Livrables Other (4) Recruitment meeting 1 - 3 rounds of recruitment meeting performed to select all ESRs. Recruitment fellows completed Recruitment fellows completed. Career plans for fellows Career plans for all individual fellows drafted according DoA Part B. Supervisory board Supervisory board of project established. Documents, reports (4) Improved NK subset Improved NK subset tested in vitro and suggested to WP4 and WP5. Stimulating activat. NKR Stimulating activat NKR evaluated in vitro and suggested to WP4 and WP5 Lessons clinical trials Available clinical trials evaluated and lessons transmitted to WP4 and WP5. Fortified NK cells NK cells fortified by CAR modification or bispecific reagents tested in vitro and suggested to WP4 and WP5 Websites, patent fillings, videos etc. (3) PhD degrees fellows Successful PhD degrees for all fellows Scientific publications fellows Scientific publications fellows obtained according DoA Part B Public dissemination events Public dissemination events performed according DoA Part B Publications Peer reviewed articles (30) NK cells and ILCs in tumor immunotherapy Auteurs: Simona Sivori, Daniela Pende, Linda Quatrini, Gabriella Pietra, Mariella Della Chiesa, Paola Vacca, Nicola Tumino, Francesca Moretta, Maria Cristina Mingari, Franco Locatelli, Lorenzo Moretta Publié dans: Molecular Aspects of Medicine, 2020, Page(s) 100870, ISSN 0098-2997 Éditeur: Pergamon Press Ltd. DOI: 10.1016/j.mam.2020.100870 Single-Cell RNA Sequencing of Tumor-Infiltrating Auteurs: Jing Ni, Xi Wang, Ana Stojanovic, Qin Zhang, Marian Wincher, Lea Bühler, Annette Arnold, Margareta P.Correia. Manuel Winkler. Philipp- Sebastian Koch. Veronika Sexl, Thomas Höfer, Adelheid Cerwenka Publié dans: Immunity, Issue 52, 2020, Page(s) 1075-1087, ISSN 1097-4180 Éditeur: Cell Press DOI: 10.1016/j.immuni.2020.05.001 CD116+ fetal precursors migrate to the perinatal lung and give rise to human alveolar macrophages Auteurs: Elza Evren, Emma Ringqvist, Jean-Marc Doisne, Anna Thaller, Natalie Sleiers, Richard A. Flavell, James P. Di Santo, Tim Willinger Publié dans: Journal of Experimental Medicine, Issue 219, 2021, Page(s) e20210987, ISSN 1540-9538 Éditeur: Rockefeller University Press DOI: 10.1084/jem.20210987 Phenotypic and Functional Characterization of NK Cells in αβT-Cell and B-Cell Depleted Haplo-HSCT to Cure Pediatric Patients with Acute Leukemia Auteurs: Raffaella Meazza, Michela Falco, Fabrizio Loiacono, Paolo Canevali, Mariella Della Chiesa, Alice Bertaina, Daria Pagliara, Pietro Merli, Valentina Indio, Federica Galaverna, Mattia Algeri, Francesca Moretta, Natalia Colomar-Carando, Letizia Muccio, Simona Sivori, Andrea Pession, Maria Cristina Mingari, Lorenzo Moretta, Alessandro Moretta, Franco Locatelli, Daniela Pende Publié dans: Cancers, Issue 12/8, 2020, Page(s) 2187, ISSN 2072-6694 Éditeur: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers12082187 An optimized platform for efficient siRNA delivery into human NK cells Auteurs: Palacios, D., Momayyezi, P., Huhn, O., Ask, E.H., Dunst, J., Malmberg, K.