Skip to main content

Targeting the metabolism-immune system connections in Cancer

Objective

"Cancer cells show common features of profound metabolic changes and escape from the immune system, independently of their tissue of origin. These metabolic adaptations are not limited to glucose metabolism (the ""Warburg effect"") but are more general and affect several metabolic pathways in cancer cells as well as in the stroma, including immune cells. This network will explore how nutrients and hypoxia regulate the tumor-immune system interplay, and how this communication is controlled by oncogenes, metabolic regulators and current or potential drugs targeting metabolism.
Understanding how metabolism can affect tumor cells and the anti-cancer immune response represents a potential therapeutic intervention point that can be exploited to develop novel therapies and new diagnostic and prognostic markers. The development of therapies targeting cancer metabolism is hampered by: 1) the complexity of the regulation that metabolism exerts on many different tumor layers, which requires multidisciplinary collaborations, and 2) the shortage of scientists that can navigate with ease between academic, industrial and clinical sectors and have the scientific and complementary skills to convert research findings into commercial and clinical applications.
This network provides a pan-European interdisciplinary and intersectoral training program of excellence bringing young researchers together with World leading academics, clinicians, pharma industry members, corporate research and dissemination and outreach specialists. As part of the research training, the consortium will conduct a coherent and integrated set of hypothesis-driven research projects that are aimed at discovering, describing and exploiting how metabolism at the cell and the whole body levels is integrated with modulation of cell death susceptibility and the immune response in the context of cancer.
"

Call for proposal

H2020-MSCA-ITN-2017
See other projects for this call

Coordinator

FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE
Address
Avenida Gran Via Hospitalet 199-203
08908 L'hospitalet De Llobregat
Spain
Activity type
Research Organisations
EU contribution
€ 743 618,88

Participants (12)

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM

Participation ended

Netherlands
EU contribution
€ 0
Address
Meibergdreef 15
1105AZ Amsterdam
Activity type
Higher or Secondary Education Establishments
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS

Participation ended

France
EU contribution
€ 0
Address
3 Avenue Victoria
75000 Paris
Activity type
Research Organisations
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 525 751,20
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
VIB VZW
Belgium
EU contribution
€ 501 120
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Activity type
Research Organisations
TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY

Participation ended

Israel
EU contribution
€ 0
Address
Senate Building Technion City
32000 Haifa
Activity type
Higher or Secondary Education Establishments
MEDIZINISCHE UNIVERSITAET WIEN
Austria
EU contribution
€ 511 868,16
Address
Spitalgasse 23
1090 Wien
Activity type
Higher or Secondary Education Establishments
IBM ISRAEL - SCIENCE AND TECHNOLOGY LTD

Participation ended

Israel
EU contribution
€ 65 075,13
Address
94 Derech Em-hamoshavot
49527 Petach Tikva
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
APPLIED RESEARCH USING OMIC SCIENCES SL
Spain
EU contribution
€ 247 872,96
Address
C Baldiri Reixac 15
08028 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EVOTEC (FRANCE) SAS
France
EU contribution
€ 262 875,60
Address
195 Route D'espagne
31036 Toulouse Cedex
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITE DE PARIS
France
EU contribution
€ 262 875,60
Address
85 Bd Saint Germain
75006 Paris
Activity type
Higher or Secondary Education Establishments
TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD
Israel
EU contribution
€ 455 525,91
Address
The Senate Building Technion City 1
32000 Haifa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
AMC MEDICAL RESEARCH BV
Netherlands
EU contribution
€ 255 374,28
Address
Meibergdreef 9
1105AZ Amsterdam Zuidoost
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (7)

Seahorse Bio (Agilent Technologies)
United States
Address

North Billerica
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Canceropole PACA
France
Address

Marseille
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BIOcomuniCAT
Spain
Address

Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
HOSPITAL SANT JOAN DE DÉU
Spain
Address
Paseo Sant Joan De Deu 2
08950 Esplugues De Llobregat
Activity type
Research Organisations
BOEHRINGER INGELHEIM RCV GMBH & CO KG
Austria
Address
Dr Boehringer Gasse 5-11
1121 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FUNDACION ESADE
Spain
Address
Avenida Pedralbes 60-62
08034 Barcelona
Activity type
Higher or Secondary Education Establishments
The FEBS Journal (FEBS)
United Kingdom
Address

Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)