Design and photo-optimization of Photosensitizer for Human Health and Food security applications or “how light can save lives”

Informations projet

POLYTHEA

N° de convention de subvention: 764837

DOI 10.3030/764837

Projet clôturé

Date de signature de la CE 27 Février 2018

Date de début 1 Janvier 2018

Date de fin 30 Juin 2022

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total € 2 548 256,76

Contribution de l’UE € 2 548 256,76

Coordonné par

UNIVERSITE DE LIMOGES
France

Livrables

Websites, patent fillings, videos etc. (1)

Polythea web portal

The POLYTHEA website is on-line

Other (15)

First thematic school

Implementation of the first thematic school as well as production of reports and training session acts.

Report on outreach activities

All communication means used and their potential impact as well as the one of scientific results on public will be periodically evaluated by the Outreach, Dissemination and Exploitation Group. A part could be confidential. Deliverable will be thus up-dated on months 36 and 48.

Doctoral Polythea conference

Implementation and organization of of the the Doctoral Polythea conference addressed to doctorate fellows outside Polythea by ESRs from the start to the end including invitation programme and budget management

Selection training session

Attendance of eligible applicants to the training session for final selection.

New joint doctorate agreements for sustainability

The POLYTHEA doctoral training has longterm objectives Thus project will have 4 years to implement the joint diploma structures in other universities involved and ensure the durability of the structure set upA part of this deliverable can be confidential

Project identity set

In order to communicate, an identity set (logo, brochure and power point template, ...) will be created.

Recruitment completion

Recruitment of the ten ESR is done

Second thematic school

Implementation of the second thematic school as well as production of reports and training session acts.

Plan for the dissemination and exploitation of the project’s results

As the Outreach, Dissemination and Exploitation Group will identify and then establish actions in order to qualify and protect the knowledge generated by the consortium, a periodic report on the strategy and past/future issues regarding the use of results will be issued and the Consortium Agreement will be updated accordingly. Same will be done for the dissemination of the research results both within the consortium and to external parties. A part could be confidential. Deliverable will be thus up-dated on months 36 and 48.

Completion of the career development plans - PhD degree deliveries

After the defense of each ESR their carer plan will be complete and PhD deliveredA part of this deliverable can be publicAs it is difficult to planned a PhD defense 4 years before this deliverable can occur between months 45 and 48 depending on ESR

Third thematic school

Implementation of the third thematic school as well as production of reports and training session acts

List of eligible applicants

Upon CV screening, a selection of eligible researchers (12 to 15) will be established. These pre-selected applicants will attend a training session for final selection.

List of members and functioning of each project board and group

The consiladated list of members and functioning of each project board and groups will be produced and send to each beneficary/partner.

Advertising vacancies for PhD fellowship

Positions will be broadly advertised, first by a general network announcement on selected general international web-sites (the Polythea Web portal, the European platform, ABG, ...) to insure large visibility. Single host institutions will also advertise their position(s), with clear mention of the Polythea project and its network nature.

Edition of diploma supplement for each ESR

After the defense of each ESR the diploma supplement for each ESR recognizing the existence of a European doctoral training will be editedAs it is difficult to planned a PhD defense 4 years before this deliverable can occur between months 45 and 48 depending on ESR

Publications

Peer reviewed articles (37)

Acetylated lignin nanoparticles as a possible vehicle for photosensitizing molecules

Auteurs: Guillaume Marchand, Gabin Fabre, Nidia Maldonado-Carmona, Nicolas Villandier, Stéphanie Leroy-Lhez
Publié dans: Nanoscale Advances, 2020, ISSN 2516-0230
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d0na00615g

Dimethyl Sulfoxide: A bio-friendly or bio-hazard chemical? The effect of DMSO in human fibroblast-like synoviocytes

Auteurs: M. Gallardo-Villagrán, L. Paulus, D. Y. Leger, B. Therrien, B.Liagre
Publié dans: Molecules, Numéro 14203049, 2022, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27144472

Conjugated Photosensitizers for Imaging and PDT in Cancer Research

Auteurs: João C. S. Simões, Sophia Sarpaki, Panagiotis Papadimitroulas, Bruno Therrien, George Loudos
Publié dans: Journal of Medicinal Chemistry, Numéro 63/23, 2020, Page(s) 14119-14150, ISSN 0022-2623
Éditeur: American Chemical Society
DOI: 10.1021/acs.jmedchem.0c00047