-J. and Hammer, Q. Publié dans: Eur. J. Immunol., Issue 52, 2022, Page(s) 1190-1193, ISSN 0014-2980 Éditeur: John Wiley & Sons Ltd. DOI: 10.1002/eji.202149710 Comprehensive analysis of nasal polyps reveals a more pronounced type 2 transcriptomic profile of epithelial cells and mast cells in aspirin-exacerbated respiratory disease Auteurs: Christine Bangert, Sergio Villazala Merino, Martin Fahrenberger, Thomas Krausgruber, Wolfgang Michael Bauer, Victoria Stanek, Nicholas James Campion, Tina Bartosik, Tamara Quint, Guenther Regelsberger, Verena Niederberger-Leppin, Christoph Bock, Sven Schneider, Julia Eckl-Dorna Publié dans: Frontiers in Immunology, Issue 13, 2022, Page(s) 850494, ISSN 1664-3224 Éditeur: Frontiers Media S.A. DOI: 10.3389/fimmu.2022.850494 Phenotypic and functional characterization of NK cells in αβT-cell and B-cell depleted haplo-HSCT to cure pediatric patients with acute leukemia Auteurs: Raffaella Meazza, Michela Falco, Fabrizio Loiacono, Paolo Canevali, Mariella Della Chiesa, Alice Bertaina, Daria Pagliara, Pietro Merli, Valentina Indio, Federica Galaverna, Mattia Algeri, Francesca Moretta, Natalia Colomar-Carando, Letizia Muccio, Simona Sivori, Andrea Pession, Maria Cristina Mingari, Lorenzo Moretta, Alessandro Moretta, Franco Locatelli§, and Daniela Pende§. (§F.L. and D.P. e Publié dans: Cancers, Issue 12, 2020, Page(s) E2187, ISSN 2072-6694 Éditeur: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers12082187 Small interfering RNA delivery into primary human natural killer cells for functional gene analyses Auteurs: Momayyezi, P., Malmberg, K., & Hammer, Q. Publié dans: Current Protocols, Issue 2, 2022, Page(s) e613, ISSN 2691-1299 Éditeur: John Wiley & Sons Inc. DOI: 10.1002/cpz1.613 Innate-like NKp30+CD8+ T cells armed with TCR/CAR target tumor heterogeneity Auteurs: Margareta P. Correia, Ana Stojanovic, Winfried S. Wels and Adelheid Cerwenka Publié dans: Oncoimmunology, Issue 10, 2021, Page(s) e1973783, ISSN 2162-4011 Éditeur: Landes Bioscience DOI: 10.1080/2162402x.2021.1973783 Exploiting Natural Killer cell engagers to control pediatric B-cell precursor acute lymphoblastic leukemia Auteurs: Colomar-Carando N., Gauthier L., Merli P., Loiacono F., Canevali P., Falco M., Galaverna F., Rossi B., Bosco F., Caratini M., Mingari M-C., Locatelli F., Vivier E., Meazza R.§, Pende D.§. (§ R.M. and D.P. share last authorship). Publié dans: Cancer Immunol Res, Issue 10, 2022, Page(s) 291-302, ISSN 2326-6074 Éditeur: American Association for Cancer Research Inc. DOI: 10.1158/2326-6066.cir-21-0843 Human NK cells, their receptors and function Auteurs: Linda Quatrini, Mariella Della Chiesa, Simona Sivori, Maria Cristina Mingari, Daniela Pende D, Lorenzo Moretta Publié dans: Eur. J. Immunol., Issue 51, 2021, Page(s) 1566–1579, ISSN 0014-2980 Éditeur: John Wiley & Sons Ltd. DOI: 10.1002/eji.202049028 Genetic Engineering of Natural Killer Cells for Enhanced Antitumor Function. Auteurs: Mantesso, S., Geerts, D., Spanholtz, J., & Kučerová, L. Publié dans: Frontiers in Immunology, Issue 11, 2020, Page(s) 607131, ISSN 1664-3224 Éditeur: Frontiers Media S.A. DOI: 10.3389/fimmu.2020.607131 Dichotomous metabolic networks govern human ILC2 proliferation and function Auteurs: Laura Surace, Jean-Marc Doisne, Carys A. Croft, Anna Thaller, Pedro Escoll, Solenne Marie, Natalia Petrosemoli, Vincent Guillemot, Valerie Dardalhon, Davide Topazio, Antonia Cama, Carmen Buchrieser, Naomi Taylor, Ido Amit, Olimpia Musumeci & James P. Di Santo Publié dans: Nature Immunology, Issue 22, 2021, Page(s) 1367-1374, ISSN 1529-2908 Éditeur: Nature Publishing Group DOI: 10.1038/s41590-021-01043-8 NK cells under hypoxia: The two faces of vascularization in tumor and pregnancy Auteurs: Irene Garcés Lázaro, Rebecca Kotzur, Ofer Mandelboim and Adelheid Cerwenka Publié dans: Front. Immunol., Issue 13, 2022, Page(s) 924775, ISSN 