Integrated Training in Dry Eye Disease Drug Development (IT-DED3)

Resultado final

All ESRs are recruited at this timepoint

Awarding of doctoral degrees (this is foreseen by month 54)

Report on closing symposium
Report on dissemination activities
Install communication plan
Report on exploitation results

Set-up website and social media pages

Publicaciones

Hyaluronic acid and Chondroitin sulfate from marine and terrestrial sources: Extraction and purification methods

Autores: Maha M. Abdallah, Naiara Fernández, Ana A. Matias, Maria do Rosário Bronze
Publicado en: Carbohydrate Polymers, Edición 243, 2020, Página(s) 116441, ISSN 0144-8617
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.carbpol.2020.116441

Lactic Acid-Based Natural Deep Eutectic Solvents to Extract Bioactives from Marine By-Products

Autores: Maha M. Abdallah; Martim Cardeira; Ana A. Matias; Maria Rosário Bronze; Naiara Fernández
Publicado en: Molecules, Edición 14203049, 2022, Página(s) 4356, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27144356

Topical treatment with a mu opioid receptor agonist alleviates corneal allodynia and corneal nerve sensitization in mice

Autores: Fanny Joubert, Adrian Guerrero-Moreno, Darine Fakih, Elodie Reboussin, Claire Gaveriaux-Ruff, Maria Carmen Acosta, Juana Gallar, José Alain Sahel, Laurence Bodineau, Christophe Baudouin, William Rostène, Stéphane Mélik-Parsadaniantz, Annabelle Réaux-Le Goazigo
Publicado en: Biomedicine & Pharmacotherapy, Edición 132, 2020, Página(s) 110794, ISSN 0753-3322
Editor: Elsevier Masson
DOI: 10.1016/j.biopha.2020.110794

Improved Ocular Delivery of Quercetin and Resveratrol: A Comparative Study Between Binary and Ternary Cyclodextrin Complexes

Autores: Luna Krstić, Pekka Jarho, Marika Ruponen, Arto Urtti, María J. González-García and Yolanda Diebold
Publicado en: International Journal of Pharmaceutics, Edición 122028, 2022, ISSN 0378-5173
Editor: Elsevier BV
DOI: 10.1016/j.ijpharm.2022.122028

Ocular Delivery of Polyphenols: Meeting the Unmet Needs

Autores: Luna Krstić, María J. González-García, Yolanda Diebold
Publicado en: Molecules, Edición 26/2, 2021, Página(s) 370, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26020370

Morphological and Functional Changes of Corneal Nerves and Their Contribution to Peripheral and Central Sensory Abnormalities

Autores: Adrian Guerrero-Moreno, Christophe Baudouin, Stéphane Melik Parsadaniantz, Annabelle Réaux-Le Goazigo
Publicado en: Frontiers in Cellular Neuroscience, Edición 14, 2020, ISSN 1662-5102
Editor: Frontiers Research Foundation
DOI: 10.3389/fncel.2020.610342

Capsazepine decreases corneal pain syndrome in severe dry eye disease

Autores: Darine Fakih, Adrian Guerrero-Moreno, Christophe Baudouin, Annabelle Réaux-Le Goazigo, Stéphane Mélik Parsadaniantz
Publicado en: Journal of Neuroinflammation, Edición 18/1, 2021, ISSN 1742-2094
Editor: BioMed Central
DOI: 10.1186/s12974-021-02162-7

One-pot synthesis of α-aminophosphonates by yttrium-catalyzed Birum–Oleksyszyn reaction

Autores: Davide Ceradini and Kirill Shubin
Publicado en: RSC Advance, Edición 11, 39147, 2021, Página(s) 39147–39152, ISSN 2046-2069
Editor: Royal Society of Chemistry
DOI: 10.1039/d1ra07718j

Improved Synthesis of the Selected Serine Protease uPA Inhibitor UAMC-00050, a Lead Compound for the Treatment of Dry Eye Disease

Autores: Davide Ceradini, Pavel Cacivkins, Alba Ramos-Llorca, and Kirill Shubin
Publicado en: Organic Process Research & Development, Edición 10836160, 2022, ISSN 1083-6160
Editor: American Chemical Society
DOI: 10.1021/acs.oprd.2c00244

Deep learning-based automatic meibomian gland segmentation and morphology assessment in infrared meibography

Autores: Md Asif Khan Setu, Jens Horstmann, Stefan Schmidt, Michael E. Stern, Philipp Steven
Publicado en: Scientific Reports, Edición 11/1, 2021, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-021-87314-8

Segmentation and Evaluation of Corneal Nerves and Dendritic Cells From In Vivo Confocal Microscopy Images Using Deep Learning

Autores: Md Asif Khan Setu; Stefan Schmidt; Gwen Musial; Michael E. Stern; Philipp Steven
Publicado en: Translational Vision Science & Technology (TVST), Edición Volume 11, Edición 6, 2022, ISSN 2164-2591
Editor: ARVO
DOI: 10.1167/tvst.11.6.24

Proteomic Analysis of Tears and Conjunctival Cells Collected with Schirmer Strips Using timsTOF Pro: Preanalytical Considerations

Autores: Murat Akkurt Arslan, Ioannis Kolman, Cédric Pionneau, Solenne Chardonnet, Romain Magny, Christophe Baudouin, Françoise Brignole-Baudouin and Karima Kessal
Publicado en: Metabolites 2022, Edición 12(1), 2, 2021, Página(s) Section Cell Metabolism, ISSN 2218-1989
Editor: MDPI
DOI: 10.3390/metabo12010002