Ligand-Targeted Delivery of Photosensitizers for Cancer Treatment

Auteurs: Piotr Gierlich, Ana I. Mata, Claire Donohoe, Rui M. M. Brito, Mathias O. Senge, Lígia C. Gomes-da-Silva
Publié dans: Molecules, Numéro 25/22, 2020, Page(s) 5317, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25225317

Combination of tetrapyridylporphyrins and arene ruthenium(II) complexes to treat synovial sarcoma by photodynamic therapy

Auteurs: Manuel Gallardo-Villagrán, Lucie Paulus, Yves Champavier, David Yannick Leger, Bruno Therrien and Bertrand Liagre
Publié dans: Journal of Porphyrins and Phthalocyanines, 2022, ISSN 1088-4246
Éditeur: Society of Porphyrins and Phthalocyanines
DOI: 10.1142/s1088424622500018

Crystal structures of 4-bromo-2-formyl-1-tosyl-1H-pyrrole, (E)-4-bromo-2-(2-nitro-vin-yl)-1-tosyl-1H-pyrrole and 6-(4-bromo-1-tosyl-pyrrol-2-yl)-4,4-di-methyl-5-nitro-hexan-2-one

Auteurs: Christopher J. Kingsbury,a Harry C. Samplea and Mathias O. Senge
Publié dans: Crystallographic Communications, 2021, ISSN 2056-9890
Éditeur: Crystallographic Communications
DOI: 10.1107/s2056989021002280

Nucleophilic Aromatic Substitution (S N Ar) and Related Reactions of Porphyrinoids: Mechanistic and Regiochemical Aspects

Auteurs: Harry C. Sample, Mathias O. Senge
Publié dans: European Journal of Organic Chemistry, Numéro 2021/1, 2021, Page(s) 7-42, ISSN 1434-193X
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/ejoc.202001183

Photophysical and Antibacterial Properties of PorphyrinsEncapsulated inside Acetylated Lignin Nanoparticles

Auteurs: N. Maldonado-Carmona, T-S. Ouk, N. Villandier, C. A. Calliste, M.J.F. Calvete, M.M. Pereira and S. Leroy-Lhez
Publié dans: Antibiotics, 2021, ISSN 2079-6382
Éditeur: Antibiotics
DOI: 10.3390/antibiotics10050513

Unraveling the Pivotal Role of Atropisomerism for Cellular Internalization

Auteurs: C. Donohoe, F. A. Schaberle, F. M. S. Rodrigues, N. P. F. Gonçalves, C.J. Kingsbury, M.M. Pereira, M.O. Senge, L.C. Gomes-da-Silva, L.G. Arnaut
Publié dans: Journal of the American Chemical Society, Numéro 00027863, 2022, ISSN 0002-7863
Éditeur: American Chemical Society
DOI: 10.1021/jacs.2c05844

Trimethoxyphenyl-BODIPYs as probes for lysosome staining

Auteurs: Piotr Gierlich, Luís Rodrigues, Fábio A. Schaberle, Susan Callaghan, Lígia C. Gomes-da-Silva and Mathias O. Senge
Publié dans: Journal of Porphyrins and Phthalocyanines, 2022, ISSN 1088-4246
Éditeur: Society of Porphyrins and Phthalocyanines
DOI: 10.1142/s1088424622500328

Steric Repulsion Induced Conformational Switchin Supramolecular Structures

Auteurs: K. Norvaisa, S. Maguire, C. Donohoe, J.E. O’Brien, B. Twamley, L.C. Gomes-da-Silva, M.O. Senge
Publié dans: Chemistry Europe, 2021, ISSN 0947-6539
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202103879

Synthesis and Properties of BODIPY Appended Tetraphenylethylene Scaffolds as Photoactive Arrays

Auteurs: H. C. Sample, G. Emandi, B. Twamley, N.Grover, B. Khurana, V. Sol, M.O. Senge
Publié dans: European Journal of Organic Chemistry, 2021, ISSN 1434-193X
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/ejoc.202100629

Dipyrrinato‐Iridium(III) Complexes for an Application in Photodynamic Therapy and Antimicrobial Photodynamic Inactivation

Auteurs: Benjamin F. Hohlfeld, Burkhard Gitter, Christopher J. Kingsbury, Keith J. Flanagan, Dorika Steen, Gerhard D. Wieland, Nora Kulak, Mathias O. Senge, Arno Wiehe
Publié dans: Chemistry – A European Journal, 2020, ISSN 0947-6539
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202004776

