Integrated Training in Dry Eye Disease Drug Development (IT-DED3)

Project Information

IT-DED3

Grant agreement ID: 765608

DOI 10.3030/765608

Project closed

EC signature date 17 August 2017

Start date 1 January 2018

End date 31 August 2022

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 3 002 689,44

EU contribution € 3 002 689,44

Coordinated by

UNIVERSITEIT ANTWERPEN
Belgium

Deliverables

Other (2)

All ESRs are recruited

All ESRs are recruited at this timepoint

Awarding of doctoral degrees

Awarding of doctoral degrees (this is foreseen by month 54)

Documents, reports (4)

Report on closing symposium
Report on dissemination activities
Install communication plan
Report on exploitation results

Websites, patent fillings, videos etc. (1)

Set-up website and social media pages

Publications

Peer reviewed articles (23)

Hyaluronic acid and Chondroitin sulfate from marine and terrestrial sources: Extraction and purification methods

Author(s): Maha M. Abdallah, Naiara Fernández, Ana A. Matias, Maria do Rosário Bronze
Published in: Carbohydrate Polymers, Issue 243, 2020, Page(s) 116441, ISSN 0144-8617
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.carbpol.2020.116441

Lactic Acid-Based Natural Deep Eutectic Solvents to Extract Bioactives from Marine By-Products

Author(s): Maha M. Abdallah; Martim Cardeira; Ana A. Matias; Maria Rosário Bronze; Naiara Fernández
Published in: Molecules, Issue 14203049, 2022, Page(s) 4356, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27144356

Topical treatment with a mu opioid receptor agonist alleviates corneal allodynia and corneal nerve sensitization in mice

Author(s): Fanny Joubert, Adrian Guerrero-Moreno, Darine Fakih, Elodie Reboussin, Claire Gaveriaux-Ruff, Maria Carmen Acosta, Juana Gallar, José Alain Sahel, Laurence Bodineau, Christophe Baudouin, William Rostène, Stéphane Mélik-Parsadaniantz, Annabelle Réaux-Le Goazigo
Published in: Biomedicine & Pharmacotherapy, Issue 132, 2020, Page(s) 110794, ISSN 0753-3322
Publisher: Elsevier Masson
DOI: 10.1016/j.biopha.2020.110794

Improved Ocular Delivery of Quercetin and Resveratrol: A Comparative Study Between Binary and Ternary Cyclodextrin Complexes

Author(s): Luna Krstić, Pekka Jarho, Marika Ruponen, Arto Urtti, María J. González-García and Yolanda Diebold
Published in: International Journal of Pharmaceutics, Issue 122028, 2022, ISSN 0378-5173
Publisher: Elsevier BV
DOI: 10.1016/j.ijpharm.2022.122028

Ocular Delivery of Polyphenols: Meeting the Unmet Needs

Author(s): Luna Krstić, María J. González-García, Yolanda Diebold
Published in: Molecules, Issue 26/2, 2021, Page(s) 370, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26020370

Morphological and Functional Changes of Corneal Nerves and Their Contribution to Peripheral and Central Sensory Abnormalities

Author(s): Adrian Guerrero-Moreno, Christophe Baudouin, Stéphane Melik Parsadaniantz, Annabelle Réaux-Le Goazigo
Published in: Frontiers in Cellular Neuroscience, Issue 14, 2020, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncel.2020.610342

Capsazepine decreases corneal pain syndrome in severe dry eye disease

Author(s): Darine Fakih, Adrian Guerrero-Moreno, Christophe Baudouin, Annabelle Réaux-Le Goazigo, Stéphane Mélik Parsadaniantz
Published in: Journal of Neuroinflammation, Issue 18/1, 2021, ISSN 1742-2094
Publisher: BioMed Central
DOI: 10.1186/s12974-021-02162-7

One-pot synthesis of α-aminophosphonates by yttrium-catalyzed Birum–Oleksyszyn reaction

Author(s): Davide Ceradini and Kirill Shubin
Published in: RSC Advance, Issue 11, 39147, 2021, Page(s) 39147–39152, ISSN 2046-2069
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1ra07718j

Improved Synthesis of the Selected Serine Protease uPA Inhibitor UAMC-00050, a Lead Compound for the Treatment of Dry Eye Disease

Author(s): Davide Ceradini, Pavel Cacivkins, Alba Ramos-Llorca, and Kirill Shubin
Published in: Organic Process Research & Development, Issue 10836160, 2022, ISSN 1083-6160
Publisher: American Chemical Society
DOI: 10.1021/acs.oprd.2c00244

Deep learning-based automatic meibomian gland segmentation and morphology assessment in infrared meibography

Author(s): Md Asif Khan Setu, Jens Horstmann, Stefan Schmidt, Michael E. Stern, Philipp Steven
Published in: Scientific Reports, Issue 11/1, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-87314-8

Segmentation and Evaluation of Corneal Nerves and Dendritic Cells From In Vivo Confocal Microscopy Images Using Deep Learning

Author(s): Md Asif Khan Setu; Stefan Schmidt; Gwen Musial; Michael E. Stern; Philipp Steven
Published in: Translational Vision Science & Technology (TVST), Issue Volume 11, Issue 6, 2022, ISSN 2164-2591
Publisher: ARVO
DOI: 10.1167/tvst.11.6.24

Proteomic Analysis of Tears and Conjunctival Cells Collected with Schirmer Strips Using timsTOF Pro: Preanalytical Considerations

