreactor (at BelBi 2018, Belgrade, Serbia)

Author(s): Milica Nikolic, Tijana Sustersic, Igor Saveljic, Nihal Engin Vrana and Nenad Filipovic
Published in: Belgrade, Serbia, Book of Abstracts, Biologia Serbica, Issue Vol. 40, No. 1, 2018, Page(s) 123, ISSN 2334-6590

Optimization of Electrospinning Procedure for Generating the Scaffold for Production of Artificial Blood Vessel

Author(s): Živanović M, Cepeda Y, Filipović N
Published in: The International Journal of Artificial Organs, Issue Vol. 41, No. 9, 2018, Page(s) 617-618, ISSN 0391-3988

Numerical simulation of electrospinning using PAK and ANSYS software

Author(s): Tijana Šušteršič, Liliana Liverani, Aldo R. Boccaccini, Slobodan Savić and Nenad Filipović
Published in: Belgrade, Serbia, Book of Abstracts, Biologia Serbica,, Issue Vol. 40, No. 1, 2018, Page(s) 130, ISSN 2334-6590

Discrete simulation of electrospinning jet’s evolution

Author(s): Ferouka I., Šušteršič T., Živanović M., Filipović N.
Published in: Belgrade BioInformatics Conference 2018 (BelBi 2018), 2018, Page(s) 107

Comparison of Properties of Conventional & 3D-printed Titanium & Their Mechano-Regulative Potential

Author(s): M. Gasik, A. Zühlke, N. E. Vrana, J. Barthes
Published in: 2019

Discrete modelling of liver cell aggregation using partial differential equations

Author(s): Tijana Sustersic, Milica Nikolic, Nihal Engin Vrana, Nenad Filipovic
Published in: CMBEBIH, Issue 16. – 18. May 2019. Banja Luka, Bosnia and Herzegovina, 2019

Monocyte Behaviour Under Perfusion Conditions for Development of Granuloma on-a-chip

Author(s): M. Nikolic, T. Sustersic, C.B. Muller4, Y.S. Zhang, N. E. Vrana, N. Filipovic
Published in: 2019

Numerical analysis of two hip implant surfaces

Author(s): Vulović, A., Filipović, N.
Published in: 2019
DOI: 10.5281/zenodo.3351176

Computational Modelling Of Corrosion Process In Medical Implant Surfaces

Author(s): Šušteršič, T., Simsek, G. M., Vrana, N. E., Filipović, N.
Published in: 7th International Congress of Serbian Society of Mechanics, 2019

USE OF POLYETHYLENE GLYCOL AND POLYCAPROLACTONE IN 3DBIOPRINT SCAFFOLD PRODUCTION

Author(s): Marko N. Živanović, Dalibor D. Nikolić, Nenad D. Filipović
Published in: 7th International Congress of Serbian Society of Mechanics, 2019

EFFECT OF THE FEMORAL BONE MATERIAL PROPERTIES ON THE NUMERICAL SIMULATION RESULTS

Author(s): Vulovć, Aleksandra; Filipović, Nenad
Published in: Issue 1, 2019
DOI: 10.5281/zenodo.3351178

Coupling Experimental Data and Numerical Simulation in Modelling Epithelial Barrier Formation with A549 Cancerous Cell Line

Author(s): Šušteršič Tijana, Nikolić Milica, Barthes Julien, Vrana Nihal Engin, Filipović Nenad
Published in: 8th International Conference on Computational Bioengineering (ICCB2019), Issue once a year, 2019, Page(s) 47-48

Optimization of Parameters for 3D-Bioprinting Scaffold Production – Blood Vessel Bioengineering

Author(s): Živanović, Marko N.; Nikolić, Dalibor D. Nikolić; Filipović, Nenad D.
Published in: 8th International Conference on Computational Bioengineering (ICCB2019), Issue 3, 2019, Page(s) 60-61
DOI: 10.5281/zenodo.3452732

