All students were enrolled in Ph.D. programs and in the different educational activities of the network. In parallel, the experimental work progress in fulfilling the different aims of the project. The internships of the students in the Aduro facilities, the industrial partner of this project, were instrumental in advancing each student’s experimental program. The work performed in the network already achieved results that were published in peer-reviewed journals:
1) A novel efficient bispecific antibody format, combining a conventional antigen-binding fragment with a single domain antibody, avoids potential heavy-light chain mis-pairing. Huang S, Segués A, Hulsik DL, Zaiss DM, Sijts AJAM, van Duijnhoven SMJ, van Elsas A. J Immunol Methods. 2020 Aug;483:112811. doi: 10.1016/j.jim.2020.112811. Epub 2020 Jun 19.
2) Bispecific antibodies targeting dual tumor-associated antigens in cancer therapy. Huang S, van Duijnhoven SMJ, Sijts AJAM, van Elsas A. J Cancer Res Clin Oncol. 2020 Dec;146(12):3111-3122. doi: 10.1007/s00432-020-03404-6. Epub 2020 Sep 28.
3) Isotype selection for antibody-based cancer therapy. Vukovic N, van Elsas A, Verbeek JS, Zaiss DMW. Clin Exp Immunol. 2021 Mar;203(3):351-365. doi: 10.1111/cei.13545. Epub 2020 Nov 30.
4) Purification of murine immunoglobulin E (IgE) by thiophilic interaction chromatography (TIC). Vukovic N, Harraou S, van Duijnhoven SMJ, Zaiss DM, van Elsas A. J Immunol Methods. 2021 Feb;489:112914. doi: 10.1016/j.jim.2020.112914. Epub 2020 Nov 14.