NanoSTARS imaging for STEM cell therapy for arthritic joints

Project Information

STARSTEM

Grant agreement ID: 761214

DOI 10.3030/761214

Project closed

EC signature date 16 October 2017

Start date 1 January 2018

End date 30 June 2022

Funded under

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies

Total cost € 5 933 952,24

EU contribution € 5 933 952,24

Coordinated by

UNIVERSITY OF GALWAY
Ireland

Deliverables

Websites, patent fillings, videos etc. (2)

Dissemination materials

Dissemination materials (brochure, flyer, posters, newsletters)

Website

Website (updated throughout the project)

Publications

Peer reviewed articles (18)

Characterization of nanosensitive multifractality in submicron scale tissue morphology and its alteration in tumor progression

Author(s): Nandan Das, Alexandrov Sergey, Katie E. Gilligan, Róisín M. Dwyer, Rolf B. Saager, Nirmalya Ghosh, Martin Leahy
Published in: Journal of Biomedical Optics, Issue 26/01, 2021, ISSN 1083-3668
Publisher: S P I E - International Society for Optical Engineering
DOI: 10.1117/1.jbo.26.1.016003

Segmentation of Knee MRI Data with Convolutional Neural Networks for Semi-Automated Three-Dimensional Surface-Based Analysis of Cartilage Morphology and Composition

Author(s): Dimitri A. Kessler, James W. MacKay, Stephen M. McDonnell, Robert L. Janiczek, Martin J. Graves, Joshua D. Kaggie, and Fiona J. Gilbert
Published in: Osteoarthritis Imaging, Issue 27726541, 2022, Page(s) 100010, ISSN 2772-6541
Publisher: Elsevier Ltd
DOI: 10.1016/j.ostima.2022.100010

Platelet Lysate Induces in Human Osteoblasts Resumption of Cell Proliferation and Activation of Pathways Relevant for Revascularization and Regeneration of Damaged Bone

Author(s): Van Thi Nguyen, Marta Nardini, Alessandra Ruggiu, Ranieri Cancedda, Fiorella Descalzi, Maddalena Mastrogiacomo
Published in: International Journal of Molecular Sciences (Int J Mol Sci), Issue 21 (14), 2020, Page(s) 5123, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21145123

Accessing depth-resolved high spatial frequency content from the optical coherence tomography signal

Author(s): Sergey Alexandrov, Anand Arangath, Yi Zhou, Mary Murphy, Niamh Duffy, Kai Neuhaus, Georgina Shaw, Ryan McAuley, Martin Leahy
Published in: Scientific Reports, Issue 11/1, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-96619-7

Magnetic resonance fingerprinting of the pancreas at 1.5 T and 3.0 T

Author(s): Eva M. Serrao, Dimitri A. Kessler, Bruno Carmo, Lucian Beer, Kevin M. Brindle, Guido Buonincontri, Ferdia A. Gallagher, Fiona J. Gilbert, Edmund Godfrey, Martin J. Graves, Mary A. McLean, Evis Sala, Rolf F. Schulte, Joshua D. Kaggie
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-74462-6

Ultra Short Echo Time MRI of Iron-Labelled Mesenchymal Stem Cells in an Ovine Osteochondral Defect Model

Author(s): Joshua D. Kaggie, Hareklea Markides, Martin J. Graves, James MacKay, Gavin Houston, Alicia El Haj, Fiona Gilbert, Frances Henson
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-64423-4

Simple Characterization Scheme for Optical Coherence Tomography Systems With Application to a Commercial and a Near-Isometric Resolution Fibre-Based System

Author(s): Rajib Dey; Yi Zhou; Kai Neuhaus; Sergey Alexandrov; Andrew Nolan; Ting-Chiao Chang; Martin Leahy
Published in: IEEE Photonics Journal, Issue 14, 1, 2022, ISSN 1943-0655
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/jphot.2021.3135058

Effectively Measuring Exercise‐Related Variations in T1ρ and T2 Relaxation Times of Healthy Articular Cartilage

Author(s): Dimitri A. Kessler, James W. MacKay, Scott McDonald, Stephen McDonnell, Andrew J. Grainger, Alexandra R. Roberts, Robert L. Janiczek, Martin J. Graves, Joshua D. Kaggie, Fiona J. Gilbert
Published in: Journal of Magnetic Resonance Imaging, Issue 52/6, 2020, Page(s) 1753-1764, ISSN 1053-1807
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/jmri.27278

Spatial frequency domain correlation mapping optical coherence tomography for nanoscale structural characterization

Author(s): Sergey Alexandrov, Paul M. McNamara, Nandan Das, Yi Zhou, Gillian Lynch, Josh Hogan, Martin Leahy
Published in: Applied Physics Letters, Issue 115/12, 2019, Page(s) 121105, ISSN 0003-6951
Publisher: American Institute of Physics
DOI: 10.1063/1.5110459

