MAnufacturing of TUmour-REactive Natural Killer cells

Livrables

Recruitment meeting

1 - 3 rounds of recruitment meeting performed to select all ESRs.

Recruitment fellows completed

Recruitment fellows completed.

Career plans for fellows

Career plans for all individual fellows drafted according DoA Part B.

Second round second.

Second round second ments performed as outlined in DocA Part B.

Supervisory board

Supervisory board of project established.

6 Winter + Summer Schools

6 Winter and Summer Schools performed at months 8,12, 18, 24, 30 and 36 as outlined in DoA Part B.

First round secondments

First round secondments performed as outlined in DocA Part B.

Final Consortium Meeting

Final Consortium Meeting performed as outlined in DocA Part B.

Improved NK subset

Improved NK subset tested in vitro and suggested to WP4 and WP5.

Stimulating activat. NKR

Stimulating activat NKR evaluated in vitro and suggested to WP4 and WP5

Lessons clinical trials

Available clinical trials evaluated and lessons transmitted to WP4 and WP5.

Fortified NK cells

NK cells fortified by CAR modification or bispecific reagents tested in vitro and suggested to WP4 and WP5

PhD degrees fellows

Successful PhD degrees for all fellows

Scientific publications fellows

Scientific publications fellows obtained according DoA Part B

Public dissemination events

Public dissemination events performed according DoA Part B

Publications

Single-Cell RNA Sequencing of Tumor-Infiltrating

Auteurs: Jing Ni, Xi Wang, Ana Stojanovic, Qin Zhang, Marian Wincher, Lea Bühler, Annette Arnold, Margareta P.Correia. Manuel Winkler. Philipp- Sebastian Koch. Veronika Sexl, Thomas Höfer, Adelheid Cerwenka
Publié dans: Immunity, Numéro 52, 2020, Page(s) 1075-1087, ISSN 1097-4180
Éditeur: Cell Press
DOI: 10.1016/j.immuni.2020.05.001

CD116+ fetal precursors migrate to the perinatal lung and give rise to human alveolar macrophages

Auteurs: Elza Evren, Emma Ringqvist, Jean-Marc Doisne, Anna Thaller, Natalie Sleiers, Richard A. Flavell, James P. Di Santo, Tim Willinger
Publié dans: Journal of Experimental Medicine, Numéro 219, 2021, Page(s) e20210987, ISSN 1540-9538
Éditeur: Rockefeller University Press
DOI: 10.1084/jem.20210987

An optimized platform for efficient siRNA delivery into human NK cells

Auteurs: Palacios, D., Momayyezi, P., Huhn, O., Ask, E.H., Dunst, J., Malmberg, K.-J. and Hammer, Q.
Publié dans: Eur. J. Immunol., Numéro 52, 2022, Page(s) 1190-1193, ISSN 0014-2980
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202149710

Comprehensive analysis of nasal polyps reveals a more pronounced type 2 transcriptomic profile of epithelial cells and mast cells in aspirin-exacerbated respiratory disease

Auteurs: Christine Bangert, Sergio Villazala Merino, Martin Fahrenberger, Thomas Krausgruber, Wolfgang Michael Bauer, Victoria Stanek, Nicholas James Campion, Tina Bartosik, Tamara Quint, Guenther Regelsberger, Verena Niederberger-Leppin, Christoph Bock, Sven Schneider, Julia Eckl-Dorna
Publié dans: Frontiers in Immunology, Numéro 13, 2022, Page(s) 850494, ISSN 1664-3224
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.850494

Phenotypic and functional characterization of NK cells in αβT-cell and B-cell depleted haplo-HSCT to cure pediatric patients with acute leukemia

Auteurs: Raffaella Meazza, Michela Falco, Fabrizio Loiacono, Paolo Canevali, Mariella Della Chiesa, Alice Bertaina, Daria Pagliara, Pietro Merli, Valentina Indio, Federica Galaverna, Mattia Algeri, Francesca Moretta, Natalia Colomar-Carando, Letizia Muccio, Simona Sivori, Andrea Pession, Maria Cristina Mingari, Lorenzo Moretta, Alessandro Moretta, Franco Locatelli§, and Daniela Pende§. (§F.L. and D.P. e
Publié dans: Cancers, Numéro 12, 2020, Page(s) E2187, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12082187

Small interfering RNA delivery into primary human natural killer cells for functional gene analyses

Auteurs: Momayyezi, P., Malmberg, K., & Hammer, Q.
Publié dans: Current Protocols, Numéro 2, 2022, Page(s) e613, ISSN 2691-1299
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/cpz1.613

Innate-like NKp30+CD8+ T cells armed with TCR/CAR target tumor heterogeneity

Auteurs: Margareta P. Correia, Ana Stojanovic, Winfried S. Wels and Adelheid Cerwenka
Publié dans: Oncoimmunology, Numéro 10, 2021, Page(s) e1973783, ISSN 2162-4011
Éditeur: Landes Bioscience
DOI: 10.1080/2162402x.2021.1973783

