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Training Network for the education of the next generation scientist in targeting the supressive capacity of regulatory T-cells specifically within tumours

Deliverables

Launch and management of the Tumor Treg Targerting website

General audience will be reached via the establishment of a project specific web-site. The web-site will make reference to the aims, the background of the project, and general as well as specific advances in the field of cancer therapy. Specific breakthrough achievements of the ESR's projects will be posted, which will regularly be updated with PDFs of publications, made available by 6 months post publication or earlier. Any press article and review articles will be available for download or upon request. ESRs will use the website to disseminate their projects. They will place short videos explaining in easily understable, non specialist language, their projects and further implications for the wider society. In addition, the web-site will be used to advertise the job offers during the recruitment period. The website will also contain special area for social media with the information that will appear on the project twitter, facebook, linkedin and Youtube.

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Publications

Isotype selection for antibody‐based cancer therapy

Author(s): N. Vukovic, A. Elsas, J. S. Verbeek, D. M. W. Zaiss
Published in: Clinical & Experimental Immunology, 203/3, 2021, Page(s) 351-365, ISSN 0009-9104
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/cei.13545

A novel efficient bispecific antibody format, combining a conventional antigen-binding fragment with a single domain antibody, avoids potential heavy-light chain mis-pairing

Author(s): Shuyu Huang, Aina Segués, David Lutje Hulsik, Dietmar M. Zaiss, Alice J.A.M. Sijts, Sander M.J. van Duijnhoven, Andrea van Elsas
Published in: Journal of Immunological Methods, 483, 2020, Page(s) 112811, ISSN 0022-1759
Publisher: Elsevier BV
DOI: 10.1016/j.jim.2020.112811

Purification of murine immunoglobulin E (IgE) by thiophilic interaction chromatography (TIC)

Author(s): Natasa Vukovic, Salim Harraou, Sander M.J. van Duijnhoven, Dietmar M. Zaiss, Andrea van Elsas
Published in: Journal of Immunological Methods, 489, 2021, Page(s) 112914, ISSN 0022-1759
Publisher: Elsevier BV
DOI: 10.1016/j.jim.2020.112914

Bispecific antibodies targeting dual tumor-associated antigens in cancer therapy

Author(s): Shuyu Huang, Sander M. J. van Duijnhoven, Alice J. A. M. Sijts, Andrea van Elsas
Published in: Journal of Cancer Research and Clinical Oncology, 2020, ISSN 0171-5216
Publisher: Springer Verlag
DOI: 10.1007/s00432-020-03404-6

Generation and characterization of novel co-stimulatory anti-mouse TNFR2 antibodies

Author(s): Aina Segués, Sander M.J. van Duijnhoven, Marc Parade, Lilian Driessen, Nataša Vukovic, Dietmar Zaiss, Alice J.A.M. Sijts, Pedro Berraondo, Andrea van Elsas
Published in: Journal of Immunological Methods, 499, 2021, Page(s) 113173, ISSN 0022-1759
Publisher: Elsevier BV
DOI: 10.1016/j.jim.2021.113173