Design and photo-optimization of Photosensitizer for Human Health and Food security applications or “how light can save lives”

Project Information

POLYTHEA

Grant agreement ID: 764837

DOI 10.3030/764837

Project closed

EC signature date 27 February 2018

Start date 1 January 2018

End date 30 June 2022

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 2 548 256,76

EU contribution € 2 548 256,76

Coordinated by

UNIVERSITE DE LIMOGES
France

Deliverables

Websites, patent fillings, videos etc. (1)

Polythea web portal

The POLYTHEA website is on-line

Other (15)

First thematic school

Implementation of the first thematic school as well as production of reports and training session acts.

Report on outreach activities

All communication means used and their potential impact as well as the one of scientific results on public will be periodically evaluated by the Outreach, Dissemination and Exploitation Group. A part could be confidential. Deliverable will be thus up-dated on months 36 and 48.

Doctoral Polythea conference

Implementation and organization of of the the Doctoral Polythea conference addressed to doctorate fellows outside Polythea by ESRs from the start to the end including invitation programme and budget management

Selection training session

Attendance of eligible applicants to the training session for final selection.

New joint doctorate agreements for sustainability

The POLYTHEA doctoral training has longterm objectives Thus project will have 4 years to implement the joint diploma structures in other universities involved and ensure the durability of the structure set upA part of this deliverable can be confidential

Project identity set

In order to communicate, an identity set (logo, brochure and power point template, ...) will be created.

Recruitment completion

Recruitment of the ten ESR is done

Second thematic school

Implementation of the second thematic school as well as production of reports and training session acts.

Plan for the dissemination and exploitation of the project’s results

As the Outreach, Dissemination and Exploitation Group will identify and then establish actions in order to qualify and protect the knowledge generated by the consortium, a periodic report on the strategy and past/future issues regarding the use of results will be issued and the Consortium Agreement will be updated accordingly. Same will be done for the dissemination of the research results both within the consortium and to external parties. A part could be confidential. Deliverable will be thus up-dated on months 36 and 48.

Completion of the career development plans - PhD degree deliveries

After the defense of each ESR their carer plan will be complete and PhD deliveredA part of this deliverable can be publicAs it is difficult to planned a PhD defense 4 years before this deliverable can occur between months 45 and 48 depending on ESR

Third thematic school

Implementation of the third thematic school as well as production of reports and training session acts

List of eligible applicants

Upon CV screening, a selection of eligible researchers (12 to 15) will be established. These pre-selected applicants will attend a training session for final selection.

List of members and functioning of each project board and group

The consiladated list of members and functioning of each project board and groups will be produced and send to each beneficary/partner.

Advertising vacancies for PhD fellowship

Positions will be broadly advertised, first by a general network announcement on selected general international web-sites (the Polythea Web portal, the European platform, ABG, ...) to insure large visibility. Single host institutions will also advertise their position(s), with clear mention of the Polythea project and its network nature.

Edition of diploma supplement for each ESR

After the defense of each ESR the diploma supplement for each ESR recognizing the existence of a European doctoral training will be editedAs it is difficult to planned a PhD defense 4 years before this deliverable can occur between months 45 and 48 depending on ESR

Publications

Peer reviewed articles (37)

Acetylated lignin nanoparticles as a possible vehicle for photosensitizing molecules

Author(s): Guillaume Marchand, Gabin Fabre, Nidia Maldonado-Carmona, Nicolas Villandier, Stéphanie Leroy-Lhez
Published in: Nanoscale Advances, 2020, ISSN 2516-0230
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0na00615g

Dimethyl Sulfoxide: A bio-friendly or bio-hazard chemical? The effect of DMSO in human fibroblast-like synoviocytes

Author(s): M. Gallardo-Villagrán, L. Paulus, D. Y. Leger, B. Therrien, B.Liagre
Published in: Molecules, Issue 14203049, 2022, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27144472

Conjugated Photosensitizers for Imaging and PDT in Cancer Research

Author(s): João C. S. Simões, Sophia Sarpaki, Panagiotis Papadimitroulas, Bruno Therrien, George Loudos
Published in: Journal of Medicinal Chemistry, Issue 63/23, 2020, Page(s) 14119-14150, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.0c00047

