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Improving Genome Editing Efficiency (IMGENE)

Deliverables

Final report on 5 ECTS in transferable skill training per ESR

Final report on 5 ECTS in transferable skill training per ESR will be written

Establishment of Supervisory Board

A Supervisory Board will be established

Common ESR outreach activity (1st Summer School)

Common ESR outreach activity (1st Summer School) will be undertaken

Common ESR outreach activity (2nd Summer School)

Common ESR outreach activity (2nd Summer School) will be undertaken

Report on recruitment

A report on recruitment will be written

Final report on 5 ECTS in ethics training per ESR

Final report on 5 ECTS in ethics training per ESR will be written

IMGENE twitter, facebook, and 3-min movies (genome editing, ethics)

IMGENE twitteraccount, facebook page, and 3-min movies (on e.g. genome editing, ethics) will be created

Common ESR outreach activity (3rd Summer School)

Common ESR outreach activity 3rd Summer School will be undertaken

Final report on 5 ECTS in outreach and dissemination training per ESR

Final report on 5 ECTS in outreach and dissemination training per ESR will be written

Data Management Plan

A Data Management Plan will be written

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Publications

CRISPR/Cas9 Epigenome Editing Potential for Rare Imprinting Diseases: A Review

Author(s): Syding, Linn Amanda; Nickl, Petr; Kasparek, Petr; Sedlacek, Radislav
Published in: CELLS, Volume: 9 Issue: 4 Article Number: 993, 2020, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells9040993

Adenoviral Vectors Meet Gene Editing: A Rising Partnership for the Genomic Engineering of Human Stem Cells and Their Progeny

Author(s): Francesca Tasca, Qian Wang, Manuel A.F.V. Gonçalves
Published in: Cells, 9/4, 2020, Page(s) 953, ISSN 2073-4409
Publisher: cells
DOI: 10.3390/cells9040953

The Chromatin Structure of CRISPR-Cas9 Target DNA Controls the Balance between Mutagenic and Homology-Directed Gene-Editing Events

Author(s): Josephine M. Janssen, Xiaoyu Chen, Jin Liu, Manuel A.F.V. Gonçalves
Published in: Molecular Therapy - Nucleic Acids, 16, 2019, Page(s) 141-154, ISSN 2162-2531
Publisher: Nature Publishing Group
DOI: 10.1016/j.omtn.2019.02.009

DNA Damage: From Threat to Treatment

Author(s): Antonio Carusillo, Claudio Mussolino
Published in: Cells, 9/7, 2020, Page(s) 1665, ISSN 2073-4409
Publisher: PMC
DOI: 10.3390/cells9071665

A versatile reporter system for multiplexed screening of effective epigenome editors

Author(s): Maria Silvia Roman Azcona, Yongxing Fang, Antonio Carusillo, Toni Cathomen, Claudio Mussolino
Published in: Nature Protocols, 15/10, 2020, Page(s) 3410-3440, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-020-0380-y

Development of an ObLiGaRe Doxycycline Inducible Cas9 system for pre-clinical cancer drug discovery

Author(s): Anders Lundin, Michelle J. Porritt, Himjyot Jaiswal, Frank Seeliger, Camilla Johansson, Abdel Wahad Bidar, Lukas Badertscher, Sandra Wimberger, Emma J. Davies, Elizabeth Hardaker, Carla P. Martins, Emily James, Therese Admyre, Amir Taheri-Ghahfarokhi, Jenna Bradley, Anna Schantz, Babak Alaeimahabadi, Maryam Clausen, Xiufeng Xu, Lorenz M. Mayr, Roberto Nitsch, Mohammad Bohlooly-Y, Simon T. Barry, M
Published in: Nature Communications, 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-18548-9

Improving Precise CRISPR Genome Editing by Small Molecules: Is there a Magic Potion?

Author(s): Nadja Bischoff, Sandra Wimberger, Marcello Maresca, Cord Brakebusch
Published in: Cells, 9/5, 2020, Page(s) 1318, ISSN 2073-4409
Publisher: cells
DOI: 10.3390/cells9051318

Expanding the editable genome and CRISPR–Cas9 versatility using DNA cutting-free gene targeting based on in trans paired nicking

Author(s): Xiaoyu Chen, Francesca Tasca, Qian Wang, Jin Liu, Josephine M Janssen, Marcella D Brescia, Milena Bellin, Karoly Szuhai, Josefin Kenrick, Richard L Frock, Manuel A F V Gonçalves
Published in: Nucleic Acids Research, 2019, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkz1121

A primer to gene therapy: Progress, prospects, and problems

Author(s): Hidde A. Zittersteijn, Manuel A.F.V. Gonçalves, Rob C. Hoeben
Published in: Journal of Inherited Metabolic Disease, JIMD,2020,1-18, https://doi.org/10.1002/jimd.12270, 2020, Page(s) 1-18, ISSN 0141-8955
Publisher: Kluwer Academic Publishers
DOI: 10.1002/jimd.12270