Exploiting Natural Killer cell engagers to control pediatric B-cell precursor acute lymphoblastic leukemia

Auteurs: Colomar-Carando N., Gauthier L., Merli P., Loiacono F., Canevali P., Falco M., Galaverna F., Rossi B., Bosco F., Caratini M., Mingari M-C., Locatelli F., Vivier E., Meazza R.§, Pende D.§. (§ R.M. and D.P. share last authorship).
Publié dans: Cancer Immunol Res, Numéro 10, 2022, Page(s) 291-302, ISSN 2326-6074
Éditeur: American Association for Cancer Research Inc.
DOI: 10.1158/2326-6066.cir-21-0843

Human NK cells, their receptors and function

Auteurs: Linda Quatrini, Mariella Della Chiesa, Simona Sivori, Maria Cristina Mingari, Daniela Pende D, Lorenzo Moretta
Publié dans: Eur. J. Immunol., Numéro 51, 2021, Page(s) 1566–1579, ISSN 0014-2980
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202049028

Genetic Engineering of Natural Killer Cells for Enhanced Antitumor Function.

Auteurs: Mantesso, S., Geerts, D., Spanholtz, J., & Kučerová, L.
Publié dans: Frontiers in Immunology, Numéro 11, 2020, Page(s) 607131, ISSN 1664-3224
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fimmu.2020.607131

Dichotomous metabolic networks govern human ILC2 proliferation and function

Auteurs: Laura Surace, Jean-Marc Doisne, Carys A. Croft, Anna Thaller, Pedro Escoll, Solenne Marie, Natalia Petrosemoli, Vincent Guillemot, Valerie Dardalhon, Davide Topazio, Antonia Cama, Carmen Buchrieser, Naomi Taylor, Ido Amit, Olimpia Musumeci & James P. Di Santo
Publié dans: Nature Immunology, Numéro 22, 2021, Page(s) 1367-1374, ISSN 1529-2908
Éditeur: Nature Publishing Group
DOI: 10.1038/s41590-021-01043-8

NK cells under hypoxia: The two faces of vascularization in tumor and pregnancy

Auteurs: Irene Garcés Lázaro, Rebecca Kotzur, Ofer Mandelboim and Adelheid Cerwenka
Publié dans: Front. Immunol., Numéro 13, 2022, Page(s) 924775, ISSN 1664-3224
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.924775

NK cells and ILCs in tumor immunotherapy

Auteurs: Simona Sivori*, Daniela Pende*, Linda Quatrini*, Gabriella Pietra, Mariella Della Chiesa, Paola Vacca, Nicola Tumino, Francesca Moretta, Maria Cristina Mingari, Franco Locatelli, Lorenzo Moretta
Publié dans: Mol. Aspects Med, Numéro 80, 2020, Page(s) 100870, ISSN 0098-2997
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.mam.2020.100870

Epitope characterization of a monoclonal antibody that selectively recognizes KIR2DL1 allotypes

Auteurs: Falco M, Meazza R, Alicata C, Canevali P, Muntasell A, Bottino C, Moretta L, Pende D, Lopez-Botet M.
Publié dans: HLA, Numéro 100, 2022, Page(s) 107-118, ISSN 2059-2310
Éditeur: Wiley
DOI: 10.1111/tan.14630

Inhibitory receptors and checkpoints in human NK cells, implications for the immunotherapy of cancer

Auteurs: Simona Sivori, Mariella Della Chiesa, Simona Carlomagno, Linda Quatrini, Enrico Munari, Paola Vacca, Nicola Tumino, Francesca Romana Mariotti, Maria Cristina Mingari, Daniela Pende§ and Lorenzo Moretta§. (§D.P. and L.M. equally contributed to this study).
Publié dans: Front Immunol, Numéro 11, 2020, Page(s) 2156, ISSN 1664-3224
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fimmu.2020.02156

Notch, RORC and IL-23 signals cooperate to promote multi-lineage human innate lymphoid cell differentiation

Auteurs: Carys A. Croft, Anna Thaller, Solenne Marie, Jean-Marc Doisne, Laura Surace, Rui Yang, Anne Puel, Jacinta Bustamante, Jean-Laurent Casanova, James P. Di Sant
Publié dans: Nature Communications, Numéro 13, 2022, Page(s) 4344, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-022-32089-3

CAR-Expressing Natural Killer Cells for Cancer Retargeting

Auteurs: Kloess S., Kretschmer A., Stahl L., Fricke S., Koehl U.
Publié dans: Transfus med and hemother, Numéro 46, 2019, Page(s) 4-13, ISSN 1424-5493
Éditeur: S. Karger AG
DOI: 10.1159/000495771

NK Cell-Based Immunotherapy for Hematological Malignancies

Auteurs: Simona Sivori, Raffaella Meazza, Concetta Quintarelli, Simona Carlomagno, Mariella Della Chiesa, Michela Falco, Lorenzo Moretta, Franco Locatelli, Daniela Pende
Publié dans: J Clin Med, Numéro 8, 2019, Page(s) 1702, ISSN 2077-0383
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm8101702

