Combatting Antimicrobial Resistance Training Network

Livrables

Kick-off Meeting

A Kick-off Meeting has been held

At least 5 public lectures

At least 5 public lectures has been given

CARTNET website established

CARTNET website has been established

ESRs trained in project specific interdisciplinary skills and broader translational skills

ESRs will be trained in project specific interdisciplinary skills and broader translational skills

"At least 4 ""new items"" in newspapers, University magazines or virtual media (apart from project website)"

At least 4 new items in newspapers University magazines or virtual media apart from project website has been produced and disseminated

Report on efficacy of antibiotic /drug combinations in reducing gene transfer in an in vivo mouse model

Report on efficacy of antibiotic drug combinations in reducing gene transfer in an in vivo mouse model has been written

Establish and Maintain a Risk Benefit Register of dialogue with different stakeholders for innovations

A Risk Benefit Register of dialogue with different stakeholders for innovations has been established and will be maintained

Abstract for first presentation at a national/international external Meeting

Abstract for first presentation at a national/international external Meeting has been written

Final Conference Proceedings at website

Final Conference Proceedings have been made public on project website

Report on genera or species containing BGCs from metagenomics data of microbiota samples

Report on genera or species containing BGCs from metagenomics data of microbiota samples has been written

Reports identifying antimicrobial-producing isolates from cultured microbiota libraries

Reports identifying antimicrobial-producing isolates from cultured microbiota libraries has been written

Standardised training documentation

Standardised training documentation has been established

Identification of sub-inhibitory combinations of antibiotics and biocides that inhibit gene transfer of antibiotic plasmids and phages

Identification of subinhibitory combinations of antibiotics and biocides that inhibit gene transfer of antibiotic plasmids and phages have been determined

Report on properties of antimicrobial producing isolates from custom metagenomic libraries of actinomycetes and soil organisms

Report on properties of antimicrobial producing isolates from custom metagenomic libraries of actinomycetes and soil organisms has been written

10 or more peer reviewed scientific publications and more than 10 poster presentations at meetings

10 or more peer reviewed scientific publications have been written and more than 10 poster presentations at meetings have been given

Establishment of Supervisory Board

The Supervisory Board has been established

Publications

Human antimicrobial peptide, LL-37, induces non-inheritable reduced susceptibility to vancomycin in Staphylococcus aureus.

Auteurs: Cathrine Friberg; Cathrine Friberg; Jakob Krause Haaber; Martin Vestergaard; Anaëlle Fait; Véronique Perrot; Bruce R. Levin; Hanne Ingmer
Publié dans: Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020), 2020, Page(s) e13221, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-020-69962-4

Integrating perspectives in actinomycete research: an ActinoBase review of 2020-21.

Auteurs: Agustina Undabarrena; Camila Cristina Galvão Francisco Pereira; Worarat Kruasuwan; Jonathan Parra; Nelly Selem-Mojica; Kristiina Vind; Jana K. Schniete
Publié dans: Microbiology, Numéro 1, 2021, ISSN 1350-0872
Éditeur: Society for General Microbiology
DOI: 10.1099/mic.0.001084

Synthesis of indazoles from 2-formylphenylboronic acids

Auteurs: Vitalii V. Solomin; Alberts Seins; Aigars Jirgensons
Publié dans: RSC Advances, Numéro RSC Adv. 2021; 11, 2021, Page(s) 22710-22714, ISSN 2046-2069
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d1ra04056a

New insights into the biodiversity of coliphages in the intestine of poultry.

Auteurs: Patricia Espenhain Sørensen; Patricia Espenhain Sørensen; Wim Van den Broeck; Kristoffer Kiil; Dziuginta Jasinskyte; Arshnee Moodley; Arshnee Moodley; An Garmyn; Hanne Ingmer; Patrick Butaye; Patrick Butaye
Publié dans: SCIENTIFIC REPORTS, Numéro Vol 10, Iss 1, 2020, Page(s) 10:15220, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-020-72177-2

Extensive antimicrobial resistance mobilization via multicopy plasmid encapsidation mediated by temperate phages.

