VIral and BacteRial Adhesin Network Training

Deliverables

Release of the modelling protocol for adhesin structure determination as software
Report with updated exploitation strategy
Report on exploitation strategy
Outreach plan

Plan for communications and outreach

White paper on best practices in the ETN
Data management plan

>10 review articles published/in press
Developed materials and methods for capture/enrichment of multiple pathogens based on adhesin-ligand binding

Developed materials and methods for captureenrichment of multiple pathogens based on adhesinligand binding

Initial website

Initial public website goes live

30 publications in high-quality open-access journals

30 publications in highquality openaccess journals

Recruitment of all ESRs
Supervisory Board of network

Compulsory Deliverable

Mapping of Interfaces between viral adhesins and receptors

Publications

Novel Biorecognition Elements against Pathogens in the Design of State-of-the Art Diagnostics

Author(s): Sande M.G, Rodrigues J.L, Ferreira D, Silva C.J, Rodrigues L. R.
Published in: Biosensors, 2021, ISSN 2079-6374
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/bios11110418

Complete Genome Sequence of Bartonella alsatica Strain IBS 382 (CIP 105477)

Author(s): Arno Thibau, Tilman G. Schultze, Wibke Ballhorn, Volkhard A. J. Kempf
Published in: Microbiology Resource Announcements, Issue Volume 9 Issue 34, 2020, ISSN 2576-098X
Publisher: American Society for Microbiology
DOI: 10.1128/mra.00769-20

Host-Pathogen Adhesion as the Basis of Innovative Diagnostics for Emerging Pathogens

Author(s): Alex van Belkum, Carina Almeida, Benjamin Bardiaux, Sarah V. Barrass, Sarah J. Butcher, Tuğçe Çaykara, Sounak Chowdhury, Rucha Datar, Ian Eastwood, Adrian Goldman, Manisha Goyal, Lotta Happonen, Nadia Izadi-Pruneyre, Theis Jacobsen, Pirjo H. Johnson, Volkhard A. J. Kempf, Andreas Kiessling, Juan Leva Bueno, Anchal Malik, Johan Malmström, Ina Meuskens, Paul A. Milner, Michael Nilges, Nicole Pam
Published in: Diagnostics, Issue 11/7, 2021, Page(s) 1259, ISSN 2075-4418
Publisher: MDPI
DOI: 10.3390/diagnostics11071259

Secondary structure and 1H, 15N & 13C resonance assignments of the periplasmic domain of OutG, Major pseudodopilin from Dickeya dadantii type II secretion system

Author(s): Jacobsen T, Dazzoni R, Renault M.G, Bardiaux B, Nilges M, Shevchik V, Izadi-Pruneyre N.
Published in: Biomol NMR Assign, 2022, ISSN 1874-2718
Publisher: Springer Verlag
DOI: 10.1007/s12104-022-10085-4

Type V Secretion Systems: An Overview of Passenger Domain Functions

Author(s): Ina Meuskens, Athanasios Saragliadis, Jack C. Leo, Dirk Linke
Published in: Frontiers in Microbiology, Issue 10, 2019, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2019.01163

Inertial focusing of microparticles, bacteria, and blood in serpentine glass channels

Author(s): Pablo Rodriguez-Mateos, Bongkot Ngamsom, Charlotte E. Dyer, Alexander Iles, Nicole Pamme
Published in: Electrophoresis, Issue 42, 2021, Page(s) 2246-2255, ISSN 0173-0835
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/elps.202100083

Dynamic relocalization of cytosolic type III secretion system components prevents premature protein secretion at low external pH

Author(s): Stephan Wimmi, Alexander Balinovic, Hannah Jeckel, Lisa Selinger, Dimitrios Lampaki, Emma Eisemann, Ina Meuskens, Dirk Linke, Knut Drescher, Ulrike Endesfelder, Andreas Diepold
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-21863-4

Molecular Organisation of Tick-Borne Encephalitis Virus

Author(s): Pulkkinen L.I.A, Barrass S. V, Domanska A, Överby A.K, Anastasina M, Butcher S. J.
Published in: Viruses, 2022, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v14040792

Long-Read Sequencing Reveals Genetic Adaptation of Bartonella Adhesin A Among Different Bartonella henselae Isolates

Author(s): Arno Thibau, Katharina Hipp, Diana J. Vaca, Sounak Chowdhury, Johan Malmström, Athanasios Saragliadis, Wibke Ballhorn, Dirk Linke, Volkhard A. J. Kempf
Published in: Frontiers in Microbiology, Issue Volume 13, Article 838267, 2022, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2022.838267

