Deliverables Documents, reports (2) ESR research outputs (publications, patent applications and presentations at conferences) and products) Report that will compile relevant information concerning the research outputs publications done patent applications obtained presentations carried out at conferences and products achieved by each ESR Dissemination of Tumor Treg Taregting results and achievements to the Scientific Community and products This report will compile all the actions urdertaken by project partners to disseminate at national and international levels the project results and achievements to the Scientific Community and Wider Public Websites, patent fillings, videos etc. (1) Launch and management of the Tumor Treg Targerting website General audience will be reached via the establishment of a project specific web-site. The web-site will make reference to the aims, the background of the project, and general as well as specific advances in the field of cancer therapy. Specific breakthrough achievements of the ESR's projects will be posted, which will regularly be updated with PDFs of publications, made available by 6 months post publication or earlier. Any press article and review articles will be available for download or upon request. ESRs will use the website to disseminate their projects. They will place short videos explaining in easily understable, non specialist language, their projects and further implications for the wider society. In addition, the web-site will be used to advertise the job offers during the recruitment period. The website will also contain special area for social media with the information that will appear on the project twitter, facebook, linkedin and Youtube. Publications Peer reviewed articles (19) Insulin Fused to Apolipoprotein A-I Reduces Body Weight and Steatosis in DB/DB Mice Author(s): Ardaiz N, Gomar C, Vasquez M, Tenesaca S, Fernandez-Sendin M, Di Trani CA, Belsué V, Escalada J, Werner U, Tennagels N, Berraondo P. Published in: Front Pharmacol., 2021, ISSN 1663-9812 Publisher: Frontiers Media S.A. DOI: 10.3389/fphar.2020.591293 Synergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosis Author(s): Bella Á, Arrizabalaga L, Di Trani CA, Cirella A, Fernandez-Sendin M, Gomar C, Russo-Cabrera JS, Rodríguez I, González-Gomariz J, Alvarez M, Teijeira Á, Medina-Echeverz J, Hinterberger M, Hochrein H, Melero I, Berraondo P, Aranda F. Published in: Oncoimmunology, 2022, ISSN 2162-4011 Publisher: Landes Bioscience DOI: 10.1080/2162402x.2022.2098657 Bispecific antibodies targeting dual tumor-associated antigens in cancer therapy. Author(s): Huang, Shuyu; van Duijnhoven, Sander M J; Sijts, Alice J A M; van Elsas, Andrea; Immunologie; dI&I RA-I&I I&I Published in: Journal of Cancer Research and Clinical Oncology, Issue 5, 2020, ISSN 0171-5216 Publisher: Springer Verlag DOI: 10.1007/s00432-020-03404-6 Three-dimensional colon cancer organoids model the response to CEA-CD3 T-cell engagers Author(s): Teijeira A, Migueliz I, Garasa S, Karanikas V, Luri C, Cirella A, Olivera I, Cañamero M, Alvarez M, Ochoa MC, Rouzaut A, Rodriguez-Ruiz ME, Sanmamed MF, Klein C, Umaña P, Ponz M, Bacac M, Melero I. Published in: Theranostics, 2022, ISSN 1838-7640 Publisher: Ivyspring International Publisher DOI: 10.7150/thno.63359 Isotype selection for antibody‐based cancer therapy Author(s): N. Vukovic, A. Elsas, J. S. Verbeek, D. M. W. Zaiss Published in: Clinical & Experimental Immunology, Issue 203/3, 2021, Page(s) 351-365, ISSN 0009-9104 Publisher: Blackwell Publishing Inc. DOI: 10.1111/cei.13545 INTERLEUKIN-12 MESSAGE IN A BOTTLE Author(s): Cirella, A. Berraondo, P. Di-Trani, C.A. Melero, I. Published in: Clin Cancer Res, 2020, ISSN 1078-0432 Publisher: American Association for Cancer Research DOI: 10.1158/1078-0432.ccr-20-3250 Mouse IgG2a Isotype Therapeutic Antibodies Elicit Superior Tumor Growth Control Compared with mIgG1 or mIgE Author(s): Vukovic N, Segués A, Huang S, Waterfall M, Sijts AJAM, Zaiss DM. Published in: Cancer Res Commun, 2023, ISSN 2767-9764 Publisher: American Association for Cancer Research DOI: 10.1158/2767-9764.crc-22-0356 Novel strategies exploiting interleukin-12 in cancer immunotherapy Author(s): Cirella A, Luri-Rey C, Di Trani CA, Teijeira A, Olivera I, Bolaños E, Castañón E, Palencia B, Brocco D, Fernández-Sendin M, Aranda F, Berraondo P, Melero I. Novel strategies exploiting interleukin-12 in cancer immunotherapy Published in: Pharmacology & Therapeutics, 2022, ISSN 0163-7258 Publisher: Pergamon Press DOI: 10.1016/j.pharmthera.2022.108189 Advances in mRNA-based drug discovery in cancer immunotherapy. Author(s): Di Trani CA, Fernandez-Sendin M, Cirella A, Segués