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Targeting the metabolism-immune system connections in Cancer

Objective

"Cancer cells show common features of profound metabolic changes and escape from the immune system, independently of their tissue of origin. These metabolic adaptations are not limited to glucose metabolism (the ""Warburg effect"") but are more general and affect several metabolic pathways in cancer cells as well as in the stroma, including immune cells. This network will explore how nutrients and hypoxia regulate the tumor-immune system interplay, and how this communication is controlled by oncogenes, metabolic regulators and current or potential drugs targeting metabolism.
Understanding how metabolism can affect tumor cells and the anti-cancer immune response represents a potential therapeutic intervention point that can be exploited to develop novel therapies and new diagnostic and prognostic markers. The development of therapies targeting cancer metabolism is hampered by: 1) the complexity of the regulation that metabolism exerts on many different tumor layers, which requires multidisciplinary collaborations, and 2) the shortage of scientists that can navigate with ease between academic, industrial and clinical sectors and have the scientific and complementary skills to convert research findings into commercial and clinical applications.
This network provides a pan-European interdisciplinary and intersectoral training program of excellence bringing young researchers together with World leading academics, clinicians, pharma industry members, corporate research and dissemination and outreach specialists. As part of the research training, the consortium will conduct a coherent and integrated set of hypothesis-driven research projects that are aimed at discovering, describing and exploiting how metabolism at the cell and the whole body levels is integrated with modulation of cell death susceptibility and the immune response in the context of cancer.
"

Coordinator

FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE
Net EU contribution
€ 743 618,88
Address
Avenida Gran Via Hospitalet 199-203
08908 L'hospitalet De Llobregat
Spain

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Participants (12)

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM

Participation ended

Netherlands
Net EU contribution
€ 0,00
Address
Meibergdreef 15
1105AZ Amsterdam

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Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS

Participation ended

France
Net EU contribution
€ 0,00
Address
3 Avenue Victoria
75000 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Net EU contribution
€ 525 751,20
Address
Rue De Tolbiac 101
75654 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
VIB VZW
Belgium
Net EU contribution
€ 501 120,00
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent

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Region
Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent
Activity type
Research Organisations
Non-EU contribution
€ 0,00
TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY

Participation ended

Israel
Net EU contribution
€ 0,00
Address
Senate Building Technion City
32000 Haifa

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
MEDIZINISCHE UNIVERSITAET WIEN
Austria
Net EU contribution
€ 511 868,16
Address
Spitalgasse 23
1090 Wien

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Region
Wien Wien
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
IBM ISRAEL - SCIENCE AND TECHNOLOGY LTD

Participation ended

Israel
Net EU contribution
€ 65 075,13
Address
94 Derech Em-hamoshavot
49527 Petach Tikva

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
APPLIED RESEARCH USING OMIC SCIENCES SL
Spain
Net EU contribution
€ 247 872,96
Address
C Baldiri Reixac 15
08028 Barcelona

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Este Cataluña Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
EVOTEC (FRANCE) SAS
France
Net EU contribution
€ 262 875,60
Address
195 Route D'espagne
31036 Toulouse Cedex

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Region
Occitanie Midi-Pyrénées Haute-Garonne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
UNIVERSITE PARIS CITE
France
Net EU contribution
€ 262 875,60
Address
85 Bd Saint Germain
75006 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD
Israel
Net EU contribution
€ 455 525,91
Address
The Senate Building Technion City 1
32000 Haifa

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
AMC MEDICAL RESEARCH BV
Netherlands
Net EU contribution
€ 255 374,28
Address
Meibergdreef 9
1105AZ Amsterdam Zuidoost

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Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00

Partners (7)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

Seahorse Bio (Agilent Technologies)
United States
Net EU contribution
€ 0,00
Address

North Billerica

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

Canceropole PACA
France
Net EU contribution
€ 0,00
Address

Marseille

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

BIOcomuniCAT
Spain
Net EU contribution
€ 0,00
Address

Barcelona

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

HOSPITAL SANT JOAN DE DÉU
Spain
Net EU contribution
€ 0,00
Address
Paseo Sant Joan De Deu 2
08950 Esplugues De Llobregat

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

BOEHRINGER INGELHEIM RCV GMBH & CO KG
Austria
Net EU contribution
€ 0,00
Address
Dr Boehringer Gasse 5-11
1121 Wien

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Region
Wien Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

FUNDACION ESADE
Spain
Net EU contribution
€ 0,00
Address
Avenida Pedralbes 60-62
08034 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

The FEBS Journal (FEBS)
United Kingdom
Net EU contribution
€ 0,00
Address

Cambridge

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00