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CORDIS

Combatting Antimicrobial Resistance Training Network

Deliverables

Kick-off Meeting

A Kick-off Meeting has been held

At least 5 public lectures

At least 5 public lectures has been given

CARTNET website established

CARTNET website has been established

ESRs trained in project specific interdisciplinary skills and broader translational skills

ESRs will be trained in project specific interdisciplinary skills and broader translational skills

"At least 4 ""new items"" in newspapers, University magazines or virtual media (apart from project website)"

At least 4 new items in newspapers University magazines or virtual media apart from project website has been produced and disseminated

Report on efficacy of antibiotic /drug combinations in reducing gene transfer in an in vivo mouse model

Report on efficacy of antibiotic drug combinations in reducing gene transfer in an in vivo mouse model has been written

Establish and Maintain a Risk Benefit Register of dialogue with different stakeholders for innovations

A Risk Benefit Register of dialogue with different stakeholders for innovations has been established and will be maintained

Abstract for first presentation at a national/international external Meeting

Abstract for first presentation at a national/international external Meeting has been written

Final Conference Proceedings at website

Final Conference Proceedings have been made public on project website

Report on genera or species containing BGCs from metagenomics data of microbiota samples

Report on genera or species containing BGCs from metagenomics data of microbiota samples has been written

Reports identifying antimicrobial-producing isolates from cultured microbiota libraries

Reports identifying antimicrobial-producing isolates from cultured microbiota libraries has been written

Standardised training documentation

Standardised training documentation has been established

Identification of sub-inhibitory combinations of antibiotics and biocides that inhibit gene transfer of antibiotic plasmids and phages

Identification of subinhibitory combinations of antibiotics and biocides that inhibit gene transfer of antibiotic plasmids and phages have been determined

Report on properties of antimicrobial producing isolates from custom metagenomic libraries of actinomycetes and soil organisms

Report on properties of antimicrobial producing isolates from custom metagenomic libraries of actinomycetes and soil organisms has been written

10 or more peer reviewed scientific publications and more than 10 poster presentations at meetings

10 or more peer reviewed scientific publications have been written and more than 10 poster presentations at meetings have been given

Establishment of Supervisory Board

The Supervisory Board has been established

Publications

Human antimicrobial peptide, LL-37, induces non-inheritable reduced susceptibility to vancomycin in Staphylococcus aureus.

Author(s): Cathrine Friberg; Cathrine Friberg; Jakob Krause Haaber; Martin Vestergaard; Anaëlle Fait; Véronique Perrot; Bruce R. Levin; Hanne Ingmer
Published in: Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020), 2020, Page(s) e13221, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-69962-4

Integrating perspectives in actinomycete research: an ActinoBase review of 2020-21.

Author(s): Agustina Undabarrena; Camila Cristina Galvão Francisco Pereira; Worarat Kruasuwan; Jonathan Parra; Nelly Selem-Mojica; Kristiina Vind; Jana K. Schniete
Published in: Microbiology, Issue 1, 2021, ISSN 1350-0872
Publisher: Society for General Microbiology
DOI: 10.1099/mic.0.001084

Synthesis of indazoles from 2-formylphenylboronic acids

Author(s): Vitalii V. Solomin; Alberts Seins; Aigars Jirgensons
Published in: RSC Advances, Issue RSC Adv. 2021; 11, 2021, Page(s) 22710-22714, ISSN 2046-2069
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1ra04056a

New insights into the biodiversity of coliphages in the intestine of poultry.

Author(s): Patricia Espenhain Sørensen; Patricia Espenhain Sørensen; Wim Van den Broeck; Kristoffer Kiil; Dziuginta Jasinskyte; Arshnee Moodley; Arshnee Moodley; An Garmyn; Hanne Ingmer; Patrick Butaye; Patrick Butaye
Published in: SCIENTIFIC REPORTS, Issue Vol 10, Iss 1, 2020, Page(s) 10:15220, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-72177-2

Extensive antimicrobial resistance mobilization via multicopy plasmid encapsidation mediated by temperate phages.