Ligand-Targeted Delivery of Photosensitizers for Cancer Treatment

Author(s): Piotr Gierlich, Ana I. Mata, Claire Donohoe, Rui M. M. Brito, Mathias O. Senge, Lígia C. Gomes-da-Silva
Published in: Molecules, Issue 25/22, 2020, Page(s) 5317, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25225317

Combination of tetrapyridylporphyrins and arene ruthenium(II) complexes to treat synovial sarcoma by photodynamic therapy

Author(s): Manuel Gallardo-Villagrán, Lucie Paulus, Yves Champavier, David Yannick Leger, Bruno Therrien and Bertrand Liagre
Published in: Journal of Porphyrins and Phthalocyanines, 2022, ISSN 1088-4246
Publisher: Society of Porphyrins and Phthalocyanines
DOI: 10.1142/s1088424622500018

Crystal structures of 4-bromo-2-formyl-1-tosyl-1H-pyrrole, (E)-4-bromo-2-(2-nitro-vin-yl)-1-tosyl-1H-pyrrole and 6-(4-bromo-1-tosyl-pyrrol-2-yl)-4,4-di-methyl-5-nitro-hexan-2-one

Author(s): Christopher J. Kingsbury,a Harry C. Samplea and Mathias O. Senge
Published in: Crystallographic Communications, 2021, ISSN 2056-9890
Publisher: Crystallographic Communications
DOI: 10.1107/s2056989021002280

Nucleophilic Aromatic Substitution (S N Ar) and Related Reactions of Porphyrinoids: Mechanistic and Regiochemical Aspects

Author(s): Harry C. Sample, Mathias O. Senge
Published in: European Journal of Organic Chemistry, Issue 2021/1, 2021, Page(s) 7-42, ISSN 1434-193X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ejoc.202001183

Photophysical and Antibacterial Properties of PorphyrinsEncapsulated inside Acetylated Lignin Nanoparticles

Author(s): N. Maldonado-Carmona, T-S. Ouk, N. Villandier, C. A. Calliste, M.J.F. Calvete, M.M. Pereira and S. Leroy-Lhez
Published in: Antibiotics, 2021, ISSN 2079-6382
Publisher: Antibiotics
DOI: 10.3390/antibiotics10050513

Unraveling the Pivotal Role of Atropisomerism for Cellular Internalization

Author(s): C. Donohoe, F. A. Schaberle, F. M. S. Rodrigues, N. P. F. Gonçalves, C.J. Kingsbury, M.M. Pereira, M.O. Senge, L.C. Gomes-da-Silva, L.G. Arnaut
Published in: Journal of the American Chemical Society, Issue 00027863, 2022, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.2c05844

Trimethoxyphenyl-BODIPYs as probes for lysosome staining

Author(s): Piotr Gierlich, Luís Rodrigues, Fábio A. Schaberle, Susan Callaghan, Lígia C. Gomes-da-Silva and Mathias O. Senge
Published in: Journal of Porphyrins and Phthalocyanines, 2022, ISSN 1088-4246
Publisher: Society of Porphyrins and Phthalocyanines
DOI: 10.1142/s1088424622500328

Steric Repulsion Induced Conformational Switchin Supramolecular Structures

Author(s): K. Norvaisa, S. Maguire, C. Donohoe, J.E. O’Brien, B. Twamley, L.C. Gomes-da-Silva, M.O. Senge
Published in: Chemistry Europe, 2021, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202103879

Synthesis and Properties of BODIPY Appended Tetraphenylethylene Scaffolds as Photoactive Arrays

Author(s): H. C. Sample, G. Emandi, B. Twamley, N.Grover, B. Khurana, V. Sol, M.O. Senge
Published in: European Journal of Organic Chemistry, 2021, ISSN 1434-193X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ejoc.202100629

Dipyrrinato‐Iridium(III) Complexes for an Application in Photodynamic Therapy and Antimicrobial Photodynamic Inactivation

Author(s): Benjamin F. Hohlfeld, Burkhard Gitter, Christopher J. Kingsbury, Keith J. Flanagan, Dorika Steen, Gerhard D. Wieland, Nora Kulak, Mathias O. Senge, Arno Wiehe
Published in: Chemistry – A European Journal, 2020, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202004776

