Livrables
The history of technological innovations has demonstrated that the early developers hardly could foresee the various ways the technology would be used and implemented later on To open up all possible narratives of the future we want to invite artists in residency to come and learn in our labs about our mission and give them the opportunity to either carry out an artistic interventions or develop some creative new types of applications of the projects technology
Report on stakeholder involvementFor ellaboration of this report we will involve a number of peers and potential users of the technology such as scientists eg conservational biologists chemists biotechnologists geologists maybe even astrobiologists people form industry small medium and large corporations governance regulatory bodies international organisations like IPCC or CBD and representatives from civil society through workshops and interviews to provide a reality check for the proposed technology
Systems-guided catalogue of sites of intervention with agents delivering NTN reactionsA suite of mathematical and computational approaches ranging from phenomenological to mechanistic will be developed for revisiting the principles that govern the function dynamics and evolution of microbial ecosystems and what allows them to accept new members with novel biochemical properties The way towards topdown synthetic ecology will require new algorithms modeldriven analysis tools and gene function annotation
Report on transposon for converting any Gram-negative bacteria in an HFR strainThis will involve a transposon able to mobilize an entire chromosome though conjugation between a donor and a DNAless recipient For this all the mobtra genes involved in conjugal transfer of superpromiscuous plasmid RP4 will be retrieved from their original genetic frame and assembled as an artificial gene cluster in a miniTn5 transposon vector Upon aquisition of such a transposon any strain will acquire the ability of selftransference and therefore will behave as an HFR strain Highfrequency of recombination that will ease the passing of the genomic information among strains with different degrees of NTN reaction evolution
Proposition of containment needs for microbial agents bearing peribolic reactionsModeling approaches will be adopted to inspect the pluses and minuses of dealing with live —but heavily refactored microbial agents that could propagate through the Biosphere. This will help to determine the needs of containment of the agents at stake. This lower-scale models will help to understand the resilience and optimal yield conditions of designed microorganisms and microbial consortia and create in silico tests of the proposed peribolic reactions.
A merged model of biogeochemical, biological and industrial matter/energy flow in EarthThe concept of Industrial Metabolism traditionally refers in a metaphoric fashion to the physical traffic of material and energy resources through the economic systems as long as similarly to biological metabolism they are processed resulting into goods and waste We wish to go beyond mere metaphores and try to develop actual integrated models of matter and energy flows through the Biosphere and how they could be deliberately or accidentally altered by the introduction at various scales of the NTN reactions entertained in MADONNA and others that could be developed with the same technologies
Detailed report a genetically optimized artificial carboxylase based on evolved Sav isoformsThe reaction conditions that accompany desired carboxylase recations are often different from physiological conditions (defined as pH of approximately 7, aqueous environments, and ambient temperatures) and turnover numbers very low. In order to make such reaction sustainable and to ultimately recruit such reactions into biology, the protein scaffold has to be evolved. Therefore, we will develope an strategy to implement an enzyme engineering trajectory towards a highly efficient Sav-Pd-catalyst for the production of acrylic acid.
Automated generation of metalloenzymes and information capture through a fitness functionWe will take the reaction invented chemically (ie CO2 capture with a metalloenzyme) and and run it in the presence of cells using a chemical droplet robot in which the biological system is programmed to generate peptides that can chelate metal ions to generate ArMs that can be symbiotically selected by the system. This links process engineering to the fitness functions and allows the systems to be linked artificially using such a chem-o-biological robot. The link is software and spectroscopy with chemical feedback. The chemicals can acts as mutagens, and also act as selection agents on the peptides expressed.
Summary and impact of public communication activitiesGiven the fundamental nature of the scope of our project we feel the responsibility to also share this with the general public through a number of science communication formats eg series of short video clips dissemination though web and social media Science Cafe With these formats we do not only aim to inform the public but also to listen to their thoughts and feedback which will be collected consider and eventually be addressed by the project team to alow for a two way communication between science and the public
Responsible innovation. Report of ethics, safety and security tasksReconciliation of geochemical, biological and industrial/human induced global cycles will not only provide a sustainable way of producing and consuming, but will inevitably change the characteristic of the three cycles, diffusing and enlarging the limits of human intervention on the planet. In this report we will ask: what rationale (world view) is behind the projects aim and goal, what other rationales co-exist, which solutions do they provide? What are the ethical dimensions of going forward with the project versus continuing with the unsustainable business-as-usual.