The use of large animals to facilitate the process of MSC going from laboratory to patient—‘bench to bedside’

Author(s): W. E. Hotham, F. M. D. Henson
Published in: Cell Biology and Toxicology, Issue 36/2, 2020, Page(s) 103-114, ISSN 0742-2091
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10565-020-09521-9

Progenitor Cells Activated by Platelet Lysate in Human Articular Cartilage as a Tool for Future Cartilage Engineering and Reparative Strategies

Author(s): Simonetta Carluccio, Daniela Martinelli, Maria Elisabetta Federica Palamà, Rui Cruz Pereira, Roberto Benelli, Ana Guijarro, Ranieri Cancedda, Chiara Gentili
Published in: Cells, Issue 9/4, 2020, Page(s) 1052, ISSN 2073-4409
Publisher: MDPI AG
DOI: 10.3390/cells9041052

Noninvasive detection of nanoscale structural changes in cornea associated with cross‐linking treatment

Author(s): Yi Zhou, Sergey Alexandrov, Andrew Nolan, Nandan Das, Rajib Dey, Martin Leahy
Published in: Journal of Biophotonics, Issue 13/6, 2020, ISSN 1864-063X
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.201960234

Nanosensitive optical coherence tomography to assess wound healing within the cornea

Author(s): Cerine Lal, Sergey Alexandrov, Sweta Rani, Yi Zhou, Thomas Ritter, Martin Leahy
Published in: Biomedical Optics Express, Issue 11/7, 2020, Page(s) 3407, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/boe.389342

Nanoscale structure detection and monitoring of tumour growth with optical coherence tomography

Author(s): Nandan Das, Alexandrov Sergey, Yi Zhou, Katie E. Gilligan, Róisín M. Dwyer, Martin Leahy
Published in: Nanoscale Advances, Issue 2/7, 2020, Page(s) 2853-2858, ISSN 2516-0230
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0na00371a

The optimisation of deep neural networks for segmenting multiple knee joint tissues from MRIs

Author(s): Dimitri A. Kessler, James W. MacKay, Victoria A. Crowe, Frances M.D. Henson, Martin J. Graves, Fiona J. Gilbert, Joshua D. Kaggie
Published in: Computerized Medical Imaging and Graphics, Issue 86, 2020, Page(s) 101793, ISSN 0895-6111
Publisher: Elsevier BV
DOI: 10.1016/j.compmedimag.2020.101793

Evaluation of signal degradation due to birefringence in a multiple reference optical coherence tomography system with polarization-based balanced detection

Author(s): Anand Arangath; Kai Neuhaus; Sergey Alexandrov; Martin Leahy
Published in: IEEE Photonics Journal, Issue 14 (4), 2022, Page(s) 1-13, ISSN 1943-0655
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/jphot.2022.3189809

Contrast agents for photoacoustic imaging: a review of stem cell tracking.

Author(s): Soorya James; Kai Neuhaus; Mary Murphy; Martin J. Leahy; Martin J. Leahy
Published in: Stem Cell Research & Therapy, Issue 12, 2021, Page(s) 511, ISSN 1757-6512
Publisher: BioMed Central
DOI: 10.1186/s13287-021-02576-3

Spatial and Spectral Mapping and Decomposition of Neural Dynamics and Organization of the Mouse Brain with Multispectral Optoacoustic Tomography.

Author(s): Ivan Olefir; Ara Ghazaryan; Hong Yang; Jaber Malekzadeh-Najafabadi; Sarah Glasl; Panagiotis Symvoulidis; Valerie B. O’Leary; George Sergiadis; Vasilis Ntziachristos; Saak V. Ovsepian
Published in: Cell Reports, Issue 26, 10, 2019, Page(s) 2833-2846.e3, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.02.020

Conference proceedings (2)

Label Free Ultra-Sensitive Imaging with Sub-Diffraction Spatial Resolution

Author(s): Sergey Alexandrov, Nandan Das, James McGrath, Peter Owens, Colin J. R. Sheppard, Francesca Boccafoschi, Cinzia Giannini, Teresa Sibillano, Hrebesh Subhash, Martin Leahy
Published in: 2019 21st International Conference on Transparent Optical Networks (ICTON), 2019, Page(s) 1-4, ISBN 978-1-7281-2779-8
Publisher: IEEE
DOI: 10.1109/icton.2019.8840220

Ultra-sensitive label free imaging below the resolution limit (Conference Presentation)

Author(s): Sergey A. Alexandrov, James McGrath, Colin Sheppard, Francesca Boccafoschi, Cinzia Giannini, Teresa Sibillano, Hrebesh Subhash, Josh Hogan, Martin Leahy
Published in: Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVI, 2019, Page(s) 4, ISBN 9781-510624252
Publisher: SPIE
DOI: 10.1117/12.2502479