The C-terminal head domain of Burkholderia pseudomallei BpaC has a striking hydrophilic core with an extensive solvente network

Author(s): Kiessling A. R, Harris S. A, Weimer K. M, Wells G, Goldman A.
Published in: Mol Microbiology, 2022, ISSN 1365-2958
Publisher: Wiley
DOI: 10.1111/mmi.14953

Different SARS-CoV-2 haplotypes associate with geographic origin and case fatality rates of COVID-19 patients

Author(s): Goyal M, De Bruyne K, van Belkum A, West B
Published in: Infection Genetics and Evolution, Issue 90, 2021, ISSN 1567-1348
Publisher: Elsevier BV
DOI: 10.1016/j.meegid.2021.104730

Automated antimicrobial susceptibility testing of slow-growing Pseudomonas aeruginosa strains in the presence of tetrazolium salt WST-1

Author(s): Datar R, Perrin G, Chalansonnet V, Perry A, Perry JD, van Belkum A, Orenga S
Published in: Journal of Microbiological Methods, Issue 186, 2021, ISSN 0167-7012
Publisher: Elsevier BV
DOI: 10.1016/j.mimet.2021.106252

The Trimeric Autotransporter Adhesin YadA of Yersina enterocolitica Serotype O:9 Binds Glycan Moieties

Author(s): Meuskens I, Leva-Bueno J, Millner P, Schutz M, Peyman SA, Linke D.
Published in: Front Microbiology, Issue Volume 22, 2022, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2021.738818

Interaction of Bartonella henselae with fibronectin represents the molecular basis for adhesion to host cells

Author(s): Diana J. Vaca, Arno Thibau, Matthias S. Leisegang, Johan Malmström, Dirk Linke, Johannes A. Eble, Wibke Ballhorn, Martin Schaller, Lotta Happonen, Volkhard A. J. Kempf
Published in: Microbiology Spectrum, 2022, ISSN 2165-0497
Publisher: American Society for Microbiology
DOI: 10.1128/spectrum.00598-22

A lab-on-a-chip platform for integrated extraction and detection of SARS-CoV-2 RNA in resource-limited settings

Author(s): Pablo Rodriguez-Mateos, Bongkot Ngamsom, Cheryl Walter, Charlotte E.Dyer, Jesse Gitaka Alexander Iles, Nicole Pamme
Published in: Analytica Chimica Acta, Issue Volume 1177, 8 September 2021, 2021, Page(s) 338758, ISSN 0003-2670
Publisher: Elsevier BV
DOI: 10.1016/j.aca.2021.338758

Distinct serotypes of streptococcal M proteins mediate fibrinogen-dependent platelet activation and pro-inflammatory effects

Author(s): Palm F, Chowdhury S, Wettemark S, Malmström J, Happonen L, Shannon O
Published in: Infect Immunology, 2022, ISSN 2379-5077
Publisher: ASM Journals
DOI: 10.1128/iai.00462-21

Contemporary diagnostics for medically relevant fastidious microorganisms belonging to the genera Anaplasma, Bartonella, Coxiella, Orientia and Rickettsia

Author(s): Diana J. Vaca, Gerhard Dobler, Silke F. Fischer, Christian Keller, Maik Konrad, Friederike D. von Loewenich, Sylvain Orenga, Siddhesh U. Sapre, Alex van Belkum, Volkhard A. J. Kempf
Published in: FEMS Microbiology Reviews, Issue fuac013, 2022, ISSN 0168-6445
Publisher: Blackwell
DOI: 10.1093/femsre/fuac013

Immunogenicity of trimeric autotransporter adhesins and their potential as vaccine targets

Author(s): Arno Thibau, Alexander A. Dichter, Diana J. Vaca, Dirk Linke, Adrian Goldman, Volkhard A. J. Kempf
Published in: Medical Microbiology and Immunology, 2019, ISSN 0300-8584
Publisher: Springer Verlag
DOI: 10.1007/s00430-019-00649-y

Interaction with the host: the role of fibronectin and extracellular matrix proteins in the adhesion of Gram-negative bacteria

Author(s): Diana J. Vaca, Arno Thibau, Monika Schütz, Peter Kraiczy, Lotta Happonen, Johan Malmström, Volkhard A. J. Kempf
Published in: Medical Microbiology and Immunology, 2019, ISSN 0300-8584
Publisher: Springer Verlag
DOI: 10.1007/s00430-019-00644-3

