Direct cell reprogramming therapy in myocardial regeneration through an engineered multifunctional platform integrating biochemical instructive cues

Project Information

BIORECAR

Grant agreement ID: 772168

DOI

10.3030/772168

Project closed

EC signature date 15 June 2018

Start date 1 July 2018

End date 28 February 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 000 000,00

EU contribution

€ 2 000 000,00

Coordinated by

POLITECNICO DI TORINO
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Conference proceedings (20)

Design of bioartificial scaffolds as in vitro models of pathological human cardiac tissue

Author(s): Irene Carmagnola, Alice Zoso, Mattia Spedicati, Gerardina Ruocco, Valeria Chiono
Published in: 5th Healthcare & Life Science & Entrepreneurship workshop, 2020, Page(s) 1
Publisher: Vision Dynamics Science & Entrepreneurship

Novel lipoplexes for efficient microRNA delivery to human cardiac fibroblasts

Author(s): Nicoletti, Letizia; Tarricone, Giulia; Paoletti, Camilla; Carla, Divieto; Ilaria, Andreana; Barbara, Stella; Silvia, Arpicco; Mattu, Clara; Chiono, Valeria
Published in: Vancouver Nanomedicine Day, 17 Sept. 2020 - Abstract Booklet, 2020
Publisher: Nanomedicine Innovation Network

In vitro models of human cardiac fibrotic tissue based on bioartificial scaffolds

Author(s): Ireme Carmagnola; Alice ZOSO; Valeria Chiono
Published in: Linz 2019 22nd European Congress on Alternatives to Animal Testing - Eusaat 2019 - 19th Annual Congress of EUSAAT - ALTEX PROCEEDINGS, 2019
Publisher: Springer Spektrum

MICRORNA-RELEASING LIPOPLEXES FOR DIRECT CARDIAC REPROGRAMMING IN PATHOLOGICAL CARDIAC TISSUE

Author(s): Letizia Nicoletti; CAMILLA PAOLETTI; Tarricone, Giulia; Carla, Divieto; Ilaria, Andreana; Barbara, Stella; Silvia, Arpicco; Clara Mattu; Valeria Chiono
Published in: "Abstract of the conference ""Nature Conferences - RNA at the Bench and Bedside II"", 11-13 November 2020", 2020
Publisher: Politecnico di Torino - IRIS

Tissue-engineered models of human pathological cardiac tissue through bioartificial scaffolds

Author(s): Ireme Carmagnola; Alice ZOSO; Spedicati, Mattia; Ruocco, Gerardina; Valeria Chiono
Published in: "Abstract of the ""11TH World Biomaterials Congress"", online, 11 - 15 Dec. 2020", 2020
Publisher: Politecnico di Torino - IRIS

“Bioartificial” scaffolds for the development of in vitro models of human cardiac fibrotic tissue

Author(s): Ireme Carmagnola; Alice ZOSO; Valeria Chiono
Published in: Abstract of the 30th Annual Conference of the European Society for Biomaterials (ESB), Dresden (Germany), Sept. 9-13, 2019; Dresden (DE)., 2019
Publisher: PORTO-IRIS

Direct reprogramming of human cardiac fibroblasts into cardiomyocytes in 2D and 3D culture microenvironments

Author(s): Paoletti Camilla, Divieto Carla, Chiono, Valeria
Published in: Joint Meeting of the ESC Working Groups on Myocardial Function and Cellular Biology of the Heart, 9-11 May 2019, Naples (Italy), 2019
Publisher: PORTO-Iris

Biomimetic scaffolds and multifunctional materials in the regeneration of pathological cardiac tissue

Author(s): Irene Carmagnola, Alice Zoso, Camilla Paoletti, Giulia Tarricone, Mattia Spedicati, Gerardina Ruocco, Franca di Meglio, Daria Nurzynska, Carla Divieto, Valeria Chiono
Published in: Abstract of NICE – 2020 International Conference, 2020
Publisher: NICE – 2020 International Conference

MicroRNA releasing lipoplexes as potential nanosystems against COVID 19

Author(s): Letizia Nicoletti; CAMILLA PAOLETTI; Tarricone, Giulia; Carla, Divieto; Ilaria, Andreana; Barbara, Stella; Silvia, Arpicco; Clara Mattu; Valeria Chiono
Published in: Virtual FISV Symposium on SARS CoV 2 Biology and COVID 19: Current research and perspectives Programme and Abstracts September 16, 2020, 2020
Publisher: Federazione Italiana Scienze della Vita

Direct reprogramming of human cardiac fibroblasts towards the cardiac phenotype through non-viral approaches.