Report on a genetically engineered artificial Fischer-Tropschase enzyme for reduction of CO/CO2 and its expression in vivoGiven that biotinfunctionalized catalysts can be anchored into a streptavidin scaffold this deliverable will report how biotinstreptavidin technology can be exploited selected for incorporation of the Fe4S4 cluster into the genetically encoded protein along with details on characterization of the cofactor and in silico docking studies of the Fe4S4cofactorstreptavidin complex
The aim here is to have the choice of destroying altogether the genetic material of E coli and P putida while preserving the whole of the biochemical networks For this the genes ungdut will be deleted and replaced by a tightly regulated ung dut bicistronic operon inducible upon exposure of cells to an external effector eg 3 methylbenzoate While the lack of ungdut will make many Ts of the genome being replaced by U residues their abrupt expression will cleave the chromosome at multiple sites thus converting the cells in a sort of chemical vesicle These will be excellent vessels to develop NTN reactions and as recipients of heavily mutated and edited artificial chromosomes
Morbidostat for heterotic computation of (bio)chemical problemsThis is about programming evolution by switching between certain combinations of nutrientssubstrates along with a simple deterministic model to compute evolution heterotically This system is an automated continuousculture device that controls substrate concentration to maintain constant growth inhibition The device runs at a certain interval and adds either fresh medium with a high substrate concentration 24dinitrotoluene DNT as the target molecule in our case or without it By giving it pulses of DNT and letting it recover we expect that the ROS produced by faulty reactions by suboptimal dioxygenases will diversify the corresponding DNA sequences until a biochemical solution is found
Genome edited strains of E. coli and P. putida entirely cyborgized for hosting NTN reactionsThe genomes of the two bacterial species adopted in this Project (E. colo and Pseudomonas putida) will be [i] erased of instability determinants and other genes encoding functions considered to be irrelevant for the sake of MADONNA and [ii] endowed with new traits to make them withstand the working conditions of the reactions of interest.
Robotic platform for reverse-reading of chemical reactions into DNAThe coding of DNA in the presence of the process will be reverseread into the system This needs us to generate artificial DNA sequences in the presence of the chemistry and also random peptide synthesis We will build a hybrid digital Complementary metaloxidesemiconductor CMOSdriven synthetic chemical platform to write DNA directly taking advantage of the speed and parallelism of CMOS aiming for GHz write rates on a single strand of DNA within a CMOS nanopore assembler and scale up using PCR this is the reverse of nanopore sequencing
Microdroplet-based environmental simulatorThis will be based on a fully autonomous chemical robot system that is able to generate random physicochemical inputs in microdroplet scale. The droplet behaviours will then be analysed, and ranked using a fitness function. This process is continued through iterated generations. This allows inspecting how the genotype is modulated through an envirotype to express the phenotype of interest.
This Deliverable implies the elaboration of an userfriendly webpage for Communication and Dissemination of Projects activities as well as for internal communication among MADONNA members
This will consist of a document specifying the formats to be followed by the partners for storing the data of interest in a joint repository as well as formal languages for description of actions and constructs
This is about application of complex networks theory to model new metabolic loops brought about by smallscale and largescale peribolism Meso and largescale models of ecosystems incorporating the NTN reactions set by MADONNA will be produced Our ecosystem description incorporates both standard habitats as well as the highenergy fuelpowered counterparts that are defined by large urban centres and industry By incorporating peribolism we will transform these type of wastesink components into new largescale chemical processes thus deeply changing the global dynamics To this goal we will develop a set of mathematical and computational tools that provide a rationale for the expected responses of this global metabolism on different scales
Publications
Auteurs:
Napiorkowska, M., Pestalozzi, L., Panke, S., Held, M., & S. Schmitt.
