Constructing a ‘Eubiosis Reinstatement Therapy’ for Asthma

Informazioni relative al progetto

CURE

ID dell’accordo di sovvenzione: 767015

DOI

10.3030/767015

Progetto chiuso

Data della firma CE 29 Agosto 2017

Data di avvio 1 Ottobre 2017

Data di completamento 31 Marzo 2022

Finanziato da

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Costo totale

€ 2 971 750,00

Contributo UE

€ 2 971 750,00

Coordinato da

ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
Greece

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (16)

Co-occurrence networks

Report on microbial cooccurrence patterns in the respiratory tract

Immune signatures

Immune signatures associated with microbiome composition in asthma

Publication on phage-bacteria interaction networks

Publication on phagebacteria interaction networks

Data Management Plan
Epithelial barrier

Association of epithelial barrier with microbiome composition in asthma

Recruitment finalised
Dysbiosis phenotypes

Report on dysbiosisbased asthma endophenotypes

Longitudinal patterns

Report on respiratory microbial ecology longitudinal patterns

Cytokine and activation markers of ILC responses to phages
Confirmatory/repeat sampling completed

Confirmatoryrepeat sampling completed

Variability in space & time

Report on respiratory microbiome variability across Europe

In-vitro interaction model established

Invitro interaction model established

Extended phage collection

Extended phage collection established

Completed patient follow-up
Gender and immune state models
Infection Networks

Report on bacterial-phage interactions by infection network analysis

Websites, patent fillings, videos etc. (2)

Science Festival
Website and logo

Production of project website, logo and project templates

Other (1)

Prediction Software

Software running the optimised predicted model

Open Research Data Pilot (1)

Deposition of metagenomic data

Deposition of metagenomic data at the European Nucleotide Archive

Demonstrators, pilots, prototypes (1)

Phage biobank

CURE phage biobank

Pubblicazioni

Peer reviewed articles (8)

Targeted metagenomics approach to capture the biodiversity of Saccharomyces genus in wild environments.

Autori: Alsammar, Haya F.; Naseeb, Samina; Brancia, Lorenzo B.; Gilman, R. Tucker; Wang, Ping; Delneri, Daniela
Pubblicato in: Environmental Microbiology Reports, 2019, ISSN 1758-2229
Editore: Wiley-Blackwell
DOI: 10.1111/1758-2229.12724

COVID-19: lambda interferon against viral load and hyperinflammation.

Autori: Evangelos Andreakos; Evangelos Andreakos; Sotirios Tsiodras
Pubblicato in: EMBO Molecular Medicine, 2020, ISSN 1757-4676
Editore: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202012465

Lambda interferons come to light: dual function cytokines mediating antiviral immunity and damage control

Autori: Evangelos Andreakos, Ivan Zanoni, Ioanna E Galani
Pubblicato in: Current Opinion in Immunology, Numero 56, 2019, Pagina/e 67-75, ISSN 0952-7915
Editore: Elsevier BV
DOI: 10.1016/j.coi.2018.10.007

Antibiofilm potential of purified environmental bacteriophage preparations against early stage Pseudomonas aeruginosa biofilms

Autori: R. Issa, N. Chanishvili, J. Caplin, E. Kakabadze, N. Bakuradze, K. Makalatia, I. Cooper
Pubblicato in: Journal of Applied Microbiology, Numero 126/6, 2019, Pagina/e 1657-1667, ISSN 1364-5072
Editore: Blackwell Publishing Inc.
DOI: 10.1111/jam.14241

Investigation of Salmonella Phage-Bacteria Infection Profiles: Network Structure Reveals a Gradient of Target-Range from Generalist to Specialist Phage Clones in Nested Subsets.

Autori: Khatuna Makalatia; Elene Kakabadze; Nata Bakuradze; Nino Grdzelishvili; Ben Stamp; Ezra Herman; Avraam Tapinos; Aidan Coffey; David Lee; Nikolaos G. Papadopoulos; David Robertson; Nina Chanishvili; Spyridon Megremis
Pubblicato in: Viruses, 2021, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13071261

Interactions of Bacteriophages and Bacteria at the Airway Mucosa: New Insights Into the Pathophysiology of Asthma

Autori: Panagiota Tzani-Tzanopoulou, Dimitrios Skliros, Spyridon Megremis, Paraskevi Xepapadaki, Evangelos Andreakos, Nina Chanishvili, Emmanouil Flemetakis, Grigoris Kaltsas, Styliani Taka, Evangelia Lebessi, Anastassios Doudoulakakis and Nikolaos G. Papadopoulos
Pubblicato in: Frontiers in Allergy, 2021, ISSN 2673-6101
Editore: Frontiers in Allergy
DOI: 10.3389/falgy.2020.617240

Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison

Autori: Ioanna E. Galani; Nikoletta Rovina; Vicky Lampropoulou; Vasiliki Triantafyllia; Maria Manioudaki; Eleftherios Pavlos; Evangelia Koukaki; Paraskevi C. Fragkou; Vasiliki Panou; Vasiliki Rapti; Ourania Koltsida; Andreas Mentis; Nikolaos Koulouris; Sotirios Tsiodras; Antonia Koutsoukou; Evangelos Andreakos; Evangelos Andreakos
Pubblicato in: Nature Immunology, 2021, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1101/2020.08.21.20179291

Dexamethasone, pro-resolving lipid mediators and resolution of inflammation in COVID-19

Autori: Evangelos Andreakos, Maria Papadaki, Charles N Serhan
Pubblicato in: Allergy, 2021, ISSN 0091-6749
Editore: Mosby Inc.
DOI: 10.1111/all.14595