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MAnufacturing of TUmour-REactive Natural Killer cells

Deliverables

Recruitment meeting

1 - 3 rounds of recruitment meeting performed to select all ESRs.

Recruitment fellows completed

Recruitment fellows completed.

Career plans for fellows

Career plans for all individual fellows drafted according DoA Part B.

Supervisory board

Supervisory board of project established.

Improved NK subset

Improved NK subset tested in vitro and suggested to WP4 and WP5.

Lessons clinical trials

Available clinical trials evaluated and lessons transmitted to WP4 and WP5.

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Publications

NK cells and ILCs in tumor immunotherapy

Author(s): Simona Sivori, Daniela Pende, Linda Quatrini, Gabriella Pietra, Mariella Della Chiesa, Paola Vacca, Nicola Tumino, Francesca Moretta, Maria Cristina Mingari, Franco Locatelli, Lorenzo Moretta
Published in: Molecular Aspects of Medicine, 2020, Page(s) 100870, ISSN 0098-2997
DOI: 10.1016/j.mam.2020.100870

Phenotypic and Functional Characterization of NK Cells in αβT-Cell and B-Cell Depleted Haplo-HSCT to Cure Pediatric Patients with Acute Leukemia

Author(s): Raffaella Meazza, Michela Falco, Fabrizio Loiacono, Paolo Canevali, Mariella Della Chiesa, Alice Bertaina, Daria Pagliara, Pietro Merli, Valentina Indio, Federica Galaverna, Mattia Algeri, Francesca Moretta, Natalia Colomar-Carando, Letizia Muccio, Simona Sivori, Andrea Pession, Maria Cristina Mingari, Lorenzo Moretta, Alessandro Moretta, Franco Locatelli, Daniela Pende
Published in: Cancers, Issue 12/8, 2020, Page(s) 2187, ISSN 2072-6694
DOI: 10.3390/cancers12082187

NK Cell-Based Immunotherapy for Hematological Malignancies

Author(s): Simona Sivori, Raffaella Meazza, Concetta Quintarelli, Simona Carlomagno, Mariella Della Chiesa, Michela Falco, Lorenzo Moretta, Franco Locatelli, Daniela Pende
Published in: Journal of Clinical Medicine, Issue 8/10, 2019, Page(s) 1702, ISSN 2077-0383
DOI: 10.3390/jcm8101702

Inhibitory Receptors and Checkpoints in Human NK Cells, Implications for the Immunotherapy of Cancer

Author(s): Simona Sivori, Mariella Della Chiesa, Simona Carlomagno, Linda Quatrini, Enrico Munari, Paola Vacca, Nicola Tumino, Francesca Romana Mariotti, Maria Cristina Mingari, Daniela Pende, Lorenzo Moretta
Published in: Frontiers in Immunology, Issue 11, 2020, ISSN 1664-3224
DOI: 10.3389/fimmu.2020.02156