Publié dans:
Small (Weinheim an der Bergstrasse, Germany),, 2020, ISSN 1613-6829
Éditeur:
John Wiley & Sons
DOI:
10.1002/smll.202005523
Auteurs:
Tellechea-Luzardo, J., Hobbs, L., Velázquez, E., Pelechova E., Woods, S., de Lorenzo, V. and Krasnogor, N.
Publié dans:
Nature Communications, 2022, ISSN 2041-1723
Éditeur:
Nature Publishing Group
DOI:
10.1038/s41467-022-28350-4
Auteurs:
Ting, S.Y., Martinez-Garcia, E., Huang, S., Bertolli, S.K., Kelly, K.A., Cutler, K.J., Su, E.D., Zhi, H., Tang, Q., Radey, M.C., Raffatellu, M., Peterson, S.B., de Lorenzo, V. and Mougous, J.D.
Publié dans:
Cell Host & Microbe, 2020, ISSN 1934-6069
Éditeur:
Elsevier
DOI:
10.1016/j.chom.2020.05.006
Auteurs:
Arce-Rodríguez, A., Benedetti I., Borrero-de Acuña, J.M., Silva-Rocha, R., de Lorenzo, V.
Publié dans:
Synthetic Biology, Numéro 23977000, 2021, ISSN 2397-7000
Éditeur:
Oxford University Press
DOI:
10.1093/synbio/ysab030
Auteurs:
Berdugo, M., Vidiella, B., Solé, R.V. and Maestre, F.T.
Publié dans:
Functional Ecology, 2021, ISSN 1365-2435
Éditeur:
British Ecological Society
DOI:
10.1111/1365-2435.13962
Auteurs:
Dvořák, P.; Kováč, Jozef; Lorenzo, Víctor de
Publié dans:
instname:Consejo Superior de Investigaciones Científicas (CSIC), Numéro 17517915, 2020, ISSN 1751-7915
Éditeur:
John Wiley & Sons
DOI:
10.1111/1751-7915.13574
Auteurs:
Simon Höllerer, Laetitia Papaxanthos, Anja Cathrin Gumpinger, Katrin Fischer, Christian Beisel, Karsten Borgwardt, Yaakov Benenson, Markus Jeschek
Publié dans:
Nature Communications, Numéro 11/1, 2020, ISSN 2041-1723
Éditeur:
Nature Publishing Group
DOI:
10.1038/s41467-020-17222-4
Auteurs:
Tobias Vornholt, Markus Jeschek
Publié dans:
ChemBioChem, Numéro 21/16, 2020, Page(s) 2241-2249, ISSN 1439-4227
Éditeur:
John Wiley & Sons Ltd.
DOI:
10.1002/cbic.202000121
Auteurs:
Arce-Rodríguez, A., Nikel, P.I., Calles, B., Chavarría, M., Platero R., Krell, T., de Lorenzo, V.
Publié dans:
Environmental Biotechnology, 2021, ISSN 1462-2912
Éditeur:
Blackwell Publishing Inc.
DOI:
10.1111/1462-2920.15422
Auteurs:
Kim, J., Silva-Rocha, R. and de Lorenzo, V.
Publié dans:
International Microbiology, 2021, ISSN 1139-6709
Éditeur:
Sociedad Espanola de Microbiologia
DOI:
10.1007/s10123-021-00194-w
Auteurs:
Nediljko Budisa, Vladimir Kubyshkin, Markus Schmidt
Publié dans:
ChemBioChem, Numéro 21/16, 2020, Page(s) 2228-2231, ISSN 1439-4227
Éditeur:
John Wiley & Sons Ltd.
DOI:
10.1002/cbic.202000141
Auteurs:
Collado-Vides, J., Gaudet, P and de Lorenzo, V.
Publié dans:
Frontiers in Physiology, 2022, ISSN 1664-042X
Éditeur:
Frontiers Research Foundation
DOI:
10.3389/fphys.2022.815874
Auteurs:
Apura, R., de Lorenzo, V., Arraiano, C.M., Martínez-García, E. and Viegas S.C.
Publié dans:
Environmental Microbiology, 2020, ISSN 1462-2912
Éditeur:
Blackwell Publishing Inc.
