The integration of mechanical and chemical signals in neuronal guidance

Informazioni relative al progetto

MECHEMGUI

ID dell’accordo di sovvenzione: 772426

DOI 10.3030/772426

Progetto chiuso

Data della firma CE 15 Maggio 2018

Data di avvio 1 Giugno 2018

Data di completamento 31 Dicembre 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 2 468 520,00

Contributo UE € 2 468 520,00

Coordinato da

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

Pubblicazioni

Peer reviewed articles (17)

Theory for Durotactic Axon Guidance

Autori: Hadrien Oliveri, Kristian Franze, Alain Goriely
Pubblicato in: Physical Review Letters, Numero 126/11, 2021, Pagina/e 118101-1 - 118101-6, ISSN 0031-9007
Editore: American Physical Society
DOI: 10.1103/physrevlett.126.118101

Cortical cell stiffness is independent of substrate mechanics

Autori: Johannes Rheinlaender, Andrea Dimitracopoulos, Bernhard Wallmeyer, Nils M. Kronenberg, Kevin J. Chalut, Malte C. Gather, Timo Betz, Guillaume Charras, Kristian Franze
Pubblicato in: Nature Materials, Numero 19/9, 2020, Pagina/e 1019-1025, ISSN 1476-1122
Editore: Nature Publishing Group
DOI: 10.1038/s41563-020-0684-x

Prevention of the foreign body response to implantable medical devices by inflammasome inhibition

Autori: Damiano G Barone, Alejandro Carnicer-Lombarte, Panagiotis Tourlomousis, Russell S Hamilton, Malwina Prater, Alexandra L Rutz, Ivan B Dimov, George G Malliaras, Stephanie P Lacour, Avril A B Robertson, Kristian Franze, James W Fawcett, Clare E Bryant
Pubblicato in: PNAS, Numero 119(12), 2022, ISSN 1091-6490
Editore: The National Academy of Sciences
DOI: 10.1073/pnas.2115857119

Unrestrained growth of correctly oriented microtubules instructs axonal microtubule orientation.

Autori: Jakobs, Maximilian AH; Zemel, Assaf; Franze, Kristian
Pubblicato in: eLife, Numero 2, 2022, ISSN 2050-084X
Editore: eLife Sciences Publications

Axons in the Chick Embryo Follow Soft Pathways Through Developing Somite Segments

Autori: Julia Schaeffer, Isabell P Weber, Amelia J Thompson, Roger J Keynes, Kristian Franze
Pubblicato in: Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Editore: Frontiers Media S.A..
DOI: 10.3389/fcell.2022.917589

StemBond hydrogels optimise the mechanical microenvironment for embryonic stem cells

Autori: Céline Labouesse; Chibeza C. Agley; Bao Xiu Tan; Moritz Hofer; Alex Winkel; Giuliano Giuseppe Stirparo; Hannah T. Stuart; Christophe M. Verstreken; William Mansfield; Paul Bertone; Kristian Franze; José C. R. Silva; Kevin J. Chalut
Pubblicato in: Nature Communications, Numero 12(1), 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-26236-5

Spatial heterogeneity of cell-matrix adhesive forces predicts human glioblastoma migration

Autori: Rasha Rezk, Bill Zong Jia, Astrid Wendler, Ivan Dimov, Colin Watts, Athina E Markaki, Kristian Franze, Alexandre J Kabla
Pubblicato in: Neuro-Oncology Advances, Numero 2/1, 2020, ISSN 2632-2498
Editore: Oxford University Press
DOI: 10.1093/noajnl/vdaa081

Effective cell membrane tension is independent of polyacrylamide substrate stiffness

Autori: Eva Kreysing; Jeffrey Mc Hugh; Sarah K Foster; Kurt Andresen; Ryan D Greenhalgh; Eva K Pillai; Andrea Dimitracopoulos; Ulrich F Keyser; Kristian Franze
Pubblicato in: PNAS Nexus, Numero 1, 2023, ISSN 2752-6542
Editore: Oxford Academic
DOI: 10.1093/pnasnexus/pgac299

Soft Polydimethylsiloxane-Supported Lipid Bilayers for Studying T Cell Interactions