1664-3224 Éditeur: Frontiers Media S.A. DOI: 10.3389/fimmu.2022.924775 NK cells and ILCs in tumor immunotherapy Auteurs: Simona Sivori*, Daniela Pende*, Linda Quatrini*, Gabriella Pietra, Mariella Della Chiesa, Paola Vacca, Nicola Tumino, Francesca Moretta, Maria Cristina Mingari, Franco Locatelli, Lorenzo Moretta Publié dans: Mol. Aspects Med, Issue 80, 2020, Page(s) 100870, ISSN 0098-2997 Éditeur: Pergamon Press Ltd. DOI: 10.1016/j.mam.2020.100870 Epitope characterization of a monoclonal antibody that selectively recognizes KIR2DL1 allotypes Auteurs: Falco M, Meazza R, Alicata C, Canevali P, Muntasell A, Bottino C, Moretta L, Pende D, Lopez-Botet M. Publié dans: HLA, Issue 100, 2022, Page(s) 107-118, ISSN 2059-2310 Éditeur: Wiley DOI: 10.1111/tan.14630 Inhibitory receptors and checkpoints in human NK cells, implications for the immunotherapy of cancer Auteurs: Simona Sivori, Mariella Della Chiesa, Simona Carlomagno, Linda Quatrini, Enrico Munari, Paola Vacca, Nicola Tumino, Francesca Romana Mariotti, Maria Cristina Mingari, Daniela Pende§ and Lorenzo Moretta§. (§D.P. and L.M. equally contributed to this study). Publié dans: Front Immunol, Issue 11, 2020, Page(s) 2156, ISSN 1664-3224 Éditeur: Frontiers Media S.A. DOI: 10.3389/fimmu.2020.02156 Notch, RORC and IL-23 signals cooperate to promote multi-lineage human innate lymphoid cell differentiation Auteurs: Carys A. Croft, Anna Thaller, Solenne Marie, Jean-Marc Doisne, Laura Surace, Rui Yang, Anne Puel, Jacinta Bustamante, Jean-Laurent Casanova, James P. Di Sant Publié dans: Nature Communications, Issue 13, 2022, Page(s) 4344, ISSN 2041-1723 Éditeur: Nature Publishing Group DOI: 10.1038/s41467-022-32089-3 CAR-Expressing Natural Killer Cells for Cancer Retargeting Auteurs: Kloess S., Kretschmer A., Stahl L., Fricke S., Koehl U. Publié dans: Transfus med and hemother, Issue 46, 2019, Page(s) 4-13, ISSN 1424-5493 Éditeur: S. Karger AG DOI: 10.1159/000495771 NK Cell-Based Immunotherapy for Hematological Malignancies Auteurs: Simona Sivori, Raffaella Meazza, Concetta Quintarelli, Simona Carlomagno, Mariella Della Chiesa, Michela Falco, Lorenzo Moretta, Franco Locatelli, Daniela Pende Publié dans: J Clin Med, Issue 8, 2019, Page(s) 1702, ISSN 2077-0383 Éditeur: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/jcm8101702 Adaptive single-KIR+NKG2C+ NK cells expanded from select superdonors show potent missing-self reactivity and efficiently control HLA-mismatched acute myeloid leukemia Auteurs: Haroun-Izquierdo, A., Vincenti, M., Netskar, H., van Ooijen, H., Zhang, B., Bendzick, L., Kanaya, M., Momayyezi, P., Li, S., Wiiger, M.T., Hoel, H.J., Krokeide, S.Z., Kremer, V., Tjønnfjord, G., Berglund, S., Wikström, K., Blomberg, P., Alici, E., Felices, M., Önfelt, B., Valamehr, B., Ljunggren, H.G., Björklund, A, Hammer, Q., Kveberg, L., Cichocki, F., Miller, J.S., Malmberg, K-J., and Sohlb Publié dans: J. Immunother Cancer, Issue 10, 2022, Page(s) e005577, ISSN 2455-8591 Éditeur: Society for Immunotherapy of Cancer - BMJ Journals DOI: 10.1136/jitc-2022-005577 Harnessing NK Cell Checkpoint-Modulating Immunotherapies Auteurs: Chauhan, S.K.S.; Koehl, U.; Klöß, S. Publié dans: Cancers, Issue 12, 2020, Page(s) 1807, ISSN 2072-6694 Éditeur: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers12071807 NK Cell-Based Immunotherapy for Hematological Malignancies Auteurs: Simona Sivori, Raffaella Meazza, Concetta Quintarelli, Simona Carlomagno, Mariella Della