Author(s): Murat Akkurt Arslan, Ioannis Kolman, Cédric Pionneau, Solenne Chardonnet, Romain Magny, Christophe Baudouin, Françoise Brignole-Baudouin and Karima Kessal
Published in: Metabolites 2022, Issue 12(1), 2, 2021, Page(s) Section Cell Metabolism, ISSN 2218-1989
Publisher: MDPI
DOI: 10.3390/metabo12010002

Olive Pomace Phenolic Compounds: From an Agro-Industrial By-Product to a Promising Ocular Surface Protection for Dry Eye Disease

Author(s): Nikolaos Katsinas, Uta Gehlsen, Laura García-Posadas, Soraya Rodríguez-Rojo, Philipp Steven, María J. González-García and Amalia Enríquez-de-Salamanca.
Published in: Journal of Clinical Medicine, Issue 11(16), 2022, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm11164703

Corneal Nerve Abnormalities in Painful Dry Eye Disease Patients

Author(s): Adrian Guerrero-Moreno, Hong Liang, Nathan Moreau, Jade Luzu, Ghislaine Rabut, Stéphane Melik Parsadaniantz, Antoine Labbé, Christophe Baudouin, Annabelle Réaux-Le Goazigo
Published in: Biomedicines, Issue 9/10, 2021, Page(s) 1424, ISSN 2227-9059
Publisher: MDPI
DOI: 10.3390/biomedicines9101424

Proteases and Their Potential Role as Biomarkers and Drug Targets in Dry Eye Disease and Ocular Surface Dysfunction

Author(s): Alba Ramos-Llorca,Camilla Scarpellini, and Koen Augustyns
Published in: International Journal of Molecular Sciences, Issue 23(17), 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23179795

Topical application of cannabinoid-ligands ameliorates experimental dry-eye disease

Author(s): Bao N. Tran, Martina Maass, GwenMusial, Michael E. Stern, Uta Gehlsen, Philipp Steven
Published in: The Ocular Surface, 2021, ISSN 1542-0124
Publisher: Ethis Communications
DOI: 10.1016/j.jtos.2021.12.008

Olive Pomace Phenolic Compounds Stability and Safety Evaluation: From Raw Material to Future Ophthalmic Applications

Author(s): Nikolaos Katsinas, Amalia Enríquez-de-Salamanca, Andreia Bento da Silva, Maria Rosário Bronze, Soraya Rodríguez-Rojo
Published in: Molecules, Issue 26/19, 2021, Page(s) 6002, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26196002

Olive Pomace Phenolic Compounds and Extracts Can Inhibit Inflammatory- and Oxidative-Related Diseases of Human Ocular Surface Epithelium

Author(s): Nikolaos Katsinas, Soraya Rodríguez-Rojo, Amalia Enríquez-de-Salamanca
Published in: Antioxidants, Issue 10/7, 2021, Page(s) 1150, ISSN 2076-3921
Publisher: MDPI
DOI: 10.3390/antiox10071150

Potential Ophthalmological Application of Extracts Obtained from Tuna Vitreous Humor Using Lactic Acid-Based Deep Eutectic Systems

Author(s): Maha Abdallah, Inês C. Leonardo, Luna Krstić, Amalia Enríquez-de-Salamanca, Yolanda Diebold, Maria J. González-García, Frédéric B. Gaspar, Ana A. Matias, Maria do Rosário Bronze and Naiara Fernández
Published in: Foods, Issue 11/3, 2022, Page(s) 342, ISSN 2304-8158
Publisher: MDPI
DOI: 10.3390/foods11030342

Physicochemical Characterization and Simulation of the Solid–Liquid Equilibrium Phase Diagram of Terpene-Based Eutectic Solvent Systems

Author(s): Maha M. Abdallah, Simon Müller, Andrés González de Castilla, Pavel Gurikov, Ana A. Matias, Maria do Rosário Bronze, Naiara Fernández
Published in: Molecules, Issue 26/6, 2021, Page(s) 1801, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26061801

Understanding dexamethasone kinetics in the rabbit tear fluid: Drug release and clearance from solution, suspension and hydrogel formulations

Author(s): Anusha Balla, Marika Ruponen, Annika Valtari, Elisa Toropainen, Marjo Tuomainen, Carmen Alvarez-Lorenzo, Eva M. del Amo, Arto Urtti and Kati-Sisko Vellonen
Published in: European Journal of Pharmaceutics and Biopharmaceutics, Issue Vol.172, 2022, Page(s) 53-60, ISSN 0939-6411
Publisher: Elsevier BV
DOI: 10.1016/j.ejpb.2022.01.005

Pressurized Liquid Extraction Optimization from Supercritical Defatted Olive Pomace: A Green and Selective Phenolic Extraction Process

Author(s): Nikolaos Katsinas, Andreia Bento da Silva, Amalia Enríquez-de-Salamanca, Naiara Fernández, Maria Rosário Bronze, Soraya Rodríguez-Rojo
Published in: ACS Sustainable Chemistry & Engineering, 2021, ISSN 2168-0485
Publisher: American Chemical Society
DOI: 10.1021/acssuschemeng.0c09426

Partitioning and Spatial Distribution of Drugs in Ocular Surface Tissues

Author(s): Anusha Balla, Seppo Auriola, Angus C. Grey, Nicholas J. Demarais, Annika Valtari, Emma M. Heikkinen, Elisa Toropainen, Arto Urtti, Kati-Sisko Vellonen, Marika Ruponen
Published in: Pharmaceutics, Issue 13/5, 2021, Page(s) 658, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13050658