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An integrated POC solution for non-invasive diagnosis and therapy monitoring of Heart Failure patients

Project description

Saliva-based diagnosis of heart failure at the point-of-care

Heart failure is a global health challenge with increasing prevalence and poor prognosis, while diagnosis and therapy monitoring lack personalised and reliable tools. To address these challenges, the EU-funded KardiaTool project aims to develop a portable device that can diagnose heart failure and monitor therapy at the point of care using saliva samples. The device will incorporate different heart failure biomarkers from saliva offering a cost-effective alternative to blood-based screening. The convenience of operation and potential for continuous monitoring offered by the KardiaTool solution are expected to improve clinical practice and care of patients with heart failure.


The aim of the KardiaTool project is to translate a laboratory proven concept of a saliva biosensor to the clinical practice for addressing the priority needs in personalized HF diagnostics and therapy monitoring at the point of care. The KardiaTool platform includes: (i) An easy to use portable POC device (KardiaPOC) with a disposable Lab-on-a-Chip (LOC), for the non-invasive, rapid and accurate qualitative and quantitative assessment of HF biomarkers, from saliva samples. KardiaPOC device will integrate a variety of sensors, actuators, Microelectromechanical systems (MEMS), micro-electronics, bio-chemicals and functionalized magnetic nanoparticles (MNPs), onto a disposable, low cost LOC. (ii) A decision support software (KardiaSoft) based on predictive modelling techniques, that analyzes the POC data and other patient’s data, directly added by the healthcare professionals, and delivers information related to HF diagnosis and therapy monitoring. The innovation lays in the incorporation of four novel saliva biomarkers that have been proven in a laboratory setting and bring a new promising concept for addressing the priority needs of the clinical arena. KardiaPOC will provide the capability of simultaneously extracting key information from the saliva biomarkers: (i) NT-proBNP, (ii) TNF-a, (iii) Interleukin- 10, (iv) Cortisol. It is expected that identifying a comparable source to blood, for biomarker information, such as saliva, that is cost effective, less invasive, more convenient and acceptable for both patients and healthcare professionals would be beneficial for the healthcare community. The challenge of KardiaTool is: (i) to translate a laboratory proven concept of a saliva biosensor into an MNBS platform, for HF diagnostics and therapy monitoring, at the point of care, following GLP (ii) to validate the MNBS platform through pre-clinical and clinical testing following GCP and (iii) to industrialize the outcomes following GMP towards progress to marketization

Call for proposal


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Sub call



Net EU contribution
€ 446 132,43
69622 Villeurbanne Cedex

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Auvergne-Rhône-Alpes Rhône-Alpes Rhône
Activity type
Higher or Secondary Education Establishments
Total cost
€ 446 132,43

Participants (16)