EXPLORING THE NEUROLOGICAL EXPOSOME

Informations projet

NEUROSOME

N° de convention de subvention: 766251

DOI

10.3030/766251

Projet clôturé

Date de signature de la CE 29 Août 2017

Date de début 1 Octobre 2017

Date de fin 31 Mars 2022

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 3 427 305,06

Contribution de l’UE

€ 3 427 305,06

Coordonné par

ARISTOTELIO PANEPISTIMIO THESSALONIKIS
Greece

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (22)

Report on online activities organization

This deliverable will report the online training activities organization (M9, M18, M27, M36, M45)

Report on the targeted in vivo assays
Leaflets

Leaflets of the project (M3 and M24)

Report on the multimedia environmental contamination modelling

This deliverable will report the results of the multimedia environmental contamination modelling

Report on the genome-wide profiling of the collected biosamples

This deliverable will report the genomewide profiling results of the collected biosamples

Report on the overall project methodology

This deliverable will outline the overall project methodology This will include the overall synthesis of the different scientific WPs aiming at providing the overall methodological approach of identifying the causal link between environmental exposure and neurodevelopmental disorders

Report on workshop outcome synthesis - overall WP5 methodology

This deliverable will summarize the training workshop outcomes on the overall WP5 methodology

Report on transcriptomics and metabolomics analysis of the collected biosamples

This deliverable will report the results of transcriptomics and metabolomics analysis of the collected biosamples

Biostatistics methods for genomic- environment wide associations

This deliverble will report big data analytics methods for genomeenvironmentwide associations with adverse health outcomes

Training material on S/T and soft skills

Training material on S/T and soft skills (M6, M10, M14, M18, M45)

Syllabus for structured training courses

This deliverable will report the syllabus for structured training courses

Report on synthesis workshop outcome - overall WP4 methodology

This deliverable will summarize the training workshop outcomes on the overall WP4 methodology

Report on the collation of HBM data and exposure biomarkers analysis

This deliverable will summarize HBM data collated and the results of the analysis of exposure biomarkers

Report on workshop outcome synthesis - overall WP6 methodology

This deliverable will summarize the training workshop outcomes on the overall WP6 methodology

Development of infrastructure for HBM (including omics) and environmental/exposure data assimilation

This deliverable will decribe the developed data infrastructure for HBM including omics and environmentalexposure data assimilation

Report on workshop outcome synthesis - overall WP7 methodology

This deliverable will summarize the training workshop outcomes on the overall WP7 methodology

Report on the targeted in vitro assays

This deliverable will report the targeted in vitro assays results

Report on the analysis of environmental samples from different media

This report summarizes the analysis of environmental samples from different media

Report on generic PBBK model taking into account mixtures interaction

This deliverable will describe the developed generic PBBK model which will take into account mixtures interaction

Report on the sensors and agent based modeling for exposure assessment

This deliverable will report results of the sensors and agent based modeling for exposure assessment

Report on the functional integration of different omics results using bioinformatics tools for the development of AOPs for neurodevelopmental disorders

This deliverable will report the functional integration of different omics results using bioinformatics tools for the development of AOPs for neurodevelopmental disorders

Newsletters

Project newsletters issued at M12, M24, M36

Websites, patent fillings, videos etc. (1)

Website

Website of the projet

Other (2)

Application and selection process – overall recruitment
Final conference

This deliverable is the final project conference M54

Publications

Peer reviewed articles (31)

Impact of Methylmercury and Other Heavy Metals Exposure on Neurocognitive Function in Children Aged 7 Years: Study Protocol of the Follow-up

Auteurs: Vecchi Brumatti L, Rosolen V, Mariuz M, Piscianz E, Valencic E, Bin M, Athanasakis E, D'Adamo P, Fragkiadoulaki E, Calamandrei G, Dinçkol Ö, Barbone F, Ronfani L.
Publié dans: Journal of Epidemiology, 2021, ISSN 0917-5040
Éditeur: Tokyo University of Agriculture
DOI: 10.2188/jea.je20190284

Demonstrating the use of a framework for risk-informed decisions with stakeholder engagement through case studies for NORM and nuclear legacy sites

Auteurs: Konti´c Branko; Black Paul; French Simon; Paulley Alan; Zhu Ming; Yankovich Tamara; Webster Michael; Pepin Stephane; Bizjak Tine; Bohanec Marko
Publié dans: Journal of Radiological Protection, Numéro 1, 2022, ISSN 0952-4746
Éditeur: Institute of Physics Publishing
DOI: 10.1088/1361-6498/ac5816

Low-Level Lead Exposure During Development Differentially Affects Neurobehavioral responses in Male and Female Mouse Offspring: A Longitudinal Study