DOI:
10.1111/1462-2920.15291
Auteurs:
Espeso, D.R. Dvořák, P., Aparicio, T. de Lorenzo, V.
Publié dans:
Microbial Biotechnology, 2020, ISSN 1751-7915
Éditeur:
John Wiley & Sons
DOI:
10.1111/1751-7915.13678
Auteurs:
Dvořák, P., Bayer, E.A., de Lorenzo, V.
Publié dans:
ACS Synthetic Biology, 2020, ISSN 2161-5063
Éditeur:
American Chemical Society
DOI:
10.1021/acssynbio.0c00276
Auteurs:
de Lorenzo, V., Krasnogor, N., Schmidt, M.
Publié dans:
New Biotechnology, 2020, ISSN 1871-6784
Éditeur:
Elsevier BV
DOI:
10.1016/j.nbt.2020.08.004
Auteurs:
de Lorenzo, V.
Publié dans:
Metode, 2020, ISSN 2174-9221
Éditeur:
Universidad de Valencia
DOI:
10.7203/metode.11.15975
Auteurs:
García-Martin, J.A., Chavarría, M., de Lorenzo, V. Pazos, F.
Publié dans:
Biology Methods and Protocols, 2020, ISSN 2396-8923
Éditeur:
Oxford University Press
DOI:
10.1093/biomethods/bpaa025
Auteurs:
Vidiella, B. and Solé, R.
Publié dans:
Iscience, 2022, ISSN 2589-0042
Éditeur:
Elsevier
DOI:
10.1016/j.isci.2022.104658
Auteurs:
Pérez-Pantoja, D., Nikel, P.I., Chavarría, M. and de Lorenzo, V.
Publié dans:
Environmental Microbiology, 2021, ISSN 1462-2912
Éditeur:
Blackwell Publishing Inc.
DOI:
10.1111/1462-2920.15472
Auteurs:
Fraile S., Briones M., Revenga-Parra, M., de Lorenzo V., Lorenzo E. and Martínez-García E
Publié dans:
ACS Synthetic Biology, 2021, ISSN 2161-5063
Éditeur:
American Chemical Society
DOI:
10.1021/acssynbio.1c00227
Auteurs:
Dvořák, P., Alvarez-Carreño, C., Paradela, A. and de Lorenzo, V.
Publié dans:
Environmental Microbiology, 2021, ISSN 1462-2912
Éditeur:
Blackwell Publishing Inc.
DOI:
10.1111/1462-2920.15628
Auteurs:
Blai Vidiella, Josep Sardanyés, Ricard V. Solé
Publié dans:
Royal Society Open Science, Numéro 7/8, 2020, Page(s) 200161, ISSN 2054-5703
Éditeur:
The Royal Society
DOI:
10.1098/rsos.200161
Auteurs:
Tas, H., Grozinger, L., Stoof, R., de Lorenzo, V, and Goni-Moreno, A.
Publié dans:
NAture Communications, 2020, ISSN 2041-1723
Éditeur:
Nature Publishing Group
DOI:
10.1038/s41467-020-20656-5
Auteurs:
Schmidt, M. & Kubyshkin, V.
Publié dans:
Chembiochem, 2020, ISSN 1439-4227
Éditeur:
John Wiley & Sons Ltd.
DOI:
10.1002/cbic.202000758
Auteurs:
de Lorenzo, V.
Publié dans:
EFB Bioeconomy Journal, 2022, ISSN 2667-0410
Éditeur:
Elsevier
DOI:
10.1016/j.bioeco.2022.100035
Auteurs:
Víctor de Lorenzo
Publié dans:
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 2022, ISSN 0962-8436
Éditeur:
Royal Society of London
DOI:
10.1098/rstb.2021.0395
Auteurs:
Páez-Espino, A.D., Nikel, P., Chavarría, M., de Lorenzo, V.
Publié dans:
Environmental Microbiology, 2020, ISSN 1462-2912
Éditeur:
Blackwell Publishing Inc.
DOI:
10.1111/1462-2920.14991
Auteurs:
Nikel, P.I., Fuhrer, T., Chavarría, M., Sánchez-Pascuala, A., Sauer, U. and de Lorenzo, V.
