Periodic Reporting for period 2 - SysOrganoid (A systems biology approach to investigate cell fate switches in intestinal organoids)
Reporting period: 2020-04-01 to 2021-09-30
Using small molecule-driven perturbations and a unique combination of ‘omics’ technologies, which are embedded in our department, we will provide a systems-wide view of the molecular (epigenetic) mechanisms that orchestrate cell fate changes in intestinal organoids. This integrative approach will identify the major regulatory networks that define the remarkable cellular plasticity of the mouse small intestinal epithelium. Beyond this basic scientific goal, our work will also have profound implications for cancer research and regenerative medicine, both of which are characterized by changes in adult stem cell homeostasis.