Author(s): Camilla Paoletti, Letizia Nicoletti, Giulia Tarricone, Carla Divieto3 Franca Di Meglio, Daria Nurzynska, Clara Mattu, Ilaria Andreana, Silvia Arpicco, Barbara Stella, Valeria Chiono
Published in: 5th Healthcare & Life Science & Entrepreneurship workshop, 2020, Page(s) 1
Publisher: Vision Dynamics Science and Entrepreneurship

Direct reprogramming of human fibroblasts as a novel tool in cardiac tissue engineering

Author(s): Valeria Chiono
Published in: TERMIS EU2019 Conference Book, 2019, Page(s) 813
Publisher: Termis

Direct reprogramming of human cardiac fibroblasts to cardiomyocytes using microRNA mimics

Author(s): Camilla Paoletti, Carla Divieto, Franca Di Meglio, Daria Nurzynska, Valeria Chiono
Published in: Termis EU 2019 Conference Book, 2019, Page(s) 1442
Publisher: Termis

Direct cell reprogramming as a new emerging strategy in cardiac regeneration

Author(s): Chiono, Valeria; Paoletti, Camilla; Carla, Divieto; Franca Di Meglio,; Clotilde, Castaldo; Daria, Nurzynska
Published in: Termis WC 2018 programme, 2018, Page(s) 14
Publisher: Termis

Lipoplexes for miRNA delivery in myocardial regeneration

Author(s): Nicoletti, Letizia; Tarricone, Giulia; Paoletti, Camilla; Carla, Divieto; Ilaria, Andreana; Barbara, Stella; Silvia, Arpicco; Mattu, Clara; Chiono, Valeria
Published in: Nano Day IV Program and Book of Abstracts (Nano Day IV; Milan, 11-14 Dec. 2020), 2019, Page(s) 136
Publisher: University of Parma and Cinsa

In vitro models of human cardiac fibrotic tissue based on bioartificial scaffolds

Author(s): Carmagnola, Irene; Zoso, Alice; Chiono, Valeria
Published in: ALTEX Proceeding, 2019, Page(s) 29, ISSN 2194-0479
Publisher: Spinger Spektrum

Thermosensitive bioartificial hydrogels as smart injectable and biocompatible systems allowing post-injection chemical crosslinking

Author(s): Chiono, Valeria; Laurano, Rossella; Zoso, Alice; Boffito, Monica
Published in: European Society for Biomaterials (ESB) programme, 2019, Page(s) "#943"
Publisher: ESB

Direct reprogramming of human cardiac fibroblasts to cardiomyocytes using microRNA mimics

Author(s): Camilla, Paoletti, Carla Divieto, Franca Di Meglio, Daria Nurzynska, Valeria Chiono
Published in: JRC Summer School 2019: Non-Animal Aprroaches in Science. Challenges & Future Directions; 21-24 May 2019, Ispra (IT), 2019, Page(s) 74
Publisher: JRC

INFLUENCE OF 3D CULTURE MICROENVIRONMENT ON MICRORNA-MEDIATED DIRECT REPROGRAMMING OF HUMAN CARDIAC FIBROBLASTS INTO CARDIOMYOCYTES

Author(s): Camilla Paoletti, Carla Divieto, Franca Di Meglio, Daria Nurzynska, Valeria Chiono
Published in: Advanced Cell Therapies and Tissue Engineering, 2019, Page(s) 32
Publisher: Ospedale San Raffaele and Nature

IN VITRO MODELS OF HUMAN PATHOLOGICAL CARDIAC TISSUE VIA BIOARTIFICIAL SCAFFOLDS

Author(s): Valeria Chiono, Alice Zoso, Mattia Spedicati, Gerardina Ruocco, Irene Carmagnola
Published in: Advanced Cell Therapies and Tissue Engineering, 2019, Page(s) 28
Publisher: Ospedale San Raffaele and Nature

