Direct cell reprogramming therapy in myocardial regeneration through an engineered multifunctional platform integrating biochemical instructive cues

Informacje na temat projektu

BIORECAR

Identyfikator umowy o grant: 772168

DOI

10.3030/772168

Projekt został zamknięty

Data podpisania przez KE 15 Czerwca 2018

Data rozpoczęcia 1 Lipca 2018

Data zakończenia 28 Lutego 2025

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity

€ 2 000 000,00

Wkład UE

€ 2 000 000,00

Koordynowany przez

POLITECNICO DI TORINO
Italy

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Publikacje

Conference proceedings (20)

Design of bioartificial scaffolds as in vitro models of pathological human cardiac tissue

Autorzy: Irene Carmagnola, Alice Zoso, Mattia Spedicati, Gerardina Ruocco, Valeria Chiono
Opublikowane w: 5th Healthcare & Life Science & Entrepreneurship workshop, 2020, Strona(/y) 1
Wydawca: Vision Dynamics Science & Entrepreneurship

Novel lipoplexes for efficient microRNA delivery to human cardiac fibroblasts

Autorzy: Nicoletti, Letizia; Tarricone, Giulia; Paoletti, Camilla; Carla, Divieto; Ilaria, Andreana; Barbara, Stella; Silvia, Arpicco; Mattu, Clara; Chiono, Valeria
Opublikowane w: Vancouver Nanomedicine Day, 17 Sept. 2020 - Abstract Booklet, 2020
Wydawca: Nanomedicine Innovation Network

In vitro models of human cardiac fibrotic tissue based on bioartificial scaffolds

Autorzy: Ireme Carmagnola; Alice ZOSO; Valeria Chiono
Opublikowane w: Linz 2019 22nd European Congress on Alternatives to Animal Testing - Eusaat 2019 - 19th Annual Congress of EUSAAT - ALTEX PROCEEDINGS, 2019
Wydawca: Springer Spektrum

MICRORNA-RELEASING LIPOPLEXES FOR DIRECT CARDIAC REPROGRAMMING IN PATHOLOGICAL CARDIAC TISSUE

Autorzy: Letizia Nicoletti; CAMILLA PAOLETTI; Tarricone, Giulia; Carla, Divieto; Ilaria, Andreana; Barbara, Stella; Silvia, Arpicco; Clara Mattu; Valeria Chiono
Opublikowane w: "Abstract of the conference ""Nature Conferences - RNA at the Bench and Bedside II"", 11-13 November 2020", 2020
Wydawca: Politecnico di Torino - IRIS

Tissue-engineered models of human pathological cardiac tissue through bioartificial scaffolds

Autorzy: Ireme Carmagnola; Alice ZOSO; Spedicati, Mattia; Ruocco, Gerardina; Valeria Chiono
Opublikowane w: "Abstract of the ""11TH World Biomaterials Congress"", online, 11 - 15 Dec. 2020", 2020
Wydawca: Politecnico di Torino - IRIS

“Bioartificial” scaffolds for the development of in vitro models of human cardiac fibrotic tissue

Autorzy: Ireme Carmagnola; Alice ZOSO; Valeria Chiono
Opublikowane w: Abstract of the 30th Annual Conference of the European Society for Biomaterials (ESB), Dresden (Germany), Sept. 9-13, 2019; Dresden (DE)., 2019
Wydawca: PORTO-IRIS

Direct reprogramming of human cardiac fibroblasts into cardiomyocytes in 2D and 3D culture microenvironments

Autorzy: Paoletti Camilla, Divieto Carla, Chiono, Valeria
Opublikowane w: Joint Meeting of the ESC Working Groups on Myocardial Function and Cellular Biology of the Heart, 9-11 May 2019, Naples (Italy), 2019
Wydawca: PORTO-Iris

Biomimetic scaffolds and multifunctional materials in the regeneration of pathological cardiac tissue

Autorzy: Irene Carmagnola, Alice Zoso, Camilla Paoletti, Giulia Tarricone, Mattia Spedicati, Gerardina Ruocco, Franca di Meglio, Daria Nurzynska, Carla Divieto, Valeria Chiono
Opublikowane w: Abstract of NICE – 2020 International Conference, 2020
Wydawca: NICE – 2020 International Conference

MicroRNA releasing lipoplexes as potential nanosystems against COVID 19

Autorzy: Letizia Nicoletti; CAMILLA PAOLETTI; Tarricone, Giulia; Carla, Divieto; Ilaria, Andreana; Barbara, Stella; Silvia, Arpicco; Clara Mattu; Valeria Chiono
Opublikowane w: Virtual FISV Symposium on SARS CoV 2 Biology and COVID 19: Current research and perspectives Programme and Abstracts September 16, 2020, 2020
Wydawca: Federazione Italiana Scienze della Vita

Direct reprogramming of human cardiac fibroblasts towards the cardiac phenotype through non-viral approaches.

