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Chromatin-localized central metabolism regulating gene expression and cell identity

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Single-cell RNA-seq with spike-in cells enables accurate quantification of cell-specific drug effects in pancreatic islets

Author(s): Brenda Marquina-Sanchez, Nikolaus Fortelny, Matthias Farlik, Andhira Vieira, Patrick Collombat, Christoph Bock, Stefan Kubicek
Published in: Genome Biology, Issue 21(1), 2020, Page(s) 106, ISSN 1474-760X
DOI: 10.1186/s13059-020-02006-2

MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation

Author(s): Sara Sdelci, André F. Rendeiro, Philipp Rathert, Wanhui You, Jung-Ming G. Lin, Anna Ringler, Gerald Hofstätter, Herwig P. Moll, Bettina Gürtl, Matthias Farlik, Sandra Schick, Freya Klepsch, Matthew Oldach, Pisanu Buphamalai, Fiorella Schischlik, Peter Májek, Katja Parapatics, Christian Schmidl, Michael Schuster, Thomas Penz, Dennis L. Buckley, Otto Hudecz, Richard Imre, Shuang-Yan Wang, Hans M
Published in: Nature Genetics, Issue 51/6, 2019, Page(s) 990-998, ISSN 1061-4036
DOI: 10.1038/s41588-019-0413-z

Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers

Author(s): Sandra Schick, André F. Rendeiro, Kathrin Runggatscher, Anna Ringler, Bernd Boidol, Melanie Hinkel, Peter Májek, Loan Vulliard, Thomas Penz, Katja Parapatics, Christian Schmidl, Jörg Menche, Guido Boehmelt, Mark Petronczki, André C. Müller, Christoph Bock, Stefan Kubicek
Published in: Nature Genetics, Issue 51/9, 2019, Page(s) 1399-1410, ISSN 1061-4036
DOI: 10.1038/s41588-019-0477-9

A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugs

Author(s): Enrico Girardi, Adrián César-Razquin, Sabrina Lindinger, Konstantinos Papakostas, Justyna Konecka, Jennifer Hemmerich, Stefanie Kickinger, Felix Kartnig, Bettina Gürtl, Kristaps Klavins, Vitaly Sedlyarov, Alvaro Ingles-Prieto, Giuseppe Fiume, Anna Koren, Charles-Hugues Lardeau, Richard Kumaran Kandasamy, Stefan Kubicek, Gerhard F. Ecker, Giulio Superti-Furga
Published in: Nature Chemical Biology, Issue 16/4, 2020, Page(s) 469-478, ISSN 1552-4450
DOI: 10.1038/s41589-020-0483-3

Pooled protein tagging, cellular imaging, and in situ sequencing for monitoring drug action in real time

Author(s): Andreas Reicher, Anna Koren, Stefan Kubicek
Published in: Genome Research, Issue 30, 2020, Page(s) 1846-1855, ISSN 1088-9051
DOI: 10.1101/gr.261503.120