Optochemical control of cell fate by activation of mRNA translation

Project Information

RNActivate

Grant agreement ID: 772280

DOI

10.3030/772280

Project closed

EC signature date 20 February 2018

Start date 1 June 2018

End date 30 November 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 990 225,00

EU contribution

€ 1 990 225,00

Coordinated by

UNIVERSITAET MUENSTER
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (13)

Covalent labeling of nucleic acids

Author(s): Nils Klöcker, Florian P. Weissenboeck, Andrea Rentmeister
Published in: Chemical Society Reviews, Issue 49/23, 2020, Page(s) 8749-8773, ISSN 0306-0012
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0cs00600a

Visible-Light Removable Photocaging Groups Accepted by MjMAT Variant: Structural Basis and Compatibility with DNA and RNA Methyltransferases.

Author(s): Aileen Peters; Eric Herrmann; Nicolas V. Cornelissen; Nils Klöcker; Daniel Kümmel; Andrea Rentmeister
Published in: ChemBioChem, Issue 4, 2022, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202100437

Engineered SAM Synthetases for Enzymatic Generation of AdoMet Analogs with Photocaging Groups and Reversible DNA Modification in Cascade Reactions

Author(s): Freideriki Michailidou, Nils Klöcker, Nicolas V. Cornelissen, Rohit K. Singh, Aileen Peters, Anna Ovcharenko, Daniel Kümmel, Andrea Rentmeister
Published in: Angewandte Chemie International Edition, Issue 60/1, 2021, Page(s) 480-485, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202012623

Chemo‐Enzymatic Modification of the 5′ Cap Maintains Translation and Increases Immunogenic Properties of mRNA

Author(s): Melissa Dülmen, Nils Muthmann, Andrea Rentmeister
Published in: Angewandte Chemie International Edition, Issue 60/24, 2021, Page(s) 13280-13286, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202100352

Tag‐Free Internal RNA Labeling and Photocaging Based on mRNA Methyltransferases

Author(s): Anna Ovcharenko, Florian P. Weissenboeck, Andrea Rentmeister
Published in: Angewandte Chemie International Edition, 2021, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202013936

Photocaged 5' cap analogues for optical control of mRNA translation in cells

Author(s): Nils Klöcker, Florian P. Weissenboeck, Melissa van Dülmen, Petr Špaček, Sabine Hüwel, Andrea Rentmeister
Published in: Nature Chemistry, 2022, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-022-00972-7

Quantification of mRNA cap-modifications by means of LC-QqQ-MS

Author(s): Nils Muthmann, Petr Špaček, Dennis Reichert, Melissa van Dülmen, Andrea Rentmeister
Published in: Methods, 2021, ISSN 1046-2023
Publisher: Academic Press
DOI: 10.1016/j.ymeth.2021.05.018

Enzymatic Modification of the 5' Cap with Photocleavable ONB-Derivatives Using GlaTgs V34A

Author(s): Nils Klöcker, Lea Anhäuser, Andrea Rentmeister
Published in: ChemBioChem, 2022, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202200522

Light-Activated Translation of Different mRNAs in Cells via Wavelength-Dependent Photouncaging

Author(s): Amarnath Bollu, Nils Klöcker, Petr Špaček, Florian P. Weissenboeck, Sabine Hüwel, Andrea Rentmeister
Published in: Angewandte Chemie International Edition, 2023, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202209975

A Benzophenone-Based Photocaging Strategy for the N7 Position of Guanosine

Author(s): Lea Anhäuser, Nils Klöcker, Fabian Muttach, Florian Mäsing, Petr Špaček, Armido Studer, Andrea Rentmeister
Published in: Angewandte Chemie International Edition, 2019, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201914573

Nucleoside-modified AdoMet analogues for differential methyltransferase targeting

Author(s): Nicolas V. Cornelissen, Freideriki Michailidou, Fabian Muttach, Kristina Rau, Andrea Rentmeister
Published in: Chemical Communications, 2020, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9cc07807j

Visible Light Activates Coumarin-Caged mRNA for Cytoplasmic Cap Methylation in Cells

Author(s): Dr. Amarnath Bollu, Helena Schepers, Nils Klöcker, Mehmet Erguven, Ann-Marie Lawrence-Dörner, Prof. Dr. Andrea Rentmeister
Published in: Chemistry - A European Journal, 2024, Page(s) e202303174, ISSN 1521-3765
Publisher: Wiley
DOI: 10.1002/chem.202303174

Bioorthogonal mRNA labeling at the poly(A) tail for imaging localization and dynamics in live zebrafish embryos

Author(s): Kim J. Westerich, Karthik S. Chandrasekaran, Theresa Gross-Thebing, Nadine Kueck, Erez Raz, Andrea Rentmeister
Published in: Chemical Science, Issue 11/11, 2020, Page(s) 3089-3095, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9sc05981d

Non-peer reviewed articles (1)

Harnessing methylation and AdoMet-utilising enzymes for selective modification in cascade reactions

Author(s): Freideriki Michailidou, Andrea Rentmeister
Published in: Organic & Biomolecular Chemistry, Issue 19/17, 2021, Page(s) 3756-3762, ISSN 1477-0520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1ob00354b