EXPLORING THE NEUROLOGICAL EXPOSOME

Deliverables

Report on online activities organization

This deliverable will report the online training activities organization (M9, M18, M27, M36, M45)

Report on the targeted in vivo assays
Leaflets

Leaflets of the project (M3 and M24)

Report on the multimedia environmental contamination modelling

This deliverable will report the results of the multimedia environmental contamination modelling

Report on the genome-wide profiling of the collected biosamples

This deliverable will report the genomewide profiling results of the collected biosamples

Report on the overall project methodology

This deliverable will outline the overall project methodology This will include the overall synthesis of the different scientific WPs aiming at providing the overall methodological approach of identifying the causal link between environmental exposure and neurodevelopmental disorders

Report on workshop outcome synthesis - overall WP5 methodology

This deliverable will summarize the training workshop outcomes on the overall WP5 methodology

Report on transcriptomics and metabolomics analysis of the collected biosamples

This deliverable will report the results of transcriptomics and metabolomics analysis of the collected biosamples

Biostatistics methods for genomic- environment wide associations

This deliverble will report big data analytics methods for genomeenvironmentwide associations with adverse health outcomes

Training material on S/T and soft skills

Training material on S/T and soft skills (M6, M10, M14, M18, M45)

Syllabus for structured training courses

This deliverable will report the syllabus for structured training courses

Report on synthesis workshop outcome - overall WP4 methodology

This deliverable will summarize the training workshop outcomes on the overall WP4 methodology

Report on the collation of HBM data and exposure biomarkers analysis

This deliverable will summarize HBM data collated and the results of the analysis of exposure biomarkers

Report on workshop outcome synthesis - overall WP6 methodology

This deliverable will summarize the training workshop outcomes on the overall WP6 methodology

Development of infrastructure for HBM (including omics) and environmental/exposure data assimilation

This deliverable will decribe the developed data infrastructure for HBM including omics and environmentalexposure data assimilation

Report on workshop outcome synthesis - overall WP7 methodology

This deliverable will summarize the training workshop outcomes on the overall WP7 methodology

Report on the targeted in vitro assays

This deliverable will report the targeted in vitro assays results

Report on the analysis of environmental samples from different media

This report summarizes the analysis of environmental samples from different media

Report on generic PBBK model taking into account mixtures interaction

This deliverable will describe the developed generic PBBK model which will take into account mixtures interaction

Report on the sensors and agent based modeling for exposure assessment

This deliverable will report results of the sensors and agent based modeling for exposure assessment

Report on the functional integration of different omics results using bioinformatics tools for the development of AOPs for neurodevelopmental disorders

This deliverable will report the functional integration of different omics results using bioinformatics tools for the development of AOPs for neurodevelopmental disorders

Newsletters

Project newsletters issued at M12, M24, M36

Website

Website of the projet

Application and selection process – overall recruitment
Final conference

This deliverable is the final project conference M54

Publications

Impact of Methylmercury and Other Heavy Metals Exposure on Neurocognitive Function in Children Aged 7 Years: Study Protocol of the Follow-up

Author(s): Vecchi Brumatti L, Rosolen V, Mariuz M, Piscianz E, Valencic E, Bin M, Athanasakis E, D'Adamo P, Fragkiadoulaki E, Calamandrei G, Dinçkol Ö, Barbone F, Ronfani L.
Published in: Journal of Epidemiology, 2021, ISSN 0917-5040
Publisher: Tokyo University of Agriculture
DOI: 10.2188/jea.je20190284

Demonstrating the use of a framework for risk-informed decisions with stakeholder engagement through case studies for NORM and nuclear legacy sites

Author(s): Konti´c Branko; Black Paul; French Simon; Paulley Alan; Zhu Ming; Yankovich Tamara; Webster Michael; Pepin Stephane; Bizjak Tine; Bohanec Marko
Published in: Journal of Radiological Protection, Issue 1, 2022, ISSN 0952-4746
Publisher: Institute of Physics Publishing
DOI: 10.1088/1361-6498/ac5816

Low-Level Lead Exposure During Development Differentially Affects Neurobehavioral responses in Male and Female Mouse Offspring: A Longitudinal Study

Author(s): Dinçkol Ö. Fuentes B., Tartaglione A.M., Pino A., Ricceri L., Calamandrei G
Published in: Neurotoxicology, 2022, ISSN 0161-813X
Publisher: Elsevier BV
DOI: 10.1016/j.neuro.2022.05.007

