Constructing a ‘Eubiosis Reinstatement Therapy’ for Asthma

Project Information

CURE

Grant agreement ID: 767015

DOI 10.3030/767015

Project closed

EC signature date 29 August 2017

Start date 1 October 2017

End date 31 March 2022

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost € 2 971 750,00

EU contribution € 2 971 750,00

Coordinated by

ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
Greece

Deliverables

Documents, reports (16)

Co-occurrence networks

Report on microbial cooccurrence patterns in the respiratory tract

Immune signatures

Immune signatures associated with microbiome composition in asthma

Publication on phage-bacteria interaction networks

Publication on phagebacteria interaction networks

Data Management Plan
Epithelial barrier

Association of epithelial barrier with microbiome composition in asthma

Recruitment finalised
Dysbiosis phenotypes

Report on dysbiosisbased asthma endophenotypes

Longitudinal patterns

Report on respiratory microbial ecology longitudinal patterns

Cytokine and activation markers of ILC responses to phages
Confirmatory/repeat sampling completed

Confirmatoryrepeat sampling completed

Variability in space & time

Report on respiratory microbiome variability across Europe

In-vitro interaction model established

Invitro interaction model established

Extended phage collection

Extended phage collection established

Completed patient follow-up
Gender and immune state models
Infection Networks

Report on bacterial-phage interactions by infection network analysis

Websites, patent fillings, videos etc. (2)

Science Festival
Website and logo

Production of project website, logo and project templates

Other (1)

Prediction Software

Software running the optimised predicted model

Open Research Data Pilot (1)

Deposition of metagenomic data

Deposition of metagenomic data at the European Nucleotide Archive

Demonstrators, pilots, prototypes (1)

Phage biobank

CURE phage biobank

Publications

Peer reviewed articles (8)

Targeted metagenomics approach to capture the biodiversity of Saccharomyces genus in wild environments.

Author(s): Alsammar, Haya F.; Naseeb, Samina; Brancia, Lorenzo B.; Gilman, R. Tucker; Wang, Ping; Delneri, Daniela
Published in: Environmental Microbiology Reports, 2019, ISSN 1758-2229
Publisher: Wiley-Blackwell
DOI: 10.1111/1758-2229.12724

COVID-19: lambda interferon against viral load and hyperinflammation.

Author(s): Evangelos Andreakos; Evangelos Andreakos; Sotirios Tsiodras
Published in: EMBO Molecular Medicine, 2020, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202012465

Lambda interferons come to light: dual function cytokines mediating antiviral immunity and damage control

Author(s): Evangelos Andreakos, Ivan Zanoni, Ioanna E Galani
Published in: Current Opinion in Immunology, Issue 56, 2019, Page(s) 67-75, ISSN 0952-7915
Publisher: Elsevier BV
DOI: 10.1016/j.coi.2018.10.007

Antibiofilm potential of purified environmental bacteriophage preparations against early stage Pseudomonas aeruginosa biofilms

Author(s): R. Issa, N. Chanishvili, J. Caplin, E. Kakabadze, N. Bakuradze, K. Makalatia, I. Cooper
Published in: Journal of Applied Microbiology, Issue 126/6, 2019, Page(s) 1657-1667, ISSN 1364-5072
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jam.14241

Investigation of Salmonella Phage-Bacteria Infection Profiles: Network Structure Reveals a Gradient of Target-Range from Generalist to Specialist Phage Clones in Nested Subsets.

Author(s): Khatuna Makalatia; Elene Kakabadze; Nata Bakuradze; Nino Grdzelishvili; Ben Stamp; Ezra Herman; Avraam Tapinos; Aidan Coffey; David Lee; Nikolaos G. Papadopoulos; David Robertson; Nina Chanishvili; Spyridon Megremis
Published in: Viruses, 2021, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13071261

Interactions of Bacteriophages and Bacteria at the Airway Mucosa: New Insights Into the Pathophysiology of Asthma

Author(s): Panagiota Tzani-Tzanopoulou, Dimitrios Skliros, Spyridon Megremis, Paraskevi Xepapadaki, Evangelos Andreakos, Nina Chanishvili, Emmanouil Flemetakis, Grigoris Kaltsas, Styliani Taka, Evangelia Lebessi, Anastassios Doudoulakakis and Nikolaos G. Papadopoulos
Published in: Frontiers in Allergy, 2021, ISSN 2673-6101
Publisher: Frontiers in Allergy
DOI: 10.3389/falgy.2020.617240

Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison

Author(s): Ioanna E. Galani; Nikoletta Rovina; Vicky Lampropoulou; Vasiliki Triantafyllia; Maria Manioudaki; Eleftherios Pavlos; Evangelia Koukaki; Paraskevi C. Fragkou; Vasiliki Panou; Vasiliki Rapti; Ourania Koltsida; Andreas Mentis; Nikolaos Koulouris; Sotirios Tsiodras; Antonia Koutsoukou; Evangelos Andreakos; Evangelos Andreakos
Published in: Nature Immunology, 2021, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1101/2020.08.21.20179291

Dexamethasone, pro-resolving lipid mediators and resolution of inflammation in COVID-19

Author(s): Evangelos Andreakos, Maria Papadaki, Charles N Serhan
Published in: Allergy, 2021, ISSN 0091-6749
Publisher: Mosby Inc.
DOI: 10.1111/all.14595