Author(s): Rodríguez-Rubio, L., Serna, C., Ares-Arroyo, M., Matamoros, B. R., Delgado-Blas, J. F., Montero, N., Bernabe-Balas, C., Wedel, E. F., Mendez, I. S., Muniesa, M., & Gonzalez-Zorn, B.
Published in: The Journal of antimicrobial chemotherapy, 2020, Page(s) 75(11), 3173–3180., ISSN 0305-7453
Publisher: Oxford University Press
DOI: 10.1093/jac/dkaa311

Classification of In Vitro Phage–Host Population Growth Dynamics

Author(s): Patricia Espenhain Sørensen; Duncan Y. K. Ng; Luc Duchateau; Hanne Ingmer; An Garmyn; Patrick Butaye
Published in: Sørensen , P E , Ng , D Y K , Duchateau , L , Ingmer , H , Garmyn , A & Butaye , P 2021 , ' Classification of in vitro phage–host population growth dynamics ' , Microorganisms , vol. 9 , no. 12 , 2470 . https://doi.org/10.3390/microorganisms9122470, Issue 9(12), 2470, 2021, ISSN 2076-2607
Publisher: MDPI
DOI: 10.3390/microorganisms9122470

Effective approaches to discover new microbial metabolites in a large strain library.

Author(s): Zdouc, M. M., Iorio, M., Vind, K., Simone, M., Serina, S., Brunati, C., Monciardini, P., Tocchetti, A., Zarazúa, G. S., Crüsemann, M., Maffioli, S. I., Sosio, M., & Donadio, S.
Published in: Journal of Industrial Microbiology and Biotechnology, Issue 48(3-4), 2021, ISSN 1367-5435
Publisher: Springer Verlag
DOI: 10.1093/jimb/kuab017

Characterization of the genetic switch from phage ɸ13 important for Staphylococcus aureus colonization in humans.

Author(s): Camilla S. Kristensen; Anders K. Varming; Helena Augusta Katharina Leinweber; Karin Hammer; Leila Lo Leggio; Hanne Ingmer; Mogens Kilstrup
Published in: Kristensen , C S , Varming , A K , Leinweber , H A K , Hammer , K , Lo Leggio , L , Ingmer , H & Kilstrup , M 2021 , ' Characterization of the genetic switch from phage ɸ13 important for Staphylococcus aureus colonization in humans ' , MicrobiologyOpen , vol. 10 , no. 5 , e1245 . https://doi.org/10.1002/mbo3.1245, Issue vol. 10, no. 5, 2021, Page(s) e1245, ISSN 2045-8827
Publisher: John Wiley and Sons Inc.
DOI: 10.1002/mbo3.1245

Biosynthetic potential of uncultured Antarctic soil bacteria revealed through long-read metagenomic sequencing.

Author(s): Valentin Waschulin; Chiara Borsetto; Robert James; Kevin K. Newsham; Stefano Donadio; Christophe Corre; Elizabeth M. H. Wellington
Published in: 1751-7362, Issue 1, 2021, ISSN 1751-7362
Publisher: Nature Publishing Group
DOI: 10.1038/s41396-021-01052-3

2-Aminoquinazolines by Chan–Evans–Lam Coupling of Guanidines with (2-Formylphenyl)boronic Acids

Author(s): Vitalii V. Solomin; Alberts Seins; Aigars Jirgensons
Published in: Synlett, Issue Synlett 2020; 31(15), 2020, Page(s) 1507-1510, ISSN 0936-5214
Publisher: Georg Thieme Verlag
DOI: 10.1055/s-0040-1707080

Spontaneous Phage Resistance in Avian Pathogenic Escherichia coli.

Author(s): Sørensen, P. E., Baig, S., Stegger, M., Ingmer, H., Garmyn, A., & Butaye, P.
Published in: Frontiers in microbiology, Issue 12, 782757, 2021, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2021.782757

In Silico Prediction and Prioritization of Novel Selective Antimicrobial Drug Targets in Escherichia coli.

Author(s): Frida Svanberg Frisinger; Bimal Jana; Stefano Donadio; Luca Guardabassi
Published in: Antibiotics (Basel, Switzerland), Issue 6, Issue 10(6), 632, 2020, ISSN 2079-6382
Publisher: MDPI
DOI: 10.3390/antibiotics10060632

Muropeptides Stimulate Growth Resumption from Stationary Phase in Escherichia coli.

Author(s): Jõers, A., Vind, K., Hernández, S. B., Maruste, R., Pereira, M., Brauer, A., Remm, M., Cava, F., & Tenson, T
Published in: Scientific reports, Issue 9(1), 18043., 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-54646-5

Staphylococcal Phages Adapt to New Hosts by Extensive Attachment Site Variability. 

Author(s): Leinweber, H., Sieber, R. N., Larsen, J., Stegger, M., & Ingmer, H.
Published in:  mBio, Issue 12(6), e0225921., 2021, ISSN 2150-7511
Publisher: ASM
DOI: 10.1128/mbio.02259-21

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