Latest trends on photodynamic disinfection of Gram-negative bacteria: photosensitizer’s structure and delivery systems

Auteurs: Nidia Maldonado-Carmona, Tan-Sothea Ouk, Stéphanie Leroy-Lhez
Publié dans: Photochemical & Photobiological Sciences, 2021, ISSN 1474-905X
Éditeur: Royal Society of Chemistry
DOI: 10.1007/s43630-021-00128-5

Synthesis and Structure of meso ‐Substituted Dibenzihomoporphyrins

Auteurs: Nitika Grover, Ganapathi Emandi, Brendan Twamley, Bhavya Khurana, Vincent Sol, Mathias O. Senge
Publié dans: European Journal of Organic Chemistry, Numéro 2020/41, 2020, Page(s) 6489-6496, ISSN 1434-193X
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/ejoc.202001165

Porphyrin-Loaded Lignin Nanoparticles Against Bacteria: A Photodynamic Antimicrobial Chemotherapy Application

Auteurs: Nidia Maldonado-Carmona, Guillaume Marchand, Nicolas Villandier, Tan-Sothea Ouk, Mariette M. Pereira, Mário J. F. Calvete, Claude Alain Calliste, Andrzej Żak4, Marta Piksa, Krzysztof J. Pawlik, Katarzyna Matczyszyn and Stéphanie Leroy-Lhez
Publié dans: Frontiers in microbiology, 2020, ISSN 1664-302X
Éditeur: Frontiers Media
DOI: 10.3389/fmicb.2020.606185

The good, the bad, and the ugly – controlling singlet oxygen through design of photosensitizers and delivery systems for photodynamic therapy

Auteurs: Susan Callaghan, Mathias O. Senge
Publié dans: Photochemical & Photobiological Sciences, 2018, ISSN 1474-905X
Éditeur: Royal Society of Chemistry
DOI: 10.1039/C8PP00008E

Acetylated Lignins: A Potential Bio-Sourced Photosensitizer

Auteurs: Guillaume Marchand, Claude A. Calliste, René M. Williams, Charlotte McLure, Stéphanie Leroy-Lhez, Nicolas Villandier
Publié dans: ChemistrySelect, Numéro 3/20, 2018, Page(s) 5512-5516, ISSN 2365-6549
Éditeur: CemistrySelect
DOI: 10.1002/slct.201801039

Pre-/post-functionalization in dipyrrin metal complexes – antitumor and antibacterial activity of their glycosylated derivatives

Auteurs: Claudia S. Gutsche, Susanna Gräfe, Burkhard Gitter, Keith J. Flanagan, Mathias O. Senge, Nora Kulak, Arno Wiehe
Publié dans: Dalton Transactions, 2018, ISSN 1477-9226
Éditeur: Royal Society of Chemistry
DOI: 10.1039/C8DT03059F

The Role of the Second Coordination Sphere in the Biological Activity of Arene Ruthenium Metalla-Assemblies

Auteurs: Bruno Therrien
Publié dans: Frontiers in Chemistry, Numéro 6, 2018, ISSN 2296-2646
Éditeur: Frontiers in Chemistry
DOI: 10.3389/fchem.2018.00602

Synthesis of Porphyrinoids, BODIPYs and (Dipyrrinato)ruthenium(II) Complexes from Pre-functionalized Dipyrromethanes

Auteurs: Benjamin F Hohlfeld, Keith J Flanagan, Nora Kulak, Mathias O. Senge, Mathias Christmann, Arno Wiehe
Publié dans: European Journal of Organic Chemistry, 2019, ISSN 1434-193X
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/ejoc.201900530

Photosensitizers Used in the Photodynamic Therapy of Rheumatoid Arthritis

Auteurs: Manuel Gallardo-Villagrán, David Yannick Leger, Bertrand Liagre, Bruno Therrien
Publié dans: International Journal of Molecular Sciences, Numéro 20/13, 2019, Page(s) 3339, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20133339

Hydrogels: soft matters in photomedicine

Auteurs: Bhavya Khurana, Piotr Gierlich, Alina Meindl, Lígia C. Gomes-da-Silva, Mathias O. Senge
Publié dans: Photochemical & Photobiological Sciences, Numéro 2019, 2019, ISSN 1474-905X
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c9pp00221a

