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Training Network for the education of the next generation scientist in targeting the supressive capacity of regulatory T-cells specifically within tumours

Objective

Tumour immune-therapy has made dramatic improvements in recent years, saving the lives of cancer patients who just a
few years ago would have been considered untreatable. It thereby became apparent that one specific type of immune cell,
so called regulatory T-cells, critically hampers the efficacy of tumour immune-therapy. Tumours, however, attract and exploit
the immune-regulatory function of Tregs to dampen local immune responses and to induce local tolerance.
In recent years, inhibitors that directly target immune-suppressive mechanisms of T cells have found clinical application with
great success. The clinical application of these so called “check-point inhibitors”, however, is accompanied by severe side
effects in treated patients. Thus improvement of the efficacy of current immune-therapeutic treatments is a major unmet
need. This proposal will employ the newest developments in antibody design to target the next generation of biologics right
towards tumour-residential Tregs or directly into the tumour micro-environment itself. In this way we will be able to
specifically shift the local immune suppressive environment within tumours, while leaving tissue homeostasis in noncancerous
tissues unaffected, and thus diminish treatment associated side-effects.
The here proposed project combines the expertise of fundamental immunologist, tumour immunologists and cell biologists
with that of a life-science biotechnology company and that of experts in clinical cancer research to address this aspect. This
group will lead a training network that aims at educating a new generation of researchers, who will be able to bridge the
innovation gap between, on the one hand, early discoveries in tumour-immunology as well as in antibody technology and, on
the other hand, the efficient translation and clinical validations of these findings in patients.

Coordinator

UNIVERSIDAD DE NAVARRA
Net EU contribution
€ 247 872,96
Address
Campus Universitario Edificio Central
31080 Pamplona
Spain

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Region
Noreste Comunidad Foral de Navarra Navarra
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (5)

THE UNIVERSITY OF EDINBURGH
United Kingdom
Net EU contribution
€ 493 436,45
Address
Old College, South Bridge
EH8 9YL Edinburgh

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Region
Eastern Scotland Edinburgh
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ADURO BIOTECH EUROPE BV

Participation ended

Netherlands
Net EU contribution
€ 249 699,30
Address
Kloosterstaat 9 Rx 1101
5349 AB Oss

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Region
Noord-Brabant Noordoost-Noord-Brabant
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA
Spain
Net EU contribution
€ 247 872,96
Address
Avenida De Pio Xii 55
31008 Pamplona

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Region
Noreste Comunidad Foral de Navarra Navarra
Activity type
Research Organisations
Non-EU contribution
€ 0,00
ONENA MEDICINES SL
Spain
Net EU contribution
€ 13 770,72
Address
Paseo Mikeletegi, 83, Edificio Kuatro Planta 3, La
20009 San Sebastian

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Noreste País Vasco Gipuzkoa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
UNIVERSITEIT UTRECHT
Netherlands
Net EU contribution
€ 21 281,19
Address
Heidelberglaan 8
3584 CS Utrecht

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Region
West-Nederland Utrecht Utrecht
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Partners (2)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
Net EU contribution
€ 0,00
Address
Albinusdreef 2
2333 ZA Leiden

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Region
West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

iOMEDICO AG
Germany
Net EU contribution
€ 0,00
Address
Hanferstr. 28
79108 Freiburg

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Region
Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00