The integration of mechanical and chemical signals in neuronal guidance

Información del proyecto

MECHEMGUI

Identificador del acuerdo de subvención: 772426

DOI

10.3030/772426

Proyecto cerrado

Fecha de la firma de la CE 15 Mayo 2018

Fecha de inicio 1 Junio 2018

Fecha de finalización 31 Diciembre 2023

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 468 520,00

Aportación de la UE

€ 2 468 520,00

Coordinado por

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (22)

Mechanics in the nervous system: From development to disease

Autores: Eva K. Pillai, Kristian Franze
Publicado en: Neuron, 2024, ISSN 0896-6273
Editor: Cell Press
DOI: 10.1016/j.neuron.2023.10.005

Regenerative capacity of neural tissue scales with changes in tissue mechanics post injury

Autores: Alejandro Carnicer-Lombarte, Damiano G. Barone, Filip Wronowski, George G. Malliaras, James W. Fawcett, Kristian Franze
Publicado en: Biomaterials, 2023, ISSN 0142-9612
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2023.122393

Theory for Durotactic Axon Guidance

Autores: Hadrien Oliveri, Kristian Franze, Alain Goriely
Publicado en: Physical Review Letters, Edición 126/11, 2021, Página(s) 118101-1 - 118101-6, ISSN 0031-9007
Editor: American Physical Society
DOI: 10.1103/physrevlett.126.118101

Cortical cell stiffness is independent of substrate mechanics

Autores: Johannes Rheinlaender, Andrea Dimitracopoulos, Bernhard Wallmeyer, Nils M. Kronenberg, Kevin J. Chalut, Malte C. Gather, Timo Betz, Guillaume Charras, Kristian Franze
Publicado en: Nature Materials, Edición 19/9, 2020, Página(s) 1019-1025, ISSN 1476-1122
Editor: Nature Publishing Group
DOI: 10.1038/s41563-020-0684-x

Prevention of the foreign body response to implantable medical devices by inflammasome inhibition

Autores: Damiano G Barone, Alejandro Carnicer-Lombarte, Panagiotis Tourlomousis, Russell S Hamilton, Malwina Prater, Alexandra L Rutz, Ivan B Dimov, George G Malliaras, Stephanie P Lacour, Avril A B Robertson, Kristian Franze, James W Fawcett, Clare E Bryant
Publicado en: PNAS, Edición 119(12), 2022, ISSN 1091-6490
Editor: The National Academy of Sciences
DOI: 10.1073/pnas.2115857119

Unrestrained growth of correctly oriented microtubules instructs axonal microtubule orientation.

Autores: Jakobs, Maximilian AH; Zemel, Assaf; Franze, Kristian
Publicado en: eLife, Edición 2, 2022, ISSN 2050-084X
Editor: eLife Sciences Publications

Axons in the Chick Embryo Follow Soft Pathways Through Developing Somite Segments

Autores: Julia Schaeffer, Isabell P Weber, Amelia J Thompson, Roger J Keynes, Kristian Franze
Publicado en: Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Editor: Frontiers Media S.A..
DOI: 10.3389/fcell.2022.917589

StemBond hydrogels optimise the mechanical microenvironment for embryonic stem cells

Autores: Céline Labouesse; Chibeza C. Agley; Bao Xiu Tan; Moritz Hofer; Alex Winkel; Giuliano Giuseppe Stirparo; Hannah T. Stuart; Christophe M. Verstreken; William Mansfield; Paul Bertone; Kristian Franze; José C. R. Silva; Kevin J. Chalut
Publicado en: Nature Communications, Edición 12(1), 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-26236-5

Mutation of the ALS-/FTD-Associated RNA-Binding Protein FUS Affects Axonal Development

Autores: Francesca W. van Tartwijk, Lucia C. S. Wunderlich, Ioanna Mela, Stanislaw Makarchuk, Maximilian A. H. Jakobs, Seema Qamar, Kristian Franze, Gabriele S. Kaminski Schierle, Peter H. St George-Hyslop, Julie Qiaojin Lin, Christine E. Holt and Clemens F. Kaminski
Publicado en: Journal of Neuroscience, 2024, ISSN 0270-6474
Editor: Society for Neuroscience
DOI: 10.1523/jneurosci.2148-23.2024

Spatial heterogeneity of cell-matrix adhesive forces predicts human glioblastoma migration

Autores: Rasha Rezk, Bill Zong Jia, Astrid Wendler, Ivan Dimov, Colin Watts, Athina E Markaki, Kristian Franze, Alexandre J Kabla
Publicado en: Neuro-Oncology Advances, Edición 2/1, 2020, ISSN 2632-2498
Editor: Oxford University Press
DOI: 10.1093/noajnl/vdaa081

Effective cell membrane tension is independent of polyacrylamide substrate stiffness

