Optochemical control of cell fate by activation of mRNA translation

Informazioni relative al progetto

RNActivate

ID dell’accordo di sovvenzione: 772280

DOI 10.3030/772280

Progetto chiuso

Data della firma CE 20 Febbraio 2018

Data di avvio 1 Giugno 2018

Data di completamento 30 Novembre 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 990 225,00

Contributo UE € 1 990 225,00

Coordinato da

UNIVERSITAET MUENSTER
Germany

Pubblicazioni

Peer reviewed articles (13)

Covalent labeling of nucleic acids

Autori: Nils Klöcker, Florian P. Weissenboeck, Andrea Rentmeister
Pubblicato in: Chemical Society Reviews, Numero 49/23, 2020, Pagina/e 8749-8773, ISSN 0306-0012
Editore: Royal Society of Chemistry
DOI: 10.1039/d0cs00600a

Visible-Light Removable Photocaging Groups Accepted by MjMAT Variant: Structural Basis and Compatibility with DNA and RNA Methyltransferases.

Autori: Aileen Peters; Eric Herrmann; Nicolas V. Cornelissen; Nils Klöcker; Daniel Kümmel; Andrea Rentmeister
Pubblicato in: ChemBioChem, Numero 4, 2022, ISSN 1439-4227
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202100437

Engineered SAM Synthetases for Enzymatic Generation of AdoMet Analogs with Photocaging Groups and Reversible DNA Modification in Cascade Reactions

Autori: Freideriki Michailidou, Nils Klöcker, Nicolas V. Cornelissen, Rohit K. Singh, Aileen Peters, Anna Ovcharenko, Daniel Kümmel, Andrea Rentmeister
Pubblicato in: Angewandte Chemie International Edition, Numero 60/1, 2021, Pagina/e 480-485, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202012623

Chemo‐Enzymatic Modification of the 5′ Cap Maintains Translation and Increases Immunogenic Properties of mRNA

Autori: Melissa Dülmen, Nils Muthmann, Andrea Rentmeister
Pubblicato in: Angewandte Chemie International Edition, Numero 60/24, 2021, Pagina/e 13280-13286, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202100352

Tag‐Free Internal RNA Labeling and Photocaging Based on mRNA Methyltransferases

Autori: Anna Ovcharenko, Florian P. Weissenboeck, Andrea Rentmeister
Pubblicato in: Angewandte Chemie International Edition, 2021, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202013936

Photocaged 5' cap analogues for optical control of mRNA translation in cells

Autori: Nils Klöcker, Florian P. Weissenboeck, Melissa van Dülmen, Petr Špaček, Sabine Hüwel, Andrea Rentmeister
Pubblicato in: Nature Chemistry, 2022, ISSN 1755-4330
Editore: Nature Publishing Group
DOI: 10.1038/s41557-022-00972-7

Quantification of mRNA cap-modifications by means of LC-QqQ-MS

Autori: Nils Muthmann, Petr Špaček, Dennis Reichert, Melissa van Dülmen, Andrea Rentmeister
Pubblicato in: Methods, 2021, ISSN 1046-2023
Editore: Academic Press
DOI: 10.1016/j.ymeth.2021.05.018

Enzymatic Modification of the 5' Cap with Photocleavable ONB-Derivatives Using GlaTgs V34A

Autori: Nils Klöcker, Lea Anhäuser, Andrea Rentmeister
Pubblicato in: ChemBioChem, 2022, ISSN 1439-4227
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202200522

Light-Activated Translation of Different mRNAs in Cells via Wavelength-Dependent Photouncaging

Autori: Amarnath Bollu, Nils Klöcker, Petr Špaček, Florian P. Weissenboeck, Sabine Hüwel, Andrea Rentmeister
Pubblicato in: Angewandte Chemie International Edition, 2023, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202209975

A Benzophenone-Based Photocaging Strategy for the N7 Position of Guanosine

Autori: Lea Anhäuser, Nils Klöcker, Fabian Muttach, Florian Mäsing, Petr Špaček, Armido Studer, Andrea Rentmeister
Pubblicato in: Angewandte Chemie International Edition, 2019, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201914573

Nucleoside-modified AdoMet analogues for differential methyltransferase targeting

Autori: Nicolas V. Cornelissen, Freideriki Michailidou, Fabian Muttach, Kristina Rau, Andrea Rentmeister
Pubblicato in: Chemical Communications, 2020, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/c9cc07807j

Visible Light Activates Coumarin-Caged mRNA for Cytoplasmic Cap Methylation in Cells

Autori: Dr. Amarnath Bollu, Helena Schepers, Nils Klöcker, Mehmet Erguven, Ann-Marie Lawrence-Dörner, Prof. Dr. Andrea Rentmeister
Pubblicato in: Chemistry - A European Journal, 2024, Pagina/e e202303174, ISSN 1521-3765
Editore: Wiley
DOI: 10.1002/chem.202303174

Bioorthogonal mRNA labeling at the poly(A) tail for imaging localization and dynamics in live zebrafish embryos

Autori: Kim J. Westerich, Karthik S. Chandrasekaran, Theresa Gross-Thebing, Nadine Kueck, Erez Raz, Andrea Rentmeister
Pubblicato in: Chemical Science, Numero 11/11, 2020, Pagina/e 3089-3095, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/c9sc05981d

Non-peer reviewed articles (1)

Harnessing methylation and AdoMet-utilising enzymes for selective modification in cascade reactions

Autori: Freideriki Michailidou, Andrea Rentmeister
Pubblicato in: Organic & Biomolecular Chemistry, Numero 19/17, 2021, Pagina/e 3756-3762, ISSN 1477-0520
Editore: Royal Society of Chemistry
DOI: 10.1039/d1ob00354b