Autori: Anna H. Lippert, Ivan B. Dimov, Alexander K. Winkel, Jane Humphrey, James McColl, Kevin Y. Chen, Ana M. Santos, Edward Jenkins, Kristian Franze, Simon J. Davis, David Klenerman
Pubblicato in: Biophysical Journal, Numero 120/1, 2021, Pagina/e 35-45, ISSN 0006-3495
Editore: Biophysical Society
DOI: 10.1016/j.bpj.2020.11.021

Defining the Adult Neural Stem Cell Niche Proteome Identifies Key Regulators of Adult Neurogenesis

Autori: Jacob Kjell, Judith Fischer-Sternjak, Amelia J. Thompson, Christian Friess, Matthew J. Sticco, Favio Salinas, Jürgen Cox, David C. Martinelli, Jovica Ninkovic, Kristian Franze, Herbert B. Schiller, Magdalena Götz
Pubblicato in: Cell Stem Cell, Numero 26/2, 2020, Pagina/e 277-293.e8, ISSN 1934-5909
Editore: Cell Press
DOI: 10.1016/j.stem.2020.01.002

Rapid changes in tissue mechanics regulate cell behaviour in the developing embryonic brain

Autori: Amelia J Thompson, Eva K Pillai, Ivan B Dimov, Sarah K Foster, Christine E Holt, Kristian Franze
Pubblicato in: eLife, Numero 8, 2019, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.39356

KymoButler, a deep learning software for automated kymograph analysis

Autori: Maximilian AH Jakobs, Andrea Dimitracopoulos, Kristian Franze
Pubblicato in: eLife, Numero 8, 2019, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.42288

Niche stiffness underlies the ageing of central nervous system progenitor cells

Autori: Michael Segel, Björn Neumann, Myfanwy F. E. Hill, Isabell P. Weber, Carlo Viscomi, Chao Zhao, Adam Young, Chibeza C. Agley, Amelia J. Thompson, Ginez A. Gonzalez, Amar Sharma, Staffan Holmqvist, David H. Rowitch, Kristian Franze, Robin J. M. Franklin, Kevin J. Chalut
Pubblicato in: Nature, Numero 573/7772, 2019, Pagina/e 130-134, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-019-1484-9

Tissue stiffness at the human maternal–fetal interface

Autori: Yassen Abbas, Alejandro Carnicer-Lombarte, Lucy Gardner, Jake Thomas, Jan J Brosens, Ashley Moffett, Andrew M Sharkey, Kristian Franze, Graham J Burton, Michelle L Oyen
Pubblicato in: Human Reproduction, Numero 34/10, 2019, Pagina/e 1999-2008, ISSN 0268-1161
Editore: Oxford University Press
DOI: 10.1093/humrep/dez139

Mechanical Regulation of Neurite Polarization and Growth: A Computational Study

Autori: Maximilian A.H. Jakobs, Kristian Franze, Assaf Zemel
Pubblicato in: Biophysical Journal, Numero 118/8, 2020, Pagina/e 1914-1920, ISSN 0006-3495
Editore: Biophysical Society
DOI: 10.1016/j.bpj.2020.02.031

Cell surface fluctuations regulate early embryonic lineage sorting

Autori: Ayaka Yanagida 1 , Elena Corujo-Simon 2 , Christopher K Revell 3 , Preeti Sahu 4 , Giuliano G Stirparo 2 , Irene M Aspalter 5 , Alex K Winkel, Ruby Peters 6 , Henry De Belly 7 , Davide A D Cassani 5 , Sarra Achouri 8 , Raphael Blumenfeld 9 , Kristian Franze 6 , Edouard Hannezo 4 , Ewa K Paluch 10 , Jennifer Nichols 11 , Kevin J Chalut 12
Pubblicato in: Cell, Numero 185(5), 2022, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2022.01.022

Integrating Chemistry and Mechanics: The Forces Driving Axon Growth

Autori: Kristian Franze
Pubblicato in: Annual Review of Cell and Developmental Biology, Numero 36/1, 2020, Pagina/e 61-83, ISSN 1081-0706
Editore: Annual Reviews, Inc.
DOI: 10.1146/annurev-cellbio-100818-125157