A systems toxicology approach to compare the heavy metal mixtures (Pb, As, MeHg) impact in neurodegenerative diseases

Author(s): Venkatanaidu Karri (PhD); Marta Schuhmacher Professor; Vikas Kumar (PhD)
Published in: Food and Chemical Toxicology, Issue 139, 2020, ISSN 0278-6915
Publisher: Elsevier BV
DOI: 10.1016/j.fct.2020.111257

Neurodevelopmental exposome: The effect of in utero co-exposure to heavy metals and phthalates on child neurodevelopment

Author(s): Denis A. Sarigiannis, Nafsika Papaioannou, Evangelos Handakas, Ourania Anesti, Kinga Polanska, Woijcek Hanke, Athanasios Salifoglou, Catherine Gabriel, Spyros Karakitsios
Published in: Environmental Research, Issue 197, 2021, ISSN 0013-9351
Publisher: Academic Press
DOI: 10.1016/j.envres.2021.110949

Changes of organochlorine compound concentrations in maternal serum during pregnancy and comparison to serum cord blood composition

Author(s): Eva Junqué; Sergi Garcia; María Ángeles Martínez; Joaquim Rovira; Marta Schuhmacher; Joan O. Grimalt
Published in: Environmental Research, Issue Vol.182, 2020, ISSN 0013-9351
Publisher: Academic Press
DOI: 10.1016/j.envres.2019.108994

Exposure of men and lactating women to environmental phenols, phthalates, and DINCH

Author(s): Agneta A. Runkel; Darja Mazej; Janja Snoj Tratnik; žiga Tkalec; Tina Kosjek; Milena Horvat
Published in: Chemosphere, Issue Volume 286, Part 3, 2022, ISSN 0045-6535
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.chemosphere.2021.131858

Urinary phthalate concentrations in the slovenian population: An attempt to exposure assessment of family units

Author(s): Agneta A. Runkel, Janja Snoj-Tratnik, Darja Mazej, Milena Horvat
Published in: Environmental Research, Issue 186, 2020, Page(s) 109548, ISSN 0013-9351
Publisher: Academic Press
DOI: 10.1016/j.envres.2020.109548

Practical Opportunities to Improve the Impact of Health Risk Assessment on Environmental and Public Health Decisions

Author(s): Bizjak, Tine; Kontić, Davor; Kontić, Branko
Published in: International Journal of Environmental Research and Public Health, Issue Vol. 19, 2022, ISSN 1661-7827
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijerph19074200

EDC-induced mechanisms of immunotoxicity: a systematic review

Author(s): Oscar Sabuz Vidal; Deepika Deepika; Marta Schuhmacher; Vikas Kumar
Published in: CRITICAL REVIEWS IN TOXICOLOGY, Issue VOL. 51, NO. 7, 2021, Page(s) 634–652, ISSN 1040-8444
Publisher: Taylor & Francis
DOI: 10.1080/10408444.2021.2009438

Risk Assessment of Perfluorooctane Sulfonate (PFOS) using Dynamic Age Dependent Physiologically based Pharmacokinetic Model (PBPK) across Human Lifetime

Author(s): Deepika Deepika, Raju Prasad Sharma, Marta Schuhmacher. Vikas Kumar
Published in: Environmental Research, Issue 199, 2021, ISSN 0013-9351
Publisher: Academic Press
DOI: 10.1016/j.envres.2021.111287

An Integrative Translational Framework for Chemical Induced Neurotoxicity- A Systematic Review

Author(s): Deepika Deepika, Raju Prasad Sharma, Marta Schuhmacher and Vikas Kumar
Published in: Critical Reviews in Toxicology, Issue VOL. 50, NO. 5, 2020, Page(s) 424–438, ISSN 1040-8444
Publisher: Taylor & Francis
DOI: 10.1080/10408444.2020.1763253

Organohalogens: A persisting burden in Slovenia?