Chiesa, Michela Falco, Lorenzo Moretta, Franco Locatelli, Daniela Pende Publié dans: Journal of Clinical Medicine, Issue 8/10, 2019, Page(s) 1702, ISSN 2077-0383 Éditeur: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/jcm8101702 NK-92 cells retain vitality and functionality when grown in standard cell culture conditions Auteurs: Kotzur, R., Duev-Cohen, A., Kol, I., Reches, A., Mandelboim, O. Publié dans: Plos One, Issue 17, 2022, Page(s) e0264897, ISSN 1932-6203 Éditeur: Public Library of Science DOI: 10.1371/journal.pone.0264897 Characterization of KIR+ NK cell subsets with a monoclonal antibody selectively recognizing KIR2DL1 and blocking the specific interaction with HLA-C Auteurs: Meazza R.§, Falco M.§, Canevali P., Loiacono F., Colomar-Carando N., Muntasell A., Rea A., Mingari M-C., Locatelli F., Moretta L., Lopez-Botet M.*, Pende D*. (§ R.M. and M.F. share first authorship and * M.L.-B. and D.P. share last authorship). Publié dans: HLA, Issue 2022, 2022, Page(s) 1-14, ISSN 2059-2302 Éditeur: Wiley Online DOI: 10.1111/tan.14640 CD137 Costimulation Counteracts TGFβ Inhibition of NK-cell Antitumor Function Auteurs: Mariona Cabo, Sara Santana-Hernández, Marcel Costa-Garcia, Anna Rea, Roberto Lozano-Rodríguez, Michelle Ataya, Francesc Balaguer, Manel Juan, Maria C Ochoa, Silvia Menéndez, Laura Comerma, Ana Rovira, Pedro Berraondo, Joan Albanell, Ignacio Melero, Miguel López-Botet, Aura Muntasell Publié dans: Cancer Immunol Res, Issue 9, 2021, Page(s) 1476-1490, ISSN 2326-6074 Éditeur: American Association of Cancer Research DOI: 10.1158/2326-6066.cir-21-0030 Human ILC3 Exert TRAIL-Mediated Cytotoxicity Towards Cancer Cells Auteurs: Jana-Julia Siegler, Margareta P. Correia, Tomáš Hofman, Isabel Prager, Emrullah Birgin, Nuh N. Rahbari, Carsten Watzl, Ana Stojanovic and Adelheid Cerwenka Publié dans: Front. Immunol., Issue 13, 2022, Page(s) 742571, ISSN 1664-3224 Éditeur: Frontiers Media S.A. DOI: 10.3389/fimmu.2022.742571 Polarized mitochondria as guardians of NK cell fitness Auteurs: Laura Surace, Jean-Marc Doisne, Pedro Escoll, Solenne Marie, Valerie Dardalhon, Carys Croft, Anna Thaller, Davide Topazio, Angelo Sparaneo, Antonia Cama, Olimpia Musumeci, Aurelio d’Ecclesia, Carmen Buchrieser, Naomi Taylor, James P. Di Santo Publié dans: Blood Advances, Issue 5, 2020, Page(s) 26-38, ISSN 2473-9537 Éditeur: The American Society of Hematology DOI: 10.1182/bloodadvances.2020003458 Inhibitory Receptors and Checkpoints in Human NK Cells, Implications for the Immunotherapy of Cancer Auteurs: Simona Sivori, Mariella Della Chiesa, Simona Carlomagno, Linda Quatrini, Enrico Munari, Paola Vacca, Nicola Tumino, Francesca Romana Mariotti, Maria Cristina Mingari, Daniela Pende, Lorenzo Moretta Publié dans: Frontiers in Immunology, Issue 11, 2020, ISSN 1664-3224 Éditeur: Frontiers Media SA DOI: 10.3389/fimmu.2020.02156 Cellular immunotherapy with multiple infusions of in vitro-expanded haploidentical natural killer cells after autologous transplantation for patients with plasma cell myeloma Auteurs: Tschan-Plessl A, Kalberer CP, Wieboldt R, Stern M, Siegler U, Wodnar-Filipowicz A, Gerull S, Halter J, Heim D, Tichelli A, Tsakiris DA, Malmberg KJ, Passweg JR, Bottos A. Publié dans: Cytotherapy, Issue 4, 2021, Page(s) 329-338, ISSN 1465-3249 Éditeur: Taylor & Francis DOI: 10.1016/j.jcyt.2020.09.009 Recherche de données OpenAIRE... Une erreur s’est produite lors de la recherche de données OpenAIRE Aucun résultat disponible