Autorzy: Camilla Paoletti, Letizia Nicoletti, Giulia Tarricone, Carla Divieto3 Franca Di Meglio, Daria Nurzynska, Clara Mattu, Ilaria Andreana, Silvia Arpicco, Barbara Stella, Valeria Chiono
Opublikowane w: 5th Healthcare & Life Science & Entrepreneurship workshop, 2020, Strona(/y) 1
Wydawca: Vision Dynamics Science and Entrepreneurship

Direct reprogramming of human fibroblasts as a novel tool in cardiac tissue engineering

Autorzy: Valeria Chiono
Opublikowane w: TERMIS EU2019 Conference Book, 2019, Strona(/y) 813
Wydawca: Termis

Direct reprogramming of human cardiac fibroblasts to cardiomyocytes using microRNA mimics

Autorzy: Camilla Paoletti, Carla Divieto, Franca Di Meglio, Daria Nurzynska, Valeria Chiono
Opublikowane w: Termis EU 2019 Conference Book, 2019, Strona(/y) 1442
Wydawca: Termis

Direct cell reprogramming as a new emerging strategy in cardiac regeneration

Autorzy: Chiono, Valeria; Paoletti, Camilla; Carla, Divieto; Franca Di Meglio,; Clotilde, Castaldo; Daria, Nurzynska
Opublikowane w: Termis WC 2018 programme, 2018, Strona(/y) 14
Wydawca: Termis

Lipoplexes for miRNA delivery in myocardial regeneration

Autorzy: Nicoletti, Letizia; Tarricone, Giulia; Paoletti, Camilla; Carla, Divieto; Ilaria, Andreana; Barbara, Stella; Silvia, Arpicco; Mattu, Clara; Chiono, Valeria
Opublikowane w: Nano Day IV Program and Book of Abstracts (Nano Day IV; Milan, 11-14 Dec. 2020), 2019, Strona(/y) 136
Wydawca: University of Parma and Cinsa

In vitro models of human cardiac fibrotic tissue based on bioartificial scaffolds

Autorzy: Carmagnola, Irene; Zoso, Alice; Chiono, Valeria
Opublikowane w: ALTEX Proceeding, 2019, Strona(/y) 29, ISSN 2194-0479
Wydawca: Spinger Spektrum

Thermosensitive bioartificial hydrogels as smart injectable and biocompatible systems allowing post-injection chemical crosslinking

Autorzy: Chiono, Valeria; Laurano, Rossella; Zoso, Alice; Boffito, Monica
Opublikowane w: European Society for Biomaterials (ESB) programme, 2019, Strona(/y) "#943"
Wydawca: ESB

Direct reprogramming of human cardiac fibroblasts to cardiomyocytes using microRNA mimics

Autorzy: Camilla, Paoletti, Carla Divieto, Franca Di Meglio, Daria Nurzynska, Valeria Chiono
Opublikowane w: JRC Summer School 2019: Non-Animal Aprroaches in Science. Challenges & Future Directions; 21-24 May 2019, Ispra (IT), 2019, Strona(/y) 74
Wydawca: JRC

INFLUENCE OF 3D CULTURE MICROENVIRONMENT ON MICRORNA-MEDIATED DIRECT REPROGRAMMING OF HUMAN CARDIAC FIBROBLASTS INTO CARDIOMYOCYTES

Autorzy: Camilla Paoletti, Carla Divieto, Franca Di Meglio, Daria Nurzynska, Valeria Chiono
Opublikowane w: Advanced Cell Therapies and Tissue Engineering, 2019, Strona(/y) 32
Wydawca: Ospedale San Raffaele and Nature

IN VITRO MODELS OF HUMAN PATHOLOGICAL CARDIAC TISSUE VIA BIOARTIFICIAL SCAFFOLDS

Autorzy: Valeria Chiono, Alice Zoso, Mattia Spedicati, Gerardina Ruocco, Irene Carmagnola
Opublikowane w: Advanced Cell Therapies and Tissue Engineering, 2019, Strona(/y) 28
Wydawca: Ospedale San Raffaele and Nature