A, Olivera I, Bolaños E, Melero I, Berraondo P. Published in: Expert Opin Drug Discov., 2022, ISSN 1746-0441 Publisher: Informa Healthcare DOI: 10.1080/17460441.2021.1978972 A novel efficient bispecific antibody format, combining a conventional antigen-binding fragment with a single domain antibody, avoids potential heavy-light chain mis-pairing Author(s): Shuyu Huang, Aina Segués, David Lutje Hulsik, Dietmar M. Zaiss, Alice J.A.M. Sijts, Sander M.J. van Duijnhoven, Andrea van Elsas Published in: Journal of Immunological Methods, Issue 483, 2020, Page(s) 112811, ISSN 0022-1759 Publisher: Elsevier BV DOI: 10.1016/j.jim.2020.112811 Mouse Models of Peritoneal Carcinomatosis to Develop Clinical Applications Author(s): Angela Bella; Claudia Augusta Di Trani; Myriam Fernandez-Sendin; Leire Arrizabalaga; Assunta Cirella; Alvaro Teijeira; José Medina-Echeverz; Ignacio Melero; Pedro Berraondo; Fernando Aranda Published in: Cancers, Issue 3, 2021, ISSN 2072-6694 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers13050963 Statins act as transient type I interferon inhibitors to enable the antitumor activity of modified vaccinia Ankara viral vectors Author(s): Shirley Tenesaca; Marcos Vasquez; Maite Alvarez; Itziar Otano; Myriam Fernandez-Sendin; Claudia Augusta Di Trani; Nuria Ardaiz; Celia Gomar; Angela Bella; Fernando Aranda; José Medina-Echeverz; Ignacio Melero; Pedro Berraondo Published in: Journal for Immunotherapy of Cancer, Issue 1, 2021, ISSN 2051-1426 Publisher: BMJ publishing group DOI: 10.1136/jitc-2020-001587 Long-Term Liver Expression of an Apolipoprotein A-I Mimetic Peptide Attenuates Interferon-Alpha-Induced Inflammation and Promotes Antiviral Activity Author(s): Fernandez-Sendin M, Di Trani CA, Bella A, Vasquez M, Ardaiz N, Gomar C, Arrizabalaga L, Ciordia S, Corrales FJ, Aranda F, Berraondo P. Published in: Frontiers in immunology, 2021, ISSN 1664-3224 Publisher: Lausanne: Frontiers Media S.A., 2010- DOI: 10.3389/fimmu.2020.620283 Differential Interleukin-8 thresholds for chemotaxis and netosis in human neutrophils Author(s): Teijeira A, Garasa S, Ochoa MDC, Cirella A, Olivera I, Glez-Vaz J, Andueza MP, Migueliz I, Alvarez M, Rodríguez-Ruiz ME, Rouzaut A, Berraondo P, Sanmamed MF, Perez Gracia JL, Melero I Published in: Eur J Immunol, 2021, ISSN 0014-2980 Publisher: John Wiley & Sons Ltd. DOI: 10.1002/eji.202049029 Purification of murine immunoglobulin E (IgE) by thiophilic interaction chromatography (TIC) Author(s): Natasa Vukovic, Salim Harraou, Sander M.J. van Duijnhoven, Dietmar M. Zaiss, Andrea van Elsas Published in: Journal of Immunological Methods, Issue 489, 2021, Page(s) 112914, ISSN 0022-1759 Publisher: Elsevier BV DOI: 10.1016/j.jim.2020.112914 A Human IgE bispecific antibody shows potent cytotoxic capacity mediated by monocytes Author(s): Vukovic, Natasa; Halabi, Samer; Russo-Cabrera, Joan Salvador; Blokhuis, Bart; Berraondo, Pedro; Redegeld, Frank A M; Zaiss, Dietmar M W; Afd Pharmacology; LS Immunologie; Pharmacology Published in: VOLUME=298;ISSUE=8;STARTPAGE=1;ISSN=0021-9258;TITLE=Journal of Biological Chemistry, Issue 7, 2022, ISSN 0021-9258 Publisher: American Society for Biochemistry and Molecular Biology Inc. DOI: 10.1016/j.jbc.2022.102153 Shortened hinge design of Fab x sdAb-Fc bispecific antibodies enhances redirected T-Cell killing of tumor cells Author(s): Shuyu Huang; Aina Segués; Martin Waterfall; David Wright; Charlotte Vayssiere; Sander M. J. van Duijnhoven; Andrea van Elsas; Alice J. A. M. Sijts; Dietmar M. Zaiss Published in: Biomolecules; Volume 12; Issue 10; Pages: 1331, Issue 1, 2020, ISSN 0171-5216 Publisher: Springer Verlag DOI: 10.3390/biom12101331 Bispecific antibodies targeting dual tumor-associated antigens in cancer therapy Author(s): Shuyu Huang, Sander M. J. van Duijnhoven, Alice J. A. M. Sijts, Andrea van Elsas Published in: Journal of Cancer Research and Clinical Oncology, 2020, ISSN 0171-5216 Publisher: Springer Verlag DOI: 10.1007/s00432-020-03404-6 Generation and characterization of novel co-stimulatory anti-mouse TNFR2 antibodies Author(s): Aina Segués, Sander M.J. van Duijnhoven, Marc Parade, Lilian Driessen, Nataša Vukovic, Dietmar Zaiss, Alice J.A.M. Sijts, Pedro Berraondo, Andrea van Elsas Published in: Journal of Immunological Methods, Issue 499, 2021, Page(s) 113173, ISSN 0022-1759 Publisher: Elsevier BV DOI: 10.1016/j.jim.2021.113173 Book chapters (1) Opportunities and challenges of bi-specific antibodies Author(s): Segués A, Huang S, Sijts A, Berraondo P, Zaiss DM Published in: Int Rev Cell Mol Biol, 2022, ISSN 1937-6448 Publisher: Elsevier Inc. DOI: 10.1016/bs.ircmb.2022.05.001 Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
