Constructing a ‘Eubiosis Reinstatement Therapy’ for Asthma

Livrables

Co-occurrence networks

Report on microbial cooccurrence patterns in the respiratory tract

Immune signatures

Immune signatures associated with microbiome composition in asthma

Publication on phage-bacteria interaction networks

Publication on phagebacteria interaction networks

Data Management Plan
Epithelial barrier

Association of epithelial barrier with microbiome composition in asthma

Recruitment finalised
Dysbiosis phenotypes

Report on dysbiosisbased asthma endophenotypes

Longitudinal patterns

Report on respiratory microbial ecology longitudinal patterns

Cytokine and activation markers of ILC responses to phages
Confirmatory/repeat sampling completed

Confirmatoryrepeat sampling completed

Variability in space & time

Report on respiratory microbiome variability across Europe

In-vitro interaction model established

Invitro interaction model established

Extended phage collection

Extended phage collection established

Completed patient follow-up
Gender and immune state models
Infection Networks

Report on bacterial-phage interactions by infection network analysis

Science Festival
Website and logo

Production of project website, logo and project templates

Prediction Software

Software running the optimised predicted model

Deposition of metagenomic data

Deposition of metagenomic data at the European Nucleotide Archive

Phage biobank

CURE phage biobank

Publications

Targeted metagenomics approach to capture the biodiversity of Saccharomyces genus in wild environments.

Auteurs: Alsammar, Haya F.; Naseeb, Samina; Brancia, Lorenzo B.; Gilman, R. Tucker; Wang, Ping; Delneri, Daniela
Publié dans: Environmental Microbiology Reports, 2019, ISSN 1758-2229
Éditeur: Wiley-Blackwell
DOI: 10.1111/1758-2229.12724

COVID-19: lambda interferon against viral load and hyperinflammation.

Auteurs: Evangelos Andreakos; Evangelos Andreakos; Sotirios Tsiodras
Publié dans: EMBO Molecular Medicine, 2020, ISSN 1757-4676
Éditeur: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202012465

Lambda interferons come to light: dual function cytokines mediating antiviral immunity and damage control

Auteurs: Evangelos Andreakos, Ivan Zanoni, Ioanna E Galani
Publié dans: Current Opinion in Immunology, Numéro 56, 2019, Page(s) 67-75, ISSN 0952-7915
Éditeur: Elsevier BV
DOI: 10.1016/j.coi.2018.10.007

Antibiofilm potential of purified environmental bacteriophage preparations against early stage Pseudomonas aeruginosa biofilms

Auteurs: R. Issa, N. Chanishvili, J. Caplin, E. Kakabadze, N. Bakuradze, K. Makalatia, I. Cooper
Publié dans: Journal of Applied Microbiology, Numéro 126/6, 2019, Page(s) 1657-1667, ISSN 1364-5072
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/jam.14241

Investigation of Salmonella Phage-Bacteria Infection Profiles: Network Structure Reveals a Gradient of Target-Range from Generalist to Specialist Phage Clones in Nested Subsets.

Auteurs: Khatuna Makalatia; Elene Kakabadze; Nata Bakuradze; Nino Grdzelishvili; Ben Stamp; Ezra Herman; Avraam Tapinos; Aidan Coffey; David Lee; Nikolaos G. Papadopoulos; David Robertson; Nina Chanishvili; Spyridon Megremis
Publié dans: Viruses, 2021, ISSN 1999-4915
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13071261

Interactions of Bacteriophages and Bacteria at the Airway Mucosa: New Insights Into the Pathophysiology of Asthma

Auteurs: Panagiota Tzani-Tzanopoulou, Dimitrios Skliros, Spyridon Megremis, Paraskevi Xepapadaki, Evangelos Andreakos, Nina Chanishvili, Emmanouil Flemetakis, Grigoris Kaltsas, Styliani Taka, Evangelia Lebessi, Anastassios Doudoulakakis and Nikolaos G. Papadopoulos
Publié dans: Frontiers in Allergy, 2021, ISSN 2673-6101
Éditeur: Frontiers in Allergy
DOI: 10.3389/falgy.2020.617240

Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison

Auteurs: Ioanna E. Galani; Nikoletta Rovina; Vicky Lampropoulou; Vasiliki Triantafyllia; Maria Manioudaki; Eleftherios Pavlos; Evangelia Koukaki; Paraskevi C. Fragkou; Vasiliki Panou; Vasiliki Rapti; Ourania Koltsida; Andreas Mentis; Nikolaos Koulouris; Sotirios Tsiodras; Antonia Koutsoukou; Evangelos Andreakos; Evangelos Andreakos
Publié dans: Nature Immunology, 2021, ISSN 1529-2908
Éditeur: Nature Publishing Group
DOI: 10.1101/2020.08.21.20179291

Dexamethasone, pro-resolving lipid mediators and resolution of inflammation in COVID-19

Auteurs: Evangelos Andreakos, Maria Papadaki, Charles N Serhan
Publié dans: Allergy, 2021, ISSN 0091-6749
Éditeur: Mosby Inc.
DOI: 10.1111/all.14595

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