Latest trends on photodynamic disinfection of Gram-negative bacteria: photosensitizer’s structure and delivery systems

Author(s): Nidia Maldonado-Carmona, Tan-Sothea Ouk, Stéphanie Leroy-Lhez
Published in: Photochemical & Photobiological Sciences, 2021, ISSN 1474-905X
Publisher: Royal Society of Chemistry
DOI: 10.1007/s43630-021-00128-5

Synthesis and Structure of meso ‐Substituted Dibenzihomoporphyrins

Author(s): Nitika Grover, Ganapathi Emandi, Brendan Twamley, Bhavya Khurana, Vincent Sol, Mathias O. Senge
Published in: European Journal of Organic Chemistry, Issue 2020/41, 2020, Page(s) 6489-6496, ISSN 1434-193X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ejoc.202001165

Porphyrin-Loaded Lignin Nanoparticles Against Bacteria: A Photodynamic Antimicrobial Chemotherapy Application

Author(s): Nidia Maldonado-Carmona, Guillaume Marchand, Nicolas Villandier, Tan-Sothea Ouk, Mariette M. Pereira, Mário J. F. Calvete, Claude Alain Calliste, Andrzej Żak4, Marta Piksa, Krzysztof J. Pawlik, Katarzyna Matczyszyn and Stéphanie Leroy-Lhez
Published in: Frontiers in microbiology, 2020, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2020.606185

The good, the bad, and the ugly – controlling singlet oxygen through design of photosensitizers and delivery systems for photodynamic therapy

Author(s): Susan Callaghan, Mathias O. Senge
Published in: Photochemical & Photobiological Sciences, 2018, ISSN 1474-905X
Publisher: Royal Society of Chemistry
DOI: 10.1039/C8PP00008E

Acetylated Lignins: A Potential Bio-Sourced Photosensitizer

Author(s): Guillaume Marchand, Claude A. Calliste, René M. Williams, Charlotte McLure, Stéphanie Leroy-Lhez, Nicolas Villandier
Published in: ChemistrySelect, Issue 3/20, 2018, Page(s) 5512-5516, ISSN 2365-6549
Publisher: CemistrySelect
DOI: 10.1002/slct.201801039

Pre-/post-functionalization in dipyrrin metal complexes – antitumor and antibacterial activity of their glycosylated derivatives

Author(s): Claudia S. Gutsche, Susanna Gräfe, Burkhard Gitter, Keith J. Flanagan, Mathias O. Senge, Nora Kulak, Arno Wiehe
Published in: Dalton Transactions, 2018, ISSN 1477-9226
Publisher: Royal Society of Chemistry
DOI: 10.1039/C8DT03059F

The Role of the Second Coordination Sphere in the Biological Activity of Arene Ruthenium Metalla-Assemblies

Author(s): Bruno Therrien
Published in: Frontiers in Chemistry, Issue 6, 2018, ISSN 2296-2646
Publisher: Frontiers in Chemistry
DOI: 10.3389/fchem.2018.00602

Synthesis of Porphyrinoids, BODIPYs and (Dipyrrinato)ruthenium(II) Complexes from Pre-functionalized Dipyrromethanes

Author(s): Benjamin F Hohlfeld, Keith J Flanagan, Nora Kulak, Mathias O. Senge, Mathias Christmann, Arno Wiehe
Published in: European Journal of Organic Chemistry, 2019, ISSN 1434-193X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ejoc.201900530

Photosensitizers Used in the Photodynamic Therapy of Rheumatoid Arthritis

Author(s): Manuel Gallardo-Villagrán, David Yannick Leger, Bertrand Liagre, Bruno Therrien
Published in: International Journal of Molecular Sciences, Issue 20/13, 2019, Page(s) 3339, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20133339

Hydrogels: soft matters in photomedicine

Author(s): Bhavya Khurana, Piotr Gierlich, Alina Meindl, Lígia C. Gomes-da-Silva, Mathias O. Senge
Published in: Photochemical & Photobiological Sciences, Issue 2019, 2019, ISSN 1474-905X
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9pp00221a

Efficient Singlet Oxygen Photogeneration by Zinc Porphyrin Dimers upon One- and Two-Photon Excitation

