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Improving Genome Editing Efficiency (IMGENE)

Deliverables

Establishment of Supervisory Board

A Supervisory Board will be established

Common ESR outreach activity (1st Summer School)

Common ESR outreach activity (1st Summer School) will be undertaken

Common ESR outreach activity (2nd Summer School)

Common ESR outreach activity (2nd Summer School) will be undertaken

Report on recruitment

A report on recruitment will be written

IMGENE twitter, facebook, and 3-min movies (genome editing, ethics)

IMGENE twitteraccount, facebook page, and 3-min movies (on e.g. genome editing, ethics) will be created

Data Management Plan

A Data Management Plan will be written

Publications

CRISPR/Cas9 Epigenome Editing Potential for Rare Imprinting Diseases: A Review

Author(s): Syding, Linn Amanda; Nickl, Petr; Kasparek, Petr; Sedlacek, Radislav
Published in: CELLS, Issue Volume: 9 Issue: 4 Article Number: 993, 2020, ISSN 2073-4409
DOI: 10.3390/cells9040993

Adenoviral Vectors Meet Gene Editing: A Rising Partnership for the Genomic Engineering of Human Stem Cells and Their Progeny

Author(s): Francesca Tasca, Qian Wang, Manuel A.F.V. Gonçalves
Published in: Cells, Issue 9/4, 2020, Page(s) 953, ISSN 2073-4409
DOI: 10.3390/cells9040953

The Chromatin Structure of CRISPR-Cas9 Target DNA Controls the Balance between Mutagenic and Homology-Directed Gene-Editing Events

Author(s): Josephine M. Janssen, Xiaoyu Chen, Jin Liu, Manuel A.F.V. Gonçalves
Published in: Molecular Therapy - Nucleic Acids, Issue 16, 2019, Page(s) 141-154, ISSN 2162-2531
DOI: 10.1016/j.omtn.2019.02.009

DNA Damage: From Threat to Treatment

Author(s): Antonio Carusillo, Claudio Mussolino
Published in: Cells, Issue 9/7, 2020, Page(s) 1665, ISSN 2073-4409
DOI: 10.3390/cells9071665

A versatile reporter system for multiplexed screening of effective epigenome editors

Author(s): Maria Silvia Roman Azcona, Yongxing Fang, Antonio Carusillo, Toni Cathomen, Claudio Mussolino
Published in: Nature Protocols, Issue 15/10, 2020, Page(s) 3410-3440, ISSN 1754-2189
DOI: 10.1038/s41596-020-0380-y

Development of an ObLiGaRe Doxycycline Inducible Cas9 system for pre-clinical cancer drug discovery

Author(s): Anders Lundin, Michelle J. Porritt, Himjyot Jaiswal, Frank Seeliger, Camilla Johansson, Abdel Wahad Bidar, Lukas Badertscher, Sandra Wimberger, Emma J. Davies, Elizabeth Hardaker, Carla P. Martins, Emily James, Therese Admyre, Amir Taheri-Ghahfarokhi, Jenna Bradley, Anna Schantz, Babak Alaeimahabadi, Maryam Clausen, Xiufeng Xu, Lorenz M. Mayr, Roberto Nitsch, Mohammad Bohlooly-Y, Simon T. Barry, M
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
DOI: 10.1038/s41467-020-18548-9

Improving Precise CRISPR Genome Editing by Small Molecules: Is there a Magic Potion?

Author(s): Nadja Bischoff, Sandra Wimberger, Marcello Maresca, Cord Brakebusch
Published in: Cells, Issue 9/5, 2020, Page(s) 1318, ISSN 2073-4409
DOI: 10.3390/cells9051318

Expanding the editable genome and CRISPR–Cas9 versatility using DNA cutting-free gene targeting based on in trans paired nicking

Author(s): Xiaoyu Chen, Francesca Tasca, Qian Wang, Jin Liu, Josephine M Janssen, Marcella D Brescia, Milena Bellin, Karoly Szuhai, Josefin Kenrick, Richard L Frock, Manuel A F V Gonçalves
Published in: Nucleic Acids Research, 2019, ISSN 0305-1048
DOI: 10.1093/nar/gkz1121

A primer to gene therapy: Progress, prospects, and problems

Author(s): Hidde A. Zittersteijn, Manuel A.F.V. Gonçalves, Rob C. Hoeben
Published in: Journal of Inherited Metabolic Disease, Issue JIMD,2020,1-18, https://doi.org/10.1002/jimd.12270, 2020, Page(s) 1-18, ISSN 0141-8955
DOI: 10.1002/jimd.12270