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Personalized And/Or Generalized Integrated Biomaterial Risk Assessment

Objective

PANBioRA aims at providing a comprehensive solution for the time- and cost-effective risk assessment of i) new biomaterials under health or disease states or ii) a given biomaterial for each patient in a personalized manner. It will standardize the evaluation of biomaterials and open the venue for pre-implantation, personalized diagnostics for biomaterial based applications.
PANBioRA will provide a modular platform to assess risks at different aspects and length scales. This comprises antibody response, cytotoxicity/genotoxicity at cell level, systemic and local effects at tissue and connected tissues (organ-on-a-chip) level. Moreover, physicochemical and biomechanical characterisation as well as predictive modelling at systems level will complement the system. This will be achieved by connecting testing modules in a structure supported by web-based modelling and risk radar tools together with a biomechanical testing system.
The platform will incorporate standardized protocols yielding significantly more information than the current methods for biomaterial risk assessment. Its accuracy will be demonstrated using known reference materials and validated in a pre-clinical setting.
PANBioRA will for the first time, predict the patient specific response to a given biomaterial before its implantation. This measure will allow for the selection of the best suitable material, minimizing side effects and improving health outcomes.
It will also accelerate the process of validation of the biocompatibility of new devices by providing an automated, comprehensive process for the parallel assessment of risks at different scales aiding new biomaterial discovery and commercialisation.
Altogether, PANBioRA will lead to a substantial economic impact due to a reduction of the amount of tests, decrease in healthcare costs due to complications. It will provide the necessary tools proper risk management related to biomaterials.

Field of science

  • /social sciences/sociology/governance/crisis management
  • /engineering and technology/industrial biotechnology/biomaterials
  • /engineering and technology/electrical engineering, electronic engineering, information engineering/information engineering/telecommunications/radio technology/radar

Call for proposal

H2020-NMBP-2017-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

STEINBEIS 2I GMBH
Address
Kienestrasse 35
70174 Stuttgart
Germany
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 499 625

Participants (17)

DOLMEN DESIGN AND INNOVATION LIMITED
Ireland
EU contribution
€ 320 625
Address
Innovation House Dcu Alpha Finglas Road Old
D11KXN4 Glasnevin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BIODEVICE SYSTEMS SRO
Czechia
EU contribution
€ 298 125
Address
Bulharska 996 20
10100 Praha
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PROTOBIOS OU
Estonia
EU contribution
€ 461 250
Address
Maealuse 4
12618 Tallinn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ELVESYS
France
EU contribution
€ 408 125
Address
172 Rue De Charonne B2 2 Eme Etage
75011 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
STREINBEIS ADVANCED RISK TECHNOLOGIES INSTITUTE DOO KRAGUJEVAC
Serbia
EU contribution
€ 311 250
Address
Kneza Milosa 25/1
34000 Kragujevac
Activity type
Other
STEINBEIS ADVANCED RISK TECHNOLOGIES GMBH
Germany
EU contribution
€ 588 750
Address
Fangelsbachstrasse 14
70178 Stuttgart
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU contribution
€ 835 511,25
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
PRO-ACTIVE
Belgium
EU contribution
€ 179 062,50
Address
Avenue Des Pinsons 32
1410 Waterloo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
AALTO KORKEAKOULUSAATIO SR
Finland
EU contribution
€ 403 240
Address
Otakaari 1
02150 Espoo
Activity type
Higher or Secondary Education Establishments
TURGUT OZAL EDUCATION SHA
Albania
EU contribution
€ 322 625
Address
S Gabrani Tek Ish Qyt Studenti
1000 Tirana
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
THE UNIVERSITY OF NOTTINGHAM
United Kingdom
EU contribution
€ 736 503,20
Address
University Park
NG7 2RD Nottingham
Activity type
Higher or Secondary Education Establishments
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 556 013,75
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
DUBLIN CITY UNIVERSITY
Ireland
EU contribution
€ 395 123,94
Address
Glasnevin
9 Dublin
Activity type
Higher or Secondary Education Establishments
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 654 245,46
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
CENTRE HOSPITALIER UNIVERSITAIRE DE LIEGE
Belgium
EU contribution
€ 405 561,83
Address
Sart Tilman B35
4000 Liege
Activity type
Research Organisations
PROTIP MEDICAL

Participation ended

France
EU contribution
€ 464 483,09
Address
8 Place De L'hopital
67000 Strasbourg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SPARTHA MEDICAL SAS
France
EU contribution
€ 152 350,98
Address
14B Rue De La Caradiere
67100 Strasbourg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)