Optochemical control of cell fate by activation of mRNA translation

Project Information

RNActivate

Grant agreement ID: 772280

DOI 10.3030/772280

Project closed

EC signature date 20 February 2018

Start date 1 June 2018

End date 30 November 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 990 225,00

EU contribution € 1 990 225,00

Coordinated by

UNIVERSITAET MUENSTER
Germany

Publications

Peer reviewed articles (13)

Covalent labeling of nucleic acids

Author(s): Nils Klöcker, Florian P. Weissenboeck, Andrea Rentmeister
Published in: Chemical Society Reviews, Issue 49/23, 2020, Page(s) 8749-8773, ISSN 0306-0012
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0cs00600a

Visible-Light Removable Photocaging Groups Accepted by MjMAT Variant: Structural Basis and Compatibility with DNA and RNA Methyltransferases.

Author(s): Aileen Peters; Eric Herrmann; Nicolas V. Cornelissen; Nils Klöcker; Daniel Kümmel; Andrea Rentmeister
Published in: ChemBioChem, Issue 4, 2022, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202100437

Engineered SAM Synthetases for Enzymatic Generation of AdoMet Analogs with Photocaging Groups and Reversible DNA Modification in Cascade Reactions

Author(s): Freideriki Michailidou, Nils Klöcker, Nicolas V. Cornelissen, Rohit K. Singh, Aileen Peters, Anna Ovcharenko, Daniel Kümmel, Andrea Rentmeister
Published in: Angewandte Chemie International Edition, Issue 60/1, 2021, Page(s) 480-485, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202012623

Chemo‐Enzymatic Modification of the 5′ Cap Maintains Translation and Increases Immunogenic Properties of mRNA

Author(s): Melissa Dülmen, Nils Muthmann, Andrea Rentmeister
Published in: Angewandte Chemie International Edition, Issue 60/24, 2021, Page(s) 13280-13286, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202100352

Tag‐Free Internal RNA Labeling and Photocaging Based on mRNA Methyltransferases

Author(s): Anna Ovcharenko, Florian P. Weissenboeck, Andrea Rentmeister
Published in: Angewandte Chemie International Edition, 2021, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202013936

Photocaged 5' cap analogues for optical control of mRNA translation in cells

Author(s): Nils Klöcker, Florian P. Weissenboeck, Melissa van Dülmen, Petr Špaček, Sabine Hüwel, Andrea Rentmeister
Published in: Nature Chemistry, 2022, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-022-00972-7

Quantification of mRNA cap-modifications by means of LC-QqQ-MS

Author(s): Nils Muthmann, Petr Špaček, Dennis Reichert, Melissa van Dülmen, Andrea Rentmeister
Published in: Methods, 2021, ISSN 1046-2023
Publisher: Academic Press
DOI: 10.1016/j.ymeth.2021.05.018

Enzymatic Modification of the 5' Cap with Photocleavable ONB-Derivatives Using GlaTgs V34A

Author(s): Nils Klöcker, Lea Anhäuser, Andrea Rentmeister
Published in: ChemBioChem, 2022, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202200522

Light-Activated Translation of Different mRNAs in Cells via Wavelength-Dependent Photouncaging

Author(s): Amarnath Bollu, Nils Klöcker, Petr Špaček, Florian P. Weissenboeck, Sabine Hüwel, Andrea Rentmeister
Published in: Angewandte Chemie International Edition, 2023, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202209975

A Benzophenone-Based Photocaging Strategy for the N7 Position of Guanosine

Author(s): Lea Anhäuser, Nils Klöcker, Fabian Muttach, Florian Mäsing, Petr Špaček, Armido Studer, Andrea Rentmeister
Published in: Angewandte Chemie International Edition, 2019, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201914573

Nucleoside-modified AdoMet analogues for differential methyltransferase targeting

Author(s): Nicolas V. Cornelissen, Freideriki Michailidou, Fabian Muttach, Kristina Rau, Andrea Rentmeister
Published in: Chemical Communications, 2020, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9cc07807j

Visible Light Activates Coumarin-Caged mRNA for Cytoplasmic Cap Methylation in Cells

Author(s): Dr. Amarnath Bollu, Helena Schepers, Nils Klöcker, Mehmet Erguven, Ann-Marie Lawrence-Dörner, Prof. Dr. Andrea Rentmeister
Published in: Chemistry - A European Journal, 2024, Page(s) e202303174, ISSN 1521-3765
Publisher: Wiley
DOI: 10.1002/chem.202303174

Bioorthogonal mRNA labeling at the poly(A) tail for imaging localization and dynamics in live zebrafish embryos

Author(s): Kim J. Westerich, Karthik S. Chandrasekaran, Theresa Gross-Thebing, Nadine Kueck, Erez Raz, Andrea Rentmeister
Published in: Chemical Science, Issue 11/11, 2020, Page(s) 3089-3095, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9sc05981d

Non-peer reviewed articles (1)

Harnessing methylation and AdoMet-utilising enzymes for selective modification in cascade reactions

Author(s): Freideriki Michailidou, Andrea Rentmeister
Published in: Organic & Biomolecular Chemistry, Issue 19/17, 2021, Page(s) 3756-3762, ISSN 1477-0520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1ob00354b