In vitro models of fibrotic cardiac tissue as a potential tool for testing cardioprotective therapies for cardiovascular diseases related to COVID-19

Author(s): Mattia Spedicati, Gerardina Ruocco, Alice Zoso, Irene Carmagnola, Valeria Chiono
Published in: Virtual FISV Symposium on SARS-CoV-2 Biology and COVID-19: Current research and perspectives, 2020, ISBN 978-88-943891-2-8
Publisher: FISV - Federazione Italiana Scienze della Vita

Peer reviewed articles (25)

Using Poloxamer® 407 as Building Block of Amphiphilic Poly(ether urethane)s: Effect of its Molecular Weight Distribution on Thermo-Sensitive Hydrogel Performances in the Perspective of Their Biomedical Application

Author(s): Rossella Laurano, Michela Abrami, Mario Grassi, Gianluca Ciardelli, Monica Boffito, Valeria Chiono
Published in: Frontiers in Materials, Issue 7, 2020, ISSN 2296-8016
Publisher: Frontiers
DOI: 10.3389/fmats.2020.594515

Human Cardiac Progenitor Cell-Derived Extracellular Vesicles Exhibit Promising Potential for Supporting Cardiac Repair in Vitro

Author(s): Veronica Romano; Immacolata Belviso; Anna Maria Sacco; Domenico Cozzolino; Daria Nurzynska; Cristiano Amarelli; Ciro Maiello; Felice Sirico; Franca Di Meglio; Clotilde Castaldo
Published in: Front Physiol, 2022, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2022.879046

The Broad Spectrum of LMNA Cardiac Diseases: From Molecular Mechanisms to Clinical Phenotype

Author(s): Silvia Crasto, Ilaria My, Elisa Di Pasquale
Published in: Frontiers in Physiology, Issue 11, 2020, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.00761

MicroRNA-Mediated Direct Reprogramming of Human Adult Fibroblasts Toward Cardiac Phenotype

Author(s): C. Paoletti, C. Divieto, G. Tarricone, F. Di Meglio, D. Nurzynska, V. Chiono
Published in: Frontiers in Bioengineering and Biotechnology, Issue 8, 2020, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2020.00529

In Vitro Mechanical Stimulation to Reproduce the Pathological Hallmarks of Human Cardiac Fibrosis on a Beating Chip and Predict The Efficacy of Drugs and Advanced Therapies

Author(s): Roberta Visone; Camilla Paoletti; Alessandro Cordiale; Letizia Nicoletti; Carla Divieto; Marco Rasponi; Valeria Chiono; Paola Occhetta
Published in: Adv Healthc Mater, 2024, ISSN 2192-2659
Publisher: World Scientific
DOI: 10.1002/adhm.202301481

Editorial: Advanced Therapies for Cardiac Regeneration

Author(s): Monica Boffito, Susanna Sartori, Ipsita Roy, Irene Carmagnola, Valeria Chiono
Published in: Frontiers in Bioengineering and Biotechnology, 2021, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2021.644076

Internally-crosslinked alginate dialdehyde/alginate/gelatin-based hydrogels as bioprinting inks for prospective cardiac tissue engineering applications

Author(s): Giovanni Paolo Stola, Camilla Paoletti, Letizia Nicoletti, Geo Paul, Claudio Cassino, Leonardo Marchese, Valeria Chiono, Elena Marcello
Published in: International Journal of Bioprinting, 2024, Page(s) 4014, ISSN 2424-7723
Publisher: AccScience Publishing
DOI: 10.36922/ijb.4014

Design of Injectable Bioartificial Hydrogels by Green Chemistry for Mini-Invasive Applications in the Biomedical or Aesthetic Medicine Fields

Author(s): Rossella Laurano; Monica Boffito; Claudio Cassino; Francesco Liberti; Gianluca Ciardelli; Valeria Chiono
Published in: Gels; Volume 9; Issue 1; Pages: 59, 2023, ISSN 2310-2861
Publisher: MDPI
DOI: 10.3390/gels9010059