"PANBioRA Mini-Symposium: ""MULTISCALE MODELLING OF EXPERIMENTAL DATA RELATED TO BIOMATERIAL RISK ASSESSMENT"

Author(s): Šušteršič, Tijana
Published in: Proceeding of VIII International Conference on Computational Bioengineering, Issue 1, 2019
DOI: 10.5281/zenodo.3452648

Effect of hip implant surface modification on shear stress distribution

Author(s): Vulović, Aleksandra; Filipović, Nenad
Published in: Proceeding of VIII International Conference on Computational Bioengineering, Issue 1, 2019, Page(s) 64-65
DOI: 10.5281/zenodo.3452769

Mathematical simulation of biodegradable material cytotoxicity in 3D hepatocellular systems in vitro.

Author(s): Alexander Makhaniok, Constantin-Edi Tanase, Amir Ghaemmaghami, Nihal Engin Vrana, Vitaly Goranov
Published in: 8th International Conference on Computational Bioengineering (ICCB2019), 2019

The Mathematical approach to disclose low Cytotoxicity of material from in vitro co-culture experiment

Author(s): Ivan Siutsou, Lydie Ploux, Nihal Engin Vrana, Vitaly Goranov
Published in: 8th International Conference on Computational Bioengineering (ICCB2019), 2019

Book chapters (4)

Biomechanical characterization of engineered tissues and implants for tissue/organ replacement applications

Author(s): Michael Gasik
Published in: Biomaterials for Organ and Tissue Regeneration, 2020, Page(s) 599-627
DOI: 10.1016/b978-0-08-102906-0.00024-6

Lung on a chip and epithelial lung cells modeling

Author(s): Milica Nikolic, Nenad Filipovic
Published in: Computational Modeling in Bioengineering and Bioinformatics, 2020, Page(s) 105-135
DOI: 10.1016/b978-0-12-819583-3.00004-7

Using 3-D Printing and Bioprinting Technologies for Personalized Implants

Author(s): Julien Barthes, Edwin-Joffrey Courtial, Esteban Brenet, Celine Blandine Muller, Helena Knopf-Marques, Christophe Marquette, Nihal Engin Vrana
Published in: Advances in Biomechanics and Tissue Regeneration, 2019, Page(s) 269-286
DOI: 10.1016/b978-0-12-816390-0.00014-5

Computer Assisted Analysis of the Hepatic Spheroid Formation

Author(s): Xhoena Polisi, Albana Halili, Constantin-Edi Tanase, Arban Uka, Nihal Engin Vrana, Amir Ghaemmaghami
Published in: Computational Bioengineering and Bioinformatics - Computer Modelling in Bioengineering, Issue 11, 2020, Page(s) 117-126
DOI: 10.1007/978-3-030-43658-2_11

Monographic books (2)

Biomaterials and Immune Response Complications, Mechanisms and Immunomodulation

Author(s): Nihal Engin Vrana
Published in: 2018

Adverse Reactions to Biomaterials: State of the Art in Biomaterial Risk Assessment, Immunomodulation and In Vitro Models for Biomaterial Testing

Author(s): NE Vrana, A Ghaemmaghami, P Zorlutuna
Published in: Frontierns in Biotechnology and Bioengineering, 2019
DOI: 10.3389/978-2-88945-822-6

Non-peer reviewed articles (1)

How to Predict Adverse Immune Reactions to Implantable Biomaterials?

Author(s): Melanie Ungemach, Timo Doll, Nihal Engin Vrana
Published in: European Journal of Immunology, Issue 49/4, 2019, Page(s) 517-520, ISSN 0014-2980
DOI: 10.1002/eji.201970045

Thesis dissertations (1)

Behaviour of Hydrogel Biomaterials under Dynamic Thermo-Mechanical Conditions

Author(s): E. Vähä-Pietilä
Published in: 2019