Integrated Training in Dry Eye Disease Drug Development (IT-DED3)

Livrables

All ESRs are recruited at this timepoint

Awarding of doctoral degrees (this is foreseen by month 54)

Report on closing symposium
Report on dissemination activities
Install communication plan
Report on exploitation results

Set-up website and social media pages

Publications

Hyaluronic acid and Chondroitin sulfate from marine and terrestrial sources: Extraction and purification methods

Auteurs: Maha M. Abdallah, Naiara Fernández, Ana A. Matias, Maria do Rosário Bronze
Publié dans: Carbohydrate Polymers, Numéro 243, 2020, Page(s) 116441, ISSN 0144-8617
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.carbpol.2020.116441

Lactic Acid-Based Natural Deep Eutectic Solvents to Extract Bioactives from Marine By-Products

Auteurs: Maha M. Abdallah; Martim Cardeira; Ana A. Matias; Maria Rosário Bronze; Naiara Fernández
Publié dans: Molecules, Numéro 14203049, 2022, Page(s) 4356, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27144356

Topical treatment with a mu opioid receptor agonist alleviates corneal allodynia and corneal nerve sensitization in mice

Auteurs: Fanny Joubert, Adrian Guerrero-Moreno, Darine Fakih, Elodie Reboussin, Claire Gaveriaux-Ruff, Maria Carmen Acosta, Juana Gallar, José Alain Sahel, Laurence Bodineau, Christophe Baudouin, William Rostène, Stéphane Mélik-Parsadaniantz, Annabelle Réaux-Le Goazigo
Publié dans: Biomedicine & Pharmacotherapy, Numéro 132, 2020, Page(s) 110794, ISSN 0753-3322
Éditeur: Elsevier Masson
DOI: 10.1016/j.biopha.2020.110794

Improved Ocular Delivery of Quercetin and Resveratrol: A Comparative Study Between Binary and Ternary Cyclodextrin Complexes

Auteurs: Luna Krstić, Pekka Jarho, Marika Ruponen, Arto Urtti, María J. González-García and Yolanda Diebold
Publié dans: International Journal of Pharmaceutics, Numéro 122028, 2022, ISSN 0378-5173
Éditeur: Elsevier BV
DOI: 10.1016/j.ijpharm.2022.122028

Ocular Delivery of Polyphenols: Meeting the Unmet Needs

Auteurs: Luna Krstić, María J. González-García, Yolanda Diebold
Publié dans: Molecules, Numéro 26/2, 2021, Page(s) 370, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26020370

Morphological and Functional Changes of Corneal Nerves and Their Contribution to Peripheral and Central Sensory Abnormalities

Auteurs: Adrian Guerrero-Moreno, Christophe Baudouin, Stéphane Melik Parsadaniantz, Annabelle Réaux-Le Goazigo
Publié dans: Frontiers in Cellular Neuroscience, Numéro 14, 2020, ISSN 1662-5102
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fncel.2020.610342

Capsazepine decreases corneal pain syndrome in severe dry eye disease

Auteurs: Darine Fakih, Adrian Guerrero-Moreno, Christophe Baudouin, Annabelle Réaux-Le Goazigo, Stéphane Mélik Parsadaniantz
Publié dans: Journal of Neuroinflammation, Numéro 18/1, 2021, ISSN 1742-2094
Éditeur: BioMed Central
DOI: 10.1186/s12974-021-02162-7

One-pot synthesis of α-aminophosphonates by yttrium-catalyzed Birum–Oleksyszyn reaction

Auteurs: Davide Ceradini and Kirill Shubin
Publié dans: RSC Advance, Numéro 11, 39147, 2021, Page(s) 39147–39152, ISSN 2046-2069
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d1ra07718j

Improved Synthesis of the Selected Serine Protease uPA Inhibitor UAMC-00050, a Lead Compound for the Treatment of Dry Eye Disease

Auteurs: Davide Ceradini, Pavel Cacivkins, Alba Ramos-Llorca, and Kirill Shubin
Publié dans: Organic Process Research & Development, Numéro 10836160, 2022, ISSN 1083-6160
Éditeur: American Chemical Society
DOI: 10.1021/acs.oprd.2c00244

Deep learning-based automatic meibomian gland segmentation and morphology assessment in infrared meibography

Auteurs: Md Asif Khan Setu, Jens Horstmann, Stefan Schmidt, Michael E. Stern, Philipp Steven
Publié dans: Scientific Reports, Numéro 11/1, 2021, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-021-87314-8

Segmentation and Evaluation of Corneal Nerves and Dendritic Cells From In Vivo Confocal Microscopy Images Using Deep Learning

Auteurs: Md Asif Khan Setu; Stefan Schmidt; Gwen Musial; Michael E. Stern; Philipp Steven
Publié dans: Translational Vision Science & Technology (TVST), Numéro Volume 11, Numéro 6, 2022, ISSN 2164-2591
Éditeur: ARVO
DOI: 10.1167/tvst.11.6.24

Proteomic Analysis of Tears and Conjunctival Cells Collected with Schirmer Strips Using timsTOF Pro: Preanalytical Considerations

Auteurs: Murat Akkurt Arslan, Ioannis Kolman, Cédric Pionneau, Solenne Chardonnet, Romain Magny, Christophe Baudouin, Françoise Brignole-Baudouin and Karima Kessal
Publié dans: Metabolites 2022, Numéro 12(1), 2, 2021, Page(s) Section Cell Metabolism, ISSN 2218-1989
Éditeur: MDPI
DOI: 10.3390/metabo12010002

