Deliverables
Define epigenetic signature of the placenta in the context of early/late onset PE with and without IUGR.
Define epigenetic signature of the placenta in the context of earlylate onset PE with and without IUGR
Report on dissemination strategy of project results to scientific community, updated annually - No. 2Report on dissemination strategy of project results to scientific community updated annually No 2
All ESRs published 3 scientific papers (2 first author) and 1 joint review per year - No. 3All ESRs published 3 scientific papers 2 first author and 1 joint review per year No 3
Determine genetic signature using genome-wide technologies genotyping of maternal circulation, cord blood and placental tissue, gene expression in PE and IUGR patients.Determine genetic signature using genomewide technologies genotyping of maternal circulation cord blood and placental tissue gene expression in PE and IUGR patients
Determining ncRNA in biopsies and extracellular vesicle cargo as a natural placental biopsy for disesed pregnanciesReport on dissemination strategy of project results to scientific community, updated annually - No. 1
Longitudinal documentation of hemodynamic effects of IUGR model in animals; correlation to morphologic analysis of selected fetal organs
Longitudinal documentation of hemodynamic effects of IUGR model in animals correlation to morphologic analysis of selected fetal organs
Assessment of a metabolic signature in the maternal and fetal (placental) circulation and in vivo models of preeclampsia and IUGR and correlated to clinical and genomic outcomes.Assessment of a metabolic signature in the maternal and fetal placental circulation and in vivo models of preeclampsia and IUGR and correlated to clinical and genomic outcomes
Annual Management Reports - No. 2Validation of novel ultrasound tools to diagnose complicated pregnancies through imaging fetal cardiovascular function in relation to maternal cardiovascular function
All ESRs published 3 scientific papers (2 first author) and 1 joint review per year - No. 2
All ESRs published 3 scientific papers 2 first author and 1 joint review per year No 2
Report on dissemination strategy of project results to scientific community, updated annually - No. 3Report on dissemination strategy of project results to scientific community updated annually No 3
Annual Management Reports - No. 3Annual Management Reports No 3
Characterisation and standardisation of murine PE model with validation of in vivo tools (iontophoresis & endoscopic laser speckle imager)Characterisation and standardisation of murine PE model with validation of in vivo tools iontophoresis endoscopic laser speckle imager
All ESRs published 3 scientific papers (2 first author) and 1 joint review per year - No. 1Assessment of the use of functional fetal brain MRI and CPR to identify fetoplacental biomarkers for prediction of IUGR
Annual Management Reports - No. 4
Annual Management Reports No 4
Validation of targets minimum 3 targets identified in WP2 by ESR5 67 8 in placentaonachip models
All ESRs presented at international conferences (2 per annum) - No. 1All ESRs presented at international conferences (2 per annum) -No. 1
Graduation of all ESRs with PhDsGenomic and expression profile (surface/angiogenic markers) of placental derived EVs from explants, organ-on-a-chip model, and human amniotic fluid and blood
Genomic and expression profile surfaceangiogenic markers of placental derived EVs from explants organonachip model and human amniotic fluid and blood
All ESRs presented at international conferences (2 per annum) - No. 3All ESRs presented at international conferences 2 per annum No 3
Generation and characterisation of 4-stable endothelial & trophoblast lines via CRISPR gene editing to mimic IUGR/PEGeneration and characterisation of 4stable endothelial trophoblast lines via CRISPR gene editing to mimic IUGRPE
All ESRs presented at international conferences (2 per annum) - No. 2All ESRs presented at international conferences 2 per annum No 2
Publications
Author(s):
Charles G. Bailey; Shailendra Gupta; Cynthia Metierre; Punkaja M. S. Amarasekera; Patrick O’Young; Wunna Kyaw; Tatyana Laletin; Habib Francis; Crystal Semaan; Mehdi Sharifi Tabar; Krishna P. Singh; Charles G. Mullighan; Olaf Wolkenhauer; Ulf Schmitz; John E. J. Rasko
Published in:
Crossref, Issue 4, 2021, Page(s) 7519-7536, ISSN 0014-4754
Publisher:
Springer
DOI:
10.1007/s00018-021-03946-z
Author(s):
Ottaviani L, Juni RP, de Abreu RC, Sansonetti M, Sampaio-Pinto V, Halkein J, Hegenbarth JC, Ring N, Knoops K, Kocken JMM, Jesus C, Ernault AC, El Azzouzi H, Rühle F, Olieslagers S, Fernandes H, Ferreira L, Braga L, Stoll M, Nascimento DS, de Windt LJ, da Costa Martins PA.