Auteurs: Dinçkol Ö. Fuentes B., Tartaglione A.M., Pino A., Ricceri L., Calamandrei G
Publié dans: Neurotoxicology, 2022, ISSN 0161-813X
Éditeur: Elsevier BV
DOI: 10.1016/j.neuro.2022.05.007

A systems toxicology approach to compare the heavy metal mixtures (Pb, As, MeHg) impact in neurodegenerative diseases

Auteurs: Venkatanaidu Karri (PhD); Marta Schuhmacher Professor; Vikas Kumar (PhD)
Publié dans: Food and Chemical Toxicology, Numéro 139, 2020, ISSN 0278-6915
Éditeur: Elsevier BV
DOI: 10.1016/j.fct.2020.111257

Neurodevelopmental exposome: The effect of in utero co-exposure to heavy metals and phthalates on child neurodevelopment

Auteurs: Denis A. Sarigiannis, Nafsika Papaioannou, Evangelos Handakas, Ourania Anesti, Kinga Polanska, Woijcek Hanke, Athanasios Salifoglou, Catherine Gabriel, Spyros Karakitsios
Publié dans: Environmental Research, Numéro 197, 2021, ISSN 0013-9351
Éditeur: Academic Press
DOI: 10.1016/j.envres.2021.110949

Changes of organochlorine compound concentrations in maternal serum during pregnancy and comparison to serum cord blood composition

Auteurs: Eva Junqué; Sergi Garcia; María Ángeles Martínez; Joaquim Rovira; Marta Schuhmacher; Joan O. Grimalt
Publié dans: Environmental Research, Numéro Vol.182, 2020, ISSN 0013-9351
Éditeur: Academic Press
DOI: 10.1016/j.envres.2019.108994

Exposure of men and lactating women to environmental phenols, phthalates, and DINCH

Auteurs: Agneta A. Runkel; Darja Mazej; Janja Snoj Tratnik; žiga Tkalec; Tina Kosjek; Milena Horvat
Publié dans: Chemosphere, Numéro Volume 286, Part 3, 2022, ISSN 0045-6535
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.chemosphere.2021.131858

Urinary phthalate concentrations in the slovenian population: An attempt to exposure assessment of family units

Auteurs: Agneta A. Runkel, Janja Snoj-Tratnik, Darja Mazej, Milena Horvat
Publié dans: Environmental Research, Numéro 186, 2020, Page(s) 109548, ISSN 0013-9351
Éditeur: Academic Press
DOI: 10.1016/j.envres.2020.109548

Practical Opportunities to Improve the Impact of Health Risk Assessment on Environmental and Public Health Decisions

Auteurs: Bizjak, Tine; Kontić, Davor; Kontić, Branko
Publié dans: International Journal of Environmental Research and Public Health, Numéro Vol. 19, 2022, ISSN 1661-7827
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijerph19074200

EDC-induced mechanisms of immunotoxicity: a systematic review

Auteurs: Oscar Sabuz Vidal; Deepika Deepika; Marta Schuhmacher; Vikas Kumar
Publié dans: CRITICAL REVIEWS IN TOXICOLOGY, Numéro VOL. 51, NO. 7, 2021, Page(s) 634–652, ISSN 1040-8444
Éditeur: Taylor & Francis
DOI: 10.1080/10408444.2021.2009438

Risk Assessment of Perfluorooctane Sulfonate (PFOS) using Dynamic Age Dependent Physiologically based Pharmacokinetic Model (PBPK) across Human Lifetime

Auteurs: Deepika Deepika, Raju Prasad Sharma, Marta Schuhmacher. Vikas Kumar
Publié dans: Environmental Research, Numéro 199, 2021, ISSN 0013-9351
Éditeur: Academic Press
DOI: 10.1016/j.envres.2021.111287

An Integrative Translational Framework for Chemical Induced Neurotoxicity- A Systematic Review

Auteurs: Deepika Deepika, Raju Prasad Sharma, Marta Schuhmacher and Vikas Kumar
Publié dans: Critical Reviews in Toxicology, Numéro VOL. 50, NO. 5, 2020, Page(s) 424–438, ISSN 1040-8444
Éditeur: Taylor & Francis
DOI: 10.1080/10408444.2020.1763253

Organohalogens: A persisting burden in Slovenia?

