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Development of the first fully biocompatible, soft actuated heart: combining in situ tissue engineering and soft robotics

Objective

The Hybrid Heart consortium envisions to develop and bring to the clinic soft biocompatible artificial organs. These will consist of a soft robotics shell with actuators (‘artificial muscles’) and sensors, enabling completely natural motion. The inner lining and structures will be made by in situ tissue engineering (TE), ensuring biocompatibility of blood-contacting surfaces.
As the first step, the consortium will develop the Hybrid Heart, which can completely replace a patient’s heart in a procedure similar to a heart transplant, to provide a cure for heart failure, which affects ~23 million people worldwide. Currently, patients with end-stage heart failure either receive a heart transplant, if available, or long-term mechanical circulatory support, which causes severe complications. To achieve the ambitious goal of providing a permanent cure for these patients, the participants will, in parallel, develop the components of the Hybrid Heart: 1) a soft elastomeric robotics shell containing actuators and sensors, 2) scaffolds for in situ TE of inner lining, valves and vessels and 3) a wireless energy transfer system. These components together will form the full Hybrid Heart, which will be soft, adaptable, wireless and fully bio- and hemocompatible. Both functionality as well as biocompatibility of the Hybrid Heart will be shown in a Proof-of-Principle study in the chronic sheep model at the end of the project.
The Hybrid Heart project will be carried out by an interdisciplinary group of (academic) researchers and high-tech SMEs, with experience in cardiac surgery, TE, soft robotics and engineering. The technology underlying the Hybrid Heart is applicable to a range of soft robotics-based artificial organs, including the bowel, lung, or muscle structures (limbs). Replacing an entire organ with bioinspired robotic elements, TE biocompatible surfaces, artificial sensors, and an external power source allows for an off-the-shelf therapy for patients with organ failure.

Field of science

  • /engineering and technology/electrical engineering, electronic engineering, information engineering/information engineering/telecommunications/wireless
  • /medical and health sciences/medical biotechnology/tissue engineering
  • /engineering and technology/electrical engineering, electronic engineering, information engineering/electronic engineering/robotics/soft robotics
  • /engineering and technology/electrical engineering, electronic engineering, information engineering/electronic engineering/robotics

Call for proposal

H2020-FETOPEN-1-2016-2017
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Address
Meibergdreef 15
1105AZ Amsterdam
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 705 000

Participants (6)

STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN
Netherlands
EU contribution
€ 396 250
Address
Winthontlaan 2
3526 KV Utrecht
Activity type
Research Organisations
SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO S ANNA
Italy
EU contribution
€ 454 375
Address
Piazza Martiri Della Liberta 33
56127 Pisa
Activity type
Higher or Secondary Education Establishments
TECHNISCHE UNIVERSITEIT EINDHOVEN
Netherlands
EU contribution
€ 585 000
Address
Groene Loper 3
5612 AE Eindhoven
Activity type
Higher or Secondary Education Establishments
DUALIS MEDTECH GMBH

Participation ended

Germany
EU contribution
€ 140 104,50
Address
Am Technologiepark 8+10
82229 Seefeld
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
XELTIS BV
Netherlands
EU contribution
€ 443 675
Address
De Lismortel R2 06 Cat Build 31
5612 AR Eindhoven
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EM-TEC GMBH WERNER HEINZE
Germany
EU contribution
€ 311 145,50
Address
Lerchenberg 20
86932 Finning
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)