Author(s): Leszek M. Mazur, Thomas Roland, Stephanie Leroy-Lhez, Vincent Sol, Marek Samoc, Ifor D.W. Samuel, Katarzyna Matczyszyn
Published in: The Journal of Physical Chemistry B, Issue 123/19, 2019, Page(s) 4271-4277, ISSN 1520-6106
Publisher: American Chemical Society
DOI: 10.1021/acs.jpcb.8b12561

Trends and targets in antiviral phototherapy

Author(s): Arno Wiehe, Jessica M. O'Brien, Mathias O. Senge
Published in: Photochemical & Photobiological Sciences, Issue 18/11, 2019, Page(s) 2565-2612, ISSN 1474-905X
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9pp00211a

Making Triplets from Photo-generated Charges: Observations, Mechanisms and Theory

Author(s): Dáire J. Gibbons, Aram Farawar, Paul Mazzella, Stéphanie Leroy-Lhez, René M. Williams
Published in: Photochemical & Photobiological Sciences, 2020, ISSN 1474-905X
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9pp00399a

Conjugating biomaterials with photosensitizers: advances and perspectives for Photodynamic Antimicrobial Chemotherapy

Author(s): Nidia Maldonado-Carmona, Tan Sothea Ouk, Mário J. F. Calvete, Mariette M. Pereira, Nicolas Villandier, Stéphanie Leroy-Lhez
Published in: Photochemical & Photobiological Sciences, 2020, ISSN 1474-905X
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9pp00398c

Synthesis and spectral properties of gem‐dimethyl chlorin photosensitizers

Author(s): Zoi Melissari, Harry Sample, Brendan Twamley, René M. Williams, Mathias O. Senge
Published in: ChemPhotoChem, 2020, ISSN 2367-0932
Publisher: Chemistry Europe
DOI: 10.1002/cptc.202000051

Flexible organic light-emitting diodes for antimicrobial photodynamic therapy

Author(s): Cheng Lian, Marta Piksa, Kou Yoshida, Saydulla Persheyev, Krzysztof J. Pawlik, Katarzyna Matczyszyn, Ifor D. W. Samuel
Published in: npj Flexible Electronics, Issue 3/1, 2019, ISSN 2397-4621
Publisher: NPJ Flexible electonics
DOI: 10.1038/s41528-019-0058-0

Evaluation of Ruthenium-Based Assemblies as Carriers of Photosensitizers to Treat Rheumatoid Arthritis by Photodynamic Therapy

Author(s): M. Gallardo-Villagrán, L. Paulus, J-L Charissoux, S. Sutour, P. Vergne-Salle, D.Y. Leger, B. Liagre, B. Therrien
Published in: Pharmaceurtics, 2021, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13122104

Ruthenium-based assemblies incorporating tetrapyridylporphyrin panels: a photosensitizerdelivery strategy for the treatment of rheumatoid arthritis by photodynamic therapy

Author(s): Manuel Gallardo-Villagrán, Lucie Paulus, Jean-Louis Charissoux, David Yannick Leger, Pascale Vergne-Salle, Bruno Therrien and Bertrand Liagre
Published in: Royal Society of Chemistry, 2022, ISSN 1473-7604
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2dt00917j

Development of Phenalenone-Triazolium Salt Derivatives for aPDT: Synthesis and Antibacterial Screening

Author(s): J. Godard, D. Gibbons, S. Leroy-Lhez, R.M. Williams, N. Villandier, T.S. Ouk, F. Brégier, V. Sol,
Published in: Antibiotics, 2021, ISSN 2079-6382
Publisher: Antibiotics
DOI: 10.3390/antibiotics10060626

Spin Orbit Coupling in Orthogonal Charge Transfer States: (TD-)DFT of Pyrene—Dimethylaniline

Author(s): Shivan Bissesar; Davita M. E. van Raamsdonk; Dáire J. Gibbons; René M. Williams
Published in: Molecules, Issue Volume 27; Issue 3; Pages: 891, 2022, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27030891

Prospects for More Efficient Multi-Photon Absorption Photosensitizers Exhibiting Both Reactive Oxygen Species Generation and Luminescence

