Objective Tumour immune-therapy has made dramatic improvements in recent years, saving the lives of cancer patients who just afew years ago would have been considered untreatable. It thereby became apparent that one specific type of immune cell,so called regulatory T-cells, critically hampers the efficacy of tumour immune-therapy. Tumours, however, attract and exploitthe immune-regulatory function of Tregs to dampen local immune responses and to induce local tolerance.In recent years, inhibitors that directly target immune-suppressive mechanisms of T cells have found clinical application withgreat success. The clinical application of these so called “check-point inhibitors”, however, is accompanied by severe sideeffects in treated patients. Thus improvement of the efficacy of current immune-therapeutic treatments is a major unmetneed. This proposal will employ the newest developments in antibody design to target the next generation of biologics righttowards tumour-residential Tregs or directly into the tumour micro-environment itself. In this way we will be able tospecifically shift the local immune suppressive environment within tumours, while leaving tissue homeostasis in noncanceroustissues unaffected, and thus diminish treatment associated side-effects.The here proposed project combines the expertise of fundamental immunologist, tumour immunologists and cell biologistswith that of a life-science biotechnology company and that of experts in clinical cancer research to address this aspect. Thisgroup will lead a training network that aims at educating a new generation of researchers, who will be able to bridge theinnovation gap between, on the one hand, early discoveries in tumour-immunology as well as in antibody technology and, onthe other hand, the efficient translation and clinical validations of these findings in patients. Fields of science medical and health sciencesbasic medicineimmunologymedical and health sciencesclinical medicineoncologymedical and health sciencesbasic medicinephysiologyhomeostasis Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.1. - Fostering new skills by means of excellent initial training of researchers Topic(s) MSCA-ITN-2017 - Innovative Training Networks Call for proposal H2020-MSCA-ITN-2017 See other projects for this call Funding Scheme MSCA-ITN-EID - European Industrial Doctorates Coordinator UNIVERSIDAD DE NAVARRA Net EU contribution € 247 872,96 Address Campus universitario edificio central 31080 Pamplona Spain See on map Region Noreste Comunidad Foral de Navarra Navarra Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (5) Sort alphabetically Sort by Net EU contribution Expand all Collapse all THE UNIVERSITY OF EDINBURGH United Kingdom Net EU contribution € 493 436,45 Address Old college, south bridge EH8 9YL Edinburgh See on map Region Scotland Eastern Scotland Edinburgh Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ADURO BIOTECH EUROPE BV Participation ended Netherlands Net EU contribution € 249 699,30 Address Kloosterstaat 9 rx 1101 5349 AB Oss See on map Region Zuid-Nederland Noord-Brabant Noordoost-Noord-Brabant Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA Spain Net EU contribution € 247 872,96 Address Avenida de pio xii 55 31008 Pamplona See on map Region Noreste Comunidad Foral de Navarra Navarra Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ONENA MEDICINES SL Spain Net EU contribution € 13 770,72 Address Paseo mikeletegi, 83, edificio kuatro planta 3, la 20009 San sebastian See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Noreste País Vasco Gipuzkoa Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITEIT UTRECHT Netherlands Net EU contribution € 21 281,19 Address Heidelberglaan 8 3584 CS Utrecht See on map Region West-Nederland Utrecht Utrecht Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Partners (2) Sort alphabetically Sort by Net EU contribution Expand all Collapse all Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. ACADEMISCH ZIEKENHUIS LEIDEN Netherlands Net EU contribution € 0,00 Address Albinusdreef 2 2333 ZA Leiden See on map Region West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. iOMEDICO AG Germany Net EU contribution € 0,00 Address Hanferstr. 28 79108 Freiburg See on map Region Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00