In vitro models of fibrotic cardiac tissue as a potential tool for testing cardioprotective therapies for cardiovascular diseases related to COVID-19

Autorzy: Mattia Spedicati, Gerardina Ruocco, Alice Zoso, Irene Carmagnola, Valeria Chiono
Opublikowane w: Virtual FISV Symposium on SARS-CoV-2 Biology and COVID-19: Current research and perspectives, 2020, ISBN 978-88-943891-2-8
Wydawca: FISV - Federazione Italiana Scienze della Vita

Peer reviewed articles (25)

Using Poloxamer® 407 as Building Block of Amphiphilic Poly(ether urethane)s: Effect of its Molecular Weight Distribution on Thermo-Sensitive Hydrogel Performances in the Perspective of Their Biomedical Application

Autorzy: Rossella Laurano, Michela Abrami, Mario Grassi, Gianluca Ciardelli, Monica Boffito, Valeria Chiono
Opublikowane w: Frontiers in Materials, Numer 7, 2020, ISSN 2296-8016
Wydawca: Frontiers
DOI: 10.3389/fmats.2020.594515

Human Cardiac Progenitor Cell-Derived Extracellular Vesicles Exhibit Promising Potential for Supporting Cardiac Repair in Vitro

Autorzy: Veronica Romano; Immacolata Belviso; Anna Maria Sacco; Domenico Cozzolino; Daria Nurzynska; Cristiano Amarelli; Ciro Maiello; Felice Sirico; Franca Di Meglio; Clotilde Castaldo
Opublikowane w: Front Physiol, 2022, ISSN 1664-042X
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fphys.2022.879046

The Broad Spectrum of LMNA Cardiac Diseases: From Molecular Mechanisms to Clinical Phenotype

Autorzy: Silvia Crasto, Ilaria My, Elisa Di Pasquale
Opublikowane w: Frontiers in Physiology, Numer 11, 2020, ISSN 1664-042X
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.00761

MicroRNA-Mediated Direct Reprogramming of Human Adult Fibroblasts Toward Cardiac Phenotype

Autorzy: C. Paoletti, C. Divieto, G. Tarricone, F. Di Meglio, D. Nurzynska, V. Chiono
Opublikowane w: Frontiers in Bioengineering and Biotechnology, Numer 8, 2020, ISSN 2296-4185
Wydawca: Frontiers
DOI: 10.3389/fbioe.2020.00529

In Vitro Mechanical Stimulation to Reproduce the Pathological Hallmarks of Human Cardiac Fibrosis on a Beating Chip and Predict The Efficacy of Drugs and Advanced Therapies

Autorzy: Roberta Visone; Camilla Paoletti; Alessandro Cordiale; Letizia Nicoletti; Carla Divieto; Marco Rasponi; Valeria Chiono; Paola Occhetta
Opublikowane w: Adv Healthc Mater, 2024, ISSN 2192-2659
Wydawca: World Scientific
DOI: 10.1002/adhm.202301481

Editorial: Advanced Therapies for Cardiac Regeneration

Autorzy: Monica Boffito, Susanna Sartori, Ipsita Roy, Irene Carmagnola, Valeria Chiono
Opublikowane w: Frontiers in Bioengineering and Biotechnology, 2021, ISSN 2296-4185
Wydawca: Frontiers
DOI: 10.3389/fbioe.2021.644076

Internally-crosslinked alginate dialdehyde/alginate/gelatin-based hydrogels as bioprinting inks for prospective cardiac tissue engineering applications

Autorzy: Giovanni Paolo Stola, Camilla Paoletti, Letizia Nicoletti, Geo Paul, Claudio Cassino, Leonardo Marchese, Valeria Chiono, Elena Marcello
Opublikowane w: International Journal of Bioprinting, 2024, Strona(/y) 4014, ISSN 2424-7723
Wydawca: AccScience Publishing
DOI: 10.36922/ijb.4014

Design of Injectable Bioartificial Hydrogels by Green Chemistry for Mini-Invasive Applications in the Biomedical or Aesthetic Medicine Fields

Autorzy: Rossella Laurano; Monica Boffito; Claudio Cassino; Francesco Liberti; Gianluca Ciardelli; Valeria Chiono
Opublikowane w: Gels; Volume 9; Numer 1; Pages: 59, 2023, ISSN 2310-2861
Wydawca: MDPI
DOI: 10.3390/gels9010059

Cardiac Tissue-like 3D Microenvironment Enhances Route towards Human Fibroblast Direct Reprogramming into Induced Cardiomyocytes by microRNAs