Author(s): E. Robbins, S. Leroy-Lhez, N. Villandier, M. Samoć, K. Matczyszyn
Published in: Molecules, 2021, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26206323

Photo-activated thin films of porphyrins for reactive oxygen species generation

Author(s): Daire J. Gibbons, Alexandre Boh, Benoit Habermeyer, Nicolas Villandier, Stephanie Leroy-Lhez and Rene M. Williams
Published in: Journal of Porphyrins and Phtalocyanines, 2022, ISSN 1088-4246
Publisher: Society of Porphyrins and Phthalocyanines
DOI: 10.1142/s1088424622500183

One-Photonand Two-PhotonPhotophysicalPropertiesofTetrafunctionalized5,10,15,20-tetrakis(m-hydroxyphenyl)chlorin(Temoporfin)DerivativesasPotentialTwo-Photon-InducedPhotodynamicTherapyAgents

Author(s): P. Gierlich, S.G. Mucha, E. Robbins, L.C. Gomes-da-Silva, K. Matczyszyn, M.O Senge
Published in: Chemistry Europe, 2021, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cptc.202100249

Porphyrinoids for Photodynamic Therapy

Author(s): Z. Melissari, R. M. Williams and M. O. Senge
Published in: Royal Society of Chemistry, 2021, ISSN 1473-7604
Publisher: Royal Society of Chemistry
DOI: 10.1039/9781839164149-00252

Other (2)

Spin Orbit Coupling in Orthogonal Charge Transfer States: (TD-)DFT of Pyrene - Dimethylaniline

Author(s): Shivan Bissesar , Davita M. E. van Raamsdonk , Dáire J. Gibbons , René M. Williams
Published in: 2021
Publisher: PrePrints
DOI: 10.20944/preprints202112.0109.v1

Structural Effects of meso-Halogenation on Porphyrins: meso-Xn-ABCD Macrocycles

Author(s): Keith J. Flanagan, Maximilian Paradiz DominguezORCID Logo, Zoi MelissariORCID Logo, Hans-Georg EckhardtORCID Logo, René M. Williams, Dáire Gibbons, Caroline Prior, Gemma M. Locke, Alina Meindl, Aoife A. Ryan and Mathias O Senge
Published in: 2021
Publisher: Beilstein Archives
DOI: 10.3762/bxiv.2021.21.v1

Thesis and dissertations (7)

Pyrrole-based Photosensitisers for Photomedicine. Synthesis, Photophysical and Photobiological Evaluation of Chlorins and Dipyrrin Complexes

Author(s): Zoi Melissari
Published in: 2022
Publisher: Trinity College Dublin

Covalently cross-linked tetrafunctionalized m-THPC chitosan hydrogels as drug delivery platforms

Author(s): Piotr Gierlich
Published in: 2022
Publisher: Trinity College Dublin

Radiolabelled porphyrinic metalla-assemblies linked to cellulose nanocrystals as PDT and imaging agents

Author(s): João Carlos Salgueiro Simões
Published in: 2021
Publisher: Université de Neuchâtel

New anti-inflammatory and pro-apoptotic photosensitizers against arthritis and synovial sarcoma

Author(s): Manuel Gallardo-Villagran
Published in: 2022
Publisher: Université de Neuchâtel

Triplet state access in multi-component heavy atom free photosensitizers in photomedicine

Author(s): Dáire J. Gibbons
Published in: 2022
Publisher: University of Amsterdam

Acetylated lignin nanoparticles as a new photosensitizer’s vehicle for Photodynamic Antimicrobial Chemotherapy (PACT)

Author(s): Nidia Maldonado Carmona
Published in: 2021
Publisher: University of Limoges

Antimicrobial formulation and functionalization of photosensitizers for antimicrobial photodynamic therapy (aPDT)

Author(s): Bhavya Khurana
Published in: 2022
Publisher: Université de Limoges

Non-peer reviewed articles (1)

Cell death in photodynamic therapy: From oxidative stress to anti-tumor immunity

Author(s): Claire Donohoe, Mathias O. Senge, Luís G. Arnaut, Lígia C. Gomes-da-Silva
Published in: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2019, ISSN 0304-419X
Publisher: Elsevier BV
DOI: 10.1016/j.bbcan.2019.07.003