Published in:
Molecular Therapy, 2022, ISSN 1525-0016
Publisher:
Nature Publishing Group
DOI:
10.1016/j.ymthe.2022.03.002
Author(s):
V. Giorgione, F. D'Antonio, A. Manji, K. Reed, A. Khalil
Published in:
Ultrasound in Obstetrics & Gynecology, 2021, ISSN 0960-7692
Publisher:
John Wiley & Sons Inc.
DOI:
10.1002/uog.23585
Author(s):
Veronica Giorgione, Anna Ridder, Erkan Kalafat, Asma Khalil, Basky Thilaganathan
Published in:
BJOG: An International Journal of Obstetrics & Gynaecology, 2020, ISSN 1470-0328
Publisher:
Blackwell Publishing Inc.
DOI:
10.1111/1471-0528.16545
Author(s):
Morales-Roselló J, Loscalzo G, García-Lopez EM, García-Gimenez JL, Perales-Marín A
Published in:
Health Sci Rep, 2022, ISSN 2398-8835
Publisher:
John Wiley & Sons
DOI:
10.1002/hsr2.558
Author(s):
Gabriela Loscalzo; Julia Scheel; José Santiago Ibañez-Cabellos; Eva García-Lopez; Shailendra Gupta; José Luis García-Gimenez; Salvador Mena-Mollá; Alfredo Perales-Marín; José Morales-Roselló
Published in:
International Journal of Molecular Sciences, Vol 23, Iss 293, p 293 (2022), Issue 3, 2021, ISSN 1422-0067
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms23010293
Author(s):
B. S. Buddeberg, R. Sharma, J. M. O'Driscoll, A. Kaelin Agten, A. Khalil, B. Thilaganathan
Published in:
Ultrasound in Obstetrics & Gynecology, Issue 56/2, 2020, Page(s) 240-246, ISSN 0960-7692
Publisher:
John Wiley & Sons Inc.
DOI:
10.1002/uog.21941
Author(s):
Charles N. Serhan, Shailendra K. Gupta, Mauro Perretti, Catherine Godson, Eoin Brennan, Yongsheng Li, Oliver Soehnlein, Takao Shimizu, Oliver Werz, Valerio Chiurchiù, Angelo Azzi, Marc Dubourdeau, Suchi Smita Gupta, Patrick Schopohl, Matti Hoch, Dragana Gjorgevikj, Faiz M. Khan, David Brauer, Anurag Tripathi, Konstantin Cesnulevicius, David Lescheid, Myron Schultz, Eva Särndahl, Dirk Repsilber,
Published in:
Molecular Aspects of Medicine, Issue 74, 2020, Page(s) 100894, ISSN 0098-2997
Publisher:
Pergamon Press Ltd.
DOI:
10.1016/j.mam.2020.100894
Author(s):
Camino S. M. Ruano, Clara Apicella, Sébastien Jacques, Géraldine Gascoin, Cassandra Gaspar, Francisco Miralles, Céline Méhats & Daniel Vaiman
Published in:
Human Genetics, 2021, ISSN 1432-1203
Publisher:
Springer
DOI:
10.1007/s00439-020-02248-x
Author(s):
Gebara, N., Scheel, J., Skovronova, R., Grange, C., Marozio, L., Gupta, S., Giorgione, V., Caicci, F., Benedetto, C., Khalil, A., & Bussolati, B.
Published in:
Journal of Extracellular Vesicles, 2022, ISSN 2001-3078
Publisher:
Wiley for the International Society for Extracellular Vesicles
DOI:
10.1002/jev2.12217
Author(s):
Manna, S.; Ruano, C.S.M.; Hegenbarth, J.-C.; Vaiman, D.; Gupta, S.; McCarthy, F.P.; Méhats, C.; McCarthy, C.; Apicella, C.; Scheel, J.
Published in:
Antioxidants (Basel), 2022, ISSN 2076-3921
Publisher:
MDPI
DOI:
10.3390/antiox11030585
Author(s):
EG Mulder, C Ghossein‐Doha, JRW Crutsen, SMJ Van Kuijk, B Thilaganathan, MEA Spaanderman
Published in:
BJOG: An International Journal of Obstetrics & Gynaecology, Issue 128/1, 2021, Page(s) 121-129, ISSN 1470-0328
Publisher:
Blackwell Publishing Inc.
