Risultati finali
UCC will manage the advertisement of positions on EURAXESS. Each beneficiary will also advertise through their own channels and contacts.
At least 6 joint research publications in high impact journalsJoint research publications in high impact journals will be a measure of the success of the project and the consortium. The aim is to publish 6 such joint publications during the lifetime of the project.
YEASTDOC will apply advanced genetic tools to understand how different genes and alleles interact with each other and the environment to produce flavours and aromas in fermented and distilled beverages The potential for new hybrids and process conditions to be used in industry will be evaluated in conjunction with industrial partners Where appropriate plans for advancing the research to a higher TRL will be developed
A report describing a set of genes or alleles that individually or in combination enhance the industrial potential of yeast strains.Genes and alleles that contribute to the improved aroma and flavour of fermented beverages will be identified in this project Strains that cope with both substrate and productinduced cellular stress and that have the ability to grow on inexpensive substrates and efficiently secrete the product will also be identified A report will be compiled describing the genes that contribute to these beneficial traits
A communication and engagement planA communication and engagement plan describing each activity, personnel involved, timeline for completion, and Key Performance Indicators (KPIs) for assessing delivery and impact, will be drawn up. This plan will be reviewed and updated annually.
An appraisal of whether the engineering strategies identified for improving industrial yeasts are effective and suitable for the improvement of diverse yeast cell factoriesEngineering strategies such as genome engineering ALE reverse engineering will be utilized in the project This report will evaluate the effectiveness of such strategies
A report detailing the effectiveness of public communication and engagement strategyA detailed public engagement plan will have been prepared at the beginning of the project This report will evaluate how successful this strategy was at engaging with the target audiences and at influencing perceptions both in the ESRs and the target audiences
A report on the effectiveness of the Industry engagement activitiesThe first route to exploitation of project outcomes naturally involves the Partner Organisations from YEASTDOC but there will also be broadly applicable outcomes that can benefit industry more widely Hence the dissemination plan will have specific components to promote engagement with additional potential industry endusers This includes interaction with industry platforms and societies This report will examine how effective these engagement strategies have been
A review of the application of advanced genetics for strain selection in beverage yeastsA new methodology developed by ULEIC that involves mating diploids to overcome hybrid sterility followed by multigenerational crosses will be employed in YEASTDOC This leads to a huge increase in gene assortment relative to simple crosses and a large increase in the diversity of the hybrid population These populations will then be used in a screening and genetics programme to identify hybrids with novel flavouraroma characteristics and the genes responsible for this The project will also develop QTL approaches to map complex traits applying these methods to identify the basis of several important fermentation traits This report will evaluate the effectiveness of these methodologies
A public website detailing the consortium and the research & training activities of YEASTDOC will be created.
Pubblicazioni
Autori:
Bertacchi, S., Jayaprakash, P., Morrissey, J.P., Branduardi, P.
Pubblicato in:
Microbial Biotechnology, Numero 17517915, 2021, ISSN 1751-7915
Editore:
Wiley
DOI:
10.1111/1751-7915.13886
Autori:
Rendulić T, Mendonça Bahia F, Soares-Silva I, Nevoigt E, Casal M.
Pubblicato in:
Journal of Fungi, Numero 2309608X, 2022, ISSN 2309-608X
Editore:
MDPI
DOI:
10.3390/jof8080822
Autori:
Coral-Medina, A., Fenton, D.A., Varela, J., Baranov, P. V, Camarasa, C., Morrissey, J.P.
Pubblicato in:
FEMS Yeast Research, Numero 15671356, 2022, Pagina/e 1 - 11, ISSN 1567-1356
Editore:
Blackwell
DOI:
10.1093/femsyr/foac044
Autori:
Zahabiya Malubhoy; Frederico Mendonça Bahia; Sophie Claire de Valk; Erik de Hulster; Toni Rendulić; Juan Paulo Ragas Ortiz; Joeline Xiberras; Mathias Klein; Robert Mans; Elke Nevoigt
Pubblicato in:
Microbial Cell Factories, Numero 14752859, 2022, ISSN 1475-2859
Editore:
BioMed Central
DOI:
10.1186/s12934-022-01817-1
Autori:
Becerra-Rodríguez, C., Taghouti, G., Portier, P., Dequin, S., Casal, M., Paiva, S., et al.
