Training Network for the education of the next generation scientist in targeting the supressive capacity of regulatory T-cells specifically within tumours

Informations projet

Tumor-Treg-Targeting

N° de convention de subvention: 765394

DOI

10.3030/765394

Projet clôturé

Date de signature de la CE 2 Août 2017

Date de début 1 Juin 2018

Date de fin 30 Novembre 2022

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 1 273 933,58

Contribution de l’UE

€ 1 273 933,58

Coordonné par

UNIVERSIDAD DE NAVARRA
Spain

Periodic Reporting for period 2 - Tumor-Treg-Targeting (Training Network for the education of the next generation scientist in targeting the supressive capacity of regulatory T-cells specifically within tumours)

Période du rapport: 2020-06-01 au 2022-11-30

Résumé du contexte et des objectifs généraux du projet

Tumour-Treg-Targeting is a collaborative research and training project established to provide innovative and comprehensive training in antibody-based drug design to next-generation scientists in academia and industry in order to enable them to develop the next generation of antibody-based biologicals targeting and shifting the immunological environment specifically within tumours. These next-generation antibodies are designed to exploit all the potential of the immune system to fight cancer.

The project addresses the following main goals:

Objective 1: to develop novel biologicals that can target cell populations - such as cancerous cells or specific subtypes of leukocytes - with unprecedented specificity.
Objective 2: to specifically engage particular cell types of the innate immune system within tumours with applied biologicals in a directed fashion.
Objective 3: to target known immune-modulating cytokines or known check-point inhibitors directly into established tumours.

Travail effectué depuis le début du projet jusqu’à la fin de la période considérée dans le rapport et principaux résultats atteints jusqu’à présent

All students were enrolled in Ph.D. programs and in the different educational activities of the network. In parallel, the experimental work progress in fulfilling the different aims of the project. The internships of the students in the Aduro facilities, the industrial partner of this project, were instrumental in advancing each student’s experimental program. The work performed in the network already achieved results that were published in peer-reviewed journals:

1) A novel efficient bispecific antibody format, combining a conventional antigen-binding fragment with a single domain antibody, avoids potential heavy-light chain mis-pairing. Huang S, Segués A, Hulsik DL, Zaiss DM, Sijts AJAM, van Duijnhoven SMJ, van Elsas A. J Immunol Methods. 2020 Aug;483:112811. doi: 10.1016/j.jim.2020.112811. Epub 2020 Jun 19.
2) Bispecific antibodies targeting dual tumor-associated antigens in cancer therapy. Huang S, van Duijnhoven SMJ, Sijts AJAM, van Elsas A. J Cancer Res Clin Oncol. 2020 Dec;146(12):3111-3122. doi: 10.1007/s00432-020-03404-6. Epub 2020 Sep 28.
3) Isotype selection for antibody-based cancer therapy. Vukovic N, van Elsas A, Verbeek JS, Zaiss DMW. Clin Exp Immunol. 2021 Mar;203(3):351-365. doi: 10.1111/cei.13545. Epub 2020 Nov 30.
4) Purification of murine immunoglobulin E (IgE) by thiophilic interaction chromatography (TIC). Vukovic N, Harraou S, van Duijnhoven SMJ, Zaiss DM, van Elsas A. J Immunol Methods. 2021 Feb;489:112914. doi: 10.1016/j.jim.2020.112914. Epub 2020 Nov 14.

Progrès au-delà de l’état des connaissances et impact potentiel prévu (y compris l’impact socio-économique et les conséquences sociétales plus larges du projet jusqu’à présent)

The different experimental projects continue to characterize further the properties of the novel therapeutic molecules developed within the network. It is expected that novel technologies will be developed, and their potential in preclinical cancer models will be demonstrated.

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