Objetivo Predictive Reagent Antibody Replacement Technology (PRe-ART) will create a foundational new technology platform to completely replace conventional antibody technology within medical diagnostics and basic life science research. In a multidisciplinary approach combining basic science, protein engineering and computational prediction, Pre-ART will generate non-antibody components which can be combined in an entirely modular fashion to create molecules that bind any peptide of choice. Such a biotechnological revolution is timely because of current failings in the reagent antibody market, after forty years still based on monoclonal antibodies (mAbs) to detect biomolecules, when 50% of all commercial reagent mAbs have been shown to not function correctly. By combining information science with directed evolution, PRe-ART will ultimately create an encyclopedia of pre-designed and experimentally pre-selected modules (like biological Lego bricks) that may be combined, without any further experiment, to generate unique binding molecules that function as antibody replacements. The PRe-ART vision is that mAbs for many applications in biological research will be replaced over the course of a decade by these designer molecules, with the potential to completely disrupt the industry selling low-quality commercial animal-derived reagent antibodies, and thus create a major new technology for biological research. Thus, PRe-ART will ultimately contribute not only to the health and wellbeing of the EU citizen through improved diagnostic capability, but also to the economy of the EU through the development of myriad detection products, enabled by this foundational platform technology. The interdisciplinary PRe-ART project will achieve this goal by bringing together three leading labs from different fields, two of which are lead by women PIs, whose joint efforts will achieve this breakthrough S&T target. The PRe-ART project thus closely addresses all specific challenges of the call. Ámbito científico engineering and technologymaterials engineeringcrystalsnatural sciencesbiological sciencesmicrobiologyvirologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinssocial sciencespolitical sciencespolitical transitionsrevolutionsnatural scienceschemical sciencesorganic chemistryamines Palabras clave Proteomics Protein Design Antibodies Armadillo Repeat Proteins Computation Molecular Modeling ProxiMAX Biological Engineering Biotechnology Directed Evolution Diagnostics Programa(s) H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET) Main Programme H2020-EU.1.2.1. - FET Open Tema(s) FETOPEN-01-2016-2017 - FET-Open research and innovation actions Convocatoria de propuestas H2020-FETOPEN-2016-2017 Consulte otros proyectos de esta convocatoria Convocatoria de subcontratación H2020-FETOPEN-1-2016-2017 Régimen de financiación RIA - Research and Innovation action Coordinador UNIVERSITAT ZURICH Aportación neta de la UEn € 1 428 750,00 Dirección RAMISTRASSE 71 8006 Zurich Suiza Ver en el mapa Región Schweiz/Suisse/Svizzera Zürich Zürich Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 1 428 750,00 Participantes (2) Ordenar alfabéticamente Ordenar por aportación neta de la UE Ampliar todo Contraer todo ASTON UNIVERSITY Reino Unido Aportación neta de la UEn € 1 189 375,00 Dirección ASTON TRIANGLE B4 7ET Birmingham Ver en el mapa Región West Midlands (England) West Midlands Birmingham Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 1 189 375,00 UNIVERSITAT BAYREUTH Alemania Aportación neta de la UEn € 970 000,00 Dirección UNIVERSITATSSTRASSE 30 95447 Bayreuth Ver en el mapa Región Bayern Oberfranken Bayreuth, Kreisfreie Stadt Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 970 000,00