Author(s): Agneta A. Runkel; Boštjan Križanec; Eva Lipičar; Mojca Baskar; Vesna Hrženjak; Zdenka Cencič Kodba; Lijana Kononenko; Tjaša Kanduč; Darja Mazej; Janja Snoj Tratnik; Milena Horvat
Published in: Environmental Research, Issue 198, 2021, ISSN 0013-9351
Publisher: Academic Press
DOI: 10.1016/j.envres.2021.111224

Impact of Contaminants on Microbiota: Linking the Gut–Brain Axis with Neurotoxicity

Author(s): Jordina Balaguer-Trias; Deepika Deepika; Marta Schuhmacher; Vikas Kumar
Published in: International Journal of Environmental Research and Public Health, Issue 19, 2022, ISSN 1661-7827
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijerph19031368

Auditing in addition to compliance monitoring: a way to improve public health

Author(s): Tine Bizjak, Branko Kontić
Published in: International Journal of Public Health, 2019, ISSN 1661-8556
Publisher: Birkhauser Verlag
DOI: 10.1007/s00038-019-01291-4

Mother-child transfer rates of organohalogen compounds up to four years of age

Author(s): Mercè Garí, Joan O. Grimalt, Esther Vizcaino, Adonina Tardón, Ana Fernández-Somoano
Published in: Environment International, Issue 133, 2019, Page(s) 105241, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2019.105241

Influence of maternal and sociodemographic characteristics on the accumulation of organohalogen compounds in Argentinian women. The EMASAR study

Author(s): Natalia Bravo, Solrunn Hansen, Inger Økland, Mercè Garí, Marisa V. Álvarez, Silvina Matiocevich, Jon-Øyvind Odland, Joan O. Grimalt
Published in: Environmental Research, Issue 158, 2017, Page(s) 759-767, ISSN 0013-9351
Publisher: Academic Press
DOI: 10.1016/j.envres.2017.07.033

Mother/child organophosphate and pyrethroid distributions

Author(s): Natalia Bravo, Joan O. Grimalt, Darja Mazej, Janja Snoj Tratnik, Dimosthenis Andreas Sarigiannis, Milena Horvat
Published in: Environment International, Issue 134, 2020, Page(s) 105264, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2019.105264

Origin of polycyclic aromatic hydrocarbons and other organic pollutants in the air particles of subway stations in Barcelona

Author(s): Barend L. van Drooge, Raimon M. Prats, Cristina Reche, MariCruz Minguillón, Xavier Querol, Joan O. Grimalt, Teresa Moreno
Published in: Science of The Total Environment, Issue 642, 2018, Page(s) 148-154, ISSN 0048-9697
Publisher: Elsevier BV
DOI: 10.1016/j.scitotenv.2018.06.032

Drivers of the accumulation of mercury and organochlorine pollutants in Mediterranean lean fish and dietary significance

Author(s): Eva Junqué, Mercè Garí, Rosa Maria Llull, Joan O. Grimalt
Published in: Science of The Total Environment, Issue 634, 2018, Page(s) 170-180, ISSN 0048-9697
Publisher: Elsevier BV
DOI: 10.1016/j.scitotenv.2018.03.335

Risk characterization of bisphenol-A in the Slovenian population starting from human biomonitoring data

Author(s): Dimosthenis A. Sarigiannis, Janja Snoj Tratnik, Darja Mazej, Tina Kosjek, Ester Heath, Milena Horvat, Ourania Anesti, Spyros P. Karakitsios
Published in: Environmental Research, Issue 170, 2019, Page(s) 293-300, ISSN 0013-9351
Publisher: Academic Press
DOI: 10.1016/j.envres.2018.12.056

Analysis of metabolites of organophosphate and pyrethroid pesticides in human urine from urban and agricultural populations (Catalonia and Galicia)

Author(s): Mercè Garí, Yolanda González-Quinteiro, Natalia Bravo, Joan O. Grimalt
Published in: Science of The Total Environment, Issue 622-623, 2018, Page(s) 526-533, ISSN 0048-9697
Publisher: Elsevier BV
DOI: 10.1016/j.scitotenv.2017.11.355

Influence of electronic cigarette vaping on the composition of indoor organic pollutants, particles, and exhaled breath of bystanders

Author(s): Barend L. van Drooge, Esther Marco, Noemi Perez, Joan O. Grimalt
Published in: Environmental Science and Pollution Research, Issue 26/5, 2019, Page(s) 4654-4666, ISSN 0944-1344
Publisher: Springer Verlag
DOI: 10.1007/s11356-018-3975-x

Urinary metabolites of organophosphate and pyrethroid pesticides in children from an Italian cohort (PHIME, Trieste)

Author(s): Natalia Bravo, Joan O. Grimalt, Beatrice Bocca, Anna Pino, Maura Bin, Liza Vecchi Brumatti, Valentina Rosolen, Fabio Barbone, Luca Ronfani, Alessandro Alimonti, Gemma Calamandrei
Published in: Environmental Research, Issue 176, 2019, Page(s) 108508, ISSN 0013-9351
Publisher: Academic Press
DOI: 10.1016/j.envres.2019.05.039