Recent advances in the understanding of trimeric autotransporter adhesions

Author(s): Andreas R. Kiessling, Anchal Malik, Adrian Goldman
Published in: Medical Microbiology and Immunology (2019), 2019, ISSN 0300-8584
Publisher: Springer Verlag
DOI: 10.1007/s00430-019-00652-3

Brexit in the channel: Europe cut off: a young German scientist's perspective

Author(s): Andreas R. Kiessling
Published in: Medical Microbiology and Immunology, 2019, ISSN 0300-8584
Publisher: Springer Verlag
DOI: 10.1007/s00430-019-00646-1

Human adenovirus binding to host cell receptors: a structural view

Author(s): Aleksandra Cecylia Stasiak, Thilo Stehle
Published in: Medical Microbiology and Immunology, 2019, ISSN 0300-8584
Publisher: Springer Verlag
DOI: 10.1007/s00430-019-00645-2

FISH and chips: a review of microfluidic platforms for FISH analysis

Author(s): Pablo Rodriguez-Mateos, Nuno Filipe Azevedo, Carina Almeida, Nicole Pamme
Published in: Medical Microbiology and Immunology, 2020, ISSN 0300-8584
Publisher: Springer Verlag
DOI: 10.1007/s00430-019-00654-1

Advances in high-throughput methods for the identification of virus receptors

Author(s): Sarah V. Barrass, Sarah J. Butcher
Published in: Medical Microbiology and Immunology, 2019, ISSN 0300-8584
Publisher: Springer Verlag
DOI: 10.1007/s00430-019-00653-2

Innovative training networks: a new way of collaboration-propped PhD training

Author(s): Ina Meuskens, Seamus Higson, Dirk Linke
Published in: Medical Microbiology and Immunology, 2019, ISSN 0300-8584
Publisher: Springer Verlag
DOI: 10.1007/s00430-019-00647-0

New solutions to capture and enrich bacteria from complex samples

Author(s): Maria G. Sande, Tugçe Çaykara, Carla Joana Silva, Ligia R. Rodrigues
Published in: Medical Microbiology and Immunology, 2020, ISSN 0300-8584
Publisher: Springer Verlag
DOI: 10.1007/s00430-020-00659-1

Structural proteomics, electron cryo-microscopy and structural modeling approaches in bacteria–human protein interactions

Author(s): Sounak Chowdhury, Lotta Happonen, Hamed Khakzad, Lars Malmström, Johan Malmström
Published in: Medical Microbiology and Immunology, 2020, ISSN 0300-8584
Publisher: Springer Verlag
DOI: 10.1007/s00430-020-00663-5

Phenotypic and Genomic Variability of Serial Peri-Lung Transplantation Pseudomonas aeruginosa Isolates From Cystic Fibrosis Patients

Author(s): Datar R, Coello Pelegrin A, Orenga S, Chalansonnet V, Mirande C, Dombrecht J, Perry JD, Perry A, Goossens H, van Belkum A
Published in: Frontiers in Microbiology, Issue Volume 12, 2021, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2021.604555

Recent Advances in Rapid Antimicrobial Susceptibility Testing

Author(s): Datar R, Orenge S, Pogorelcnik R, Rochas O, Simner PJ, van Belkum A
Published in: Clinical Chemistry, Issue Volume 68, Issue 1, 2021, ISSN 0009-9147
Publisher: American Association for Clinical Chemistry, Inc.
DOI: 10.1093/clinchem/hvab207

Streptococcus pyogenes Forms Serotype- and Local Environment-Dependent Interspecies Protein Complexes

Author(s): Chowdhury S, Khakzad H, Bergdahl GE, Lood R, Ekström S, Linke D, Malmström L, Happonen L, Malmström J.
Published in: mSystems, 2021, ISSN 2379-5077
Publisher: ASM Journals
DOI: 10.1128/msystems.00271-21

Retrospective Definition of Clostridioides difficile PCR Ribotypes on the Basis of Whole Genome Polymorphisms: A Proof of Principle Study

Author(s): Goyal M, Hauben L, Pouseele H, Jaillard M, De Bruyne K, van Belkum A, Goering R
Published in: Diagnostics, Issue 10(12), 2020, ISSN 2075-4418
Publisher: MDPI
DOI: 10.3390/diagnostics10121078

Proteome-wide cross-linking mass spectrometry to identify specific virus capsid-host interactions between tick-borne encephalitis virus and neuroblastoma cells

Author(s): Barrass S. V, Pulkkinen L.I.A, Vapalahti O, Kuivanen S. H, Anastasina M, Happonen L, Butcher S. J.
Published in: bioRxiv, 2021, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2021.10.29.464531

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