DOI:
10.1111/1471-0528.16435
Author(s):
Hegenbarth Jana-Charlotte, Lezzoche Giuliana, De Windt Leon J., Stoll Monika
Published in:
Frontiers in Molecular Medicine, 2022, ISSN 2674-0095
Publisher:
Lausanne Frontiers Media SA
DOI:
10.3389/fmmed.2022.839338
Author(s):
Clara Apicella, Camino S. M. Ruano, Sébastien Jacques, Géraldine Gascoin, Céline Méhats, Daniel Vaiman, Francisco Miralles
Published in:
Frontiers in Cell and Developmental Biology, Issue 9, 2021, ISSN 2296-634X
Publisher:
Frontiers Media
DOI:
10.3389/fcell.2021.633937
Author(s):
Veronica Giorgione, Amar Bhide, Rohan Bhate, Keith Reed, Asma Khalil
Published in:
Journal of Clinical Medicine, Issue 9/10, 2020, Page(s) 3276, ISSN 2077-0383
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/jcm9103276
Author(s):
Dongqing Guo, Colin E. Murdoch, Tianhua Liu, Jia Qu, Shihong Jiao, Yong Wang, Wei Wang, Xing Chen
Published in:
Frontiers in Pharmacology, Issue 9, 2018, ISSN 1663-9812
Publisher:
Frontiers Media S.A.
DOI:
10.3389/fphar.2018.00428
Author(s):
Samprikta Manna, Cathal McCarthy, Fergus P. McCarthy
Published in:
Oxidative Medicine and Cellular Longevity, Issue 2019, 2019, Page(s) 1-11, ISSN 1942-0900
Publisher:
Landes Bioscience
DOI:
10.1155/2019/3095383
Author(s):
Basky Thilaganathan, Erkan Kalafat
Published in:
Hypertension, Issue 73/3, 2019, Page(s) 522-531, ISSN 0194-911X
Publisher:
Lippincott Williams & Wilkins Ltd.
DOI:
10.1161/hypertensionaha.118.11191
Author(s):
Anna Ridder, Veronica Giorgione, Asma Khalil, Basky Thilaganathan
Published in:
International Journal of Molecular Sciences, Issue 20/13, 2019, Page(s) 3263, ISSN 1422-0067
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms20133263
Author(s):
Clara Apicella, Camino S. M. Ruano, Céline Méhats, Francisco Miralles, Daniel Vaiman
Published in:
International Journal of Molecular Sciences, Issue 20/11, 2019, Page(s) 2837, ISSN 1422-0067
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms20112837
Author(s):
Lermant, Murdoch
Published in:
Antioxidants, Issue 8/8, 2019, Page(s) 315, ISSN 2076-3921
Publisher:
Antioxidants
DOI:
10.3390/antiox8080315
Author(s):
Karen Melchiorre, Basky Thilaganathan, Veronica Giorgione, Anna Ridder, Alessia Memmo, Asma Khalil
Published in:
Frontiers in Cardiovascular Medicine, Issue 7, 2020, ISSN 2297-055X
Publisher:
Frontiers Media
DOI:
10.3389/fcvm.2020.00059
Author(s):
Natalia Gebara, Andrea Rossi, Renata Skovronova, Justine Mariam Aziz, Amish Asthana, Benedetta Bussolati
Published in:
Current Transplantation Reports, Issue 2020, 2020, ISSN 2196-3029
Publisher:
Springer Nature
DOI:
10.1007/s40472-020-00282-2
Author(s):
Aurélien Ducat, Betty Couderc, Anthony Bouter, Louise Biquard, Rajaa Aouache, Bruno Passet, Ludivine Doridot, Marie-Benoîte Cohen, Pascale Ribaux, Clara Apicella, Irène Gaillard, Sophia Palfray, Yulian Chen, Alexandra Vargas, Amélie Julé, Léo Frelin, Julie Cocquet, Camino Ruano San Martin, Sébastien Jacques, Florence Busato, Jorg Tost, Céline Méhats, Paul Laissue, Jean-Luc Vilotte, Franci
Published in:
iScience, Issue 23/5, 2020, Page(s) 101086, ISSN 2589-0042
Publisher:
Cell Press
DOI:
10.1016/j.isci.2020.101086
Author(s):
Kristin Kräker, Till Schütte, Jamie O’Driscoll, Anna Birukov, Olga Patey, Florian Herse, Dominik N. Müller, Basky Thilaganathan, Nadine Haase, Ralf Dechend
Published in:
International Journal of Molecular Sciences, Issue 21/3, 2020, Page(s) 1162, ISSN 1422-0067
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms21031162
Author(s):
Morales-Roselló J, Khalil A, Loscalzo G, Buongiorno S, Brik M, Mendoza M, Di Fabrizio C, Scarinci E, Salvi S, Lanzone A, Perales Marín A.