Autorzy: Camilla Paoletti; Elena Marcello; Maria Luna Melis; Carla Divieto; Daria Nurzynska; Valeria Chiono
Opublikowane w: Cells; Volume 11; Numer 5; Pages: 800, Numer 17, 2022, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.3390/cells11050800

Lipoplexes for effective in vitro delivery of microRNAs to adult human cardiac fibroblasts for perspective direct cardiac cell reprogramming

Autorzy: Letizia Nicoletti; Camilla Paoletti; Giulia Tarricone; Ilaria Andreana; Barbara Stella; Silvia Arpicco; Carla Divieto; Clara Mattu; Valeria Chiono
Opublikowane w: Nanomedicine . 2022 Sep;45:102589. doi: 10.1016/j.nano.2022.102589. Epub 2022 Jul 28, Numer 20, 2022, ISSN 1549-9634
Wydawca: Elsevier BV
DOI: 10.1016/j.nano.2022.102589

Zein as a renewable material for the preparation of green nanoparticles for drug delivery

Autorzy: Tivano, Francesca; Chiono, Valeria
Opublikowane w: Frontiers in Biomaterials Science, 2023, ISSN 2813-3749
Wydawca: Frontiers
DOI: 10.3389/fbiom.2023.1156403

Impact of Biomaterials on Differentiation and Reprogramming Approaches for the Generation of Functional Cardiomyocytes

Autorzy: Camilla Paoletti, Carla Divieto, Valeria Chiono
Opublikowane w: Cells, Numer 7/9, 2018, Strona(/y) 114, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.3390/cells7090114

MicroRNA delivery through nanoparticles

Autorzy: Sharon Wei Ling Lee, Camilla Paoletti, Marco Campisi, Tatsuya Osaki, Giulia Adriani, Roger D. Kamm, Clara Mattu, Valeria Chiono
Opublikowane w: Journal of Controlled Release, Numer 313, 2019, Strona(/y) 80-95, ISSN 0168-3659
Wydawca: Elsevier BV
DOI: 10.1016/j.jconrel.2019.10.007

In vitro models of human cardiac fibrotic tissue on ‘bioartificial’ scaffolds

Autorzy: Alice Zoso, Irene Carmagnola, Gerardina Ruocco, Mattia Spedicati, Valeria Chiono
Opublikowane w: Biomedical Science and Engineering, 2020, Strona(/y) 1, ISSN 2531-9892
Wydawca: Page Press
DOI: 10.4081/bse.2019.122

iPS, organoids and 3D models as advanced tools for in vitro toxicology

Autorzy: Nathalie Steimberg
Opublikowane w: ALTEX, 2020, Strona(/y) 136-140, ISSN 1868-596X
Wydawca: Springer Spektrum | Springer-Verlag GmbH
DOI: 10.14573/altex.1911071

Toward Cardiac Regeneration: Combination of Pluripotent Stem Cell-Based Therapies and Bioengineering Strategies

Autorzy: Marta Mazzola, Elisa Di Pasquale
Opublikowane w: Frontiers in Bioengineering and Biotechnology, Numer 8, 2020, Strona(/y) 23, ISSN 2296-4185
Wydawca: Frontiers
DOI: 10.3389/fbioe.2020.00455

Biomimetic design of bioartificial scaffolds for the in vitro modelling of human cardiac fibrosis

Autorzy: Mattia Spedicati, Gerardina Ruocco, Alice Zoso, Leonardo Mortati, Andrea Lapini, Andrea Delledonne, Carla Divieto, Veronica Romano, Clotilde Castaldo, Franca Di Meglio, Daria Nurzynska, Irene Carmagnola, Valeria Chiono
Opublikowane w: Front. Bioeng. Biotechnol., 2022, ISSN 2296-4185
Wydawca: Frontiers
DOI: 10.3389/fbioe.2022.983872

Biomaterials-Enhanced Intranasal Delivery of Drugs as a Direct Route for Brain Targeting

Autorzy: Elena Marcello; Valeria Chiono
Opublikowane w: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24043390

Electroconductive Photo-Curable PEGDA-Gelatin/PEDOT:PSS Hydrogels for Prospective Cardiac Tissue Engineering Application

Autorzy: Daniele Testore, Alice Zoso, Galder Kortaberria, Marco Sangermano, Valeria Chiono
Opublikowane w: Front. Bioeng. Biotechnol., 24 June 2022 Sec. Biomaterials, Volume 10 - 2022, Numer 10, 2022, ISSN 2296-4185
Wydawca: Frontiers
DOI: 10.3389/fbioe.2022.897575