Autores: Eva Kreysing; Jeffrey Mc Hugh; Sarah K Foster; Kurt Andresen; Ryan D Greenhalgh; Eva K Pillai; Andrea Dimitracopoulos; Ulrich F Keyser; Kristian Franze
Publicado en: PNAS Nexus, Edición 1, 2023, ISSN 2752-6542
Editor: Oxford Academic
DOI: 10.1093/pnasnexus/pgac299

Soft Polydimethylsiloxane-Supported Lipid Bilayers for Studying T Cell Interactions

Autores: Anna H. Lippert, Ivan B. Dimov, Alexander K. Winkel, Jane Humphrey, James McColl, Kevin Y. Chen, Ana M. Santos, Edward Jenkins, Kristian Franze, Simon J. Davis, David Klenerman
Publicado en: Biophysical Journal, Edición 120/1, 2021, Página(s) 35-45, ISSN 0006-3495
Editor: Biophysical Society
DOI: 10.1016/j.bpj.2020.11.021

Defining the Adult Neural Stem Cell Niche Proteome Identifies Key Regulators of Adult Neurogenesis

Autores: Jacob Kjell, Judith Fischer-Sternjak, Amelia J. Thompson, Christian Friess, Matthew J. Sticco, Favio Salinas, Jürgen Cox, David C. Martinelli, Jovica Ninkovic, Kristian Franze, Herbert B. Schiller, Magdalena Götz
Publicado en: Cell Stem Cell, Edición 26/2, 2020, Página(s) 277-293.e8, ISSN 1934-5909
Editor: Cell Press
DOI: 10.1016/j.stem.2020.01.002

Brain tissue mechanics is governed by microscale relations of the tissue constituents

Autores: P Sáez, C Borau, N Antonovaite, K Franze
Publicado en: Biomaterials, 2023, ISSN 0142-9612
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2023.122273

Tensed axons are on fire

Autores: Kristian Franze
Publicado en: PNAS, 2024, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2321811121

Rapid changes in tissue mechanics regulate cell behaviour in the developing embryonic brain

Autores: Amelia J Thompson, Eva K Pillai, Ivan B Dimov, Sarah K Foster, Christine E Holt, Kristian Franze
Publicado en: eLife, Edición 8, 2019, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.39356

KymoButler, a deep learning software for automated kymograph analysis

Autores: Maximilian AH Jakobs, Andrea Dimitracopoulos, Kristian Franze
Publicado en: eLife, Edición 8, 2019, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.42288

Niche stiffness underlies the ageing of central nervous system progenitor cells

Autores: Michael Segel, Björn Neumann, Myfanwy F. E. Hill, Isabell P. Weber, Carlo Viscomi, Chao Zhao, Adam Young, Chibeza C. Agley, Amelia J. Thompson, Ginez A. Gonzalez, Amar Sharma, Staffan Holmqvist, David H. Rowitch, Kristian Franze, Robin J. M. Franklin, Kevin J. Chalut
Publicado en: Nature, Edición 573/7772, 2019, Página(s) 130-134, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-019-1484-9

Tissue stiffness at the human maternal–fetal interface

Autores: Yassen Abbas, Alejandro Carnicer-Lombarte, Lucy Gardner, Jake Thomas, Jan J Brosens, Ashley Moffett, Andrew M Sharkey, Kristian Franze, Graham J Burton, Michelle L Oyen
Publicado en: Human Reproduction, Edición 34/10, 2019, Página(s) 1999-2008, ISSN 0268-1161
Editor: Oxford University Press
DOI: 10.1093/humrep/dez139

Mechanical Regulation of Neurite Polarization and Growth: A Computational Study

Autores: Maximilian A.H. Jakobs, Kristian Franze, Assaf Zemel
Publicado en: Biophysical Journal, Edición 118/8, 2020, Página(s) 1914-1920, ISSN 0006-3495
Editor: Biophysical Society
DOI: 10.1016/j.bpj.2020.02.031

Cell surface fluctuations regulate early embryonic lineage sorting

Autores: Ayaka Yanagida 1 , Elena Corujo-Simon 2 , Christopher K Revell 3 , Preeti Sahu 4 , Giuliano G Stirparo 2 , Irene M Aspalter 5 , Alex K Winkel, Ruby Peters 6 , Henry De Belly 7 , Davide A D Cassani 5 , Sarra Achouri 8 , Raphael Blumenfeld 9 , Kristian Franze 6 , Edouard Hannezo 4 , Ewa K Paluch 10 , Jennifer Nichols 11 , Kevin J Chalut 12
Publicado en: Cell, Edición 185(5), 2022, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2022.01.022

Integrating Chemistry and Mechanics: The Forces Driving Axon Growth

Autores: Kristian Franze
Publicado en: Annual Review of Cell and Developmental Biology, Edición 36/1, 2020, Página(s) 61-83, ISSN 1081-0706
Editor: Annual Reviews, Inc.
DOI: 10.1146/annurev-cellbio-100818-125157