Auteurs: Agneta A. Runkel; Boštjan Križanec; Eva Lipičar; Mojca Baskar; Vesna Hrženjak; Zdenka Cencič Kodba; Lijana Kononenko; Tjaša Kanduč; Darja Mazej; Janja Snoj Tratnik; Milena Horvat
Publié dans: Environmental Research, Numéro 198, 2021, ISSN 0013-9351
Éditeur: Academic Press
DOI: 10.1016/j.envres.2021.111224

Impact of Contaminants on Microbiota: Linking the Gut–Brain Axis with Neurotoxicity

Auteurs: Jordina Balaguer-Trias; Deepika Deepika; Marta Schuhmacher; Vikas Kumar
Publié dans: International Journal of Environmental Research and Public Health, Numéro 19, 2022, ISSN 1661-7827
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijerph19031368

Auditing in addition to compliance monitoring: a way to improve public health

Auteurs: Tine Bizjak, Branko Kontić
Publié dans: International Journal of Public Health, 2019, ISSN 1661-8556
Éditeur: Birkhauser Verlag
DOI: 10.1007/s00038-019-01291-4

Mother-child transfer rates of organohalogen compounds up to four years of age

Auteurs: Mercè Garí, Joan O. Grimalt, Esther Vizcaino, Adonina Tardón, Ana Fernández-Somoano
Publié dans: Environment International, Numéro 133, 2019, Page(s) 105241, ISSN 0160-4120
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2019.105241

Influence of maternal and sociodemographic characteristics on the accumulation of organohalogen compounds in Argentinian women. The EMASAR study

Auteurs: Natalia Bravo, Solrunn Hansen, Inger Økland, Mercè Garí, Marisa V. Álvarez, Silvina Matiocevich, Jon-Øyvind Odland, Joan O. Grimalt
Publié dans: Environmental Research, Numéro 158, 2017, Page(s) 759-767, ISSN 0013-9351
Éditeur: Academic Press
DOI: 10.1016/j.envres.2017.07.033

Mother/child organophosphate and pyrethroid distributions

Auteurs: Natalia Bravo, Joan O. Grimalt, Darja Mazej, Janja Snoj Tratnik, Dimosthenis Andreas Sarigiannis, Milena Horvat
Publié dans: Environment International, Numéro 134, 2020, Page(s) 105264, ISSN 0160-4120
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2019.105264

Origin of polycyclic aromatic hydrocarbons and other organic pollutants in the air particles of subway stations in Barcelona

Auteurs: Barend L. van Drooge, Raimon M. Prats, Cristina Reche, MariCruz Minguillón, Xavier Querol, Joan O. Grimalt, Teresa Moreno
Publié dans: Science of The Total Environment, Numéro 642, 2018, Page(s) 148-154, ISSN 0048-9697
Éditeur: Elsevier BV
DOI: 10.1016/j.scitotenv.2018.06.032

Drivers of the accumulation of mercury and organochlorine pollutants in Mediterranean lean fish and dietary significance

Auteurs: Eva Junqué, Mercè Garí, Rosa Maria Llull, Joan O. Grimalt
Publié dans: Science of The Total Environment, Numéro 634, 2018, Page(s) 170-180, ISSN 0048-9697
Éditeur: Elsevier BV
DOI: 10.1016/j.scitotenv.2018.03.335

Risk characterization of bisphenol-A in the Slovenian population starting from human biomonitoring data

Auteurs: Dimosthenis A. Sarigiannis, Janja Snoj Tratnik, Darja Mazej, Tina Kosjek, Ester Heath, Milena Horvat, Ourania Anesti, Spyros P. Karakitsios
Publié dans: Environmental Research, Numéro 170, 2019, Page(s) 293-300, ISSN 0013-9351
Éditeur: Academic Press
DOI: 10.1016/j.envres.2018.12.056

Analysis of metabolites of organophosphate and pyrethroid pesticides in human urine from urban and agricultural populations (Catalonia and Galicia)

Auteurs: Mercè Garí, Yolanda González-Quinteiro, Natalia Bravo, Joan O. Grimalt
Publié dans: Science of The Total Environment, Numéro 622-623, 2018, Page(s) 526-533, ISSN 0048-9697
Éditeur: Elsevier BV
DOI: 10.1016/j.scitotenv.2017.11.355

Influence of electronic cigarette vaping on the composition of indoor organic pollutants, particles, and exhaled breath of bystanders

Auteurs: Barend L. van Drooge, Esther Marco, Noemi Perez, Joan O. Grimalt
Publié dans: Environmental Science and Pollution Research, Numéro 26/5, 2019, Page(s) 4654-4666, ISSN 0944-1344
Éditeur: Springer Verlag
DOI: 10.1007/s11356-018-3975-x

Urinary metabolites of organophosphate and pyrethroid pesticides in children from an Italian cohort (PHIME, Trieste)

Auteurs: Natalia Bravo, Joan O. Grimalt, Beatrice Bocca, Anna Pino, Maura Bin, Liza Vecchi Brumatti, Valentina Rosolen, Fabio Barbone, Luca Ronfani, Alessandro Alimonti, Gemma Calamandrei
Publié dans: Environmental Research, Numéro 176, 2019, Page(s) 108508, ISSN 0013-9351
Éditeur: Academic Press
DOI: 10.1016/j.envres.2019.05.039