Olive Pomace Phenolic Compounds: From an Agro-Industrial By-Product to a Promising Ocular Surface Protection for Dry Eye Disease

Auteurs: Nikolaos Katsinas, Uta Gehlsen, Laura García-Posadas, Soraya Rodríguez-Rojo, Philipp Steven, María J. González-García and Amalia Enríquez-de-Salamanca.
Publié dans: Journal of Clinical Medicine, Numéro 11(16), 2022, ISSN 2077-0383
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm11164703

Corneal Nerve Abnormalities in Painful Dry Eye Disease Patients

Auteurs: Adrian Guerrero-Moreno, Hong Liang, Nathan Moreau, Jade Luzu, Ghislaine Rabut, Stéphane Melik Parsadaniantz, Antoine Labbé, Christophe Baudouin, Annabelle Réaux-Le Goazigo
Publié dans: Biomedicines, Numéro 9/10, 2021, Page(s) 1424, ISSN 2227-9059
Éditeur: MDPI
DOI: 10.3390/biomedicines9101424

Proteases and Their Potential Role as Biomarkers and Drug Targets in Dry Eye Disease and Ocular Surface Dysfunction

Auteurs: Alba Ramos-Llorca,Camilla Scarpellini, and Koen Augustyns
Publié dans: International Journal of Molecular Sciences, Numéro 23(17), 2022, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23179795

Topical application of cannabinoid-ligands ameliorates experimental dry-eye disease

Auteurs: Bao N. Tran, Martina Maass, GwenMusial, Michael E. Stern, Uta Gehlsen, Philipp Steven
Publié dans: The Ocular Surface, 2021, ISSN 1542-0124
Éditeur: Ethis Communications
DOI: 10.1016/j.jtos.2021.12.008

Olive Pomace Phenolic Compounds Stability and Safety Evaluation: From Raw Material to Future Ophthalmic Applications

Auteurs: Nikolaos Katsinas, Amalia Enríquez-de-Salamanca, Andreia Bento da Silva, Maria Rosário Bronze, Soraya Rodríguez-Rojo
Publié dans: Molecules, Numéro 26/19, 2021, Page(s) 6002, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26196002

Olive Pomace Phenolic Compounds and Extracts Can Inhibit Inflammatory- and Oxidative-Related Diseases of Human Ocular Surface Epithelium

Auteurs: Nikolaos Katsinas, Soraya Rodríguez-Rojo, Amalia Enríquez-de-Salamanca
Publié dans: Antioxidants, Numéro 10/7, 2021, Page(s) 1150, ISSN 2076-3921
Éditeur: MDPI
DOI: 10.3390/antiox10071150

Potential Ophthalmological Application of Extracts Obtained from Tuna Vitreous Humor Using Lactic Acid-Based Deep Eutectic Systems

Auteurs: Maha Abdallah, Inês C. Leonardo, Luna Krstić, Amalia Enríquez-de-Salamanca, Yolanda Diebold, Maria J. González-García, Frédéric B. Gaspar, Ana A. Matias, Maria do Rosário Bronze and Naiara Fernández
Publié dans: Foods, Numéro 11/3, 2022, Page(s) 342, ISSN 2304-8158
Éditeur: MDPI
DOI: 10.3390/foods11030342

Physicochemical Characterization and Simulation of the Solid–Liquid Equilibrium Phase Diagram of Terpene-Based Eutectic Solvent Systems

Auteurs: Maha M. Abdallah, Simon Müller, Andrés González de Castilla, Pavel Gurikov, Ana A. Matias, Maria do Rosário Bronze, Naiara Fernández
Publié dans: Molecules, Numéro 26/6, 2021, Page(s) 1801, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26061801

Understanding dexamethasone kinetics in the rabbit tear fluid: Drug release and clearance from solution, suspension and hydrogel formulations

Auteurs: Anusha Balla, Marika Ruponen, Annika Valtari, Elisa Toropainen, Marjo Tuomainen, Carmen Alvarez-Lorenzo, Eva M. del Amo, Arto Urtti and Kati-Sisko Vellonen
Publié dans: European Journal of Pharmaceutics and Biopharmaceutics, Numéro Vol.172, 2022, Page(s) 53-60, ISSN 0939-6411
Éditeur: Elsevier BV
DOI: 10.1016/j.ejpb.2022.01.005

Pressurized Liquid Extraction Optimization from Supercritical Defatted Olive Pomace: A Green and Selective Phenolic Extraction Process

Auteurs: Nikolaos Katsinas, Andreia Bento da Silva, Amalia Enríquez-de-Salamanca, Naiara Fernández, Maria Rosário Bronze, Soraya Rodríguez-Rojo
Publié dans: ACS Sustainable Chemistry & Engineering, 2021, ISSN 2168-0485
Éditeur: American Chemical Society
DOI: 10.1021/acssuschemeng.0c09426

Partitioning and Spatial Distribution of Drugs in Ocular Surface Tissues

Auteurs: Anusha Balla, Seppo Auriola, Angus C. Grey, Nicholas J. Demarais, Annika Valtari, Emma M. Heikkinen, Elisa Toropainen, Arto Urtti, Kati-Sisko Vellonen, Marika Ruponen
Publié dans: Pharmaceutics, Numéro 13/5, 2021, Page(s) 658, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13050658

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