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CORDIS - EU research results
CORDIS

Yeast Biotechnology Doctoral Training Programme

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Advertisement of Vacancies (opens in new window)

UCC will manage the advertisement of positions on EURAXESS. Each beneficiary will also advertise through their own channels and contacts.

At least 6 joint research publications in high impact journals (opens in new window)

Joint research publications in high impact journals will be a measure of the success of the project and the consortium. The aim is to publish 6 such joint publications during the lifetime of the project.

An appraisal of the potential application of novel, flavour-producing yeast strains for production of fermented beverages. (opens in new window)

YEASTDOC will apply advanced genetic tools to understand how different genes and alleles interact with each other and the environment to produce flavours and aromas in fermented and distilled beverages The potential for new hybrids and process conditions to be used in industry will be evaluated in conjunction with industrial partners Where appropriate plans for advancing the research to a higher TRL will be developed

A report describing a set of genes or alleles that individually or in combination enhance the industrial potential of yeast strains. (opens in new window)

Genes and alleles that contribute to the improved aroma and flavour of fermented beverages will be identified in this project Strains that cope with both substrate and productinduced cellular stress and that have the ability to grow on inexpensive substrates and efficiently secrete the product will also be identified A report will be compiled describing the genes that contribute to these beneficial traits

A communication and engagement plan (opens in new window)

A communication and engagement plan describing each activity, personnel involved, timeline for completion, and Key Performance Indicators (KPIs) for assessing delivery and impact, will be drawn up. This plan will be reviewed and updated annually.

An appraisal of whether the engineering strategies identified for improving industrial yeasts are effective and suitable for the improvement of diverse yeast cell factories (opens in new window)

Engineering strategies such as genome engineering ALE reverse engineering will be utilized in the project This report will evaluate the effectiveness of such strategies

A report detailing the effectiveness of public communication and engagement strategy (opens in new window)

A detailed public engagement plan will have been prepared at the beginning of the project This report will evaluate how successful this strategy was at engaging with the target audiences and at influencing perceptions both in the ESRs and the target audiences

A report on the effectiveness of the Industry engagement activities (opens in new window)

The first route to exploitation of project outcomes naturally involves the Partner Organisations from YEASTDOC but there will also be broadly applicable outcomes that can benefit industry more widely Hence the dissemination plan will have specific components to promote engagement with additional potential industry endusers This includes interaction with industry platforms and societies This report will examine how effective these engagement strategies have been

A review of the application of advanced genetics for strain selection in beverage yeasts (opens in new window)

A new methodology developed by ULEIC that involves mating diploids to overcome hybrid sterility followed by multigenerational crosses will be employed in YEASTDOC This leads to a huge increase in gene assortment relative to simple crosses and a large increase in the diversity of the hybrid population These populations will then be used in a screening and genetics programme to identify hybrids with novel flavouraroma characteristics and the genes responsible for this The project will also develop QTL approaches to map complex traits applying these methods to identify the basis of several important fermentation traits This report will evaluate the effectiveness of these methodologies

A public access website (opens in new window)

A public website detailing the consortium and the research & training activities of YEASTDOC will be created.

Publications

Interdependence between lignocellulosic biomasses, enzymatic hydrolysis and yeast cell factories in biorefineries. (opens in new window)

Author(s): Bertacchi, S., Jayaprakash, P., Morrissey, J.P., Branduardi, P.
Published in: Microbial Biotechnology, Issue 17517915, 2021, ISSN 1751-7915
Publisher: Wiley
DOI: 10.1111/1751-7915.13886

The Dicarboxylate Transporters from the AceTr Family and Dct-02 Oppositely Affect Succinic Acid (opens in new window)

Author(s): Rendulić T, Mendonça Bahia F, Soares-Silva I, Nevoigt E, Casal M.
Published in: Journal of Fungi, 2022, ISSN 2309-608X
Publisher: MDPI
DOI: 10.3390/jof8080822

The evolution and role of the periplasmic asparaginase Asp3 in yeast. . 22, 1–11. https://doi.org/10.1093/femsyr/foac044 (opens in new window)

Author(s): Coral-Medina, A., Fenton, D.A., Varela, J., Baranov, P. V, Camarasa, C., Morrissey, J.P.
Published in: FEMS Yeast Research, Issue 22, 2022, Page(s) 1 - 11, ISSN 1567-1356
Publisher: Blackwell
DOI: 10.1093/femsyr/foac044

Carbon dioxide fixation via production of succinic acid from glycerol in engineered Saccharomyces cerevisiae (opens in new window)

Author(s): Zahabiya Malubhoy; Frederico Mendonça Bahia; Sophie Claire de Valk; Erik de Hulster; Toni Rendulić; Juan Paulo Ragas Ortiz; Joeline Xiberras; Mathias Klein; Robert Mans; Elke Nevoigt
Published in: Microbial Cell Factories, 2022, ISSN 1475-2859
Publisher: BioMed Central
DOI: 10.1186/s12934-022-01817-1

Yeast Plasma Membrane Fungal Oligopeptide Transporters Display Distinct Substrate Preferences despite Their High Sequence Identity. (opens in new window)