Olive Pomace Phenolic Compounds: From an Agro-Industrial By-Product to a Promising Ocular Surface Protection for Dry Eye Disease

Autores: Nikolaos Katsinas, Uta Gehlsen, Laura García-Posadas, Soraya Rodríguez-Rojo, Philipp Steven, María J. González-García and Amalia Enríquez-de-Salamanca.
Publicado en: Journal of Clinical Medicine, Edición 11(16), 2022, ISSN 2077-0383
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm11164703

Corneal Nerve Abnormalities in Painful Dry Eye Disease Patients

Autores: Adrian Guerrero-Moreno, Hong Liang, Nathan Moreau, Jade Luzu, Ghislaine Rabut, Stéphane Melik Parsadaniantz, Antoine Labbé, Christophe Baudouin, Annabelle Réaux-Le Goazigo
Publicado en: Biomedicines, Edición 9/10, 2021, Página(s) 1424, ISSN 2227-9059
Editor: MDPI
DOI: 10.3390/biomedicines9101424

Proteases and Their Potential Role as Biomarkers and Drug Targets in Dry Eye Disease and Ocular Surface Dysfunction

Autores: Alba Ramos-Llorca,Camilla Scarpellini, and Koen Augustyns
Publicado en: International Journal of Molecular Sciences, Edición 23(17), 2022, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23179795

Topical application of cannabinoid-ligands ameliorates experimental dry-eye disease

Autores: Bao N. Tran, Martina Maass, GwenMusial, Michael E. Stern, Uta Gehlsen, Philipp Steven
Publicado en: The Ocular Surface, 2021, ISSN 1542-0124
Editor: Ethis Communications
DOI: 10.1016/j.jtos.2021.12.008

Olive Pomace Phenolic Compounds Stability and Safety Evaluation: From Raw Material to Future Ophthalmic Applications

Autores: Nikolaos Katsinas, Amalia Enríquez-de-Salamanca, Andreia Bento da Silva, Maria Rosário Bronze, Soraya Rodríguez-Rojo
Publicado en: Molecules, Edición 26/19, 2021, Página(s) 6002, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26196002

Olive Pomace Phenolic Compounds and Extracts Can Inhibit Inflammatory- and Oxidative-Related Diseases of Human Ocular Surface Epithelium

Autores: Nikolaos Katsinas, Soraya Rodríguez-Rojo, Amalia Enríquez-de-Salamanca
Publicado en: Antioxidants, Edición 10/7, 2021, Página(s) 1150, ISSN 2076-3921
Editor: MDPI
DOI: 10.3390/antiox10071150

Potential Ophthalmological Application of Extracts Obtained from Tuna Vitreous Humor Using Lactic Acid-Based Deep Eutectic Systems

Autores: Maha Abdallah, Inês C. Leonardo, Luna Krstić, Amalia Enríquez-de-Salamanca, Yolanda Diebold, Maria J. González-García, Frédéric B. Gaspar, Ana A. Matias, Maria do Rosário Bronze and Naiara Fernández
Publicado en: Foods, Edición 11/3, 2022, Página(s) 342, ISSN 2304-8158
Editor: MDPI
DOI: 10.3390/foods11030342

Physicochemical Characterization and Simulation of the Solid–Liquid Equilibrium Phase Diagram of Terpene-Based Eutectic Solvent Systems

Autores: Maha M. Abdallah, Simon Müller, Andrés González de Castilla, Pavel Gurikov, Ana A. Matias, Maria do Rosário Bronze, Naiara Fernández
Publicado en: Molecules, Edición 26/6, 2021, Página(s) 1801, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26061801

Understanding dexamethasone kinetics in the rabbit tear fluid: Drug release and clearance from solution, suspension and hydrogel formulations

Autores: Anusha Balla, Marika Ruponen, Annika Valtari, Elisa Toropainen, Marjo Tuomainen, Carmen Alvarez-Lorenzo, Eva M. del Amo, Arto Urtti and Kati-Sisko Vellonen
Publicado en: European Journal of Pharmaceutics and Biopharmaceutics, Edición Vol.172, 2022, Página(s) 53-60, ISSN 0939-6411
Editor: Elsevier BV
DOI: 10.1016/j.ejpb.2022.01.005

Pressurized Liquid Extraction Optimization from Supercritical Defatted Olive Pomace: A Green and Selective Phenolic Extraction Process

Autores: Nikolaos Katsinas, Andreia Bento da Silva, Amalia Enríquez-de-Salamanca, Naiara Fernández, Maria Rosário Bronze, Soraya Rodríguez-Rojo
Publicado en: ACS Sustainable Chemistry & Engineering, 2021, ISSN 2168-0485
Editor: American Chemical Society
DOI: 10.1021/acssuschemeng.0c09426

Partitioning and Spatial Distribution of Drugs in Ocular Surface Tissues

Autores: Anusha Balla, Seppo Auriola, Angus C. Grey, Nicholas J. Demarais, Annika Valtari, Emma M. Heikkinen, Elisa Toropainen, Arto Urtti, Kati-Sisko Vellonen, Marika Ruponen
Publicado en: Pharmaceutics, Edición 13/5, 2021, Página(s) 658, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13050658

Resultado final

Publicaciones

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