Published in:
Fetal Diagn Ther, 2022, ISSN 1015-3837
Publisher:
S. Karger AG
DOI:
10.1159/000525162
Author(s):
Veronica Giorgione, Corey Briffa, Carolina Di Fabrizio, Rohan Bhate, Asma Khalil
Published in:
Journal of Clinical Medicine, Issue 10/4, 2021, Page(s) 643, ISSN 2077-0383
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/jcm10040643
Author(s):
Ostaszewski, Marek; Niarakis, Anna; Mazein, Alexander; Kuperstein, Inna; Phair, Robert; Orta-Resendiz, Aurelio; Singh, Vidisha; Aghamiri, Sara,; Acencio, Marcio,; Glaab, Enrico; Ruepp, Andreas; Fobo, Gisela; Montrone, Corinna; Brauner, Barbara; Frishman, Goar; Monraz Gómez, Luis Cristóbal; Somers, Julia; Hoch, Matti; Kumar Gupta, Shailendra; Scheel, Julia; Borlinghaus, Hanna; Czauderna, Tobias;
Published in:
Molecular Systems Biology, Vol 17, Iss 10, Pp n/a-n/a (2021), Issue 6, 2021, Page(s) e10387, ISSN 1744-4292
Publisher:
Nature Publishing Group
DOI:
10.17863/cam.77076
Author(s):
Morales-Roselló J, Galindo A, Scarinci E, Herraiz I, Buongiorno S, Loscalzo G, Gómez Arriaga PI, Cañada Martínez AJ, Rosati P, Lanzone A, Perales Marín A
Published in:
J Obstet Gynaecol., 2022, ISSN 0144-3615
Publisher:
Taylor & Francis
DOI:
10.1080/01443615.2021.1998891
Author(s):
De Majo, F., Martens, L., Hegenbarth, J. C., Rühle, F., Hamczyk, M. R., Nevado, R. M., Andrés, V., Hilbold, E., Bär, C., Thum, T., de Boer, M., Duncker, D. J., Schroen, B., Armand, A. S., Stoll, M., & De Windt, L. J.
Published in:
PNAS, 2021, ISSN 0027-8424
Publisher:
National Academy of Sciences
DOI:
10.1073/pnas.2022974118
Author(s):
Morales-Roselló J, Loscalzo G, Jakaitė V, Buongiorno S, Perales Marín A.
Published in:
J Matern Fetal Neonatal Med, 2022, ISSN 1476-7058
Publisher:
Parthenon Publishing Group
DOI:
10.1080/14767058.2022.2057794
Author(s):
D. Basurto, N. Sananès, E. Verbeken, D. Sharma, E. Corno, I. Valenzuela, L. Van Der Veeken, R. Favre, F. M. Russo, J. Deprest
Published in:
Ultrasound in Obstetrics & Gynecology, 2020, ISSN 0960-7692
Publisher:
John Wiley & Sons Inc.
DOI:
10.1002/uog.22132
Author(s):
Natalia Gebara, Yolanda Correia, Keqing Wang, Benedetta Bussolati
Published in:
International Journal of Molecular Sciences, Issue 22/10, 2021, Page(s) 5402, ISSN 1422-0067
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms22105402
Author(s):
Conrado Milani Coutinho; Conrado Milani Coutinho; V. Giorgione; Laure Noel; Becky Liu; Edwin Chandraharan; J. Pryce; A. P. Frick; Baskaran Thilaganathan; Baskaran Thilaganathan; Amar Bhide
Published in:
Ultrasound in Obstetrics & Gynecology, Issue 5, 2021, ISSN 1469-0705
Publisher:
Wiley
DOI:
10.1002/uog.23100
Author(s):
De Majo F, Hegenbarth JC, Rühle F, Bär C, Thum T, de Boer M, Duncker DJ, Schroen B, Armand AS, Stoll M, De Windt LJ.