Pubblicato in:
Journal of Fungi, Numero 2309608X, 2021, ISSN 2309-608X
Editore:
MDPI
DOI:
10.3390/jof7110963
Autori:
Lorena Donzella; Javier A. Varela; Maria João Sousa; John P. Morrissey
Pubblicato in:
FEMS Yeast Research, Numero 15671356, 2021, ISSN 1567-1356
Editore:
Blackwell
DOI:
10.1093/femsyr/foab026
Autori:
Andreia Pacheco, Lorena Donzella, Maria Jose Hernandez-Lopez, Maria Judite Almeida, Jose Antonio Prieto, Francisca Randez-Gil, John P Morrissey, Maria João Sousa
Pubblicato in:
FEMS Yeast Research, Numero 20/1, 2020, ISSN 1567-1356
Editore:
Blackwell
DOI:
10.1093/femsyr/foaa004
Autori:
Carmen Becerra-Rodríguez, Souhir Marsit, Virginie Galeote
Pubblicato in:
Frontiers in Genetics, Numero 11, 2020, ISSN 1664-8021
Editore:
Frontiers Media
DOI:
10.3389/fgene.2020.00602
Autori:
I Soares-Silva, D Ribas, M Sousa-Silva, J Azevedo-Silva, T Rendulić, M Casal
Pubblicato in:
FEMS Microbiology Letters, 2020, ISSN 0378-1097
Editore:
Blackwell
DOI:
10.1093/femsle/fnaa118
Autori:
Gyurchev, N.Y., Coral-Medina, Á., Weening, S.M., Almayouf, S., Kuijpers, N.G.A., Nevoigt, E., Louis, E.J.
Pubblicato in:
Frontiers Microbiology, Numero 1664302X, 2022, ISSN 1664-302X
Editore:
Frontiers Media
DOI:
10.3389/fmicb.2022.1025132
Autori:
Luís Ferraz, Karola Vorauer-Uhl, Michael Sauer, Maria J. Sousa, Paola Branduardi
Pubblicato in:
Yeast, 2022, ISSN 1097-0061
Editore:
John Wiley & Sons Ltd
DOI:
10.1002/yea.3828
Autori:
Coral-Medina, A., Morrissey, J.P., Camarasa, C.
Pubblicato in:
J. Ind. Microbiol. Biotechnol., Numero 14765535, 2022, ISSN 1476-5535
Editore:
Oxford University Press
DOI:
10.1093/jimb/kuac025
Autori:
Rendulić, T. Alves, J., Azevedo-Silva,J. Soares-Silva,I., Casal,M.
Pubblicato in:
Computational and Structural Biotechnology Journal, Numero 20010370, 2021, ISSN 2001-0370
Editore:
Elsevier
DOI:
10.1016/j.csbj.2021.08.002
Autori:
Lisa Solieri; Stefano Cassanelli; Franziska Huff; Franziska Huff; Liliane Barroso; Liliane Barroso; Paola Branduardi; Edward J. Louis; John P. Morrissey
Pubblicato in:
FEMS Yeast Research, Numero 15671356, 2021, ISSN 1567-1356
Editore:
Blackwell
DOI:
10.1093/femsyr/foab058
Autori:
Ferraz, L., Sauer, M., Sousa, M.J., Branduardi, P.
Pubblicato in:
Frontiers Microbiology, Numero 1664302x, 2021, ISSN 1664-302x
Editore:
Frontiers Media
DOI:
10.3389/fmicb.2021.715891
Autori:
Angela Coral-Medina, Darren A. Fenton, Javier Varela, Carole Camarasa, Pavel V. Baranov, John P. Morrissey
Pubblicato in:
bioRxiv, Numero 26928205, 2022, ISSN 2692-8205
Editore:
Cold Spring Harbor Laboratory
DOI:
10.1101/2022.04.27.489738
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