Alginate dialdehyde-gelatin bioinks exploiting internal gelation mechanism for cardiac tissue engineering

Autorzy: E. Marcello, G. P. Stola, C. Paoletti, L. Nicoletti, V. Chiono
Opublikowane w: Biomedical Science and Engineering, Numer 4, 2023, ISSN 2531-9892
Wydawca: PAGEPress Publications
DOI: 10.4081/bse.212

3D bioartificial stretchable scaffolds mimicking the mechanical hallmarks of human cardiac fibrotic tissue

Autorzy: Mattia Spedicati, Francesca Tivano, Alice Zoso, Janira Bei, Mario Lavella, Irene Carmagnola, Valeria Chiono
Opublikowane w: International Journal of Bioprinting, 2024, Strona(/y) 2247, ISSN 2424-7723
Wydawca: AccScience Publishing
DOI: 10.36922/ijb.2247

Biomimetic Electrospun Scaffold-Based In Vitro Model Resembling the Hallmarks of Human Myocardial Fibrotic Tissue

Autorzy: Gerardina Ruocco; Alice Zoso; Leonardo Mortati; Irene Carmagnola; Valeria Chiono
Opublikowane w: ACS Biomater. Sci. Eng., 2023, ISSN 2373-9878
Wydawca: ACS
DOI: 10.1021/acsbiomaterials.3c00483

Design and Validation of Hybrid Polymer‐Lipid Nanoparticles as Novel Transfection Vectors for MicroRNA Delivery to Human Cardiac Fibroblasts

Autorzy: Letizia Nicoletti, Camilla Paoletti, Martina Coletto, Elena Marcello, Giovanni Paolo Stola, Francesca Cossetta, Francesco Schiavone, Ilaria Andreana, Barbara Stella, Silvia Arpicco, Clara Mattu, Valeria Chiono
Opublikowane w: Advanced Healthcare Materials, 2025, ISSN 2192-2640
Wydawca: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202500971

Bioengineering Methods in MicroRNA-Mediated Direct Reprogramming of Fibroblasts Into Cardiomyocytes.

Autorzy: Camilla Paoletti; Valeria Chiono
Opublikowane w: Frontiers in Cardiovascular Medicine, Numer 9, 2021, ISSN 2297-055X
Wydawca: Frontiers
DOI: 10.3389/fcvm.2021.750438

Modeling Nanocarrier Transport across a 3D In Vitro Human Blood‐Brain–Barrier Microvasculature

Autorzy: Sharon Wei Ling Lee, Marco Campisi, Tatsuya Osaki, Luca Possenti, Clara Mattu, Giulia Adriani, Roger Dale Kamm, Valeria Chiono
Opublikowane w: Advanced Healthcare Materials, Numer 9/7, 2020, Strona(/y) 1901486, ISSN 2192-2640
Wydawca: John Wiley and Sons Ltd
DOI: 10.1002/adhm.201901486

Book chapters (2)

Direct Reprogramming of Adult Human Cardiac Fibroblasts into Induced Cardiomyocytes Using miRcombo

Autorzy: Camilla Paoletti, Carla Divieto, Valeria Chiono
Opublikowane w: Cardiac Gene Therapy. Methods in Molecular Biology, Numer 2573, 2022, ISBN 978-1-0716-2706-8
Wydawca: Springer Protocols
DOI: 10.1007/978-1-0716-2707-5_3

Cell–biomaterial interactions: the role of ligand functionalization

Autorzy: Alice Zoso, Monica Boffito, Rossella Laurano, Irene Carmagnola, Valeria Chiono
Opublikowane w: Handbook of Biomaterials Biocompatibility, 2020, Strona(/y) 139-173, ISBN 9780081029671
Wydawca: Woodhead Publishing Series in Biomaterials - Elsevier
DOI: 10.1016/b978-0-08-102967-1.00009-8

Prawa własności intelektualnej

Patent (1)

METHOD FOR THE PREPARATION OF HYBRID POLYMERIC NANOPARTICLES FOR THE RELEASE OF OLIGONUCLEOTIDE DRUGS IN PHARMACOLOGICAL THERAPIES FOR REGENERATIVE, CURATIVE, AND PREVENTIVE PURPOSES

Numer wniosku/publikacji: 22 843885
Data: 2022-12-22
Wnioskodawca/wnioskodawcy: POLITECNICO DI TORINO