Published in:
Scientific Reports, 2020, ISSN 2045-2322
Publisher:
Nature Publishing Group
DOI:
10.1038/s41598-020-65115-9
Author(s):
Gwenaёlle Rabussier, Ivan Bünter, Josse Bouwhuis, Camilla Soragni, Chee Ping Ng, Karel Dormansky, Leon J. de Windt, Paul Vulto, Colin E. Murdoch, Kristin M. Bircsak, Henriёtte L. Lanz
Published in:
2022
Publisher:
NA
DOI:
10.1101/2022.06.30.498115
Author(s):
iPLACENTA Symposium Committee
Published in:
2021
Publisher:
iPLACENTA
DOI:
10.5281/zenodo.4954997
Author(s):
Morales-Roselló, José; Loscalzo, Gabriela; Perez, Gemma; Soriano Paya, Alicia; Jakaitė, Vaidilė; Perales Marín, Alfredo
Published in:
The Journal of Maternal-Fetal & Neonatal Medicine, 2021
Publisher:
Zenodo (preprint)
DOI:
10.5281/zenodo.5006139
Author(s):
Morales-Roselló, José; García Gimenez, José Luis; Martinez Priego, Llucia; González-Rodríguez, Daymé; Mena-Mollá, Salvador; Maquieira Catalá, Angel; Loscalzo, Gabriela; Buongiorno, Silvia; Jakaite, Vaidile; Cañada Martínez, Antonio José; Perales Marín, Alfredo
Published in:
Fetal Diagnosis and Therapy, 2021
Publisher:
Zenodo (pre-print)
DOI:
10.5281/zenodo.4059846
Author(s):
Serhan, Charles N.; Gupta, Shailendra; Perretti, Mauro; Godson, Catherine; Brennan, Eoin; Li, Yongsheng; Soehnlein, Oliver; Shimizu, Takao; Werz, Oliver; Chiurchiù, Valerio; Azzi, Angelo; Dubourdeau, Marc; Gupta, Suchi Smita; Schopohl, Patrick; Hoch, Matti; Gjorgevikj, Dragana; Khan, Faiz M.; Brauer, David; Tripathi, Anurag; Cesnulevicius, Konstantin; Lescheid, David; Schultz, Myron; Repsilber, D
Published in:
biorxiv, Issue 4, 2021, Page(s) 1, ISSN 2692-8205
Publisher:
biorxiv
DOI:
10.1101/2020.01.27.921882
Author(s):
Markwalder L, Sneddon C, Gush R, Krstajic N, Murdoch C
Published in:
Physiology 2021 Abstract Book, Issue 12-16 July 2021, 2021
Publisher:
Physiology
Author(s):
Agathe Lermant, Claire Sneddon, Jack Hanna, Lukas Markwalder, Colin E Murdoch
Published in:
Heart Journal - SCF, 2020, Page(s) A7.1-A7
Publisher:
BMJ Publishing Group Ltd and British Cardiovascular Society
DOI:
10.1136/heartjnl-2020-scf.14
Author(s):
Natalia Gebara, Corinne Lampietro, Benedetta Bussolati, Chiara Benedetto and Luca Marozio
Published in:
ISEV2019 Abstract Book, in Journal of Extracellular Vesicles, Issue 8/sup1, 2019
Publisher:
Taylor and Francis
Author(s):
Scheel, Julia & Gupta, Shailendra & Wolkenhauer, Olaf.
Published in:
Placenta, Issue 112, 2021, Page(s) e35, ISSN 0143-4004
Publisher:
W. B. Saunders Co., Ltd.
DOI:
10.1016/j.placenta.2021.07.114
Author(s):
Loscalzo G, Moralles-Roselló J, García Gimenez JL, Martinez Priego L, González-Rodríguez D, Mena Mollá S, Maquieira Catalá A, Buongiorno S, Cañada Martínez AJ, Perales Marín A
Published in:
8th International Conference on Fetal Growth, Issue 2019, 2019, Page(s) Abstract 28
Publisher:
Perinatal Institute
Author(s):
Soragni C, Rabussier G, Lanz HL, de Windt LJ, Trietsch SJ, Ng CP
Published in:
International Cell Culture Under Flow Meeting 2020, Abstract Book, Issue 2020, 2020
Publisher:
Biomedical Center Munich
Author(s):
José Morales‐Roselló, Gabriela Loscalzo, Silvia Buongiorno, Vaidilė Jakaitė, Alfredo Perales‐Marín
Published in:
BJOG: An International Journal of Obstetrics & Gynaecology, 2020, ISSN 1470-0328
Publisher:
Blackwell Publishing Inc.
DOI:
10.1111/1471-0528.16376
Author(s):
I. Couck, I. Valenzuela, F. Russo, L. Lewi
Published in:
Ultrasound in Obstetrics & Gynecology, Issue 55/6, 2020, Page(s) 839-840, ISSN 0960-7692
Publisher:
John Wiley & Sons Inc.
DOI:
10.1002/uog.21897
Author(s):
Andre Gie, Ignacio Valenzuela, Thomas Salaets, Jan Deprest, Jaan Toelen
Published in:
Tantalizing Therapeutics in Bronchopulmonary Dysplasia, 2020, Page(s) 169-191, ISBN 9780128189870
Publisher:
Elsevier
DOI:
10.1016/b978-0-12-818987-0.00009-6
Searching for OpenAIRE data...
There was an error trying to search data from OpenAIRE
No results available