Publié dans:
ISME Journal, 2020, ISSN 1751-7362
Éditeur:
Nature Publishing Group
DOI:
10.1038/s41396-020-00884-9
Auteurs:
Al-ramahi, Y., Nyerges, A., Margolles, Y., Cerdán, L., Ferenc G., Pál, C., Fernández, L.A. and de Lorenzo, V.
Publié dans:
Communications Biology, 2021, ISSN 2399-3642
Éditeur:
Nature Communications
DOI:
10.1038/s42003-021-02702-0
Auteurs:
T. Vornholt, F. Christoffel, M. M. Pellizzoni, S. Panke, T. R. Ward, M. Jeschek
Publié dans:
Science Advances, 2022, ISSN 2375-2548
Éditeur:
American Association for the Advancement of Science
DOI:
10.1126/sciadv.abe4208
Auteurs:
Ángeles Hueso‐Gil, Belén Calles, Víctor Lorenzo
Publié dans:
Environmental Microbiology, Numéro 22/8, 2020, Page(s) 3535-3547, ISSN 1462-2912
Éditeur:
Blackwell Publishing Inc.
DOI:
10.1111/1462-2920.15126
Auteurs:
Álvarez, B., Mencía, M., de Lorenzo, V., Fernández, LA.
Publié dans:
Nature Communications, Numéro 20411723, 2020, ISSN 2041-1723
Éditeur:
Nature Publishing Group
DOI:
10.1038/s41467-020-20230-z
Auteurs:
Tas, H., Goni-Moreno, A. and de Lorenzo, V.
Publié dans:
ACS Synthetic Biology, 2020, ISSN 2161-5063
Éditeur:
American Chemical Society
DOI:
10.1021/acssynbio.0c00529
Auteurs:
Tobias Vornholt; Fadri Christoffel; Michela M. Pellizzoni; Sven Panke; Thomas R. Ward; Markus Jeschek
Publié dans:
SCIENCE ADVANCES, Numéro 23752548, 2021, ISSN 2375-2548
Éditeur:
American Association for the Advancement of Science
DOI:
10.3929/ethz-b-000467617
Auteurs:
Velázquez, E., Álvarez, B., Fernández, L.A. and de Lorenzo, V.
Publié dans:
Microbial Biotechnology, 2022, ISSN 1751-7915
Éditeur:
John Wiley & Sons
DOI:
10.1111/1751-7915.14098
Auteurs:
Maull, V. and Solé, R.,
Publié dans:
Philosophical Transactions of the Royal Society B,, 2022, ISSN 0962-8436
Éditeur:
Royal Society of London
DOI:
10.1098/rstb.2021.0396
Auteurs:
Víctor de Lorenzo
Publié dans:
Life Sciences, Society and Policy, Numéro 14/1, 2018, ISSN 2195-7819
Éditeur:
Springer
DOI:
10.1186/s40504-018-0086-x
Auteurs:
Gonzalo Durante-Rodríguez, Víctor de Lorenzo, Pablo I. Nikel
Publié dans:
ACS Synthetic Biology, Numéro 7/11, 2018, Page(s) 2686-2697, ISSN 2161-5063
Éditeur:
American Chemical Society
DOI:
10.1021/acssynbio.8b00345
Auteurs:
Özlem Akkaya, Danilo R. Pérez-Pantoja, Belén Calles, Pablo I. Nikel, Víctor de Lorenzo
Publié dans:
mBio, Numéro 9/4, 2018, ISSN 2150-7511
Éditeur:
ASM
DOI:
10.1128/mbio.01512-18
Auteurs:
Tomás Aparicio, Víctor de Lorenzo, Esteban Martínez-García
Publié dans:
Biotechnology Journal, Numéro 14/1, 2019, Page(s) 1800483, ISSN 1860-6768
Éditeur:
Wiley - VCH Verlag GmbH & CO. KGaA
DOI:
10.1002/biot.201800483
Auteurs:
Özlem Akkaya, Pablo I. Nikel, Danilo Pérez-Pantoja, Víctor de Lorenzo
Publié dans:
Environmental Microbiology, Numéro 21/1, 2019, Page(s) 314-326, ISSN 1462-2912
Éditeur:
Blackwell Publishing Inc.
