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Chromatin-localized central metabolism regulating gene expression and cell identity

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Publications

Acute BAF perturbation causes immediate changes in chromatin accessibility

Author(s): Sandra Schick, Sarah Grosche, Katharina Eva Kohl, Danica Drpic, Martin G. Jaeger, Nara C. Marella, Hana Imrichova, Jung-Ming G. Lin, Gerald Hofstätter, Michael Schuster, André F. Rendeiro, Anna Koren, Mark Petronczki, Christoph Bock, André C. Müller, Georg E. Winter, Stefan Kubicek
Published in: Nature Genetics, 53/3, 2021, Page(s) 269-278, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-021-00777-3

Single-cell RNA-seq with spike-in cells enables accurate quantification of cell-specific drug effects in pancreatic islets

Author(s): Brenda Marquina-Sanchez, Nikolaus Fortelny, Matthias Farlik, Andhira Vieira, Patrick Collombat, Christoph Bock, Stefan Kubicek
Published in: Genome Biology, 21(1), 2020, Page(s) 106, ISSN 1474-760X
Publisher: Biomed Central
DOI: 10.1186/s13059-020-02006-2

Cell-surface SLC nucleoside transporters and purine levels modulate BRD4-dependent chromatin states

Author(s): Kai-Chun Li, Enrico Girardi, Felix Kartnig, Sarah Grosche, Tea Pemovska, Johannes W. Bigenzahn, Ulrich Goldmann, Vitaly Sedlyarov, Ariel Bensimon, Sandra Schick, Jung-Ming G. Lin, Bettina Gürtl, Daniela Reil, Kristaps Klavins, Stefan Kubicek, Sara Sdelci, Giulio Superti-Furga
Published in: Nature Metabolism, 3/5, 2021, Page(s) 651-664, ISSN 2522-5812
Publisher: Nature Metabolism
DOI: 10.1038/s42255-021-00386-8

Therapeutic targeting of chromatin: Status and opportunities

Author(s): Marton Siklos, Stefan Kubicek
Published in: The FEBS Journal, 2021, ISSN 1742-464X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/febs.15966

MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation

Author(s): Sara Sdelci, André F. Rendeiro, Philipp Rathert, Wanhui You, Jung-Ming G. Lin, Anna Ringler, Gerald Hofstätter, Herwig P. Moll, Bettina Gürtl, Matthias Farlik, Sandra Schick, Freya Klepsch, Matthew Oldach, Pisanu Buphamalai, Fiorella Schischlik, Peter Májek, Katja Parapatics, Christian Schmidl, Michael Schuster, Thomas Penz, Dennis L. Buckley, Otto Hudecz, Richard Imre, Shuang-Yan Wang, Hans M
Published in: Nature Genetics, 51/6, 2019, Page(s) 990-998, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-019-0413-z

Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers

Author(s): Sandra Schick, André F. Rendeiro, Kathrin Runggatscher, Anna Ringler, Bernd Boidol, Melanie Hinkel, Peter Májek, Loan Vulliard, Thomas Penz, Katja Parapatics, Christian Schmidl, Jörg Menche, Guido Boehmelt, Mark Petronczki, André C. Müller, Christoph Bock, Stefan Kubicek
Published in: Nature Genetics, 51/9, 2019, Page(s) 1399-1410, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-019-0477-9

A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugs

Author(s): Enrico Girardi, Adrián César-Razquin, Sabrina Lindinger, Konstantinos Papakostas, Justyna Konecka, Jennifer Hemmerich, Stefanie Kickinger, Felix Kartnig, Bettina Gürtl, Kristaps Klavins, Vitaly Sedlyarov, Alvaro Ingles-Prieto, Giuseppe Fiume, Anna Koren, Charles-Hugues Lardeau, Richard Kumaran Kandasamy, Stefan Kubicek, Gerhard F. Ecker, Giulio Superti-Furga
Published in: Nature Chemical Biology, 16/4, 2020, Page(s) 469-478, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-020-0483-3

Pooled protein tagging, cellular imaging, and in situ sequencing for monitoring drug action in real time

Author(s): Andreas Reicher, Anna Koren, Stefan Kubicek
Published in: Genome Research, 30, 2020, Page(s) 1846-1855, ISSN 1088-9051
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.261503.120