Drivers of maternal accumulation of organohalogen pollutants in Arctic areas (Chukotka, Russia) and 4,4′-DDT effects on the newborns

Auteurs: Natalia Bravo, Joan O. Grimalt, Max Chashchin, Valery P. Chashchin, Jon-Øyvind Odland
Publié dans: Environment International, Numéro 124, 2019, Page(s) 541-552, ISSN 0160-4120
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2019.01.049

Atmospheric pattern of volatile organochlorine compounds and hexachlorobenzene in the surroundings of a chlor-alkali plant

Auteurs: Barend L. van Drooge, Esther Marco, Joan O. Grimalt
Publié dans: Science of The Total Environment, Numéro 628-629, 2018, Page(s) 782-790, ISSN 0048-9697
Éditeur: Elsevier BV
DOI: 10.1016/j.scitotenv.2018.02.088

Organophosphate metabolite concentrations in maternal urine during pregnancy

Auteurs: Natalia Bravo; Soraya Peralta; Joan O. Grimalt; Maria Ángeles Martínez; Joaquim Rovira; Marta Schuhmacher
Publié dans: Environmental Research, Numéro 182, 2020, ISSN 0013-9351
Éditeur: Academic Press
DOI: 10.1016/j.envres.2019.109003

Evaluating the success of Slovenia’s policy on the health of children and adolescents: results of an audit

Auteurs: Tine Bizjak, Rok Novak, Marko Vudrag, Andreja Kukec, Branko Kontić
Publié dans: International Journal of Public Health, Numéro 65/8, 2020, Page(s) 1225-1234, ISSN 1661-8556
Éditeur: Birkhauser Verlag
DOI: 10.1007/s00038-020-01432-0

Multi-omics analysis reveals that co-exposure to phthalates and metals disturbs urea cycle and choline metabolism

Auteurs: Nafsika Papaioannou, Emilie Distel, Eliandre de Oliveira, Catherine Gabriel, Ilias S. Frydas, Ourania Anesti, Eleonore A. Attignon, Antonia Odena, Ramon Díaz, Мartine Aggerbeck, Milena Horvat, Robert Barouki, Spyros Karakitsios,Denis A. Sarigiannis
Publié dans: Environmental Research, Numéro 192, 2021, ISSN 0013-9351
Éditeur: Academic Press
DOI: 10.1016/j.envres.2020.110041

Human Biomonitoring Data in Health Risk Assessments Published in Peer-Reviewed Journals between 2016 and 2021: Confronting Reality after a Preliminary Review

Auteurs: Tine Bizjak; Marco Capodiferro; Deepika Deepika; Öykü Dinçkol; Vazha Dzhedzheia; Lorena Lopez-Suarez; Ioannis Petridis; Agneta A. Runkel; Dayna R. Schultz; Branko Kontić
Publié dans: International Journal of Environmental Research and Public Health, Numéro 19, 2022, ISSN 1661-7827
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijerph19063362

Assessment of susceptibility to phthalate and DINCH exposure through CYP and UGT single nucleotide polymorphisms

Auteurs: Anja Stajnko; Agneta Annika Runkel; Tina Kosjek; Janja Snoj Tratnik; Darja Mazej; Ingrid Falnoga; Milena Horvat
Publié dans: Environment International, Numéro 159, 2022, ISSN 0160-4120
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2021.107046

Book chapters (2)

Developmental Neurotoxicity of Endocrine Disruptor Chemicals: A Challenge for Behavioral Toxicology

Auteurs: Gemma Calamandrei, Laura Ricceri
Publié dans: Advances in Neurotoxicology, Numéro Chapter 7, Volume 2, 2018, Page(s) 197-225, ISBN 978-0-12-815551-6
Éditeur: Elsevier Inc.
DOI: 10.1016/bs.ant.2018.03.008

Integrated Translation Framework for Endocrine Disruptors in the Area of Computational Toxicology

Auteurs: Kumar, V, Deepika Deepika, and R P Sharma
Publié dans: Challenges in Endocrine Disruptor Toxicology and Risk Assessment, Numéro Chapter 4, 2021, ISBN 978-1-78801-741-1
Éditeur: The Royal Society of Chemistry
DOI: 10.1039/9781839160738-00080

Conference proceedings (1)

La nostra salut està ancorada en la de la mar

Auteurs: JOAN O. GRIMALT, MARCO CAPODIFERRO, EVA JUNQUÉ, MERCÈ GARÍ
Publié dans: NATURA, ÚS O ABÚS? (2018-2019), 2020, ISBN 978-84-9965-457-7
Éditeur: Institut d’Estudis Catalans
DOI: 10.2436/15.0110.22.6