DOI:
10.1111/1462-2920.14459
Auteurs:
Ricard V. Solé, Raúl Montañez, Salva Duran-Nebreda, Daniel Rodriguez-Amor, Blai Vidiella, Josep Sardanyés
Publié dans:
Royal Society Open Science, Numéro 5/7, 2018, Page(s) 180121, ISSN 2054-5703
Éditeur:
Royal Society
DOI:
10.1098/rsos.180121
Auteurs:
Max Chavarría, Víctor de Lorenzo
Publié dans:
Molecular Microbiology, Numéro 109/3, 2018, Page(s) 273-277, ISSN 0950-382X
Éditeur:
Blackwell Publishing Inc.
DOI:
10.1111/mmi.14080
Auteurs:
Pavel Dvořák, Víctor de Lorenzo
Publié dans:
Metabolic Engineering, Numéro 48, 2018, Page(s) 94-108, ISSN 1096-7176
Éditeur:
Academic Press
DOI:
10.1016/j.ymben.2018.05.019
Auteurs:
Pablo I. Nikel, Víctor de Lorenzo
Publié dans:
Metabolic Engineering, Numéro 50, 2018, Page(s) 142-155, ISSN 1096-7176
Éditeur:
Academic Press
DOI:
10.1016/j.ymben.2018.05.005
Auteurs:
Blai Vidiella, Josep Sardanyés, Ricard Solé
Publié dans:
Journal of The Royal Society Interface, Numéro 15/143, 2018, Page(s) 20180083, ISSN 1742-5689
Éditeur:
The Royal Society
DOI:
10.1098/rsif.2018.0083
Auteurs:
Tomás Aparicio, Víctor Lorenzo, Esteban Martínez‐García
Publié dans:
Microbial Biotechnology, Numéro 12/5, 2019, Page(s) 1076-1089, ISSN 1751-7915
Éditeur:
John Wiley & Sons
DOI:
10.1111/1751-7915.13453
Auteurs:
Esteban Martínez-García, Angel Goñi-Moreno, Bryan Bartley, James McLaughlin, Lucas Sánchez-Sampedro, Héctor Pascual del Pozo, Clara Prieto Hernández, Ada Serena Marletta, Davide De Lucrezia, Guzmán Sánchez-Fernández, Sofía Fraile, Víctor de Lorenzo
Publié dans:
Nucleic Acids Research, Numéro 48/D1, 2019, Page(s) D1164-D1170, ISSN 0305-1048
Éditeur:
Oxford University Press
DOI:
10.1093/nar/gkz1024
Auteurs:
Ángeles Hueso‐Gil, Belén Calles, George A. O'Toole, Víctor Lorenzo
Publié dans:
Microbial Biotechnology, Numéro 13/1, 2020, Page(s) 263-273, ISSN 1751-7915
Éditeur:
Society for Applied Microbiology
DOI:
10.1111/1751-7915.13404
Auteurs:
David Espeso, Esteban Martínez-García, Víctor Lorenzo
Publié dans:
BIO-PROTOCOL, Numéro 9/10, 2019, ISSN 2331-8325
Éditeur:
Bio-Protocol
DOI:
10.21769/bioprotoc.3238
Auteurs:
Angeles Hueso-Gil, Ákos Nyerges, Csaba Pál, Belén Calles, Víctor de Lorenzo
Publié dans:
ACS Synthetic Biology, Numéro 9/1, 2019, Page(s) 104-114, ISSN 2161-5063
Éditeur:
American Chemical Society
DOI:
10.1021/acssynbio.9b00375
Auteurs:
Belén Calles, Ángel Goñi‐Moreno, Víctor Lorenzo
Publié dans:
Molecular Systems Biology, Numéro 15/12, 2019, ISSN 1744-4292
Éditeur:
Nature Publishing Group
DOI:
10.15252/msb.20188777
Auteurs:
Tomas Aparicio, Akos Nyerges, István Nagy, Csaba Pal, Esteban Martínez‐García, Víctor Lorenzo
Publié dans:
Environmental Microbiology, Numéro 22/1, 2019, Page(s) 45-58, ISSN 1462-2912
Éditeur:
Blackwell Publishing Inc.