Auteurs: Rodríguez-Rubio, L., Serna, C., Ares-Arroyo, M., Matamoros, B. R., Delgado-Blas, J. F., Montero, N., Bernabe-Balas, C., Wedel, E. F., Mendez, I. S., Muniesa, M., & Gonzalez-Zorn, B.
Publié dans: The Journal of antimicrobial chemotherapy, 2020, Page(s) 75(11), 3173–3180., ISSN 0305-7453
Éditeur: Oxford University Press
DOI: 10.1093/jac/dkaa311

Classification of In Vitro Phage–Host Population Growth Dynamics

Auteurs: Patricia Espenhain Sørensen; Duncan Y. K. Ng; Luc Duchateau; Hanne Ingmer; An Garmyn; Patrick Butaye
Publié dans: Sørensen , P E , Ng , D Y K , Duchateau , L , Ingmer , H , Garmyn , A & Butaye , P 2021 , ' Classification of in vitro phage–host population growth dynamics ' , Microorganisms , vol. 9 , no. 12 , 2470 . https://doi.org/10.3390/microorganisms9122470, Numéro 9(12), 2470, 2021, ISSN 2076-2607
Éditeur: MDPI
DOI: 10.3390/microorganisms9122470

Effective approaches to discover new microbial metabolites in a large strain library.

Auteurs: Zdouc, M. M., Iorio, M., Vind, K., Simone, M., Serina, S., Brunati, C., Monciardini, P., Tocchetti, A., Zarazúa, G. S., Crüsemann, M., Maffioli, S. I., Sosio, M., & Donadio, S.
Publié dans: Journal of Industrial Microbiology and Biotechnology, Numéro 48(3-4), 2021, ISSN 1367-5435
Éditeur: Springer Verlag
DOI: 10.1093/jimb/kuab017

Characterization of the genetic switch from phage ɸ13 important for Staphylococcus aureus colonization in humans.

Auteurs: Camilla S. Kristensen; Anders K. Varming; Helena Augusta Katharina Leinweber; Karin Hammer; Leila Lo Leggio; Hanne Ingmer; Mogens Kilstrup
Publié dans: Kristensen , C S , Varming , A K , Leinweber , H A K , Hammer , K , Lo Leggio , L , Ingmer , H & Kilstrup , M 2021 , ' Characterization of the genetic switch from phage ɸ13 important for Staphylococcus aureus colonization in humans ' , MicrobiologyOpen , vol. 10 , no. 5 , e1245 . https://doi.org/10.1002/mbo3.1245, Numéro vol. 10, no. 5, 2021, Page(s) e1245, ISSN 2045-8827
Éditeur: John Wiley and Sons Inc.
DOI: 10.1002/mbo3.1245

Biosynthetic potential of uncultured Antarctic soil bacteria revealed through long-read metagenomic sequencing.

Auteurs: Valentin Waschulin; Chiara Borsetto; Robert James; Kevin K. Newsham; Stefano Donadio; Christophe Corre; Elizabeth M. H. Wellington
Publié dans: 1751-7362, Numéro 1, 2021, ISSN 1751-7362
Éditeur: Nature Publishing Group
DOI: 10.1038/s41396-021-01052-3

2-Aminoquinazolines by Chan–Evans–Lam Coupling of Guanidines with (2-Formylphenyl)boronic Acids

Auteurs: Vitalii V. Solomin; Alberts Seins; Aigars Jirgensons
Publié dans: Synlett, Numéro Synlett 2020; 31(15), 2020, Page(s) 1507-1510, ISSN 0936-5214
Éditeur: Georg Thieme Verlag
DOI: 10.1055/s-0040-1707080

Spontaneous Phage Resistance in Avian Pathogenic Escherichia coli.

Auteurs: Sørensen, P. E., Baig, S., Stegger, M., Ingmer, H., Garmyn, A., & Butaye, P.
Publié dans: Frontiers in microbiology, Numéro 12, 782757, 2021, ISSN 1664-302X
Éditeur: Frontiers Media
DOI: 10.3389/fmicb.2021.782757

In Silico Prediction and Prioritization of Novel Selective Antimicrobial Drug Targets in Escherichia coli.

Auteurs: Frida Svanberg Frisinger; Bimal Jana; Stefano Donadio; Luca Guardabassi
Publié dans: Antibiotics (Basel, Switzerland), Numéro 6, Numéro 10(6), 632, 2020, ISSN 2079-6382
Éditeur: MDPI
DOI: 10.3390/antibiotics10060632

Muropeptides Stimulate Growth Resumption from Stationary Phase in Escherichia coli.

Auteurs: Jõers, A., Vind, K., Hernández, S. B., Maruste, R., Pereira, M., Brauer, A., Remm, M., Cava, F., & Tenson, T
Publié dans: Scientific reports, Numéro 9(1), 18043., 2019, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-019-54646-5

Staphylococcal Phages Adapt to New Hosts by Extensive Attachment Site Variability.

Auteurs: Leinweber, H., Sieber, R. N., Larsen, J., Stegger, M., & Ingmer, H.
Publié dans: mBio, Numéro 12(6), e0225921., 2021, ISSN 2150-7511
Éditeur: ASM
DOI: 10.1128/mbio.02259-21

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