Cardiac Tissue-like 3D Microenvironment Enhances Route towards Human Fibroblast Direct Reprogramming into Induced Cardiomyocytes by microRNAs

Author(s): Camilla Paoletti; Elena Marcello; Maria Luna Melis; Carla Divieto; Daria Nurzynska; Valeria Chiono
Published in: Cells; Volume 11; Issue 5; Pages: 800, Issue 17, 2022, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells11050800

Lipoplexes for effective in vitro delivery of microRNAs to adult human cardiac fibroblasts for perspective direct cardiac cell reprogramming

Author(s): Letizia Nicoletti; Camilla Paoletti; Giulia Tarricone; Ilaria Andreana; Barbara Stella; Silvia Arpicco; Carla Divieto; Clara Mattu; Valeria Chiono
Published in: Nanomedicine . 2022 Sep;45:102589. doi: 10.1016/j.nano.2022.102589. Epub 2022 Jul 28, Issue 20, 2022, ISSN 1549-9634
Publisher: Elsevier BV
DOI: 10.1016/j.nano.2022.102589

Zein as a renewable material for the preparation of green nanoparticles for drug delivery

Author(s): Tivano, Francesca; Chiono, Valeria
Published in: Frontiers in Biomaterials Science, 2023, ISSN 2813-3749
Publisher: Frontiers
DOI: 10.3389/fbiom.2023.1156403

Impact of Biomaterials on Differentiation and Reprogramming Approaches for the Generation of Functional Cardiomyocytes

Author(s): Camilla Paoletti, Carla Divieto, Valeria Chiono
Published in: Cells, Issue 7/9, 2018, Page(s) 114, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells7090114

MicroRNA delivery through nanoparticles

Author(s): Sharon Wei Ling Lee, Camilla Paoletti, Marco Campisi, Tatsuya Osaki, Giulia Adriani, Roger D. Kamm, Clara Mattu, Valeria Chiono
Published in: Journal of Controlled Release, Issue 313, 2019, Page(s) 80-95, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2019.10.007

In vitro models of human cardiac fibrotic tissue on ‘bioartificial’ scaffolds

Author(s): Alice Zoso, Irene Carmagnola, Gerardina Ruocco, Mattia Spedicati, Valeria Chiono
Published in: Biomedical Science and Engineering, 2020, Page(s) 1, ISSN 2531-9892
Publisher: Page Press
DOI: 10.4081/bse.2019.122

iPS, organoids and 3D models as advanced tools for in vitro toxicology

Author(s): Nathalie Steimberg
Published in: ALTEX, 2020, Page(s) 136-140, ISSN 1868-596X
Publisher: Springer Spektrum | Springer-Verlag GmbH
DOI: 10.14573/altex.1911071

Toward Cardiac Regeneration: Combination of Pluripotent Stem Cell-Based Therapies and Bioengineering Strategies

Author(s): Marta Mazzola, Elisa Di Pasquale
Published in: Frontiers in Bioengineering and Biotechnology, Issue 8, 2020, Page(s) 23, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2020.00455

Biomimetic design of bioartificial scaffolds for the in vitro modelling of human cardiac fibrosis

Author(s): Mattia Spedicati, Gerardina Ruocco, Alice Zoso, Leonardo Mortati, Andrea Lapini, Andrea Delledonne, Carla Divieto, Veronica Romano, Clotilde Castaldo, Franca Di Meglio, Daria Nurzynska, Irene Carmagnola, Valeria Chiono
Published in: Front. Bioeng. Biotechnol., 2022, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2022.983872

Biomaterials-Enhanced Intranasal Delivery of Drugs as a Direct Route for Brain Targeting

Author(s): Elena Marcello; Valeria Chiono
Published in: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24043390

Electroconductive Photo-Curable PEGDA-Gelatin/PEDOT:PSS Hydrogels for Prospective Cardiac Tissue Engineering Application

Author(s): Daniele Testore, Alice Zoso, Galder Kortaberria, Marco Sangermano, Valeria Chiono
Published in: Front. Bioeng. Biotechnol., 24 June 2022 Sec. Biomaterials, Volume 10 - 2022, Issue 10, 2022, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2022.897575