DOI:
10.1111/1462-2920.14814
Auteurs:
Nuria Conde-Pueyo, Blai Vidiella, Josep Sardanyés, Miguel Berdugo, Fernando T. Maestre, Victor de Lorenzo, Ricard Solé
Publié dans:
Life, Numéro 10/2, 2020, Page(s) 14, ISSN 2075-1729
Éditeur:
MDPI
DOI:
10.3390/life10020014
Auteurs:
Tomas Aparicio, Akos Nyerges, Esteban Martínez-García, Víctor de Lorenzo
Publié dans:
iScience, Numéro 23/3, 2020, Page(s) 100946, ISSN 2589-0042
Éditeur:
Elsevier
DOI:
10.1016/j.isci.2020.100946
Auteurs:
Alberto Sánchez-Pascuala, Lorena Fernández-Cabezón, Víctor de Lorenzo, Pablo I. Nikel
Publié dans:
Metabolic Engineering, Numéro 54, 2019, Page(s) 200-211, ISSN 1096-7176
Éditeur:
Academic Press
DOI:
10.1016/j.ymben.2019.04.005
Auteurs:
Esteban Martínez-García, Víctor de Lorenzo
Publié dans:
Current Opinion in Biotechnology, Numéro 59, 2019, Page(s) 111-121, ISSN 0958-1669
Éditeur:
Elsevier BV
DOI:
10.1016/j.copbio.2019.03.012
Auteurs:
Juhyun Kim, Angel Goñi‐Moreno, Belén Calles, Víctor de Lorenzo
Publié dans:
Environmental Microbiology, Numéro 21/5, 2019, Page(s) 1645-1658, ISSN 1462-2912
Éditeur:
Blackwell Publishing Inc.
DOI:
10.1111/1462-2920.14544
Auteurs:
Velázquez, V., Al-Ramahi, Y., Tellechea-Luzardo, J., Krasnogor, N., de Lorenzo, V.
Publié dans:
ACS Synthetic Biology, 2021, ISSN 2161-5063
Éditeur:
American Chemical Society
DOI:
10.1021/acssynbio.1c00199
Auteurs:
Espeso D. R., Algar, E., Martínez-García, E., de Lorenzo, V.
Publié dans:
Exploiting geometric similarity for statistical quantification of fluorescence spatial patterns in bacterial colonies, 2020, ISSN 1471-2105
Éditeur:
BioMed Central
DOI:
10.1186/s12859-020-3490-1
Auteurs:
Espeso, D.R., Martínez-García, E., de Lorenzo, V.
Publié dans:
Water Research, 2020, ISSN 0043-1354
Éditeur:
Elsevier BV
DOI:
10.1016/j.watres.2020.116468
Auteurs:
Markus Schmidt
Publié dans:
Biosystems, Numéro 185, 2019, Page(s) 104015, ISSN 0303-2647
Éditeur:
Elsevier BV
DOI:
10.1016/j.biosystems.2019.104015
Auteurs:
Tas, H., Grozinger, L., Goni-Moreno, A., de Lorenzo, V.
Publié dans:
Synthetic Biology, 2021, ISSN 2397-7000
Éditeur:
Oxford University Press
DOI:
10.1093/synbio/ysab024
Auteurs:
Durante-Rodríguez, G., Páez-Espino, D and de Lorenzo, V.
Publié dans:
Frontiers in Microbiology, 2021, ISSN 1664-302X
Éditeur:
Frontiers Media
DOI:
10.3389/fmicb.2021.641440
Auteurs:
Pei, L., Garfinkel, M. & Schmidt, M.
Publié dans:
Nature Communications, 2022, ISSN 2041-1723
Éditeur:
Nature Publishing Group
DOI:
10.1038/s41467-022-29889-y
Auteurs:
Kim, J., Goñi-Moreno, A., de Lorenzo, V.
