Genetically engineered human pluripotent stem cells, functionalized silk-fibroin platforms and bio-inks: a novel solution for large-scale ex-vivo platelet production, transfusion and drug research

Deliverables

Summary report of the published scientific papers

Bioengineering a 3D silk platform for large-scale platelet production

Bioengineering the first 3D chemically functionalized silk platform for large-scale production of human platelets

Targeted stakeholders identified and informed about the project_12

Links to stakeholders as well as experts on Transfusional Medicine and experts on Bioengineering will be established online and by distributing leaflets, poster and press releases

Workshops_12

Summary report of the performed workshops and training sessions

Targeted stakeholders identified and informed about the project_24

Links to stakeholders as well as experts on Transfusional Medicine and experts on Bioengineering will be established online and by distributing leaflets, poster and press releases

Obtaining a high efficient hPSC lines for producing human platelets for transfusion

A three-level bio-banking system will be applied for the first high efficient hPSC lines

Workshops_24

Summary report of the performed workshops and training sessions

Public Project website

Public Project website and logo will be developed and continuously updated

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Publications

Multi-channel silk sponge mimicking bone marrow vascular niche for platelet production

Author(s): Lorenzo Tozzi, Pierre-Alexandre Laurent, Christian A. Di Buduo, Xuan Mu, Angelo Massaro, Ross Bretherton, Whitney Stoppel, David L. Kaplan, Alessandra Balduini
Published in: Biomaterials, Issue 178, 2018, Page(s) 122-133, ISSN 0142-9612
DOI: 10.1016/j.biomaterials.2018.06.018

Structurally graduated collagen scaffolds applied to the ex vivo generation of platelets from human pluripotent stem cell-derived megakaryocytes: Enhancing production and purity

Author(s): Jennifer H. Shepherd, Daniel Howard, Amie K. Waller, Holly Rebecca Foster, Annett Mueller, Thomas Moreau, Amanda L. Evans, Meera Arumugam, Guénaëlle Bouët Chalon, Eleonora Vriend, Natalia Davidenko, Cedric Ghevaert, Serena M. Best, Ruth E. Cameron
Published in: Biomaterials, Issue 182, 2018, Page(s) 135-144, ISSN 0142-9612
DOI: 10.1016/j.biomaterials.2018.08.019

Mechanisms of platelet release: in vivo studies and in vitro modeling

Published in: ISSN 0953-7104
DOI: 10.1080/09537104.2020.1774532

In vitro-derived platelets: the challenges we will have to face to assess quality and safety

Published in: ISSN 0953-7104
DOI: 10.1080/09537104.2020.1769051

Disrupted filamin A/αIIbβ3 interaction induces macrothrombocytopenia by increasing RhoA activity

Author(s): Alessandro Donada, Nathalie Balayn, Dominika Sliwa, Larissa Lordier, Valentina Ceglia, Francesco Baschieri, Cyril Goizet, Rémi Favier, Lucie Tosca, Gérard Tachdjian, Cecile V. Denis, Isabelle Plo, William Vainchenker, Najet Debili, Jean-Philippe Rosa, Marijke Bryckaert, Hana Raslova
Published in: Blood, Issue 133/16, 2019, Page(s) 1778-1788, ISSN 0006-4971
DOI: 10.1182/blood-2018-07-861427

Deliverables

Publications

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