Efficient Singlet Oxygen Photogeneration by Zinc Porphyrin Dimers upon One- and Two-Photon Excitation

Auteurs: Leszek M. Mazur, Thomas Roland, Stephanie Leroy-Lhez, Vincent Sol, Marek Samoc, Ifor D.W. Samuel, Katarzyna Matczyszyn
Publié dans: The Journal of Physical Chemistry B, Numéro 123/19, 2019, Page(s) 4271-4277, ISSN 1520-6106
Éditeur: American Chemical Society
DOI: 10.1021/acs.jpcb.8b12561

Trends and targets in antiviral phototherapy

Auteurs: Arno Wiehe, Jessica M. O'Brien, Mathias O. Senge
Publié dans: Photochemical & Photobiological Sciences, Numéro 18/11, 2019, Page(s) 2565-2612, ISSN 1474-905X
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c9pp00211a

Making Triplets from Photo-generated Charges: Observations, Mechanisms and Theory

Auteurs: Dáire J. Gibbons, Aram Farawar, Paul Mazzella, Stéphanie Leroy-Lhez, René M. Williams
Publié dans: Photochemical & Photobiological Sciences, 2020, ISSN 1474-905X
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c9pp00399a

Conjugating biomaterials with photosensitizers: advances and perspectives for Photodynamic Antimicrobial Chemotherapy

Auteurs: Nidia Maldonado-Carmona, Tan Sothea Ouk, Mário J. F. Calvete, Mariette M. Pereira, Nicolas Villandier, Stéphanie Leroy-Lhez
Publié dans: Photochemical & Photobiological Sciences, 2020, ISSN 1474-905X
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c9pp00398c

Synthesis and spectral properties of gem‐dimethyl chlorin photosensitizers

Auteurs: Zoi Melissari, Harry Sample, Brendan Twamley, René M. Williams, Mathias O. Senge
Publié dans: ChemPhotoChem, 2020, ISSN 2367-0932
Éditeur: Chemistry Europe
DOI: 10.1002/cptc.202000051

Flexible organic light-emitting diodes for antimicrobial photodynamic therapy

Auteurs: Cheng Lian, Marta Piksa, Kou Yoshida, Saydulla Persheyev, Krzysztof J. Pawlik, Katarzyna Matczyszyn, Ifor D. W. Samuel
Publié dans: npj Flexible Electronics, Numéro 3/1, 2019, ISSN 2397-4621
Éditeur: NPJ Flexible electonics
DOI: 10.1038/s41528-019-0058-0

Evaluation of Ruthenium-Based Assemblies as Carriers of Photosensitizers to Treat Rheumatoid Arthritis by Photodynamic Therapy

Auteurs: M. Gallardo-Villagrán, L. Paulus, J-L Charissoux, S. Sutour, P. Vergne-Salle, D.Y. Leger, B. Liagre, B. Therrien
Publié dans: Pharmaceurtics, 2021, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13122104

Ruthenium-based assemblies incorporating tetrapyridylporphyrin panels: a photosensitizerdelivery strategy for the treatment of rheumatoid arthritis by photodynamic therapy

Auteurs: Manuel Gallardo-Villagrán, Lucie Paulus, Jean-Louis Charissoux, David Yannick Leger, Pascale Vergne-Salle, Bruno Therrien and Bertrand Liagre
Publié dans: Royal Society of Chemistry, 2022, ISSN 1473-7604
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d2dt00917j

Development of Phenalenone-Triazolium Salt Derivatives for aPDT: Synthesis and Antibacterial Screening

Auteurs: J. Godard, D. Gibbons, S. Leroy-Lhez, R.M. Williams, N. Villandier, T.S. Ouk, F. Brégier, V. Sol,
Publié dans: Antibiotics, 2021, ISSN 2079-6382
Éditeur: Antibiotics
DOI: 10.3390/antibiotics10060626

Spin Orbit Coupling in Orthogonal Charge Transfer States: (TD-)DFT of Pyrene—Dimethylaniline

Auteurs: Shivan Bissesar; Davita M. E. van Raamsdonk; Dáire J. Gibbons; René M. Williams
Publié dans: Molecules, Numéro Volume 27; Numéro 3; Pages: 891, 2022, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27030891

Prospects for More Efficient Multi-Photon Absorption Photosensitizers Exhibiting Both Reactive Oxygen Species Generation and Luminescence