Publié dans:
mBio, 2021, ISSN 2150-7511
Éditeur:
American Society for Microbiology
DOI:
10.1128/mbio.03685-20
Auteurs:
Akkaya, Ö., Aparicio, T., Perez-Pantoja, D., de Lorenzo, V.
Publié dans:
Environmental Microbiology, 2020, ISSN 1462-2912
Éditeur:
Blackwell Publishing Inc.
DOI:
10.1111/1462-2920.15384
Auteurs:
Miguel Berdugo, Manuel Delgado-Baquerizo, Santiago Soliveres, Rocío Hernández-Clemente, Yanchuang Zhao, Juan J. Gaitán, Nicolas Gross, Hugo Saiz, Vincent Maire, Anika Lehmann, Matthias C. Rillig, Ricard V. Solé, Fernando T. Maestre
Publié dans:
Science, Numéro 367/6479, 2020, Page(s) 787-790, ISSN 0036-8075
Éditeur:
American Association for the Advancement of Science
DOI:
10.1126/science.aay5958
Auteurs:
Silbert, J., de Lorenzo, V. and Aparicio, T.
Publié dans:
ACS Synthetic Biology, 2021, ISSN 2161-5063
Éditeur:
American Chemical Society
DOI:
10.1021/acssynbio.0c00611
Auteurs:
Algar, E., Al-Ramahi, Y., de Lorenzo, V. and Martínez-García, E.
Publié dans:
ChemBioChem, 2020, ISSN 1439-7633
Éditeur:
John Wiley & Sons
DOI:
10.1002/cbic.202000330
Auteurs:
Aparicio, T., Silbert, J., Cepeda, S. and de Lorenzo, V.
Publié dans:
BioDesign Research, 2022, ISSN 2693-1257
Éditeur:
American Association for the Advancement of Science
DOI:
10.34133/2022/9850305
Auteurs:
Solé, R. and Levin, S.
Publié dans:
Philosophical Transactions of the Royal Society B,, 2022, ISSN 0962-8436
Éditeur:
Royal Society of London
DOI:
10.1098/rstb.2021.0376
Auteurs:
Martínez-García, E., Fraile, S., Rodríguez-Espeso, R., Vecchietti, D., Bertoni, G., de Lorenzo, V.
Publié dans:
ACS Synthetic Biology, 2020, ISSN 2161-5063
Éditeur:
American Chemical Society
DOI:
10.1021/acssynbio.0c00272
Auteurs:
Nikel, P.I., Benedetti, I., Wirth, N.T., de Lorenzo, V. and Calles, B.
Publié dans:
Microbial Biotechnology, 2022, ISSN 1751-7915
Éditeur:
John Wiley & Sons
DOI:
10.1111/1751-7915.14063
Auteurs:
Doran, David; Abul-Haija, Yousef M.; Cronin, Leroy
Publié dans:
Angewandte Chemie (International Ed. in English), Numéro 1, 2019
Éditeur:
American Chemical Society (ACS), Chinese Chemical Society, Chemical Society of Japan, German Chemical Society (GDCh) and the Royal Society of Chemistry
DOI:
10.26434/chemrxiv.7712297.v1
Auteurs:
Aparicio, T., de Lorenzo, V., Martínez-García, E.
Publié dans:
Recombineering. Methods in Molecular Biology, 2022, ISBN 978-1-0716-2233-9
Éditeur:
Springer Nature
DOI:
10.1007/978-1-0716-2233-9_4
Auteurs:
Markus Schmidt, Nediljko Budisa
Publié dans:
Art as We Don’t Know It, 2020, Page(s) 20-36, ISBN 978-952-60-8823-5
Éditeur:
Aalto University Press
Auteurs:
Víctor de Lorenzo, Hiren Joshi
Publié dans:
Consequences of Microbial Interactions with Hydrocarbons, Oils, and Lipids: Biodegradation and Bioremediation, 2019, Page(s) 1-15, ISBN 978-3-319-44535-9
Éditeur:
Springer International Publishing
DOI:
10.1007/978-3-319-44535-9_25-1
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