Drivers of maternal accumulation of organohalogen pollutants in Arctic areas (Chukotka, Russia) and 4,4′-DDT effects on the newborns

Author(s): Natalia Bravo, Joan O. Grimalt, Max Chashchin, Valery P. Chashchin, Jon-Øyvind Odland
Published in: Environment International, Issue 124, 2019, Page(s) 541-552, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2019.01.049

Atmospheric pattern of volatile organochlorine compounds and hexachlorobenzene in the surroundings of a chlor-alkali plant

Author(s): Barend L. van Drooge, Esther Marco, Joan O. Grimalt
Published in: Science of The Total Environment, Issue 628-629, 2018, Page(s) 782-790, ISSN 0048-9697
Publisher: Elsevier BV
DOI: 10.1016/j.scitotenv.2018.02.088

Organophosphate metabolite concentrations in maternal urine during pregnancy

Author(s): Natalia Bravo; Soraya Peralta; Joan O. Grimalt; Maria Ángeles Martínez; Joaquim Rovira; Marta Schuhmacher
Published in: Environmental Research, Issue 182, 2020, ISSN 0013-9351
Publisher: Academic Press
DOI: 10.1016/j.envres.2019.109003

Evaluating the success of Slovenia’s policy on the health of children and adolescents: results of an audit

Author(s): Tine Bizjak, Rok Novak, Marko Vudrag, Andreja Kukec, Branko Kontić
Published in: International Journal of Public Health, Issue 65/8, 2020, Page(s) 1225-1234, ISSN 1661-8556
Publisher: Birkhauser Verlag
DOI: 10.1007/s00038-020-01432-0

Multi-omics analysis reveals that co-exposure to phthalates and metals disturbs urea cycle and choline metabolism

Author(s): Nafsika Papaioannou, Emilie Distel, Eliandre de Oliveira, Catherine Gabriel, Ilias S. Frydas, Ourania Anesti, Eleonore A. Attignon, Antonia Odena, Ramon Díaz, Мartine Aggerbeck, Milena Horvat, Robert Barouki, Spyros Karakitsios,Denis A. Sarigiannis
Published in: Environmental Research, Issue 192, 2021, ISSN 0013-9351
Publisher: Academic Press
DOI: 10.1016/j.envres.2020.110041

Human Biomonitoring Data in Health Risk Assessments Published in Peer-Reviewed Journals between 2016 and 2021: Confronting Reality after a Preliminary Review

Author(s): Tine Bizjak; Marco Capodiferro; Deepika Deepika; Öykü Dinçkol; Vazha Dzhedzheia; Lorena Lopez-Suarez; Ioannis Petridis; Agneta A. Runkel; Dayna R. Schultz; Branko Kontić
Published in: International Journal of Environmental Research and Public Health, Issue 19, 2022, ISSN 1661-7827
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijerph19063362

Assessment of susceptibility to phthalate and DINCH exposure through CYP and UGT single nucleotide polymorphisms

Author(s): Anja Stajnko; Agneta Annika Runkel; Tina Kosjek; Janja Snoj Tratnik; Darja Mazej; Ingrid Falnoga; Milena Horvat
Published in: Environment International, Issue 159, 2022, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2021.107046

Developmental Neurotoxicity of Endocrine Disruptor Chemicals: A Challenge for Behavioral Toxicology

Author(s): Gemma Calamandrei, Laura Ricceri
Published in: Advances in Neurotoxicology, Issue Chapter 7, Volume 2, 2018, Page(s) 197-225, ISBN 978-0-12-815551-6
Publisher: Elsevier Inc.
DOI: 10.1016/bs.ant.2018.03.008

Integrated Translation Framework for Endocrine Disruptors in the Area of Computational Toxicology

Author(s): Kumar, V, Deepika Deepika, and R P Sharma
Published in: Challenges in Endocrine Disruptor Toxicology and Risk Assessment, Issue Chapter 4, 2021, ISBN 978-1-78801-741-1
Publisher: The Royal Society of Chemistry
DOI: 10.1039/9781839160738-00080

La nostra salut està ancorada en la de la mar

Author(s): JOAN O. GRIMALT, MARCO CAPODIFERRO, EVA JUNQUÉ, MERCÈ GARÍ
Published in: NATURA, ÚS O ABÚS? (2018-2019), 2020, ISBN 978-84-9965-457-7
Publisher: Institut d’Estudis Catalans
DOI: 10.2436/15.0110.22.6

Deliverables

Publications

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