Auteurs: E. Robbins, S. Leroy-Lhez, N. Villandier, M. Samoć, K. Matczyszyn
Publié dans: Molecules, 2021, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26206323

Photo-activated thin films of porphyrins for reactive oxygen species generation

Auteurs: Daire J. Gibbons, Alexandre Boh, Benoit Habermeyer, Nicolas Villandier, Stephanie Leroy-Lhez and Rene M. Williams
Publié dans: Journal of Porphyrins and Phtalocyanines, 2022, ISSN 1088-4246
Éditeur: Society of Porphyrins and Phthalocyanines
DOI: 10.1142/s1088424622500183

One-Photonand Two-PhotonPhotophysicalPropertiesofTetrafunctionalized5,10,15,20-tetrakis(m-hydroxyphenyl)chlorin(Temoporfin)DerivativesasPotentialTwo-Photon-InducedPhotodynamicTherapyAgents

Auteurs: P. Gierlich, S.G. Mucha, E. Robbins, L.C. Gomes-da-Silva, K. Matczyszyn, M.O Senge
Publié dans: Chemistry Europe, 2021, ISSN 0947-6539
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/cptc.202100249

Porphyrinoids for Photodynamic Therapy

Auteurs: Z. Melissari, R. M. Williams and M. O. Senge
Publié dans: Royal Society of Chemistry, 2021, ISSN 1473-7604
Éditeur: Royal Society of Chemistry
DOI: 10.1039/9781839164149-00252

Other (2)

Spin Orbit Coupling in Orthogonal Charge Transfer States: (TD-)DFT of Pyrene - Dimethylaniline

Auteurs: Shivan Bissesar , Davita M. E. van Raamsdonk , Dáire J. Gibbons , René M. Williams
Publié dans: 2021
Éditeur: PrePrints
DOI: 10.20944/preprints202112.0109.v1

Structural Effects of meso-Halogenation on Porphyrins: meso-Xn-ABCD Macrocycles

Auteurs: Keith J. Flanagan, Maximilian Paradiz DominguezORCID Logo, Zoi MelissariORCID Logo, Hans-Georg EckhardtORCID Logo, René M. Williams, Dáire Gibbons, Caroline Prior, Gemma M. Locke, Alina Meindl, Aoife A. Ryan and Mathias O Senge
Publié dans: 2021
Éditeur: Beilstein Archives
DOI: 10.3762/bxiv.2021.21.v1

Thesis and dissertations (7)

Pyrrole-based Photosensitisers for Photomedicine. Synthesis, Photophysical and Photobiological Evaluation of Chlorins and Dipyrrin Complexes

Auteurs: Zoi Melissari
Publié dans: 2022
Éditeur: Trinity College Dublin

Covalently cross-linked tetrafunctionalized m-THPC chitosan hydrogels as drug delivery platforms

Auteurs: Piotr Gierlich
Publié dans: 2022
Éditeur: Trinity College Dublin

Radiolabelled porphyrinic metalla-assemblies linked to cellulose nanocrystals as PDT and imaging agents

Auteurs: João Carlos Salgueiro Simões
Publié dans: 2021
Éditeur: Université de Neuchâtel

New anti-inflammatory and pro-apoptotic photosensitizers against arthritis and synovial sarcoma

Auteurs: Manuel Gallardo-Villagran
Publié dans: 2022
Éditeur: Université de Neuchâtel

Triplet state access in multi-component heavy atom free photosensitizers in photomedicine

Auteurs: Dáire J. Gibbons
Publié dans: 2022
Éditeur: University of Amsterdam

Acetylated lignin nanoparticles as a new photosensitizer’s vehicle for Photodynamic Antimicrobial Chemotherapy (PACT)

Auteurs: Nidia Maldonado Carmona
Publié dans: 2021
Éditeur: University of Limoges

Antimicrobial formulation and functionalization of photosensitizers for antimicrobial photodynamic therapy (aPDT)

Auteurs: Bhavya Khurana
Publié dans: 2022
Éditeur: Université de Limoges

Non-peer reviewed articles (1)

Cell death in photodynamic therapy: From oxidative stress to anti-tumor immunity

Auteurs: Claire Donohoe, Mathias O. Senge, Luís G. Arnaut, Lígia C. Gomes-da-Silva
Publié dans: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2019, ISSN 0304-419X
Éditeur: Elsevier BV
DOI: 10.1016/j.bbcan.2019.07.003