Author(s): Becerra-Rodríguez, C., Taghouti, G., Portier, P., Dequin, S., Casal, M., Paiva, S., et al.
Published in: Journal of Fungi, 2021, ISSN 2309-608X
Publisher: MDPI
DOI: 10.3390/jof7110963

Identification of novel pentose transporters in Kluyveromyces marxianus using a new screening platform. (opens in new window)

Author(s): Lorena Donzella; Javier A. Varela; Maria João Sousa; John P. Morrissey
Published in: FEMS Yeast Research, Issue 12, 2021, ISSN 1567-1356
Publisher: Blackwell
DOI: 10.1093/femsyr/foab026

Hexose transport in Torulaspora delbrueckii: identification of Igt1, a new dual-affinity transporter (opens in new window)

Author(s): Andreia Pacheco, Lorena Donzella, Maria Jose Hernandez-Lopez, Maria Judite Almeida, Jose Antonio Prieto, Francisca Randez-Gil, John P Morrissey, Maria João Sousa
Published in: FEMS Yeast Research, Issue 20/1, 2020, ISSN 1567-1356
Publisher: Blackwell
DOI: 10.1093/femsyr/foaa004

Diversity of Oligopeptide Transport in Yeast and Its Impact on Adaptation to Winemaking Conditions (opens in new window)

Author(s): Carmen Becerra-Rodríguez, Souhir Marsit, Virginie Galeote
Published in: Frontiers in Genetics, Issue 11, 2020, ISSN 1664-8021
Publisher: Frontiers Media
DOI: 10.3389/fgene.2020.00602

Membrane transporters in the bioproduction of organic acids: state of the art and future perspectives for industrial applications (opens in new window)

Author(s): I Soares-Silva, D Ribas, M Sousa-Silva, J Azevedo-Silva, T Rendulić, M Casal
Published in: FEMS Microbiology Letters, 2020, ISSN 0378-1097
Publisher: Blackwell
DOI: 10.1093/femsle/fnaa118

Beyond Saccharomyces pastorianus for modern lager brews: Exploring non-cerevisiae Saccharomyces hybrids with heterotic maltotriose consumption and novel aroma profile. (opens in new window)

Author(s): Gyurchev, N.Y., Coral-Medina, Á., Weening, S.M., Almayouf, S., Kuijpers, N.G.A., Nevoigt, E., Louis, E.J.
Published in: Frontiers Microbiology, 2022, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2022.1025132

Impact of ergosterol content on acetic and lactic acids toxicity to Saccharomyces cerevisiae (opens in new window)

Author(s): Luís Ferraz, Karola Vorauer-Uhl, Michael Sauer, Maria J. Sousa, Paola Branduardi
Published in: Yeast, 2022, ISSN 1097-0061
Publisher: John Wiley & Sons Ltd
DOI: 10.1002/yea.3828

The growth and metabolome of Saccharomyces uvarum in wine fermentations is strongly influenced by the route of nitrogen assimilation. (opens in new window)

Author(s): Coral-Medina, A., Morrissey, J.P., Camarasa, C.
Published in: J. Ind. Microbiol. Biotechnol., Issue 14765535, 2022, ISSN 1476-5535
Publisher: Oxford University Press
DOI: 10.1093/jimb/kuac025

New insights into the acetate uptake transporter (AceTr) family: Unveiling amino acid residues critical for specificity and activity. (opens in new window)

Author(s): Rendulić, T. Alves, J., Azevedo-Silva,J. Soares-Silva,I., Casal,M.
Published in: Computational and Structural Biotechnology Journal, 2021, ISSN 2001-0370
Publisher: Elsevier
DOI: 10.1016/j.csbj.2021.08.002

Insights on life cycle and cell identity regulatory circuits for unlocking genetic improvement in Zygosaccharomyces and Kluyveromyces yeasts. (opens in new window)

Author(s): Lisa Solieri; Stefano Cassanelli; Franziska Huff; Franziska Huff; Liliane Barroso; Liliane Barroso; Paola Branduardi; Edward J. Louis; John P. Morrissey
Published in: FEMS Yeast Research, Issue 15671356, 2021, ISSN 1567-1356
Publisher: Blackwell
DOI: 10.1093/femsyr/foab058

The plasma Membrane at the cornerstone between flexibility and adaptability: implications for Saccharomyces cerevisiae as a cell factory. (opens in new window)

Author(s): Ferraz, L., Sauer, M., Sousa, M.J., Branduardi, P.
Published in: Frontiers Microbiology, Issue 1664302x, 2021, ISSN 1664-302x
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2021.715891

Regulated use of alternative Transcription Start Sites controls the production of cytosolic or mitochondrial forms of branched-chain aminotransferase in Kluyveromyces marxianus (opens in new window)

Author(s): Angela Coral-Medina, Darren A. Fenton, Javier Varela, Carole Camarasa, Pavel V. Baranov, John P. Morrissey
Published in: bioRxiv, Issue 26928205, 2022, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.04.27.489738

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