Alginate dialdehyde-gelatin bioinks exploiting internal gelation mechanism for cardiac tissue engineering

Author(s): E. Marcello, G. P. Stola, C. Paoletti, L. Nicoletti, V. Chiono
Published in: Biomedical Science and Engineering, Issue 4, 2023, ISSN 2531-9892
Publisher: PAGEPress Publications
DOI: 10.4081/bse.212

3D bioartificial stretchable scaffolds mimicking the mechanical hallmarks of human cardiac fibrotic tissue

Author(s): Mattia Spedicati, Francesca Tivano, Alice Zoso, Janira Bei, Mario Lavella, Irene Carmagnola, Valeria Chiono
Published in: International Journal of Bioprinting, 2024, Page(s) 2247, ISSN 2424-7723
Publisher: AccScience Publishing
DOI: 10.36922/ijb.2247

Biomimetic Electrospun Scaffold-Based In Vitro Model Resembling the Hallmarks of Human Myocardial Fibrotic Tissue

Author(s): Gerardina Ruocco; Alice Zoso; Leonardo Mortati; Irene Carmagnola; Valeria Chiono
Published in: ACS Biomater. Sci. Eng., 2023, ISSN 2373-9878
Publisher: ACS
DOI: 10.1021/acsbiomaterials.3c00483

Design and Validation of Hybrid Polymer‐Lipid Nanoparticles as Novel Transfection Vectors for MicroRNA Delivery to Human Cardiac Fibroblasts

Author(s): Letizia Nicoletti, Camilla Paoletti, Martina Coletto, Elena Marcello, Giovanni Paolo Stola, Francesca Cossetta, Francesco Schiavone, Ilaria Andreana, Barbara Stella, Silvia Arpicco, Clara Mattu, Valeria Chiono
Published in: Advanced Healthcare Materials, 2025, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202500971

Bioengineering Methods in MicroRNA-Mediated Direct Reprogramming of Fibroblasts Into Cardiomyocytes.

Author(s): Camilla Paoletti; Valeria Chiono
Published in: Frontiers in Cardiovascular Medicine, Issue 9, 2021, ISSN 2297-055X
Publisher: Frontiers
DOI: 10.3389/fcvm.2021.750438

Modeling Nanocarrier Transport across a 3D In Vitro Human Blood‐Brain–Barrier Microvasculature

Author(s): Sharon Wei Ling Lee, Marco Campisi, Tatsuya Osaki, Luca Possenti, Clara Mattu, Giulia Adriani, Roger Dale Kamm, Valeria Chiono
Published in: Advanced Healthcare Materials, Issue 9/7, 2020, Page(s) 1901486, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.201901486

Book chapters (2)

Direct Reprogramming of Adult Human Cardiac Fibroblasts into Induced Cardiomyocytes Using miRcombo

Author(s): Camilla Paoletti, Carla Divieto, Valeria Chiono
Published in: Cardiac Gene Therapy. Methods in Molecular Biology, Issue 2573, 2022, ISBN 978-1-0716-2706-8
Publisher: Springer Protocols
DOI: 10.1007/978-1-0716-2707-5_3

Cell–biomaterial interactions: the role of ligand functionalization

Author(s): Alice Zoso, Monica Boffito, Rossella Laurano, Irene Carmagnola, Valeria Chiono
Published in: Handbook of Biomaterials Biocompatibility, 2020, Page(s) 139-173, ISBN 9780081029671
Publisher: Woodhead Publishing Series in Biomaterials - Elsevier
DOI: 10.1016/b978-0-08-102967-1.00009-8

Intellectual Property Rights

Patent (1)

METHOD FOR THE PREPARATION OF HYBRID POLYMERIC NANOPARTICLES FOR THE RELEASE OF OLIGONUCLEOTIDE DRUGS IN PHARMACOLOGICAL THERAPIES FOR REGENERATIVE, CURATIVE, AND PREVENTIVE PURPOSES

Application/Publication number: 22 843885
Date: 2022-12-22
Applicant(s): POLITECNICO DI TORINO