Adaptive single-KIR+NKG2C+ NK cells expanded from select superdonors show potent missing-self reactivity and efficiently control HLA-mismatched acute myeloid leukemia

Auteurs: Haroun-Izquierdo, A., Vincenti, M., Netskar, H., van Ooijen, H., Zhang, B., Bendzick, L., Kanaya, M., Momayyezi, P., Li, S., Wiiger, M.T., Hoel, H.J., Krokeide, S.Z., Kremer, V., Tjønnfjord, G., Berglund, S., Wikström, K., Blomberg, P., Alici, E., Felices, M., Önfelt, B., Valamehr, B., Ljunggren, H.G., Björklund, A, Hammer, Q., Kveberg, L., Cichocki, F., Miller, J.S., Malmberg, K-J., and Sohlb
Publié dans: J. Immunother Cancer, Numéro 10, 2022, Page(s) e005577, ISSN 2455-8591
Éditeur: Society for Immunotherapy of Cancer - BMJ Journals
DOI: 10.1136/jitc-2022-005577

Harnessing NK Cell Checkpoint-Modulating Immunotherapies

Auteurs: Chauhan, S.K.S.; Koehl, U.; Klöß, S.
Publié dans: Cancers, Numéro 12, 2020, Page(s) 1807, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12071807

NK-92 cells retain vitality and functionality when grown in standard cell culture conditions

Auteurs: Kotzur, R., Duev-Cohen, A., Kol, I., Reches, A., Mandelboim, O.
Publié dans: Plos One, Numéro 17, 2022, Page(s) e0264897, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0264897

Characterization of KIR+ NK cell subsets with a monoclonal antibody selectively recognizing KIR2DL1 and blocking the specific interaction with HLA-C

Auteurs: Meazza R.§, Falco M.§, Canevali P., Loiacono F., Colomar-Carando N., Muntasell A., Rea A., Mingari M-C., Locatelli F., Moretta L., Lopez-Botet M.*, Pende D*. (§ R.M. and M.F. share first authorship and * M.L.-B. and D.P. share last authorship).
Publié dans: HLA, Numéro 2022, 2022, Page(s) 1-14, ISSN 2059-2302
Éditeur: Wiley Online
DOI: 10.1111/tan.14640

CD137 Costimulation Counteracts TGFβ Inhibition of NK-cell Antitumor Function

Auteurs: Mariona Cabo, Sara Santana-Hernández, Marcel Costa-Garcia, Anna Rea, Roberto Lozano-Rodríguez, Michelle Ataya, Francesc Balaguer, Manel Juan, Maria C Ochoa, Silvia Menéndez, Laura Comerma, Ana Rovira, Pedro Berraondo, Joan Albanell, Ignacio Melero, Miguel López-Botet, Aura Muntasell
Publié dans: Cancer Immunol Res, Numéro 9, 2021, Page(s) 1476-1490, ISSN 2326-6074
Éditeur: American Association of Cancer Research
DOI: 10.1158/2326-6066.cir-21-0030

Human ILC3 Exert TRAIL-Mediated Cytotoxicity Towards Cancer Cells

Auteurs: Jana-Julia Siegler, Margareta P. Correia, Tomáš Hofman, Isabel Prager, Emrullah Birgin, Nuh N. Rahbari, Carsten Watzl, Ana Stojanovic and Adelheid Cerwenka
Publié dans: Front. Immunol., Numéro 13, 2022, Page(s) 742571, ISSN 1664-3224
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.742571

Polarized mitochondria as guardians of NK cell fitness

Auteurs: Laura Surace, Jean-Marc Doisne, Pedro Escoll, Solenne Marie, Valerie Dardalhon, Carys Croft, Anna Thaller, Davide Topazio, Angelo Sparaneo, Antonia Cama, Olimpia Musumeci, Aurelio d’Ecclesia, Carmen Buchrieser, Naomi Taylor, James P. Di Santo
Publié dans: Blood Advances, Numéro 5, 2020, Page(s) 26-38, ISSN 2473-9537
Éditeur: The American Society of Hematology
DOI: 10.1182/bloodadvances.2020003458

Cellular immunotherapy with multiple infusions of in vitro-expanded haploidentical natural killer cells after autologous transplantation for patients with plasma cell myeloma

Auteurs: Tschan-Plessl A, Kalberer CP, Wieboldt R, Stern M, Siegler U, Wodnar-Filipowicz A, Gerull S, Halter J, Heim D, Tichelli A, Tsakiris DA, Malmberg KJ, Passweg JR, Bottos A.
Publié dans: Cytotherapy, Numéro 4, 2021, Page(s) 329-338, ISSN 1465-3249
Éditeur: Taylor & Francis
DOI: 10.1016/j.jcyt.2020.09.009

Livrables

Publications

Partager cette page

Télécharger